Mitochondrial iron dyshomeostasis and its potential as a therapeutic target for Parkinson's disease
Exp Neurol. 2023 Nov 23:114614. doi: 10.1016/j.expneurol.2023.114614. Online ahead of print.ABSTRACTAbnormal iron accumulation has been implicated in the etiology of Parkinson's disease (PD). Understanding how iron damages dopaminergic neurons in the substantia nigra (SN) of PD is particularly important for developing targeted neurotherapeutic strategies for the disease. However, it is still not fully understood how excess iron contributes to the neurodegeneration of dopaminergic neurons in PD. There has been increased attention on mitochondrial iron dyshomeostasis, iron-induced mitochondrial dysfunction and ferroptosis in...
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Zhixin Xiao Xiaoya Wang Xuening Pan Junxia Xie Huamin Xu Source Type: research
Neonatal di-(2-ethylhexyl)phthalate exposure induces permanent alterations in secretory CRH neuron characteristics in the hypothalamus paraventricular region of adult male rats
Exp Neurol. 2023 Nov 23:114616. doi: 10.1016/j.expneurol.2023.114616. Online ahead of print.ABSTRACTCorticotrophin-releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) play a critical role in the modulation of the hypothalamic-pituitary-adrenal (HPA) axis. Early-life exposure to di-(2-ethylhexyl) phthalate (DEHP) has been associated with an increased risk of developing psychiatric disorders in adulthood. The present work was designed to explore the impact of neonatal exposure to DEHP on adult PVN CRH neuronal activity. DEHP or vehicle was given to male rat pups from PND16 to PND22. Then, anxiet...
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Li Li Ying Su Siyuan Wang Chengyu Wang Naqi Ruan Zhiyan Hu Xin Cheng Jiajia Chen Kaiming Yuan Peijun Li Pei Fan Source Type: research
Cognitive-exercise dual-task attenuates chronic cerebral ischemia-induced cognitive impairment by activating cAMP/PKA pathway through inhibiting EphrinA3/EphA4
CONCLUSION: Cognitive-exercise dual-task can significantly improve the cognitive impairment induced by CCI, and this effect may be better than that of the cognitive or exercise single-task intervention. The improvement may be related to the inhibition of EphrinA3/EphA4, followed by activation of the cAMP/PKA pathway.PMID:38007209 | DOI:10.1016/j.expneurol.2023.114617 (Source: Experimental Neurology)
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Ziman Zhu Xue Tao Tengteng Dai Jilin Wu Conglin Han Peiling Huang Weijun Gong Source Type: research
Mitochondrial iron dyshomeostasis and its potential as a therapeutic target for Parkinson's disease
Exp Neurol. 2023 Nov 23:114614. doi: 10.1016/j.expneurol.2023.114614. Online ahead of print.ABSTRACTAbnormal iron accumulation has been implicated in the etiology of Parkinson's disease (PD). Understanding how iron damages dopaminergic neurons in the substantia nigra (SN) of PD is particularly important for developing targeted neurotherapeutic strategies for the disease. However, it is still not fully understood how excess iron contributes to the neurodegeneration of dopaminergic neurons in PD. There has been increased attention on mitochondrial iron dyshomeostasis, iron-induced mitochondrial dysfunction and ferroptosis in...
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Zhixin Xiao Xiaoya Wang Xuening Pan Junxia Xie Huamin Xu Source Type: research
Neonatal di-(2-ethylhexyl)phthalate exposure induces permanent alterations in secretory CRH neuron characteristics in the hypothalamus paraventricular region of adult male rats
Exp Neurol. 2023 Nov 23:114616. doi: 10.1016/j.expneurol.2023.114616. Online ahead of print.ABSTRACTCorticotrophin-releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) play a critical role in the modulation of the hypothalamic-pituitary-adrenal (HPA) axis. Early-life exposure to di-(2-ethylhexyl) phthalate (DEHP) has been associated with an increased risk of developing psychiatric disorders in adulthood. The present work was designed to explore the impact of neonatal exposure to DEHP on adult PVN CRH neuronal activity. DEHP or vehicle was given to male rat pups from PND16 to PND22. Then, anxiet...
