Corrigendum to "Compounds co-targeting kinases in axon regulatory pathways promote regeneration and behavioral recovery after spinal cord injury in mice" [Exp. Neurol. 355 (2022) 114117]
Exp Neurol. 2023 Dec 26:114669. doi: 10.1016/j.expneurol.2023.114669. Online ahead of print.NO ABSTRACTPMID:38151457 | DOI:10.1016/j.expneurol.2023.114669 (Source: Experimental Neurology)
Source: Experimental Neurology - December 27, 2023 Category: Neurology Authors: Kar Men Mah Wei Wu Hassan Al-Ali Yan Sun Qi Han Ying Ding Melissa Mu ñoz Xiao-Ming Xu Vance P Lemmon John L Bixby Source Type: research
Corrigendum to "Compounds co-targeting kinases in axon regulatory pathways promote regeneration and behavioral recovery after spinal cord injury in mice" [Exp. Neurol. 355 (2022) 114117]
Exp Neurol. 2023 Dec 26:114669. doi: 10.1016/j.expneurol.2023.114669. Online ahead of print.NO ABSTRACTPMID:38151457 | DOI:10.1016/j.expneurol.2023.114669 (Source: Experimental Neurology)
Source: Experimental Neurology - December 27, 2023 Category: Neurology Authors: Kar Men Mah Wei Wu Hassan Al-Ali Yan Sun Qi Han Ying Ding Melissa Mu ñoz Xiao-Ming Xu Vance P Lemmon John L Bixby Source Type: research
Corrigendum to "Compounds co-targeting kinases in axon regulatory pathways promote regeneration and behavioral recovery after spinal cord injury in mice" [Exp. Neurol. 355 (2022) 114117]
Exp Neurol. 2023 Dec 26:114669. doi: 10.1016/j.expneurol.2023.114669. Online ahead of print.NO ABSTRACTPMID:38151457 | DOI:10.1016/j.expneurol.2023.114669 (Source: Experimental Neurology)
Source: Experimental Neurology - December 27, 2023 Category: Neurology Authors: Kar Men Mah Wei Wu Hassan Al-Ali Yan Sun Qi Han Ying Ding Melissa Mu ñoz Xiao-Ming Xu Vance P Lemmon John L Bixby Source Type: research
Corrigendum to "Compounds co-targeting kinases in axon regulatory pathways promote regeneration and behavioral recovery after spinal cord injury in mice" [Exp. Neurol. 355 (2022) 114117]
Exp Neurol. 2023 Dec 26:114669. doi: 10.1016/j.expneurol.2023.114669. Online ahead of print.NO ABSTRACTPMID:38151457 | DOI:10.1016/j.expneurol.2023.114669 (Source: Experimental Neurology)
Source: Experimental Neurology - December 27, 2023 Category: Neurology Authors: Kar Men Mah Wei Wu Hassan Al-Ali Yan Sun Qi Han Ying Ding Melissa Mu ñoz Xiao-Ming Xu Vance P Lemmon John L Bixby Source Type: research
Corrigendum to "Compounds co-targeting kinases in axon regulatory pathways promote regeneration and behavioral recovery after spinal cord injury in mice" [Exp. Neurol. 355 (2022) 114117]
Exp Neurol. 2023 Dec 26:114669. doi: 10.1016/j.expneurol.2023.114669. Online ahead of print.NO ABSTRACTPMID:38151457 | DOI:10.1016/j.expneurol.2023.114669 (Source: Experimental Neurology)
Source: Experimental Neurology - December 27, 2023 Category: Neurology Authors: Kar Men Mah Wei Wu Hassan Al-Ali Yan Sun Qi Han Ying Ding Melissa Mu ñoz Xiao-Ming Xu Vance P Lemmon John L Bixby Source Type: research
The role of α-synuclein in exocytosis
Exp Neurol. 2023 Dec 24:114668. doi: 10.1016/j.expneurol.2023.114668. Online ahead of print.ABSTRACTThe pathogenesis of degeneration in Parkinson's disease (PD) remains poorly understood but multiple lines of evidence have converged on the presynaptic protein α-synuclein (αsyn). αSyn has been shown to regulate several cellular processes, however, its normal function remains poorly understood. In this review, we will specifically focus on its role in exocytosis.PMID:38147972 | DOI:10.1016/j.expneurol.2023.114668 (Source: Experimental Neurology)
