High-fat diet induces cognitive impairment through repression of SIRT1/AMPK-mediated autophagy
CONCLUSIONS: HFD may inhibit the expression of SIRT1/AMPK pathway and disrupt autophagy flux, and result in tau hyperphosphorylation and synaptic dysfunction during aging, which ultimately lead to cognitive decline.PMID:37898395 | DOI:10.1016/j.expneurol.2023.114591 (Source: Experimental Neurology)
Source: Experimental Neurology - October 28, 2023 Category: Neurology Authors: Wenmin Yi Fei Chen Minghao Yuan Chuanling Wang Shengyuan Wang Jie Wen Qian Zou Yinshuang Pu Zhiyou Cai Source Type: research
Hydrogen sulfide ameliorates lipopolysaccharide-induced anxiety-like behavior by inhibiting checkpoint kinase 1 activation in the hippocampus of mice
Exp Neurol. 2023 Oct 26:114586. doi: 10.1016/j.expneurol.2023.114586. Online ahead of print.ABSTRACTHydrogen sulfide (H2S), an endogenous gasotransmitter, exhibits the anxiolytic roles through its anti-inflammatory effects, although its underlying mechanisms remain largely elusive. Emerging evidence has documented that cell cycle checkpoint kinase 1 (Chk1)-regulated DNA damage plays an important role in the neurodegenerative diseases; however, there are few relevant reports on the research of Chk1 in neuropsychiatric diseases. Here, we aimed to investigate the regulatory role of H2S on Chk1 in lipopolysaccharide (LPS)-indu...
Source: Experimental Neurology - October 28, 2023 Category: Neurology Authors: Yangping Shentu Mengfan Chen Hui Wang Xiaotong Du Wenjing Zhang Guizhen Xie Shaoyan Zhou Lu Ding Yun Zhu Min Zhu Nan Zhang Congkuo Du Jianshe Ma Ran Chen Jinge Yang Xiaofang Fan Yongsheng Gong Hongyu Zhang Junming Fan Source Type: research
High-fat diet induces cognitive impairment through repression of SIRT1/AMPK-mediated autophagy
CONCLUSIONS: HFD may inhibit the expression of SIRT1/AMPK pathway and disrupt autophagy flux, and result in tau hyperphosphorylation and synaptic dysfunction during aging, which ultimately lead to cognitive decline.PMID:37898395 | DOI:10.1016/j.expneurol.2023.114591 (Source: Experimental Neurology)
Source: Experimental Neurology - October 28, 2023 Category: Neurology Authors: Wenmin Yi Fei Chen Minghao Yuan Chuanling Wang Shengyuan Wang Jie Wen Qian Zou Yinshuang Pu Zhiyou Cai Source Type: research
Hydrogen sulfide ameliorates lipopolysaccharide-induced anxiety-like behavior by inhibiting checkpoint kinase 1 activation in the hippocampus of mice
Exp Neurol. 2023 Oct 26:114586. doi: 10.1016/j.expneurol.2023.114586. Online ahead of print.ABSTRACTHydrogen sulfide (H2S), an endogenous gasotransmitter, exhibits the anxiolytic roles through its anti-inflammatory effects, although its underlying mechanisms remain largely elusive. Emerging evidence has documented that cell cycle checkpoint kinase 1 (Chk1)-regulated DNA damage plays an important role in the neurodegenerative diseases; however, there are few relevant reports on the research of Chk1 in neuropsychiatric diseases. Here, we aimed to investigate the regulatory role of H2S on Chk1 in lipopolysaccharide (LPS)-indu...
Source: Experimental Neurology - October 28, 2023 Category: Neurology Authors: Yangping Shentu Mengfan Chen Hui Wang Xiaotong Du Wenjing Zhang Guizhen Xie Shaoyan Zhou Lu Ding Yun Zhu Min Zhu Nan Zhang Congkuo Du Jianshe Ma Ran Chen Jinge Yang Xiaofang Fan Yongsheng Gong Hongyu Zhang Junming Fan Source Type: research
Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats
CONCLUSION: OPN attenuates inflammatory responses after SAH by promoting an anti-inflammatory microglial state, potentially mediated through the integrin-FAK-STAT3 and NF-κB signaling pathways.PMID:37884185 | DOI:10.1016/j.expneurol.2023.114585 (Source: Experimental Neurology)
Source: Experimental Neurology - October 26, 2023 Category: Neurology Authors: Chengmei Sun Muhammad Saif Ur Rahman Budbazar Enkhjargal Jianhua Peng Keren Zhou Zhiyi Xie Lingyun Wu Tongyu Zhang Qiquan Zhu Jiping Tang Yujia Zeng John H Zhang Shanshan Xu Source Type: research
