European Journal of Pharmaceutics and Biopharmaceutics 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.An in vitro gastrointestinal model to evaluate the tolerance of encapsulated Lactobacillus and Lactococcus strains with synbiotic containing lactobionic acid via lyophilization technique to harsh gastric conditions during storage time
This study used a gastrointestinal model to represent the pH variation and gastric enzymes that are involved in the digestion process. Eight Lactobacillus strains and one Lactococcus strain were encapsulated using sodium alginate. The aim of this study was to compare free probiotic bacteria with encapsulated probiotic bacteria and determine the number of viable probiotic cells that might reach the human intestine. Microencapsulation of probiotic organisms followed the extrusion method with an alginate compound. Microencapsulated and free probiotic bacteria were inoculated into 200 ml of MRS (Man, Rogosa, Sharpe) broth. Sim...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 15, 2023 Category: Drugs & Pharmacology Authors: Kamila Goderska Sonia Agudo Pena Source Type: research
HER2-specific liposomes loaded with proteinaceous BRET pair as a promising tool for targeted self-excited photodynamic therapy
Eur J Pharm Biopharm. 2023 Nov 11:S0939-6411(23)00297-7. doi: 10.1016/j.ejpb.2023.11.008. Online ahead of print.ABSTRACTPhotodynamic therapy (PDT) for deep-seated tumors is still challenging due to the limited penetration of visible light through tissues. To resolve this limitation, systems based on bioluminescence resonance energy transfer (BRET), that do not require an external light source are proposed. Herein, for BRET-activated PDT we developed proteinaceous BRET-pair consisting of luciferase NanoLuc, which acts as energy donor upon addition of luciferase specific substrate furimazine, and phototoxic protein SOPP3 as ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 13, 2023 Category: Drugs & Pharmacology Authors: Elena I Shramova Victoriya P Filimonova Anastasiya Yu Frolova Eugene N Pichkur Vlad R Fedotov Andrey L Konevega Sergey M Deyev Galina M Proshkina Source Type: research
Evaluation of the effects of storage conditions on spray-dried siRNA-LNPs before and after subsequent drying
This study confirms the stability of spray-dried and subsequently dried LNPs over at least 90 days at 4 °C and 25 °C emphasizing the potential of dry powder inhalation of RNA-loaded LNPs as a therapy option for pulmonary diseases.PMID:37956785 | DOI:10.1016/j.ejpb.2023.11.007 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 13, 2023 Category: Drugs & Pharmacology Authors: Christoph M Zimmermann Leonie De ßloch David C J ürgens Paola Luciani Olivia M Merkel Source Type: research
HER2-specific liposomes loaded with proteinaceous BRET pair as a promising tool for targeted self-excited photodynamic therapy
Eur J Pharm Biopharm. 2023 Nov 11:S0939-6411(23)00297-7. doi: 10.1016/j.ejpb.2023.11.008. Online ahead of print.ABSTRACTPhotodynamic therapy (PDT) for deep-seated tumors is still challenging due to the limited penetration of visible light through tissues. To resolve this limitation, systems based on bioluminescence resonance energy transfer (BRET), that do not require an external light source are proposed. Herein, for BRET-activated PDT we developed proteinaceous BRET-pair consisting of luciferase NanoLuc, which acts as energy donor upon addition of luciferase specific substrate furimazine, and phototoxic protein SOPP3 as ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 13, 2023 Category: Drugs & Pharmacology Authors: Elena I Shramova Victoriya P Filimonova Anastasiya Yu Frolova Eugene N Pichkur Vlad R Fedotov Andrey L Konevega Sergey M Deyev Galina M Proshkina Source Type: research
Evaluation of the effects of storage conditions on spray-dried siRNA-LNPs before and after subsequent drying
This study confirms the stability of spray-dried and subsequently dried LNPs over at least 90 days at 4 °C and 25 °C emphasizing the potential of dry powder inhalation of RNA-loaded LNPs as a therapy option for pulmonary diseases.PMID:37956785 | DOI:10.1016/j.ejpb.2023.11.007 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 13, 2023 Category: Drugs & Pharmacology Authors: Christoph M Zimmermann Leonie De ßloch David C J ürgens Paola Luciani Olivia M Merkel Source Type: research
Activation of the complement system by nanoparticles and strategies for complement inhibition
