European Journal of Pharmaceutics and Biopharmaceutics 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Combination Techniques Towards Novel Drug Delivery Systems Manufacturing: 3D PCL Scaffolds Enriched with Tetracycline-loaded PVP Nanoparticles
Eur J Pharm Biopharm. 2023 Nov 28:S0939-6411(23)00311-9. doi: 10.1016/j.ejpb.2023.11.022. Online ahead of print.ABSTRACTDrug delivery systems based on synthetic and natural polymers offer a new approach with a capacity to control the release of bio-active agents within time. In this work, we present different designs of Polycaprolactone (PCL) 3D scaffolds containing Polyvinylpyrrolidone (PVP) nanoparticles that can store a hydrophilic drug. The drug delivery system, combined of PCL and PVP polymers fabricated by additive manufacturing, aims for a solution for longer and more stabled drug delivery carrier. The drug, planned...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 30, 2023 Category: Drugs & Pharmacology Authors: Sumeyye Cesur Source Type: research
Influence of water and trehalose on α- and β-relaxation of freeze-dried lysozyme formulations
Eur J Pharm Biopharm. 2023 Nov 27:S0939-6411(23)00308-9. doi: 10.1016/j.ejpb.2023.11.019. Online ahead of print.ABSTRACTMolecular mobility in form of alpha and beta relaxations is considered crucial for characterization of amorphous lyophilizates and reflected in the transition temperatures Tgα and Tgβ. Based on an overview of applied methods to study beta relaxations, Dynamic Mechanical analysis was used to measure Tgα and Tgβ in amorphous freeze-dried samples. Lysozyme and trehalose as well as their mixtures in varying ratios were investigated. Three different residual moisture levels, ranging from roughly 0.5-7 % (w...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 29, 2023 Category: Drugs & Pharmacology Authors: Bernadette Vallaster Florian Engelsing Holger Grohganz Source Type: research
Rapid liposomal formulation for nucleolin targeting to rhabdomyosarcoma cells
Eur J Pharm Biopharm. 2023 Nov 27:S0939-6411(23)00309-0. doi: 10.1016/j.ejpb.2023.11.020. Online ahead of print.ABSTRACTRhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. More effective and less toxic therapies are urgently needed for high-risk patients. Peptide-guided targeted drug delivery can increase the therapeutic index of encapsulated drugs and improve patients' well-being. To apply this strategy to RMS, we identified the peptide F3 in a screening for peptides binding to RMS cells surface. F3 binds to nucleolin, which is present on the surface of RMS cells and is abundantly expressed at the mRN...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 29, 2023 Category: Drugs & Pharmacology Authors: Dzhangar Dzhumashev Stenija Anton-Joseph Victoria J Morel Andrea Timpanaro Gregor Bordon Caroline Piccand Simone Aleandri Paola Luciani Jochen R össler Michele Bernasconi Source Type: research
Influence of water and trehalose on α- and β-relaxation of freeze-dried lysozyme formulations
Eur J Pharm Biopharm. 2023 Nov 27:S0939-6411(23)00308-9. doi: 10.1016/j.ejpb.2023.11.019. Online ahead of print.ABSTRACTMolecular mobility in form of alpha and beta relaxations is considered crucial for characterization of amorphous lyophilizates and reflected in the transition temperatures Tgα and Tgβ. Based on an overview of applied methods to study beta relaxations, Dynamic Mechanical analysis was used to measure Tgα and Tgβ in amorphous freeze-dried samples. Lysozyme and trehalose as well as their mixtures in varying ratios were investigated. Three different residual moisture levels, ranging from roughly 0.5-7 % (w...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 29, 2023 Category: Drugs & Pharmacology Authors: Bernadette Vallaster Florian Engelsing Holger Grohganz Source Type: research
