TRIM27 ameliorates ischemic stroke by regulating NLRP3 inflammasome-mediated pyroptosis via the Akt/Nrf2/HO-1 signaling
This study provides a novel target for treatment of ischemic stroke.PMID:37914066 | DOI:10.1016/j.expneurol.2023.114599 (Source: Experimental Neurology)
Source: Experimental Neurology - November 1, 2023 Category: Neurology Authors: Xinya Wei Tianqi Zhang Chi Ma Minxue Zhang Liwei Jin Xu Ma Zhuobo Zhang Source Type: research
Neddylation in the chronically hypoperfused corpus callosum: MLN4924 reduces blood-brain barrier injury via ERK5/KLF2 signaling
Exp Neurol. 2023 Oct 31;371:114587. doi: 10.1016/j.expneurol.2023.114587. Online ahead of print.ABSTRACTBlood-brain barrier (BBB) breakdown and cerebrovascular dysfunction may contribute to the pathology in white matter lesions and consequent cognitive decline caused by cerebral hypoperfusion. Neddylation is the process of attaching a ubiquitin-like molecule NEDD8 (neuronal precursor cell-expressed developmentally downregulated protein 8) to specific targets. By modifying protein substrates, neddylation plays critical roles in various important biological processes. However, whether neddylation influences the pathogenesis ...
Source: Experimental Neurology - November 1, 2023 Category: Neurology Authors: Xing Yang Luping Chang Zhongwang Liu Xue Geng Ranran Wang Xuhui Yin Wenying Fan Bing-Qiao Zhao Source Type: research
Human stem cells hold the key to the study of human neural infectious disorders
Exp Neurol. 2023 Oct 18:114575. doi: 10.1016/j.expneurol.2023.114575. Online ahead of print.NO ABSTRACTPMID:37914567 | DOI:10.1016/j.expneurol.2023.114575 (Source: Experimental Neurology)
Source: Experimental Neurology - November 1, 2023 Category: Neurology Authors: Tongguang Wang Source Type: research
TRIM27 ameliorates ischemic stroke by regulating NLRP3 inflammasome-mediated pyroptosis via the Akt/Nrf2/HO-1 signaling
This study provides a novel target for treatment of ischemic stroke.PMID:37914066 | DOI:10.1016/j.expneurol.2023.114599 (Source: Experimental Neurology)
Source: Experimental Neurology - November 1, 2023 Category: Neurology Authors: Xinya Wei Tianqi Zhang Chi Ma Minxue Zhang Liwei Jin Xu Ma Zhuobo Zhang Source Type: research
Neddylation in the chronically hypoperfused corpus callosum: MLN4924 reduces blood-brain barrier injury via ERK5/KLF2 signaling
Exp Neurol. 2023 Oct 30:114587. doi: 10.1016/j.expneurol.2023.114587. Online ahead of print.ABSTRACTBlood-brain barrier (BBB) breakdown and cerebrovascular dysfunction may contribute to the pathology in white matter lesions and consequent cognitive decline caused by cerebral hypoperfusion. Neddylation is the process of attaching a ubiquitin-like molecule NEDD8 (neuronal precursor cell-expressed developmentally downregulated protein 8) to specific targets. By modifying protein substrates, neddylation plays critical roles in various important biological processes. However, whether neddylation influences the pathogenesis of h...