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Li Li Ying Su Siyuan Wang Chengyu Wang Naqi Ruan Zhiyan Hu Xin Cheng Jiajia Chen Kaiming Yuan Peijun Li Pei Fan Source Type: research
Cognitive-exercise dual-task attenuates chronic cerebral ischemia-induced cognitive impairment by activating cAMP/PKA pathway through inhibiting EphrinA3/EphA4
CONCLUSION: Cognitive-exercise dual-task can significantly improve the cognitive impairment induced by CCI, and this effect may be better than that of the cognitive or exercise single-task intervention. The improvement may be related to the inhibition of EphrinA3/EphA4, followed by activation of the cAMP/PKA pathway.PMID:38007209 | DOI:10.1016/j.expneurol.2023.114617 (Source: Experimental Neurology)
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Ziman Zhu Xue Tao Tengteng Dai Jilin Wu Conglin Han Peiling Huang Weijun Gong Source Type: research
Mitochondrial iron dyshomeostasis and its potential as a therapeutic target for Parkinson's disease
Exp Neurol. 2023 Nov 23:114614. doi: 10.1016/j.expneurol.2023.114614. Online ahead of print.ABSTRACTAbnormal iron accumulation has been implicated in the etiology of Parkinson's disease (PD). Understanding how iron damages dopaminergic neurons in the substantia nigra (SN) of PD is particularly important for developing targeted neurotherapeutic strategies for the disease. However, it is still not fully understood how excess iron contributes to the neurodegeneration of dopaminergic neurons in PD. There has been increased attention on mitochondrial iron dyshomeostasis, iron-induced mitochondrial dysfunction and ferroptosis in...
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Zhixin Xiao Xiaoya Wang Xuening Pan Junxia Xie Huamin Xu Source Type: research
Neonatal di-(2-ethylhexyl)phthalate exposure induces permanent alterations in secretory CRH neuron characteristics in the hypothalamus paraventricular region of adult male rats
Exp Neurol. 2023 Nov 23:114616. doi: 10.1016/j.expneurol.2023.114616. Online ahead of print.ABSTRACTCorticotrophin-releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) play a critical role in the modulation of the hypothalamic-pituitary-adrenal (HPA) axis. Early-life exposure to di-(2-ethylhexyl) phthalate (DEHP) has been associated with an increased risk of developing psychiatric disorders in adulthood. The present work was designed to explore the impact of neonatal exposure to DEHP on adult PVN CRH neuronal activity. DEHP or vehicle was given to male rat pups from PND16 to PND22. Then, anxiet...
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Li Li Ying Su Siyuan Wang Chengyu Wang Naqi Ruan Zhiyan Hu Xin Cheng Jiajia Chen Kaiming Yuan Peijun Li Pei Fan Source Type: research
Cognitive-exercise dual-task attenuates chronic cerebral ischemia-induced cognitive impairment by activating cAMP/PKA pathway through inhibiting EphrinA3/EphA4
CONCLUSION: Cognitive-exercise dual-task can significantly improve the cognitive impairment induced by CCI, and this effect may be better than that of the cognitive or exercise single-task intervention. The improvement may be related to the inhibition of EphrinA3/EphA4, followed by activation of the cAMP/PKA pathway.PMID:38007209 | DOI:10.1016/j.expneurol.2023.114617 (Source: Experimental Neurology)
Source: Experimental Neurology - November 25, 2023 Category: Neurology Authors: Ziman Zhu Xue Tao Tengteng Dai Jilin Wu Conglin Han Peiling Huang Weijun Gong Source Type: research
GW0742 reduces mast cells degranulation and attenuates neurological impairments via PPAR < sub > β/δ < /sub > /CD300a/SHP1 pathway after GMH in neonatal rats
CONCLUSIONS: GW0742 inhibited mast cell-induced inflammation and improved neurobehavior after GMH, which is mediated by PPARβ/δ/CD300a/SHP1 pathway. GW0742 may serve as a potential treatment to reduce brain injury for GMH patients.PMID:37995951 | DOI:10.1016/j.expneurol.2023.114615 (Source: Experimental Neurology)
Source: Experimental Neurology - November 23, 2023 Category: Neurology Authors: Weitian Lu Juan Huang Jerry Flores Peng Li Wenna Wang Shengpeng Liu John H Zhang Jiping Tang Source Type: research
Model matters: Differential outcomes in traumatic optic neuropathy pathophysiology between blunt and blast-wave mediated head injuries
Exp Neurol. 2023 Nov 21:114613. doi: 10.1016/j.expneurol.2023.114613. Online ahead of print.ABSTRACTOver 3 million people in the United States live with long-term disability because of a traumatic brain injury (TBI). The purpose of this study was to characterize and compare two different animal models of TBI (blunt head trauma and blast TBI) to determine common and divergent characteristics of these models. With recent literature reviews noting the prevalence of visual system injury in animal models of TBI, coupled with clinical estimates of 50-75% of all TBI cases, we decided to assess commonalities, if they existed, thro...