Rapid liposomal formulation for nucleolin targeting to rhabdomyosarcoma cells
Eur J Pharm Biopharm. 2023 Nov 27:S0939-6411(23)00309-0. doi: 10.1016/j.ejpb.2023.11.020. Online ahead of print.ABSTRACTRhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. More effective and less toxic therapies are urgently needed for high-risk patients. Peptide-guided targeted drug delivery can increase the therapeutic index of encapsulated drugs and improve patients' well-being. To apply this strategy to RMS, we identified the peptide F3 in a screening for peptides binding to RMS cells surface. F3 binds to nucleolin, which is present on the surface of RMS cells and is abundantly expressed at the mRN...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 29, 2023 Category: Drugs & Pharmacology Authors: Dzhangar Dzhumashev Stenija Anton-Joseph Victoria J Morel Andrea Timpanaro Gregor Bordon Caroline Piccand Simone Aleandri Paola Luciani Jochen R össler Michele Bernasconi Source Type: research
Comments on "Overview and thermodynamic modelling of deep eutectic solvents as co-solvents to enhance drug solubilities in water"
Eur J Pharm Biopharm. 2023 Nov 23:S0939-6411(23)00306-5. doi: 10.1016/j.ejpb.2023.11.018. Online ahead of print.ABSTRACTThis communication highlights the significance of the final pH of the solution and the potential instability of deep eutectic solvent (DES) within aqueous solutions, and introducing a challenging aspect regarding solute solubilization by DESs.PMID:38000516 | DOI:10.1016/j.ejpb.2023.11.018 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 24, 2023 Category: Drugs & Pharmacology Authors: Raha Kaviani Ali Shayanfar Source Type: research
Responses to comments on "Overview and thermodynamic modelling of deep eutectic solvents as cosolvents to enhance drug solubilities in water" (Eur. J. Pharm. Biopharm. 2023, 193, 1-15)
Eur J Pharm Biopharm. 2023 Nov 23:S0939-6411(23)00307-7. doi: 10.1016/j.ejpb.2023.11.017. Online ahead of print.NO ABSTRACTPMID:38000517 | DOI:10.1016/j.ejpb.2023.11.017 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 24, 2023 Category: Drugs & Pharmacology Authors: Reza Haghbakhsh Sona Raeissi Source Type: research
Comments on "Overview and thermodynamic modelling of deep eutectic solvents as co-solvents to enhance drug solubilities in water"
Eur J Pharm Biopharm. 2023 Nov 23:S0939-6411(23)00306-5. doi: 10.1016/j.ejpb.2023.11.018. Online ahead of print.ABSTRACTThis communication highlights the significance of the final pH of the solution and the potential instability of deep eutectic solvent (DES) within aqueous solutions, and introducing a challenging aspect regarding solute solubilization by DESs.PMID:38000516 | DOI:10.1016/j.ejpb.2023.11.018 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 24, 2023 Category: Drugs & Pharmacology Authors: Raha Kaviani Ali Shayanfar Source Type: research
Responses to comments on "Overview and thermodynamic modelling of deep eutectic solvents as cosolvents to enhance drug solubilities in water" (Eur. J. Pharm. Biopharm. 2023, 193, 1-15)
Eur J Pharm Biopharm. 2023 Nov 22:S0939-6411(23)00307-7. doi: 10.1016/j.ejpb.2023.11.017. Online ahead of print.NO ABSTRACTPMID:38000517 | DOI:10.1016/j.ejpb.2023.11.017 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 24, 2023 Category: Drugs & Pharmacology Authors: Reza Haghbakhsh Sona Raeissi Source Type: research
Comments on "Overview and thermodynamic modelling of deep eutectic solvents as co-solvents to enhance drug solubilities in water"
Eur J Pharm Biopharm. 2023 Nov 22:S0939-6411(23)00306-5. doi: 10.1016/j.ejpb.2023.11.018. Online ahead of print.ABSTRACTThis communication highlights the significance of the final pH of the solution and the potential instability of DES within aqueous solutions, introducing a challenging aspect regarding solute solubilization by DESs.PMID:38000516 | DOI:10.1016/j.ejpb.2023.11.018 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 24, 2023 Category: Drugs & Pharmacology Authors: Raha Kaviani Ali Shayanfar Source Type: research