Source: Experimental Neurology - November 1, 2023 Category: Neurology Authors: Xing Yang Luping Chang Zhongwang Liu Xue Geng Ranran Wang Xuhui Yin Wenying Fan Bing-Qiao Zhao Source Type: research
Human stem cells hold the key to the study of human neural infectious disorders
Exp Neurol. 2023 Oct 18:114575. doi: 10.1016/j.expneurol.2023.114575. Online ahead of print.NO ABSTRACTPMID:37914567 | DOI:10.1016/j.expneurol.2023.114575 (Source: Experimental Neurology)
Source: Experimental Neurology - November 1, 2023 Category: Neurology Authors: Tongguang Wang Source Type: research
TRIM27 ameliorates ischemic stroke by regulating NLRP3 inflammasome-mediated pyroptosis via the Akt/Nrf2/HO-1 signaling
This study provides a novel target for treatment of ischemic stroke.PMID:37914066 | DOI:10.1016/j.expneurol.2023.114599 (Source: Experimental Neurology)
Source: Experimental Neurology - November 1, 2023 Category: Neurology Authors: Xinya Wei Tianqi Zhang Chi Ma Minxue Zhang Liwei Jin Xu Ma Zhuobo Zhang Source Type: research
Neddylation in the chronically hypoperfused corpus callosum: MLN4924 reduces blood-brain barrier injury via ERK5/KLF2 signaling
Exp Neurol. 2023 Oct 30:114587. doi: 10.1016/j.expneurol.2023.114587. Online ahead of print.ABSTRACTBlood-brain barrier (BBB) breakdown and cerebrovascular dysfunction may contribute to the pathology in white matter lesions and consequent cognitive decline caused by cerebral hypoperfusion. Neddylation is the process of attaching a ubiquitin-like molecule NEDD8 (neuronal precursor cell-expressed developmentally downregulated protein 8) to specific targets. By modifying protein substrates, neddylation plays critical roles in various important biological processes. However, whether neddylation influences the pathogenesis of h...
Source: Experimental Neurology - November 1, 2023 Category: Neurology Authors: Xing Yang Luping Chang Zhongwang Liu Xue Geng Ranran Wang Xuhui Yin Wenying Fan Bing-Qiao Zhao Source Type: research
Human stem cells hold the key to the study of human neural infectious disorders
Exp Neurol. 2023 Oct 18:114575. doi: 10.1016/j.expneurol.2023.114575. Online ahead of print.NO ABSTRACTPMID:37914567 | DOI:10.1016/j.expneurol.2023.114575 (Source: Experimental Neurology)
Source: Experimental Neurology - November 1, 2023 Category: Neurology Authors: Tongguang Wang Source Type: research
Neuronal aerobic glycolysis exacerbates synapse loss in aging mice
Exp Neurol. 2023 Oct 29:114590. doi: 10.1016/j.expneurol.2023.114590. Online ahead of print.ABSTRACTBrain consumes nearly 20% supply of energy from glucose metabolism by oxidative phosphorylation and aerobic glycolysis. Less active state of glycolytic enzymes results in a limited capacity of glycolysis in the neurons of adult brain. Here we identified that Warburg effect is enhanced in hippocampal neurons during aging. As hippocampal neurons age, lactate levels progressively increase. Notably, we observed upregulated protein levels of PFKFB3 in the hippocampus of 20-month-old mice compared to young mice, and this higher PF...
Source: Experimental Neurology - October 31, 2023 Category: Neurology Authors: Wenhui Zhou Xingyue Yang Huixia Wang Wenjuan Yao Dandan Chu Feng Wu Source Type: research
Subclinical respiratory dysfunction and impaired ventilatory adaptation in degenerative cervical myelopathy
Exp Neurol. 2023 Oct 29:114600. doi: 10.1016/j.expneurol.2023.114600. Online ahead of print.ABSTRACTDegenerative cervical myelopathy (DCM) is a debilitating neurological condition characterized by chronic compression of the cervical spinal cord leading to impaired upper and lower limb function. Despite damage to areas of the cervical spinal cord that house the respiratory network, respiratory dysfunction is not a common symptom of DCM. However, DCM may be associated with respiratory dysfunction, and this can affect the ventilatory response to respiratory challenges during emergence from anesthesia, exercise, or pulmonary d...
