European Journal of Pharmaceutics and Biopharmaceutics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Reducing hydrophobic drug adsorption in an in-vitro extracorporeal membrane oxygenation model
Eur J Pharm Biopharm. 2024 Mar 13:114261. doi: 10.1016/j.ejpb.2024.114261. Online ahead of print.ABSTRACTExtracorporeal membrane oxygenation (ECMO) is a life-saving cardiopulmonary bypass technology for critically ill patients with heart and lung failure. Patients treated with ECMO receive a range of drugs that are used to treat underlying diseases and critical illnesses. However, the dosing guidelines for these drugs used in ECMO patients are unclear. Mortality rate for patients on ECMO exceeds 40% partly due to inaccurate dosing information, caused in part by the adsorption of drugs in the ECMO circuit and its components...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 15, 2024 Category: Drugs & Pharmacology Authors: Nitish Khurana Kamiya Watkins Debika Ghatak Jane Staples Oliver Hubbard Venkata Yellepeddi Kevin Watt Hamidreza Ghandehari Source Type: research

Comprehensive ocular and systemic pharmacokinetics of dexamethasone after subconjunctival and intravenous injections in rabbits
Eur J Pharm Biopharm. 2024 Mar 12:114260. doi: 10.1016/j.ejpb.2024.114260. Online ahead of print.ABSTRACTEven though subconjunctival injections are used in clinics, their quantitative pharmacokinetics has not been studied systematically. For this purpose, we evaluated the ocular and plasma pharmacokinetics of subconjunctival dexamethasone in rabbits. Intravenous injection was also given to enable a better understanding of the systemic pharmacokinetics. Dexamethasone concentrations in plasma (after subconjunctival and intravenous injections) and four ocular tissues (iris-ciliary body, aqueous humour, neural retina and vitre...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 14, 2024 Category: Drugs & Pharmacology Authors: Annika Valtari Susanna Posio Elisa Toropainen Anusha Balla Jooseppi Puranen Amir Sadeghi Marika Ruponen Veli-Pekka Ranta Kati-Sisko Vellonen Arto Urtti Eva M Del Amo Source Type: research

Phage-Based antibacterial hydrogels for bacterial targeting and Ablation: Progress and perspective
Eur J Pharm Biopharm. 2024 Mar 11:114258. doi: 10.1016/j.ejpb.2024.114258. Online ahead of print.ABSTRACTThe emergence of drug-resistant bacteria makes antibiotics inadequate to treat bacterial infections, which is now a global problem. Phage as a virus with specific recognition ability can effectively kill the bacteria, which is an efficacious antibacterial material to replace antibiotics. Phage-based hydrogels have good biocompatibility and antibacterial effect at the site of infection. Phage hydrogels have remarkable antibacterial effects on targeted bacteria because of their specific targeted bactericidal ability, but ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 13, 2024 Category: Drugs & Pharmacology Authors: Haoran Bai Qinggele Borjihan Zheng Li Peiran Qin Jingli Cheng Douxin Xiao Alideertu Dong Source Type: research

Recent advances of ultrasound-responsive nanosystems in tumor immunotherapy
Eur J Pharm Biopharm. 2024 Mar 11:114246. doi: 10.1016/j.ejpb.2024.114246. Online ahead of print.ABSTRACTImmunotherapy has revolutionized cancer treatment by boosting the immune system and preventing disease escape mechanisms. Despite its potential, challenges like limited response rates and adverse immune effects impede its widespread clinical adoption. Ultrasound (US), known for its safety and effectiveness in tumor diagnosis and therapy, has been shown to significantly enhance immunotherapy when used with nanosystems. High-intensity focused ultrasound (HIFU) can obliterate tumor cells and elicit immune reactions through...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 13, 2024 Category: Drugs & Pharmacology Authors: Penghui Wang Ji Chen Runming Zhong Yuanyuan Xia Zhina Wu Chunye Zhang Hai Yao Source Type: research