Eur J Pharm Biopharm. 2023 Nov 8:S0939-6411(23)00295-3. doi: 10.1016/j.ejpb.2023.11.006. Online ahead of print.ABSTRACTThe complement system is a multicomponent and multifunctional arm of the innate immune system. Complement contributes to non-specific host defence and maintains homeostasis through multifaceted processes and pathways, including cross talk with the adaptive immune system, the contact (coagulation) and the kinin systems, and alarmin high-mobility group box 1. Complement is also present intracellularly, intriguingly orchestrating a wide range of housekeeping and physiological processes in both immune and noni...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 10, 2023 Category: Drugs & Pharmacology Authors: Hajira B Haroon Elisha Dhillon Z Shadi Farhangrazi Panagiotis N Trohopoulos Dmitri Simberg S Moein Moghimi Source Type: research
Inhibition of USP1 ameliorates hypertensive nephropathy through regulating oxidative stress and ferroptosis: a precise treatment via SJB3-019A nanodelivery
In this study, an angiotensin II (Ang II)-induced renal cell system was established, and the expression of ubiquitin specific peptidase 1 (USP1) in human kidney (HK-2) cells was found to be regulated by Ang II treatment through quantitative RT-PCR and Western blot assay. The detection of glutathione peroxidase (GSH-Px), malondialdehyde (MDA) and lipid reactive oxygen species (ROS) levels revealed that interference with USP1 reversed Ang II-induced oxidative stress and ferroptosis, which was enhanced by overexpression of USP1. Subsequently, USP1 inhibitor SJB3-019A loaded in MIL-100 and PEGTK was modified to fabricate SJB3-...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 10, 2023 Category: Drugs & Pharmacology Authors: Fangyi Hao Ying Li Yunzhu Zhang Yangwenxuan Han Jing Shang Lu Gan Jiaxin Zheng Chunjian Zhang Source Type: research
Activation of the complement system by nanoparticles and strategies for complement inhibition
Eur J Pharm Biopharm. 2023 Nov 8:S0939-6411(23)00295-3. doi: 10.1016/j.ejpb.2023.11.006. Online ahead of print.ABSTRACTThe complement system is a multicomponent and multifunctional arm of the innate immune system. Complement contributes to non-specific host defence and maintains homeostasis through multifaceted processes and pathways, including cross talk with the adaptive immune system, the contact (coagulation) and the kinin systems, and alarmin high-mobility group box 1. Complement is also present intracellularly, intriguingly orchestrating a wide range of housekeeping and physiological processes in both immune and noni...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 10, 2023 Category: Drugs & Pharmacology Authors: Hajira B Haroon Elisha Dhillon Z Shadi Farhangrazi Panagiotis N Trohopoulos Dmitri Simberg S Moein Moghimi Source Type: research
Inhibition of USP1 ameliorates hypertensive nephropathy through regulating oxidative stress and ferroptosis: a precise treatment via SJB3-019A nanodelivery
In this study, an angiotensin II (Ang II)-induced renal cell system was established, and the expression of ubiquitin specific peptidase 1 (USP1) in human kidney (HK-2) cells was found to be regulated by Ang II treatment through quantitative RT-PCR and Western blot assay. The detection of glutathione peroxidase (GSH-Px), malondialdehyde (MDA) and lipid reactive oxygen species (ROS) levels revealed that interference with USP1 reversed Ang II-induced oxidative stress and ferroptosis, which was enhanced by overexpression of USP1. Subsequently, USP1 inhibitor SJB3-019A loaded in MIL-100 and PEGTK was modified to fabricate SJB3-...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 10, 2023 Category: Drugs & Pharmacology Authors: Fangyi Hao Ying Li Yunzhu Zhang Yangwenxuan Han Jing Shang Lu Gan Jiaxin Zheng Chunjian Zhang Source Type: research
Activation of the complement system by nanoparticles and strategies for complement inhibition
Eur J Pharm Biopharm. 2023 Nov 8:S0939-6411(23)00295-3. doi: 10.1016/j.ejpb.2023.11.006. Online ahead of print.ABSTRACTThe complement system is a multicomponent and multifunctional arm of the innate immune system. Complement contributes to non-specific host defence and maintains homeostasis through multifaceted processes and pathways, including cross talk with the adaptive immune system, the contact (coagulation) and the kinin systems, and alarmin high-mobility group box 1. Complement is also present intracellularly, intriguingly orchestrating a wide range of housekeeping and physiological processes in both immune and noni...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 10, 2023 Category: Drugs & Pharmacology Authors: Hajira B Haroon Elisha Dhillon Z Shadi Farhangrazi Panagiotis N Trohopoulos Dmitri Simberg S Moein Moghimi Source Type: research
Inhibition of USP1 ameliorates hypertensive nephropathy through regulating oxidative stress and ferroptosis: a precise treatment via SJB3-019A nanodelivery