Source: Experimental Neurology - October 31, 2023 Category: Neurology Authors: Hannah Sweetman Mahmudur Rahman Aditya Vedantam Kajana Satkunendrarajah Source Type: research
Dynamic electrical stimulation enhances the recruitment of spinal interneurons by corticospinal input
Exp Neurol. 2023 Oct 29:114589. doi: 10.1016/j.expneurol.2023.114589. Online ahead of print.ABSTRACTHighly varying patterns of electrostimulation (Dynamic Stimulation, DS) delivered to the dorsal cord through an epidural array with 18 independent electrodes transiently facilitate corticospinal motor responses, even after spinal injury. To partly unravel how corticospinal input are affected by DS, we introduced a corticospinal platform that allows selective cortical stimulation during the multisite acquisition of cord dorsum potentials (CDPs) and the simultaneous supply of DS. Firstly, the epidural interface was validated b...
Source: Experimental Neurology - October 31, 2023 Category: Neurology Authors: Giuliano Taccola Roger Kissane Stanislav Culaclii Rosamaria Apicella Wentai Liu Parag Gad Ronaldo M Ichiyama Samit Chakrabarty V Reggie Edgerton Source Type: research
LIPUS-induced neurogenesis:A potential therapeutic strategy for cognitive dysfunction in traumatic brain injury
Exp Neurol. 2023 Oct 29:114588. doi: 10.1016/j.expneurol.2023.114588. Online ahead of print.ABSTRACTTraumatic brain injury (TBI) precipitates cellular membrane degeneration, phospholipid degradation, neuronal demise, impaired brain electrical activity, and compromised neuroplasticity, ultimately leading to acute and chronic brain dysfunction. Low-intensity pulsed ultrasound (LIPUS) is an emerging brain therapy with the characteristics of non-invasive, high spatial resolution, and high stimulation depth. Herein, we established a controlled cortical impact model to investigate the potential reparative mechanisms of LIPUS in ...
Source: Experimental Neurology - October 31, 2023 Category: Neurology Authors: Wenzhu Wang Zihan Li Yitong Yan Shuo Wu Xinyu Yao Chen Gao Lanxiang Liu Yan Yu Source Type: research
High-fat diet induces cognitive impairment through repression of SIRT1/AMPK-mediated autophagy
CONCLUSIONS: HFD may inhibit the expression of SIRT1/AMPK pathway and disrupt autophagy flux, and result in tau hyperphosphorylation and synaptic dysfunction during aging, which ultimately lead to cognitive decline.PMID:37898395 | DOI:10.1016/j.expneurol.2023.114591 (Source: Experimental Neurology)
Source: Experimental Neurology - October 28, 2023 Category: Neurology Authors: Wenmin Yi Fei Chen Minghao Yuan Chuanling Wang Shengyuan Wang Jie Wen Qian Zou Yinshuang Pu Zhiyou Cai Source Type: research
Hydrogen sulfide ameliorates lipopolysaccharide-induced anxiety-like behavior by inhibiting checkpoint kinase 1 activation in the hippocampus of mice
Exp Neurol. 2023 Oct 26:114586. doi: 10.1016/j.expneurol.2023.114586. Online ahead of print.ABSTRACTHydrogen sulfide (H2S), an endogenous gasotransmitter, exhibits the anxiolytic roles through its anti-inflammatory effects, although its underlying mechanisms remain largely elusive. Emerging evidence has documented that cell cycle checkpoint kinase 1 (Chk1)-regulated DNA damage plays an important role in the neurodegenerative diseases; however, there are few relevant reports on the research of Chk1 in neuropsychiatric diseases. Here, we aimed to investigate the regulatory role of H2S on Chk1 in lipopolysaccharide (LPS)-indu...
Source: Experimental Neurology - October 28, 2023 Category: Neurology Authors: Yangping Shentu Mengfan Chen Hui Wang Xiaotong Du Wenjing Zhang Guizhen Xie Shaoyan Zhou Lu Ding Yun Zhu Min Zhu Nan Zhang Congkuo Du Jianshe Ma Ran Chen Jinge Yang Xiaofang Fan Yongsheng Gong Hongyu Zhang Junming Fan Source Type: research