Source: Experimental Neurology - November 23, 2023 Category: Neurology Authors: S M Hetzer C O'Connell V Lallo M Robson N K Evanson Source Type: research
GW0742 reduces mast cells degranulation and attenuates neurological impairments via PPAR < sub > β/δ < /sub > /CD300a/SHP1 pathway after GMH in neonatal rats
CONCLUSIONS: GW0742 inhibited mast cell-induced inflammation and improved neurobehavior after GMH, which is mediated by PPARβ/δ/CD300a/SHP1 pathway. GW0742 may serve as a potential treatment to reduce brain injury for GMH patients.PMID:37995951 | DOI:10.1016/j.expneurol.2023.114615 (Source: Experimental Neurology)
Source: Experimental Neurology - November 23, 2023 Category: Neurology Authors: Weitian Lu Juan Huang Jerry Flores Peng Li Wenna Wang Shengpeng Liu John H Zhang Jiping Tang Source Type: research
Model matters: Differential outcomes in traumatic optic neuropathy pathophysiology between blunt and blast-wave mediated head injuries
Exp Neurol. 2023 Nov 21:114613. doi: 10.1016/j.expneurol.2023.114613. Online ahead of print.ABSTRACTOver 3 million people in the United States live with long-term disability because of a traumatic brain injury (TBI). The purpose of this study was to characterize and compare two different animal models of TBI (blunt head trauma and blast TBI) to determine common and divergent characteristics of these models. With recent literature reviews noting the prevalence of visual system injury in animal models of TBI, coupled with clinical estimates of 50-75% of all TBI cases, we decided to assess commonalities, if they existed, thro...
Source: Experimental Neurology - November 23, 2023 Category: Neurology Authors: S M Hetzer C O'Connell V Lallo M Robson N K Evanson Source Type: research
Combined effect of trifluoperazine and sodium cromoglycate on reducing acute edema and limiting lasting functional impairments after spinal cord injury in rats
In this study, we characterize the edema kinetic after T9-10 spinal contusion. We use trifluoperazine (TFP) to block the expression and the functional subcellular localization of aquaporin-4 supposed to be implicated in the cytotoxic edema formation. We also use sodium cromoglycate (SCG) to deactivate mast cell degranulation known to be implicated in the vasogenic edema formation. Our results show a significant reduction of edema after TFP treatment and after TFP-SCG combined treatment compared to control. This reduction is correlated with limited onset of initial sensorimotor impairments particularly after combined treatm...
Source: Experimental Neurology - November 22, 2023 Category: Neurology Authors: Mostafa Seblani C éline Ertlen Thelma Coyle Patrick Decherchi Jean-Michel Brezun Source Type: research
Combined effect of trifluoperazine and sodium cromoglycate on reducing acute edema and limiting lasting functional impairments after spinal cord injury in rats
In this study, we characterize the edema kinetic after T9-10 spinal contusion. We use trifluoperazine (TFP) to block the expression and the functional subcellular localization of aquaporin-4 supposed to be implicated in the cytotoxic edema formation. We also use sodium cromoglycate (SCG) to deactivate mast cell degranulation known to be implicated in the vasogenic edema formation. Our results show a significant reduction of edema after TFP treatment and after TFP-SCG combined treatment compared to control. This reduction is correlated with limited onset of initial sensorimotor impairments particularly after combined treatm...
Source: Experimental Neurology - November 22, 2023 Category: Neurology Authors: Mostafa Seblani C éline Ertlen Thelma Coyle Patrick Decherchi Jean-Michel Brezun Source Type: research
