European Journal of Pharmaceutics and Biopharmaceutics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Development of a simple paste for 3D printing of drug formulations containing a mesoporous material loaded with a poorly water-soluble drug
This study showcases the feasibility of a straightforward yet groundbreaking hybrid 3D printing system employing SSE to incorporate drug-loaded mesoporous magnesium carbonate (MMC) into two different drug formulations, each designed for distinct administration routes. MMC was loaded with the poorly water-soluble drug ibuprofen via a solvent evaporation method and mixed with PEG 400 as a binder and lubricant, facilitating subsequent SSE. The formulation is non-aqueous, unlike most pastes which are used for SSE, and thus is beneficial for the incorporation of poorly water-soluble drugs. The 3D printing process yielded tablet...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 27, 2024 Category: Drugs & Pharmacology Authors: Christos S Katsiotis Evgenii Tikhomirov Christos Leliopoulos Maria Str ømme Ken Welch Source Type: research

Silymarin enriched gelatin methacrylamide bioink imparts hepatoprotectivity to 3D bioprinted liver construct against carbon tetrachloride induced toxicity
In this study, Silymarin, a flavonoid with the hepatoprotective properties were introduced into the GelMA bioink formulation to protect the bioprinted liver against hepatotoxicity. The concentration of silymarin to be added in GelMA was optimised, bioink properties were evaluated, and HepG2 cells were used to bioprint liver tissue. Carbon tetrachloride (CCl4) was used to induce hepatotoxicity in bioprinted liver, and the effect of this chemical on the metabolic activities of HepG2 cells was studied. The results showed that Silymarin helps with albumin synthesis and shields liver tissue from the damaging effects of CCl4. Ac...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 27, 2024 Category: Drugs & Pharmacology Authors: J Anupama Sekar Shiny Velayudhan M Senthilkumar P R Anil Kumar Source Type: research

Sucrose ester embedded lipid carrier for DNA delivery
Eur J Pharm Biopharm. 2024 Mar 23:114269. doi: 10.1016/j.ejpb.2024.114269. Online ahead of print.ABSTRACTSucrose esters (SEs) have great potential in the field of nucleic acid delivery due to their unique physical and chemical properties and good biosafety. However, the mechanism of the effect of SEs structure on delivery efficiency has not been studied. The liposomes containing peptide lipids and SEs were constructed, and the effects of SEs on the interaction between the liposomes and DNA were studied. The addition of SEs affects the binding rate of liposomes to DNA, and the binding rate gradually decreases with the incre...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 25, 2024 Category: Drugs & Pharmacology Authors: Yinan Zhao Wanting Ma Kexin Tian Zhe Wang Xingxing Fu Qi Zuo Yanfei Qi Shubiao Zhang Source Type: research

Corrigendum to "Sequentially dynamic polymeric micelles with detachable PEGylation for enhanced chemotherapeutic efficacy" [Eur. J. Pharm. Biopharm. 145 (2019) 54-64]
Eur J Pharm Biopharm. 2024 Mar 22:114268. doi: 10.1016/j.ejpb.2024.114268. Online ahead of print.NO ABSTRACTPMID:38521661 | DOI:10.1016/j.ejpb.2024.114268 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 23, 2024 Category: Drugs & Pharmacology Authors: Guoqing Yan Yan Huang Dapeng Li Yong Xu Jun Wang Xin Wang Rupei Tang Source Type: research

Exploring the potential of P-glycoprotein inhibitors in the targeted delivery of anti-cancer drugs: A comprehensive review
Eur J Pharm Biopharm. 2024 Mar 19:114267. doi: 10.1016/j.ejpb.2024.114267. Online ahead of print.ABSTRACTDue to the high prevalence of cancer, progress in the management of cancer is the need of the hour. Most cancer patients develop chemotherapeutic drug resistance, and many remain insidious due to overexpression of Multidrug Resistance Protein 1 (MDR1), also known as Permeability-glycoprotein (P-gp) or ABCB1 transporter (ATP-binding cassette subfamily B member 1). P-gp, a transmembrane protein that protects vital organs from outside chemicals, expels medications from malignant cells. The blood-brain barrier (BBB), gastro...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 21, 2024 Category: Drugs & Pharmacology Authors: Dhvani Patel Nutan Sethi Paresh Patel Shreeraj Shah Kaushika Patel Source Type: research

Lipid nanoparticles for local delivery of mRNA to the respiratory tract: Effect of PEG-lipid content and administration route
In this study, we aimed to optimize the PEG-lipid content for mucosal delivery and to investigatethe effect of administration route on the kinetics of mRNA expression. Our results show that increasing the PEG-lipid content improves the colloidal stability during the aerosolization process, but has a negative impact on the transfection efficiencyin vitro. The kinetics of protein expressionin vivois dependent on the route of administration, and we found that pulmonaryadministration of mRNA-LNPs to mice results inlonger protein expression than nasaladministration. These results demonstrate that the design of the delivery syst...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 18, 2024 Category: Drugs & Pharmacology Authors: Melike Ongun Abhijeet Girish Lokras Saahil Baghel Zhenning Shi Signe Tandrup Schmidt Henrik Franzyk Thomas Rades Federica Sebastiani Aneesh Thakur Camilla Foged Source Type: research

Don't shake it! Mechanical stress testing of mRNA-lipid nanoparticles
We report that vertical and horizontal shaking of both polyA- and eGFP-LNPs led to white deposits on the inner glass vial surface, depending on time, rpm, and temperature. Increasing the fill volume/smaller headspace (0.3 versus 0.9 mL fill) did not mitigate this phenomenon in the studied configuration, and the use of hydrophobic primary packaging even accelerated the formation of white deposits. In contrast, we demonstrated that a lyophilized polyA-LNP dosage form was less susceptible to shaking and maintained cake integrity and product properties. Multiple vortexing steps resulted in an increase in LNP size, PDI, and a d...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 16, 2024 Category: Drugs & Pharmacology Authors: Anna Ruppl Denis Kiesewetter Franziska Str ütt Monika K öll-Weber Regine S üss Andrea Allmendinger Source Type: research

Meta-analysis guided development of a standard artificial urine
In this study, we present the first meta-analysis of human urine reported in the literature, drawing data from a total of 35 articles with a combined participant count of 14,021. Through this analysis, we have developed an artificial urine (AU) composition that can be adjusted within typical physiological parameters for in vitro applications. Our findings demonstrate the utility of this AU in determining the solubility of nitrofurantoin, particularly in the context of crystalluria. Notably, we observe that in saline, nitrofurantoin solubility, within the framework of its urinary pharmacokinetics, suggests a risk of crystal...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 16, 2024 Category: Drugs & Pharmacology Authors: Kimberley A Noble Hayley K Y Chan Ois ín N Kavanagh Source Type: research