MARK1 regulates dendritic spine morphogenesis and cognitive functions in vivo
Exp Neurol. 2024 Mar 12:114752. doi: 10.1016/j.expneurol.2024.114752. Online ahead of print.ABSTRACTDendritic spines play a pivotal role in synaptic communication and are crucial for learning and memory processes. Abnormalities in spine morphology and plasticity are observed in neurodevelopmental and neuropsychiatric disorders, yet the underlying signaling mechanisms remain poorly understood. The microtubule affinity regulating kinase 1 (MARK1) has been implicated in neurodevelopmental disorders, and the MARK1 gene shows accelerated evolution in the human lineage suggesting a role in cognition. However, the in vivo role of...
Source: Experimental Neurology - March 14, 2024 Category: Neurology Authors: Emily C Kelly-Castro Rebecca Shear Ankitha H Dindigal Maitreyee Bhagwat Huaye Zhang Source Type: research
The role of dorsolateral striatum in the effects of deep cerebellar stimulation-mediated motor recovery following ischemic stroke in rodents
In this study, we compared the motor rehabilitative effects of deep cerebellar stimulation in two rodent models of cerebral ischemia: a) cortical ischemia; and b) combined striatal and cortical ischemia. All animals underwent the same procedures, including implantation of the electrodes and tethered connections for stimulation. Both experimental groups received four weeks of continuous lateral cerebellar nucleus (LCN) DBS and each was paired with a no stimulation, sham, group. Fine motor function was indexed using the pasta matrix task. Brain tissue was harvested for histology and immunohistochemical analyses. In the corti...
Source: Experimental Neurology - March 14, 2024 Category: Neurology Authors: Hugh H Chan Nicole D Mathews Hemen Khanna Nymisha Mandava Olivia Hogue Andre G Machado Kenneth B Baker Source Type: research
Characterization of the intrahippocampal kainic acid model in female mice with a special focus on seizure suppression by antiseizure medications
Exp Neurol. 2024 Mar 11;376:114749. doi: 10.1016/j.expneurol.2024.114749. Online ahead of print.ABSTRACTDespite special challenges in the medical treatment of women with epilepsy, in particular preclinical animal studies were focused on males for decades and females have only recently moved into the focus of scientific interest. The intrahippocampal kainic acid (IHKA) mouse model of temporal lobe epilepsy (TLE) is one of the most studied models in males reproducing electroencephalographic (EEG) and histopathological features of human TLE. Hippocampal paroxysmal discharges (HPDs) were described as drug resistant focal seizu...
Source: Experimental Neurology - March 11, 2024 Category: Neurology Authors: Melanie Widmann Andreas Lieb Barbara Fogli Angela Steck Anna Mutti Christoph Schwarzer Source Type: research
Characterization of the intrahippocampal kainic acid model in female mice with a special focus on seizure suppression by antiseizure medications
Exp Neurol. 2024 Mar 9:114749. doi: 10.1016/j.expneurol.2024.114749. Online ahead of print.ABSTRACTDespite special challenges in the medical treatment of women with epilepsy, in particular preclinical animal studies were focused on males for decades and females have only recently moved into the focus of scientific interest. The intrahippocampal kainic acid (IHKA) mouse model of temporal lobe epilepsy (TLE) is one of the most studied models in males reproducing electroencephalographic (EEG) and histopathological features of human TLE. Hippocampal paroxysmal discharges (HPDs) were described as drug resistant focal seizures i...
Source: Experimental Neurology - March 11, 2024 Category: Neurology Authors: Melanie Widmann Andreas Lieb Barbara Fogli Angela Steck Anna Mutti Christoph Schwarzer Source Type: research
Characterization of the intrahippocampal kainic acid model in female mice with a special focus on seizure suppression by antiseizure medications
Exp Neurol. 2024 Mar 9:114749. doi: 10.1016/j.expneurol.2024.114749. Online ahead of print.ABSTRACTDespite special challenges in the medical treatment of women with epilepsy, in particular preclinical animal studies were focused on males for decades and females have only recently moved into the focus of scientific interest. The intrahippocampal kainic acid (IHKA) mouse model of temporal lobe epilepsy (TLE) is one of the most studied models in males reproducing electroencephalographic (EEG) and histopathological features of human TLE. Hippocampal paroxysmal discharges (HPDs) were described as drug resistant focal seizures i...