Synthesis of folate targeted theranostic cubosomal platform for co-delivery of bismuth oxide and doxorubicin to melanoma in vitro and in vivo
Eur J Pharm Biopharm. 2024 Mar 11:114259. doi: 10.1016/j.ejpb.2024.114259. Online ahead of print.ABSTRACTLiquid crystalline nanoparticles (LCNPs) have gained much attention in cancer nanomedicines due to their unique features such as high surface area, storage stability, and sustained-release profile. In the current study, a novel LCNP for co-encapsulation of Bi2O3 and hydrophilic doxorubicin (DOX) was fabricated and functionalized with folic acid (FA) to achieve efficient tumor targeting toward CT-scan imaging and chemotherapy of melanoma in vitro and in vivo. LCNPs Bi2O3 NPs were prepared using glycerol monooleate-pluron...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 13, 2024 Category: Drugs & Pharmacology Authors: Mahsa Zahiri Hosein Kamali Khalil Abnous Seyed Mohammad Taghdisi Sirous Nekooei Negar Nekooei Mohammad Ramezani Mona Alibolandi Source Type: research

Phototoxicity in vitro and safety in vivo of the emulsion photosensitizer based on furanocoumarins of Heracleum sosnowskyi
In this study, we utilized furanocoumarins from the Heracleum sosnowskyi plant to create an experimental emulsion dosage form (EmFHS). The EmFHS was finely dispersed (481.8 nm ± 71.1 nm), shelf-stable, and contained predominantly 8-methoxypsoralen at a concentration of 1 mg/ml. Phototoxicity analysis of EmFHS for THP-1 cells under UV (365 nm) irradiation showed an IC50 of 19.1 µg/ml (24 h) and 6.3 µg/ml (48 h). In relation to spheroids (L929), EmFHS exhibited a phototoxic effect in the concentration range of 31.25-125 µg/ml8-MOP. A full phototoxic effect was observed 48 h after UV irradiation. The phototoxic effect of ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 13, 2024 Category: Drugs & Pharmacology Authors: Oleg A Kulikov Vasilisa I Shlyapkina Ekaterina P Brodovskaya Amina M Al-Khadj Aioub Valentin P Ageev Mikhail N Zharkov Denis E Yakobson Daniil S Sokushev Nikolay A Pyataev Gleb B Sukhorukov Source Type: research

Cyclodextrin microneedles for the delivery of a nanoparticle-based peptide antigen vaccine
This study highlights the potential of cyclodextrin-based dissolving MNs as a versatile platform for intradermal vaccine delivery, providing a compatible matrix for nanoparticulate formulations to enhance immune responses.PMID:38467334 | DOI:10.1016/j.ejpb.2024.114249 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 11, 2024 Category: Drugs & Pharmacology Authors: Silvana Geissh üsler Frida Nilsson Nicole Ziak Zuzanna Kotkowska Marta Paolucci Marina Green Buzhor Nicole Zoratto P ål Johansen Jean-Christophe Leroux Source Type: research

Identification of structural origins of complex charge heterogeneity in therapeutic ACE2Fc fusion protein facilitated by free-flow isoelectric focusing
Eur J Pharm Biopharm. 2024 Mar 9:114248. doi: 10.1016/j.ejpb.2024.114248. Online ahead of print.ABSTRACTFc Fusion protein represents a versatile molecular platform with considerable potential as protein therapeutics of which the charge heterogeneity should be well characterized according to regulatory guidelines. Angiotensin-converting enzyme 2 Fc fusion protein (ACE2Fc) has been investigated as a potential neutralizing agent to various coronaviruses, including the lingering SARS-CoV-2, as this coronavirus must bind to ACE2 to allow for its entry into host cells. ACE2Fc, an investigational new drug developed by Henlius (Sh...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 11, 2024 Category: Drugs & Pharmacology Authors: Lingyu Wang Hai Wu Ting Cao Hongyang Li Pengcheng Shen Lihong Lu Zhongli Zhang Source Type: research

Antimicrobial peptide A < sub > 9 < /sub > K as a gene delivery vector in cancer cells
Eur J Pharm Biopharm. 2024 Mar 9:114244. doi: 10.1016/j.ejpb.2024.114244. Online ahead of print.ABSTRACTDesigned peptides are promising biomaterials for biomedical applications. The amphiphilic cationic antimicrobial peptide (AMP), A9K, can self-assemble into nano-rod structures and has shown cancer cell selectivity and could therefore be a promising candidate for therapeutic delivery into cancer cells. In this paper, we investigate the selectivity of A9K for cancer cell models, examining its effect on two human cancer cell lines, A431 and HCT-116. Little or no activity was instead observed on the control, human dermal fib...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 11, 2024 Category: Drugs & Pharmacology Authors: Silvia Cirillo Bo Zhang Stephen Brown Xiubo Zhao Source Type: research