A new metal ion chelator attenuates human tau accumulation-induced neurodegeneration and memory deficits in mice
Exp Neurol. 2023 Dec 21:114657. doi: 10.1016/j.expneurol.2023.114657. Online ahead of print.ABSTRACTNeuronal neurofibrillary tangles containing Tau hyperphosphorylation proteins are a typical pathological marker of Alzheimer's disease (AD). The level of tangles in neurons correlates positively with severe dementia. However, how Tau induces cognitive dysfunction is still unknown, which leads to a lack of effective treatments for AD. Metal ions deposition occurs with tangles in AD brain autopsy. Reduced metal ion can improve the pathology of AD. To explore whether abnormally phosphorylated Tau causes metal ion deposition, we...
Source: Experimental Neurology - December 23, 2023 Category: Neurology Authors: Yue Zuo Hui-Ting Liu Lai-Biao Lin Rui-Zhu Yue Huan-Huan Liu Hong-Wei Wang Lu Wang Ruan-Ling Hou Wei-Zhen Liu Chang-Zheng Li Jian-Zhi Wang Peng Li Ya-Ling Yin Source Type: research
Ferrostatin-1 improves neurological impairment induced by ischemia/reperfusion injury in the spinal cord through ERK1/2/SP1/GPX4
In conclusion, our results indicate that Fer-1 inhibited ferroptosis in spinal cord anterior horn neurons, improving neurological impairment and BSCB damage after SCIRI through the ERK1/2/SP1/GPX4 signaling pathway in rats.PMID:38141803 | DOI:10.1016/j.expneurol.2023.114659 (Source: Experimental Neurology)
Source: Experimental Neurology - December 23, 2023 Category: Neurology Authors: Sidan Liu Fengshou Chen Jie Han Limei Wang Yan Dong Source Type: research
Research progress on post-stroke depression
This article summarizes the mechanism research, animal models and related treatments of PSD. Further improvements are needed in the screening of research subjects and the construction of animal models in the study of PSD. At the same time, in the study of the mechanism of PSD, we need to consider the interaction between multiple systems. The treatment of PSD requires more careful consideration. This can help us to find something new in the study of the mechanism of complex PSD, which provides a new direction for us to develop new treatment delivery.PMID:38141804 | DOI:10.1016/j.expneurol.2023.114660 (Source: Experimental Neurology)
Source: Experimental Neurology - December 23, 2023 Category: Neurology Authors: Hui Zhou Yu-Jiao Wei Guang-Yao Xie Source Type: research
Transcutaneous electrical acupoint stimulation attenuated neuroinflammation and oxidative stress by activating SIRT1-induced signaling pathway in MCAO/R rat models
CONCLUSIONS: In summary, these findings clearly suggested that TEAS attenuated brain damage by suppressing apoptosis, oxidative stress and neuroinflammation through modulating SIRT1/FOXO3a and SIRT1/BRCC3/NLRP3 signaling pathways following ischemic stroke, which can be a promising treatment for stroke patients.PMID:38141805 | DOI:10.1016/j.expneurol.2023.114658 (Source: Experimental Neurology)
Source: Experimental Neurology - December 23, 2023 Category: Neurology Authors: Zixuan Tan Fang Dong Linyu Wu Guangyu Xu Feng Zhang Source Type: research
Intranasal administration of recombinant prosaposin attenuates neuronal apoptosis through GPR37/PI3K/Akt/ASK1 pathway in MCAO rats
In conclusion, rPSAP attenuated neuronal apoptosis and improved neurological function through GPR37/PI3K/Akt/ASK1 pathway after MCAO in rats. Therefore, further exploration of PSAP as a potential treatment option in ischemic stroke is warranted.PMID:38114054 | DOI:10.1016/j.expneurol.2023.114656 (Source: Experimental Neurology)
Source: Experimental Neurology - December 19, 2023 Category: Neurology Authors: Jing Yu Jinlan Li Nathanael Matei Wenna Wang Lihui Tang Jinwei Pang Xue Li Lili Fang Jiping Tang John H Zhang Min Yan Source Type: research
Intranasal administration of recombinant prosaposin attenuates neuronal apoptosis through GPR37/PI3K/Akt/ASK1 pathway in MCAO rats
In conclusion, rPSAP attenuated neuronal apoptosis and improved neurological function through GPR37/PI3K/Akt/ASK1 pathway after MCAO in rats. Therefore, further exploration of PSAP as a potential treatment option in ischemic stroke is warranted.PMID:38114054 | DOI:10.1016/j.expneurol.2023.114656 (Source: Experimental Neurology)