Source: Experimental Neurology - March 11, 2024 Category: Neurology Authors: Melanie Widmann Andreas Lieb Barbara Fogli Angela Steck Anna Mutti Christoph Schwarzer Source Type: research
Floralozone regulates MiR-7a-5p expression through AMPK α2 activation to improve cognitive dysfunction in vascular dementia
CONCLUSION: Floralozone could regulate miR-7a-5p expression level by activating the protein expression of AMPKα2, control the protein expression of TRPM2 and NR2B, improve the morphology and structure of hippocampus neurons, reduce the apoptosis of hippocampus neurons, promote neurogenesis and improve the cognitive dysfunction.PMID:38458310 | DOI:10.1016/j.expneurol.2024.114748 (Source: Experimental Neurology)
Source: Experimental Neurology - March 8, 2024 Category: Neurology Authors: Yu-Ting Song Shan-Shan Li Chun-Yan Chao None Shuang-Guo Gui-Zi Chen Shuang-Xi Wang Ming-Xiang Zhang Ya-Ling Yin Peng Li Source Type: research
Floralozone regulates MiR-7a-5p expression through AMPK α2 activation to improve cognitive dysfunction in vascular dementia
CONCLUSION: Floralozone could regulate miR-7a-5p expression level by activating the protein expression of AMPKα2, control the protein expression of TRPM2 and NR2B, improve the morphology and structure of hippocampus neurons, reduce the apoptosis of hippocampus neurons, promote neurogenesis and improve the cognitive dysfunction.PMID:38458310 | DOI:10.1016/j.expneurol.2024.114748 (Source: Experimental Neurology)
Source: Experimental Neurology - March 8, 2024 Category: Neurology Authors: Yu-Ting Song Shan-Shan Li Chun-Yan Chao None Shuang-Guo Gui-Zi Chen Shuang-Xi Wang Ming-Xiang Zhang Ya-Ling Yin Peng Li Source Type: research
Floralozone regulates MiR-7a-5p expression through AMPK α2 activation to improve cognitive dysfunction in vascular dementia
CONCLUSION: Floralozone could regulate miR-7a-5p expression level by activating the protein expression of AMPKα2, control the protein expression of TRPM2 and NR2B, improve the morphology and structure of hippocampus neurons, reduce the apoptosis of hippocampus neurons, promote neurogenesis and improve the cognitive dysfunction.PMID:38458310 | DOI:10.1016/j.expneurol.2024.114748 (Source: Experimental Neurology)
Source: Experimental Neurology - March 8, 2024 Category: Neurology Authors: Yu-Ting Song Shan-Shan Li Chun-Yan Chao None Shuang-Guo Gui-Zi Chen Shuang-Xi Wang Ming-Xiang Zhang Ya-Ling Yin Peng Li Source Type: research
Corrigendum to 'Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats' [Experimental Neurology 371 (2024) 114585]
Exp Neurol. 2024 Mar 6:114747. doi: 10.1016/j.expneurol.2024.114747. Online ahead of print.NO ABSTRACTPMID:38448282 | DOI:10.1016/j.expneurol.2024.114747 (Source: Experimental Neurology)
Source: Experimental Neurology - March 6, 2024 Category: Neurology Authors: Chengmei Sun Muhammad Saif Ur Rahman Budbazar Enkhjargal Jianhua Peng Keren Zhou Zhiyi Xie Lingyun Wu Tongyu Zhang Qiquan Zhu Jiping Tang Yujia Zeng John H Zhang Shanshan Xu Source Type: research
Corrigendum to 'Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats' [Experimental Neurology 371 (2024) 114585]
Exp Neurol. 2024 Mar 6:114747. doi: 10.1016/j.expneurol.2024.114747. Online ahead of print.NO ABSTRACTPMID:38448282 | DOI:10.1016/j.expneurol.2024.114747 (Source: Experimental Neurology)
Source: Experimental Neurology - March 6, 2024 Category: Neurology Authors: Chengmei Sun Muhammad Saif Ur Rahman Budbazar Enkhjargal Jianhua Peng Keren Zhou Zhiyi Xie Lingyun Wu Tongyu Zhang Qiquan Zhu Jiping Tang Yujia Zeng John H Zhang Shanshan Xu Source Type: research
Lipopolysaccharide-induced intestinal inflammation on AIM2-mediated pyroptosis in the brain of rats with cerebral small vessel disease
This study investigated whether lipopolysaccharide-induced intestinal inflammation enhanced the level of pyroptosis in the brain of rats with CSVD. The bilateral carotid artery occlusion (BCAO) model was selected as the object of study. Firstly, behavioral tests and Hematoxylin-eosin staining (HE staining) were performed to determine whether the model was successful, and then the AIM2 inflammasome and pyroptosis indexes (AIM2, ASC, Caspase-1, IL-1β, GSDMD, N-GSDMD) in the brain were detected by Western blotting and Immunohistochemistry (IHC). Finally, a single intraperitoneal injection of lipopolysaccharide (LPS) was used...