Source: Experimental Neurology - December 26, 2023 Category: Neurology Authors: Gautam M Runwal Robert H Edwards Source Type: research
The role of α-synuclein in exocytosis
Exp Neurol. 2023 Dec 24:114668. doi: 10.1016/j.expneurol.2023.114668. Online ahead of print.ABSTRACTThe pathogenesis of degeneration in Parkinson's disease (PD) remains poorly understood but multiple lines of evidence have converged on the presynaptic protein α-synuclein (αsyn). αSyn has been shown to regulate several cellular processes, however, its normal function remains poorly understood. In this review, we will specifically focus on its role in exocytosis.PMID:38147972 | DOI:10.1016/j.expneurol.2023.114668 (Source: Experimental Neurology)
Source: Experimental Neurology - December 26, 2023 Category: Neurology Authors: Gautam M Runwal Robert H Edwards Source Type: research
A new metal ion chelator attenuates human tau accumulation-induced neurodegeneration and memory deficits in mice
Exp Neurol. 2023 Dec 21:114657. doi: 10.1016/j.expneurol.2023.114657. Online ahead of print.ABSTRACTNeuronal neurofibrillary tangles containing Tau hyperphosphorylation proteins are a typical pathological marker of Alzheimer's disease (AD). The level of tangles in neurons correlates positively with severe dementia. However, how Tau induces cognitive dysfunction is still unknown, which leads to a lack of effective treatments for AD. Metal ions deposition occurs with tangles in AD brain autopsy. Reduced metal ion can improve the pathology of AD. To explore whether abnormally phosphorylated Tau causes metal ion deposition, we...
Source: Experimental Neurology - December 23, 2023 Category: Neurology Authors: Yue Zuo Hui-Ting Liu Lai-Biao Lin Rui-Zhu Yue Huan-Huan Liu Hong-Wei Wang Lu Wang Ruan-Ling Hou Wei-Zhen Liu Chang-Zheng Li Jian-Zhi Wang Peng Li Ya-Ling Yin Source Type: research
Ferrostatin-1 improves neurological impairment induced by ischemia/reperfusion injury in the spinal cord through ERK1/2/SP1/GPX4
In conclusion, our results indicate that Fer-1 inhibited ferroptosis in spinal cord anterior horn neurons, improving neurological impairment and BSCB damage after SCIRI through the ERK1/2/SP1/GPX4 signaling pathway in rats.PMID:38141803 | DOI:10.1016/j.expneurol.2023.114659 (Source: Experimental Neurology)
Source: Experimental Neurology - December 23, 2023 Category: Neurology Authors: Sidan Liu Fengshou Chen Jie Han Limei Wang Yan Dong Source Type: research
Research progress on post-stroke depression
This article summarizes the mechanism research, animal models and related treatments of PSD. Further improvements are needed in the screening of research subjects and the construction of animal models in the study of PSD. At the same time, in the study of the mechanism of PSD, we need to consider the interaction between multiple systems. The treatment of PSD requires more careful consideration. This can help us to find something new in the study of the mechanism of complex PSD, which provides a new direction for us to develop new treatment delivery.PMID:38141804 | DOI:10.1016/j.expneurol.2023.114660 (Source: Experimental Neurology)
Source: Experimental Neurology - December 23, 2023 Category: Neurology Authors: Hui Zhou Yu-Jiao Wei Guang-Yao Xie Source Type: research
Transcutaneous electrical acupoint stimulation attenuated neuroinflammation and oxidative stress by activating SIRT1-induced signaling pathway in MCAO/R rat models
