European Journal of Pharmaceutics and Biopharmaceutics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Functionalized calcium carbonate (FCC) as a novel carrier to solidify supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS)
In conclusion, FCC showed potential as a carrier for solidification of SNEDDS and for the development of novel supersaturated solid SNEDDS for the oral delivery of poorly water-soluble drugs.PMID:37926269 | DOI:10.1016/j.ejpb.2023.11.001 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 5, 2023 Category: Drugs & Pharmacology Authors: Jumana Merchant Anette M üllertz Thomas Rades Jacob Bannow Source Type: research

Combinatorial nanochemotherapy of brain tumor using polymeric nanoparticles loaded with doxorubicin and paclitaxel: An in vitro and in vivo study
This study aims to overcome physiological barriers and increase the therapeutic index for the treatment of glioblastoma (GBM) tumors by using Paclitaxel (PTX) loaded Poly(lactic co-glycolic acid) nanoparticles (PTX-PLGA-NPs) and Doxorubicin (DOX) loaded Poly (lactic co-glycolic acid) nanoparticles (DOX-PLGA-NPs). The hydrodynamic diameter of nanoparticles (NPs) was characterized by dynamic light scattering (DLS) which was 94 ± 4 nm and 133 ± 6 nm for DOX-PLGA-NPs, and PTX-PLGA-NPs, respectively. The zeta potential for DOX-PLGA-NPs and PTX-PLGA-NPs were -15.2 ± 0.18 mV and -17.3 ± 0.34 mV, respectively. The cytotoxicity...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 5, 2023 Category: Drugs & Pharmacology Authors: Mohammad Reza Malekpour Saereh Hosseindoost Fatemeh Madani Morteza Kamali Masood Khosravani Mahdi Adabi Source Type: research

Layer-by-layer assembly of poly-l-lysine/hyaluronic acid protein reservoirs on poly(glycerol sebacate) surfaces
In this study, we investigated the layer-by-layer (LbL) deposition of polyelectrolyte multilayer protein reservoirs consisting of poly-l-lysine (PLL) and hyaluronic acid (HA) on the hydrophobic surface of poly(glycerol sebacate) (PGS) elastomer. Using the methods of isothermal titration calorimetry and surface plasmon resonance, we systematically investigated the interactions between the polyelectrolytes and evaluated the deposition process in real time, providing insight into the phenomena associated with film assembly. PLL/HA LbL films deposited on PGS showed an exceptional ability to incorporate bone morphogenetic prote...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 4, 2023 Category: Drugs & Pharmacology Authors: Tomasz Urbaniak Pawe ł Piszko Dana Kubies Zuzanna Podg órniak Ognen Pop-Georgievski Tom áš Riedel Konrad Szustakiewicz Witold Musia ł Source Type: research

Challenges of nanoparticle albumin bound (nab ™) technology: Comparative study of Abraxane® with a newly developed albumin-stabilized itraconazole nanosuspension
In this study, the commercially available product Abraxane® was characterized in comparison to an albumin stabilized nanosuspension for the poorly water-soluble drug itraconazole. The aim of this study was to identify critical product parameters of the nanosuspensions depending on the manufacturing process in order to assess the transferability of nab™ technology to other drugs. The colloidal properties, stabilizing protein composition and particle disintegration behavior were analyzed. In addition, studies were carried out on the impact of the key process step, the high-pressure homogenization, using a design of experi...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 2, 2023 Category: Drugs & Pharmacology Authors: Annika Adick Werner Hoheisel Stefan Schneid Dennis Mulac Suna Azhdari Klaus Langer Source Type: research

Structured solubility behaviour in fed simulated intestinal fluids
This study has utilised nine bioequivalent simulated fed intestinal media recipes that cover over 90% of the compositional variability of sampled fed human intestinal fluid. The solubility of 24 drugs (Acidic; furosemide, ibuprofen, indomethacin, mefenamic acid, naproxen, phenytoin, piroxicam, valsartan, zafirlukast: Basic; aprepitant, atazanavir, bromocriptine, carvedilol, dipyridamole, posaconazole, tadalafil: Neutral; acyclovir, carbamazepine, felodipine, fenofibrate, griseofulvin, itraconazole, paracetamol, probucol) has been assessed to determine if structured solubility behaviour is present. The measured solubility b...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 27, 2023 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research