Source: Experimental Neurology - December 19, 2023 Category: Neurology Authors: Jing Yu Jinlan Li Nathanael Matei Wenna Wang Lihui Tang Jinwei Pang Xue Li Lili Fang Jiping Tang John H Zhang Min Yan Source Type: research
Intranasal administration of recombinant prosaposin attenuates neuronal apoptosis through GPR37/PI3K/Akt/ASK1 pathway in MCAO rats
In conclusion, rPSAP attenuated neuronal apoptosis and improved neurological function through GPR37/PI3K/Akt/ASK1 pathway after MCAO in rats. Therefore, further exploration of PSAP as a potential treatment option in ischemic stroke is warranted.PMID:38114054 | DOI:10.1016/j.expneurol.2023.114656 (Source: Experimental Neurology)
Source: Experimental Neurology - December 19, 2023 Category: Neurology Authors: Jing Yu Jinlan Li Nathanael Matei Wenna Wang Lihui Tang Jinwei Pang Xue Li Lili Fang Jiping Tang John H Zhang Min Yan Source Type: research
Intranasal administration of recombinant prosaposin attenuates neuronal apoptosis through GPR37/PI3K/Akt/ASK1 pathway in MCAO rats
In conclusion, rPSAP attenuated neuronal apoptosis and improved neurological function through GPR37/PI3K/Akt/ASK1 pathway after MCAO in rats. Therefore, further exploration of PSAP as a potential treatment option in ischemic stroke is warranted.PMID:38114054 | DOI:10.1016/j.expneurol.2023.114656 (Source: Experimental Neurology)
Source: Experimental Neurology - December 19, 2023 Category: Neurology Authors: Jing Yu Jinlan Li Nathanael Matei Wenna Wang Lihui Tang Jinwei Pang Xue Li Lili Fang Jiping Tang John H Zhang Min Yan Source Type: research
Crosstalk between Nrf2 signaling pathway and inflammation in ischemic stroke: Mechanisms of action and therapeutic implications
Exp Neurol. 2023 Dec 16:114655. doi: 10.1016/j.expneurol.2023.114655. Online ahead of print.ABSTRACTOne of the major causes of long-term disability and mortality is ischemic stroke that enjoys limited treatment approaches. On the one hand, oxidative stress, induced by excessive generation of reactive oxygen species (ROS), plays a critical role in post-stroke inflammatory response. Increased ROS generation is one of the basic factors in the progression of stroke-induced neuroinflammation. Moreover, intravenous (IV) thrombolysis using recombinant tissue plasminogen activator (rtPA) as the only medication approved for patient...
Source: Experimental Neurology - December 18, 2023 Category: Neurology Authors: Negar Khassafi Abolfazl Azami Tameh Hamed Mirzaei Ali Rafat Shirin Barati Negin Khassafi Zeinab Vahidinia Source Type: research
Crosstalk between Nrf2 signaling pathway and inflammation in ischemic stroke: Mechanisms of action and therapeutic implications
Exp Neurol. 2023 Dec 16:114655. doi: 10.1016/j.expneurol.2023.114655. Online ahead of print.ABSTRACTOne of the major causes of long-term disability and mortality is ischemic stroke that enjoys limited treatment approaches. On the one hand, oxidative stress, induced by excessive generation of reactive oxygen species (ROS), plays a critical role in post-stroke inflammatory response. Increased ROS generation is one of the basic factors in the progression of stroke-induced neuroinflammation. Moreover, intravenous (IV) thrombolysis using recombinant tissue plasminogen activator (rtPA) as the only medication approved for patient...
Source: Experimental Neurology - December 18, 2023 Category: Neurology Authors: Negar Khassafi Abolfazl Azami Tameh Hamed Mirzaei Ali Rafat Shirin Barati Negin Khassafi Zeinab Vahidinia Source Type: research
Involvement of CKS1B in the anti-inflammatory effects of cannabidiol in experimental stroke models
Exp Neurol. 2023 Dec 15:114654. doi: 10.1016/j.expneurol.2023.114654. Online ahead of print.ABSTRACTWe have previously demonstrated that treatment with cannabidiol (CBD) ameliorates mitochondrial dysfunction and attenuates neuronal injury in rats following cerebral ischemia. However, the role of CBD in the progression of ischemic stroke-induced inflammation and the molecules involved remain unclear. Here, we found that CBD suppressed the production of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), reduced the activation of microglia, ameliorated mitochondrial deficits, and decreased the phosphorylation of ...
