Axonal injury mediated by neuronal p75NTR/TRAF6/JNK pathway contributes to cognitive impairment after repetitive mTBI
In this study, we showed that after rmTBI, the activation of neuronal p75NTR signaling contributes to abnormal axonal morphology and impaired axonal transport, which further leads to cognitive dysfunction in mice. By neuron-specific knockdown of p75NTR or treatment with p75NTR inhibitor LM11A-31, we observed better recovery of axonal integrity and cognitive function after brain trauma. Further analysis revealed that p75NTR relies on its adaptor protein TRAF6 to activate downstream signaling via TAK1 and JNK. Overall, our results provide novel insight into the role of neuronal p75NTR in axonal injury and suggest that p75NTR...
Source: Experimental Neurology - November 29, 2023 Category: Neurology Authors: Gang Liu Meijun He Chaoran Wu Pin Lv Hao Sun Heng Wang Xiaoyan Xin Hong Liao Source Type: research

Bone marrow mesenchymal stem cells therapy regulates sphingolipid and glycerophospholipid metabolism to promote neurological recovery in stroke rats: A metabolomics analysis
In conclusion, our study provides novel insight into the potential mechanisms of BMSCs treatment in stroke and sheds light on the possible clinical translation of BMSCs.PMID:38029808 | DOI:10.1016/j.expneurol.2023.114619 (Source: Experimental Neurology)
Source: Experimental Neurology - November 29, 2023 Category: Neurology Authors: Shixin Xu Aiqin Zhong Yunsha Zhang Linna Zhao Yuying Guo Xiaodan Bai Penglin Yin Shengyu Hua Source Type: research

Mild traumatic brain injury in Drosophila melanogaster alters reactive oxygen and nitrogen species in a sex-dependent manner
Exp Neurol. 2023 Nov 27:114621. doi: 10.1016/j.expneurol.2023.114621. Online ahead of print.ABSTRACTTraumatic brain injury (TBI) is an outside force causing a modification in brain function and/or structural brain pathology that upregulates brain inducible nitric oxide synthase (iNOS), instigating increased levels of nitric oxide activity which is implicated in secondary pathology leading to behavioral deficits (Hall et al., 2012; Garry et al., 2015; Kozlov et al., 2017). In mammals, TBI-induced NO production activates an immune response and potentiates metabolic crisis through mitochondrial dysfunction coupled with vascul...
Source: Experimental Neurology - November 29, 2023 Category: Neurology Authors: T Bucky Jones Tracy Mackey Amber N Juba Kush Amin Amruth Atyam Madison McDole Jarod Yancy Theresa Currier Thomas Lori M Buhlman Source Type: research

Sleep loss, caffeine, sleep aids and sedation modify brain abnormalities of mild traumatic brain injury
Exp Neurol. 2023 Nov 27:114620. doi: 10.1016/j.expneurol.2023.114620. Online ahead of print.ABSTRACTLittle evidence exists about how mild traumatic brain injury (mTBI) is affected by commonly encountered exposures of sleep loss, sleep aids, and caffeine that might be potential therapeutic opportunities. In addition, while propofol sedation is administered in severe TBI, its potential utility in mild TBI is unclear. Each of these exposures is known to have pronounced effects on cerebral metabolism and blood flow and neurochemistry. We hypothesized that they each interact with cerebral metabolic dynamics post-injury and chan...
Source: Experimental Neurology - November 29, 2023 Category: Neurology Authors: Carol A Everson Aniko Szabo Cade Plyer Thomas A Hammeke Brian D Stemper Mathew D Budde Source Type: research

Mitochondrial iron dyshomeostasis and its potential as a therapeutic target for Parkinson's disease
Exp Neurol. 2023 Nov 23;372:114614. doi: 10.1016/j.expneurol.2023.114614. Online ahead of print.ABSTRACTAbnormal iron accumulation has been implicated in the etiology of Parkinson's disease (PD). Understanding how iron damages dopaminergic neurons in the substantia nigra (SN) of PD is particularly important for developing targeted neurotherapeutic strategies for the disease. However, it is still not fully understood how excess iron contributes to the neurodegeneration of dopaminergic neurons in PD. There has been increased attention on mitochondrial iron dyshomeostasis, iron-induced mitochondrial dysfunction and ferroptosi...
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Zhixin Xiao Xiaoya Wang Xuening Pan Junxia Xie Huamin Xu Source Type: research