Responses to comments on "Overview and thermodynamic modelling of deep eutectic solvents as cosolvents to enhance drug solubilities in water" (Eur. J. Pharm. Biopharm. 2023, 193, 1-15)
Eur J Pharm Biopharm. 2023 Nov 22:S0939-6411(23)00307-7. doi: 10.1016/j.ejpb.2023.11.017. Online ahead of print.NO ABSTRACTPMID:38000517 | DOI:10.1016/j.ejpb.2023.11.017 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 24, 2023 Category: Drugs & Pharmacology Authors: Reza Haghbakhsh Sona Raeissi Source Type: research
Comments on "Overview and thermodynamic modelling of deep eutectic solvents as co-solvents to enhance drug solubilities in water"
Eur J Pharm Biopharm. 2023 Nov 22:S0939-6411(23)00306-5. doi: 10.1016/j.ejpb.2023.11.018. Online ahead of print.ABSTRACTThis communication highlights the significance of the final pH of the solution and the potential instability of DES within aqueous solutions, introducing a challenging aspect regarding solute solubilization by DESs.PMID:38000516 | DOI:10.1016/j.ejpb.2023.11.018 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 24, 2023 Category: Drugs & Pharmacology Authors: Raha Kaviani Ali Shayanfar Source Type: research
Responses to comments on "Overview and thermodynamic modelling of deep eutectic solvents as cosolvents to enhance drug solubilities in water" (Eur. J. Pharm. Biopharm. 2023, 193, 1-15)
Eur J Pharm Biopharm. 2023 Nov 22:S0939-6411(23)00307-7. doi: 10.1016/j.ejpb.2023.11.017. Online ahead of print.NO ABSTRACTPMID:38000517 | DOI:10.1016/j.ejpb.2023.11.017 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 24, 2023 Category: Drugs & Pharmacology Authors: Reza Haghbakhsh Sona Raeissi Source Type: research
Potential strategy of microneedle-based transdermal drug delivery system for effective management of skin-related immune disorders
Eur J Pharm Biopharm. 2023 Nov 21:S0939-6411(23)00302-8. doi: 10.1016/j.ejpb.2023.11.013. Online ahead of print.ABSTRACTSkin-related immune disorders are a category of diseases that lead to the dysregulation of the body's immune response due to imbalanced immune regulation. These disorders exhibit diverse clinical manifestations and complicated pathogenesis. The long-term use of corticosteroids, anti-inflammatory drugs, and immunosuppressants as traditional treatment methods for skin-related immune disorders frequently leads to adverse reactions in patients. In addition, the effect of external preparations is not ideal in ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 23, 2023 Category: Drugs & Pharmacology Authors: Peng Xu Wei Xiao Kun Xu Yuan He Xiaoqing Miao Yan Dong Lin Sun Source Type: research
Potential strategy of microneedle-based transdermal drug delivery system for effective management of skin-related immune disorders
Eur J Pharm Biopharm. 2023 Nov 21:S0939-6411(23)00302-8. doi: 10.1016/j.ejpb.2023.11.013. Online ahead of print.ABSTRACTSkin-related immune disorders are a category of diseases that lead to the dysregulation of the body's immune response due to imbalanced immune regulation. These disorders exhibit diverse clinical manifestations and complicated pathogenesis. The long-term use of corticosteroids, anti-inflammatory drugs, and immunosuppressants as traditional treatment methods for skin-related immune disorders frequently leads to adverse reactions in patients. In addition, the effect of external preparations is not ideal in ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - November 23, 2023 Category: Drugs & Pharmacology Authors: Peng Xu Wei Xiao Kun Xu Yuan He Xiaoqing Miao Yan Dong Lin Sun Source Type: research