Source: Experimental Neurology - December 17, 2023 Category: Neurology Authors: Kechun Chen Bingtian Xu Xuan Xiao Lu Long Qian Zhao Zicen Fang Xingxing Tu Jiakang Wang Jiangping Xu Haitao Wang Source Type: research
TREK-1 inhibition promotes synaptic plasticity in the prelimbic cortex
Exp Neurol. 2023 Dec 14:114652. doi: 10.1016/j.expneurol.2023.114652. Online ahead of print.ABSTRACTSynaptic plasticity is one of the putative mechanisms involved in the maturation of the prefrontal cortex (PFC) during postnatal development. Early life stress (ELS) affects the shaping of cortical circuitries through impairment of synaptic plasticity supporting the onset of mood disorders. Growing evidence suggests that dysfunctional postnatal maturation of the prelimbic division (PL) of the PFC might be related to the emergence of depression. The potassium channel TREK-1 has attracted particular interest among many factors...
Source: Experimental Neurology - December 16, 2023 Category: Neurology Authors: Jos é Francis-Oliveira Guilherme Shigueto Vilar Higa Felipe Jos é Costa Viana Emily Cruvinel Estev ão Carlos Lima Fernando da Silva Borges Thais Zampieri Fernanda Pereira Rebello Henning Ulrich Roberto De Pasquale Source Type: research
Corrigendum to "Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease" [Experimental neurology 2023 May;363:114370]
Exp Neurol. 2023 Dec 15:114640. doi: 10.1016/j.expneurol.2023.114640. Online ahead of print.NO ABSTRACTPMID:38104017 | DOI:10.1016/j.expneurol.2023.114640 (Source: Experimental Neurology)
Source: Experimental Neurology - December 16, 2023 Category: Neurology Authors: Sara Corsi Simona Scheggi Alessandra Pardu Giulia Braccagni Donatella Caruso Lucia Cioffi Silvia Diviccaro Mauro Gentile Silvia Fanni Roberto Stancampiano Carla Gambarana Roberto Cosimo Melcangi Roberto Frau Manolo Carta Source Type: research
TREK-1 inhibition promotes synaptic plasticity in the prelimbic cortex
Exp Neurol. 2023 Dec 14:114652. doi: 10.1016/j.expneurol.2023.114652. Online ahead of print.ABSTRACTSynaptic plasticity is one of the putative mechanisms involved in the maturation of the prefrontal cortex (PFC) during postnatal development. Early life stress (ELS) affects the shaping of cortical circuitries through impairment of synaptic plasticity supporting the onset of mood disorders. Growing evidence suggests that dysfunctional postnatal maturation of the prelimbic division (PL) of the PFC might be related to the emergence of depression. The potassium channel TREK-1 has attracted particular interest among many factors...
Source: Experimental Neurology - December 16, 2023 Category: Neurology Authors: Jos é Francis-Oliveira Guilherme Shigueto Vilar Higa Felipe Jos é Costa Viana Emily Cruvinel Estev ão Carlos Lima Fernando da Silva Borges Thais Zampieri Fernanda Pereira Rebello Henning Ulrich Roberto De Pasquale Source Type: research
Corrigendum to "Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease" [Experimental neurology 2023 May;363:114370]
Exp Neurol. 2023 Dec 15:114640. doi: 10.1016/j.expneurol.2023.114640. Online ahead of print.NO ABSTRACTPMID:38104017 | DOI:10.1016/j.expneurol.2023.114640 (Source: Experimental Neurology)
Source: Experimental Neurology - December 16, 2023 Category: Neurology Authors: Sara Corsi Simona Scheggi Alessandra Pardu Giulia Braccagni Donatella Caruso Lucia Cioffi Silvia Diviccaro Mauro Gentile Silvia Fanni Roberto Stancampiano Carla Gambarana Roberto Cosimo Melcangi Roberto Frau Manolo Carta Source Type: research