CONCLUSIONS: In summary, these findings clearly suggested that TEAS attenuated brain damage by suppressing apoptosis, oxidative stress and neuroinflammation through modulating SIRT1/FOXO3a and SIRT1/BRCC3/NLRP3 signaling pathways following ischemic stroke, which can be a promising treatment for stroke patients.PMID:38141805 | DOI:10.1016/j.expneurol.2023.114658 (Source: Experimental Neurology)
Source: Experimental Neurology - December 23, 2023 Category: Neurology Authors: Zixuan Tan Fang Dong Linyu Wu Guangyu Xu Feng Zhang Source Type: research
A new metal ion chelator attenuates human tau accumulation-induced neurodegeneration and memory deficits in mice
Exp Neurol. 2023 Dec 21:114657. doi: 10.1016/j.expneurol.2023.114657. Online ahead of print.ABSTRACTNeuronal neurofibrillary tangles containing Tau hyperphosphorylation proteins are a typical pathological marker of Alzheimer's disease (AD). The level of tangles in neurons correlates positively with severe dementia. However, how Tau induces cognitive dysfunction is still unknown, which leads to a lack of effective treatments for AD. Metal ions deposition occurs with tangles in AD brain autopsy. Reduced metal ion can improve the pathology of AD. To explore whether abnormally phosphorylated Tau causes metal ion deposition, we...
Source: Experimental Neurology - December 23, 2023 Category: Neurology Authors: Yue Zuo Hui-Ting Liu Lai-Biao Lin Rui-Zhu Yue Huan-Huan Liu Hong-Wei Wang Lu Wang Ruan-Ling Hou Wei-Zhen Liu Chang-Zheng Li Jian-Zhi Wang Peng Li Ya-Ling Yin Source Type: research
Ferrostatin-1 improves neurological impairment induced by ischemia/reperfusion injury in the spinal cord through ERK1/2/SP1/GPX4
In conclusion, our results indicate that Fer-1 inhibited ferroptosis in spinal cord anterior horn neurons, improving neurological impairment and BSCB damage after SCIRI through the ERK1/2/SP1/GPX4 signaling pathway in rats.PMID:38141803 | DOI:10.1016/j.expneurol.2023.114659 (Source: Experimental Neurology)
Source: Experimental Neurology - December 23, 2023 Category: Neurology Authors: Sidan Liu Fengshou Chen Jie Han Limei Wang Yan Dong Source Type: research
Research progress on post-stroke depression
This article summarizes the mechanism research, animal models and related treatments of PSD. Further improvements are needed in the screening of research subjects and the construction of animal models in the study of PSD. At the same time, in the study of the mechanism of PSD, we need to consider the interaction between multiple systems. The treatment of PSD requires more careful consideration. This can help us to find something new in the study of the mechanism of complex PSD, which provides a new direction for us to develop new treatment delivery.PMID:38141804 | DOI:10.1016/j.expneurol.2023.114660 (Source: Experimental Neurology)
Source: Experimental Neurology - December 23, 2023 Category: Neurology Authors: Hui Zhou Yu-Jiao Wei Guang-Yao Xie Source Type: research
Transcutaneous electrical acupoint stimulation attenuated neuroinflammation and oxidative stress by activating SIRT1-induced signaling pathway in MCAO/R rat models
CONCLUSIONS: In summary, these findings clearly suggested that TEAS attenuated brain damage by suppressing apoptosis, oxidative stress and neuroinflammation through modulating SIRT1/FOXO3a and SIRT1/BRCC3/NLRP3 signaling pathways following ischemic stroke, which can be a promising treatment for stroke patients.PMID:38141805 | DOI:10.1016/j.expneurol.2023.114658 (Source: Experimental Neurology)
Source: Experimental Neurology - December 23, 2023 Category: Neurology Authors: Zixuan Tan Fang Dong Linyu Wu Guangyu Xu Feng Zhang Source Type: research