In this study, an angiotensin II (Ang II)-induced renal cell system was established, and the expression of ubiquitin specific peptidase 1 (USP1) in human kidney (HK-2) cells was found to be regulated by Ang II treatment through quantitative RT-PCR and Western blot assay. The detection of glutathione peroxidase (GSH-Px), malondialdehyde (MDA) and lipid reactive oxygen species (ROS) levels revealed that interference with USP1 reversed Ang II-induced oxidative stress and ferroptosis, which was enhanced by overexpression of USP1. Subsequently, USP1 inhibitor SJB3-019A loaded in MIL-100 and PEGTK was modified to fabricate SJB3-...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 10, 2023 Category: Drugs & Pharmacology Authors: Fangyi Hao Ying Li Yunzhu Zhang Yangwenxuan Han Jing Shang Lu Gan Jiaxin Zheng Chunjian Zhang Source Type: research
Encapsulation in oleyl-modified hyaluronic acid nanogels substantially improves the clinical potential of the antimicrobial peptides SAAP-148 and Ab-Cath
Eur J Pharm Biopharm. 2023 Nov 7:S0939-6411(23)00294-1. doi: 10.1016/j.ejpb.2023.11.005. Online ahead of print.ABSTRACTAntimicrobial peptides (AMPs) are promising alternatives to antibiotics for treatment of antimicrobial resistant (AMR) bacterial infections. However, their narrow therapeutic window due to in vivo toxicity and limited stability hampers their clinical use. Here, we evaluated encapsulation of two amphiphilic AMPs, SAAP-148 and snake cathelicidin Ab-Cath, into oleyl-modified hyaluronic acid (OL-HA) nanogels to improve their selectivity index. The AMP-loaded OL-HA nanogels ranged 181-206 nm in size with a PDI ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 9, 2023 Category: Drugs & Pharmacology Authors: Miriam E van Gent Sylvia N Klodzinska Jan Wouter Drijfhout Hanne M Nielsen Peter H Nibbering Source Type: research
Effect of magnesium stearate solid lipid nanoparticles as a lubricant on the properties of tablets by direct compression
This study discusses the lubricant properties of magnesium stearate solid lipid nanoparticles (MgSt-SLN) and their effect on the tabletability, mechanical properties, disintegration, and acetaminophen-model dissolution time of microcrystalline cellulose (MCC) tablets prepared by direct compression. The behavior of MgSt-SLN was compared to reference material (RM) to identify advantages and drawbacks. The nanoprecipitation/ion exchange method was employed to prepare the MgSt-SLN. Particle size, zeta potential, specific surface area, morphology, and true density were measured to characterize the nanosystem. The MgSt-SLN parti...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 9, 2023 Category: Drugs & Pharmacology Authors: Lizbeth Mart ínez-Acevedo Moises Job Galindo-P érez Gustavo Vidal-Romero Alicia Del Real Mar ía de la Luz Zambrano-Zaragoza David Quintanar-Guerrero Source Type: research
Encapsulation in oleyl-modified hyaluronic acid nanogels substantially improves the clinical potential of the antimicrobial peptides SAAP-148 and Ab-Cath
Eur J Pharm Biopharm. 2023 Nov 7:S0939-6411(23)00294-1. doi: 10.1016/j.ejpb.2023.11.005. Online ahead of print.ABSTRACTAntimicrobial peptides (AMPs) are promising alternatives to antibiotics for treatment of antimicrobial resistant (AMR) bacterial infections. However, their narrow therapeutic window due to in vivo toxicity and limited stability hampers their clinical use. Here, we evaluated encapsulation of two amphiphilic AMPs, SAAP-148 and snake cathelicidin Ab-Cath, into oleyl-modified hyaluronic acid (OL-HA) nanogels to improve their selectivity index. The AMP-loaded OL-HA nanogels ranged 181-206 nm in size with a PDI ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 9, 2023 Category: Drugs & Pharmacology Authors: Miriam E van Gent Sylvia N Klodzinska Jan Wouter Drijfhout Hanne M Nielsen Peter H Nibbering Source Type: research
Effect of magnesium stearate solid lipid nanoparticles as a lubricant on the properties of tablets by direct compression
This study discusses the lubricant properties of magnesium stearate solid lipid nanoparticles (MgSt-SLN) and their effect on the tabletability, mechanical properties, disintegration, and acetaminophen-model dissolution time of microcrystalline cellulose (MCC) tablets prepared by direct compression. The behavior of MgSt-SLN was compared to reference material (RM) to identify advantages and drawbacks. The nanoprecipitation/ion exchange method was employed to prepare the MgSt-SLN. Particle size, zeta potential, specific surface area, morphology, and true density were measured to characterize the nanosystem. The MgSt-SLN parti...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 9, 2023 Category: Drugs & Pharmacology Authors: Lizbeth Mart ínez-Acevedo Moises Job Galindo-P érez Gustavo Vidal-Romero Alicia Del Real Mar ía de la Luz Zambrano-Zaragoza David Quintanar-Guerrero Source Type: research