Source: Experimental Neurology - March 1, 2024 Category: Neurology Authors: Huiping Xu Han Xiao Qiqiang Tang Source Type: research
Lipopolysaccharide-induced intestinal inflammation on AIM2-mediated pyroptosis in the brain of rats with cerebral small vessel disease
This study investigated whether lipopolysaccharide-induced intestinal inflammation enhanced the level of pyroptosis in the brain of rats with CSVD. The bilateral carotid artery occlusion (BCAO) model was selected as the object of study. Firstly, behavioral tests and Hematoxylin-eosin staining (HE staining) were performed to determine whether the model was successful, and then AIM2-mediated inflammasome and pyroptosis indexes(GSDMD、N-GSDMD)in brain tissue were detected by Western blotting and Immunohistochemistry. Finally, a single intraperitoneal injection of lipopolysaccharide (LPS) was used to induce intestinal inflamm...
Source: Experimental Neurology - March 1, 2024 Category: Neurology Authors: Huiping Xu Han Xiao Qiqiang Tang Source Type: research
Lipopolysaccharide-induced intestinal inflammation on AIM2-mediated pyroptosis in the brain of rats with cerebral small vessel disease
This study investigated whether lipopolysaccharide-induced intestinal inflammation enhanced the level of pyroptosis in the brain of rats with CSVD. The bilateral carotid artery occlusion (BCAO) model was selected as the object of study. Firstly, behavioral tests and Hematoxylin-eosin staining (HE staining) were performed to determine whether the model was successful, and then AIM2-mediated inflammasome and pyroptosis indexes(GSDMD、N-GSDMD)in brain tissue were detected by Western blotting and Immunohistochemistry. Finally, a single intraperitoneal injection of lipopolysaccharide (LPS) was used to induce intestinal inflamm...
Source: Experimental Neurology - March 1, 2024 Category: Neurology Authors: Huiping Xu Han Xiao Qiqiang Tang Source Type: research
Lipopolysaccharide-induced intestinal inflammation on AIM2-mediated pyroptosis in the brain of rats with cerebral small vessel disease
This study investigated whether lipopolysaccharide-induced intestinal inflammation enhanced the level of pyroptosis in the brain of rats with CSVD. The bilateral carotid artery occlusion (BCAO) model was selected as the object of study. Firstly, behavioral tests and Hematoxylin-eosin staining (HE staining) were performed to determine whether the model was successful, and then AIM2-mediated inflammasome and pyroptosis indexes(GSDMD、N-GSDMD)in brain tissue were detected by Western blotting and Immunohistochemistry. Finally, a single intraperitoneal injection of lipopolysaccharide (LPS) was used to induce intestinal inflamm...
Source: Experimental Neurology - March 1, 2024 Category: Neurology Authors: Huiping Xu Han Xiao Qiqiang Tang Source Type: research
BMSC-Exosomes attenuate ALP dysfunction by restoring lysosomal function via the mTOR/TFEB Axis to reduce cerebral ischemia-reperfusion injury
CONCLUSION: BMSC-Exos could attenuate ALP dysfunction by restoring lysosomal function after CIRI by inhibiting mTOR and then promoting TFEB nucleus translocation.PMID:38403042 | DOI:10.1016/j.expneurol.2024.114726 (Source: Experimental Neurology)
Source: Experimental Neurology - February 25, 2024 Category: Neurology Authors: Haining Liu Chen Li Xiaofeng Zhang Hui Chen Qi Zhang Yuting Zeng Shuqi Zheng Jihua Zou Yijin Zhao Xiaoyan Zheng Guozhi Huang Qing Zeng Source Type: research