Neonatal di-(2-ethylhexyl)phthalate exposure induces permanent alterations in secretory CRH neuron characteristics in the hypothalamus paraventricular region of adult male rats
Exp Neurol. 2023 Nov 23:114616. doi: 10.1016/j.expneurol.2023.114616. Online ahead of print.ABSTRACTCorticotrophin-releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) play a critical role in the modulation of the hypothalamic-pituitary-adrenal (HPA) axis. Early-life exposure to di-(2-ethylhexyl) phthalate (DEHP) has been associated with an increased risk of developing psychiatric disorders in adulthood. The present work was designed to explore the impact of neonatal exposure to DEHP on adult PVN CRH neuronal activity. DEHP or vehicle was given to male rat pups from PND16 to PND22. Then, anxiet...
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Li Li Ying Su Siyuan Wang Chengyu Wang Naqi Ruan Zhiyan Hu Xin Cheng Jiajia Chen Kaiming Yuan Peijun Li Pei Fan Source Type: research

Cognitive-exercise dual-task attenuates chronic cerebral ischemia-induced cognitive impairment by activating cAMP/PKA pathway through inhibiting EphrinA3/EphA4
CONCLUSION: Cognitive-exercise dual-task can significantly improve the cognitive impairment induced by CCI, and this effect may be better than that of the cognitive or exercise single-task intervention. The improvement may be related to the inhibition of EphrinA3/EphA4, followed by activation of the cAMP/PKA pathway.PMID:38007209 | DOI:10.1016/j.expneurol.2023.114617 (Source: Experimental Neurology)
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Ziman Zhu Xue Tao Tengteng Dai Jilin Wu Conglin Han Peiling Huang Weijun Gong Source Type: research

Mitochondrial iron dyshomeostasis and its potential as a therapeutic target for Parkinson's disease
Exp Neurol. 2023 Nov 23:114614. doi: 10.1016/j.expneurol.2023.114614. Online ahead of print.ABSTRACTAbnormal iron accumulation has been implicated in the etiology of Parkinson's disease (PD). Understanding how iron damages dopaminergic neurons in the substantia nigra (SN) of PD is particularly important for developing targeted neurotherapeutic strategies for the disease. However, it is still not fully understood how excess iron contributes to the neurodegeneration of dopaminergic neurons in PD. There has been increased attention on mitochondrial iron dyshomeostasis, iron-induced mitochondrial dysfunction and ferroptosis in...
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Zhixin Xiao Xiaoya Wang Xuening Pan Junxia Xie Huamin Xu Source Type: research

Neonatal di-(2-ethylhexyl)phthalate exposure induces permanent alterations in secretory CRH neuron characteristics in the hypothalamus paraventricular region of adult male rats
Exp Neurol. 2023 Nov 23:114616. doi: 10.1016/j.expneurol.2023.114616. Online ahead of print.ABSTRACTCorticotrophin-releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) play a critical role in the modulation of the hypothalamic-pituitary-adrenal (HPA) axis. Early-life exposure to di-(2-ethylhexyl) phthalate (DEHP) has been associated with an increased risk of developing psychiatric disorders in adulthood. The present work was designed to explore the impact of neonatal exposure to DEHP on adult PVN CRH neuronal activity. DEHP or vehicle was given to male rat pups from PND16 to PND22. Then, anxiet...
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Li Li Ying Su Siyuan Wang Chengyu Wang Naqi Ruan Zhiyan Hu Xin Cheng Jiajia Chen Kaiming Yuan Peijun Li Pei Fan Source Type: research

Cognitive-exercise dual-task attenuates chronic cerebral ischemia-induced cognitive impairment by activating cAMP/PKA pathway through inhibiting EphrinA3/EphA4
CONCLUSION: Cognitive-exercise dual-task can significantly improve the cognitive impairment induced by CCI, and this effect may be better than that of the cognitive or exercise single-task intervention. The improvement may be related to the inhibition of EphrinA3/EphA4, followed by activation of the cAMP/PKA pathway.PMID:38007209 | DOI:10.1016/j.expneurol.2023.114617 (Source: Experimental Neurology)
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Ziman Zhu Xue Tao Tengteng Dai Jilin Wu Conglin Han Peiling Huang Weijun Gong Source Type: research

Mitochondrial iron dyshomeostasis and its potential as a therapeutic target for Parkinson's disease
Exp Neurol. 2023 Nov 23:114614. doi: 10.1016/j.expneurol.2023.114614. Online ahead of print.ABSTRACTAbnormal iron accumulation has been implicated in the etiology of Parkinson's disease (PD). Understanding how iron damages dopaminergic neurons in the substantia nigra (SN) of PD is particularly important for developing targeted neurotherapeutic strategies for the disease. However, it is still not fully understood how excess iron contributes to the neurodegeneration of dopaminergic neurons in PD. There has been increased attention on mitochondrial iron dyshomeostasis, iron-induced mitochondrial dysfunction and ferroptosis in...
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Zhixin Xiao Xiaoya Wang Xuening Pan Junxia Xie Huamin Xu Source Type: research

Neonatal di-(2-ethylhexyl)phthalate exposure induces permanent alterations in secretory CRH neuron characteristics in the hypothalamus paraventricular region of adult male rats
Exp Neurol. 2023 Nov 23:114616. doi: 10.1016/j.expneurol.2023.114616. Online ahead of print.ABSTRACTCorticotrophin-releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) play a critical role in the modulation of the hypothalamic-pituitary-adrenal (HPA) axis. Early-life exposure to di-(2-ethylhexyl) phthalate (DEHP) has been associated with an increased risk of developing psychiatric disorders in adulthood. The present work was designed to explore the impact of neonatal exposure to DEHP on adult PVN CRH neuronal activity. DEHP or vehicle was given to male rat pups from PND16 to PND22. Then, anxiet...
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Li Li Ying Su Siyuan Wang Chengyu Wang Naqi Ruan Zhiyan Hu Xin Cheng Jiajia Chen Kaiming Yuan Peijun Li Pei Fan Source Type: research

Cognitive-exercise dual-task attenuates chronic cerebral ischemia-induced cognitive impairment by activating cAMP/PKA pathway through inhibiting EphrinA3/EphA4
CONCLUSION: Cognitive-exercise dual-task can significantly improve the cognitive impairment induced by CCI, and this effect may be better than that of the cognitive or exercise single-task intervention. The improvement may be related to the inhibition of EphrinA3/EphA4, followed by activation of the cAMP/PKA pathway.PMID:38007209 | DOI:10.1016/j.expneurol.2023.114617 (Source: Experimental Neurology)
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Ziman Zhu Xue Tao Tengteng Dai Jilin Wu Conglin Han Peiling Huang Weijun Gong Source Type: research

Mitochondrial iron dyshomeostasis and its potential as a therapeutic target for Parkinson's disease
Exp Neurol. 2023 Nov 23:114614. doi: 10.1016/j.expneurol.2023.114614. Online ahead of print.ABSTRACTAbnormal iron accumulation has been implicated in the etiology of Parkinson's disease (PD). Understanding how iron damages dopaminergic neurons in the substantia nigra (SN) of PD is particularly important for developing targeted neurotherapeutic strategies for the disease. However, it is still not fully understood how excess iron contributes to the neurodegeneration of dopaminergic neurons in PD. There has been increased attention on mitochondrial iron dyshomeostasis, iron-induced mitochondrial dysfunction and ferroptosis in...
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Zhixin Xiao Xiaoya Wang Xuening Pan Junxia Xie Huamin Xu Source Type: research

Neonatal di-(2-ethylhexyl)phthalate exposure induces permanent alterations in secretory CRH neuron characteristics in the hypothalamus paraventricular region of adult male rats
Exp Neurol. 2023 Nov 23:114616. doi: 10.1016/j.expneurol.2023.114616. Online ahead of print.ABSTRACTCorticotrophin-releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) play a critical role in the modulation of the hypothalamic-pituitary-adrenal (HPA) axis. Early-life exposure to di-(2-ethylhexyl) phthalate (DEHP) has been associated with an increased risk of developing psychiatric disorders in adulthood. The present work was designed to explore the impact of neonatal exposure to DEHP on adult PVN CRH neuronal activity. DEHP or vehicle was given to male rat pups from PND16 to PND22. Then, anxiet...
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Li Li Ying Su Siyuan Wang Chengyu Wang Naqi Ruan Zhiyan Hu Xin Cheng Jiajia Chen Kaiming Yuan Peijun Li Pei Fan Source Type: research