European Journal of Pharmaceutics and Biopharmaceutics 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Development of an in vitro co-culture model using Caco-2 and J774A.1 cells to mimic intestinal inflammation
Eur J Pharm Biopharm. 2024 Mar 1:114243. doi: 10.1016/j.ejpb.2024.114243. Online ahead of print.ABSTRACTIn vitro models that mimic the pathophysiology in vivo are important tools to study mechanisms of disease and assess the pharmacology and toxicity of drugs. In this work, we report the development of a novel model of intestinal inflammation. This model is based on the co-culture of intestinal epithelial Caco-2 cells and murine J774A.1 macrophages. The model is shown to mimic the intestinal barrier in both healthy and inflamed state. In the healthy state, without external stimulation, Caco-2 and J774A.1 cells were co-cult...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 3, 2024 Category: Drugs & Pharmacology Authors: Mona Belaid Jana Javorovic Giorgia Pastorin Driton Vllasaliu Source Type: research
A systematic investigation of external lubrication of mini-tablets on a rotary tablet press with focus on the tensile strength
Eur J Pharm Biopharm. 2024 Feb 27:114236. doi: 10.1016/j.ejpb.2024.114236. Online ahead of print.ABSTRACTExternal lubrication is an alternative to internal lubrication and its related detrimental effects on properties of tablets like tensile strength (TS). However, to date there are hardly any systematic investigations on external lubrication of mini-tablets on rotary tablet presses. Aim of this study was the systematic investigation of the impact of parameters tableting pressure, tableting speed, dosing rate and air pressure on the TS of mini-tablets. Both studies, the Central Composite Design (CCD) with SMCC 90 and the s...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 29, 2024 Category: Drugs & Pharmacology Authors: Valentin ë Lura Stefan Klinken J örg Breitkreutz Source Type: research
A systematic investigation of external lubrication of mini-tablets on a rotary tablet press with focus on the tensile strength
Eur J Pharm Biopharm. 2024 Feb 27:114236. doi: 10.1016/j.ejpb.2024.114236. Online ahead of print.ABSTRACTExternal lubrication is an alternative to internal lubrication and its related detrimental effects on properties of tablets like tensile strength (TS). However, to date there are hardly any systematic investigations on external lubrication of mini-tablets on rotary tablet presses. Aim of this study was the systematic investigation of the impact of parameters tableting pressure, tableting speed, dosing rate and air pressure on the TS of mini-tablets. Both studies, the Central Composite Design (CCD) with SMCC 90 and the s...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 29, 2024 Category: Drugs & Pharmacology Authors: Valentin ë Lura Stefan Klinken J örg Breitkreutz Source Type: research
A systematic investigation of external lubrication of mini-tablets on a rotary tablet press with focus on the tensile strength
Eur J Pharm Biopharm. 2024 Feb 27:114236. doi: 10.1016/j.ejpb.2024.114236. Online ahead of print.ABSTRACTExternal lubrication is an alternative to internal lubrication and its related detrimental effects on properties of tablets like tensile strength (TS). However, to date there are hardly any systematic investigations on external lubrication of mini-tablets on rotary tablet presses. Aim of this study was the systematic investigation of the impact of parameters tableting pressure, tableting speed, dosing rate and air pressure on the TS of mini-tablets. Both studies, the Central Composite Design (CCD) with SMCC 90 and the s...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 29, 2024 Category: Drugs & Pharmacology Authors: Valentin ë Lura Stefan Klinken J örg Breitkreutz Source Type: research
Development of cationic solid lipid nanoparticles incorporating cholesteryl-9-carboxynonanoate (9CCN) for delivery of antagomiRs to macrophages
Eur J Pharm Biopharm. 2024 Feb 26:114238. doi: 10.1016/j.ejpb.2024.114238. Online ahead of print.ABSTRACTLipid-based nanoparticles are a useful tool for nucleic acids delivery and have been regarded as a promising approach for diverse diseases. However, off-targets effects are a matter of concern and some strategies to improve selectivity of solid lipid nanoparticles (SLNs) were reported. The goal of this study was to test formulations of SLNs incorporating lipid cholesteryl-9-carboxynonanoate (9CCN) as "eat-me" signal to target antagomiR oligonucleotides to macrophages. We formulate four SLNs, and those with a mean diamet...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 28, 2024 Category: Drugs & Pharmacology Authors: Adrian Mall én David A Narv áez-Narváez M D Pujol Estanis Navarro Josep Maria Su ñé-Negre Encarna Garc ía-Montoya Pilar P érez-Lozano Benjam ín Torrejón-Escribano Marc Su ñé-Pou Miguel Hueso Source Type: research
Development of cationic solid lipid nanoparticles incorporating cholesteryl-9-carboxynonanoate (9CCN) for delivery of antagomiRs to macrophages
Eur J Pharm Biopharm. 2024 Feb 26:114238. doi: 10.1016/j.ejpb.2024.114238. Online ahead of print.ABSTRACTLipid-based nanoparticles are a useful tool for nucleic acids delivery and have been regarded as a promising approach for diverse diseases. However, off-targets effects are a matter of concern and some strategies to improve selectivity of solid lipid nanoparticles (SLNs) were reported. The goal of this study was to test formulations of SLNs incorporating lipid cholesteryl-9-carboxynonanoate (9CCN) as "eat-me" signal to target antagomiR oligonucleotides to macrophages. We formulate four SLNs, and those with a mean diamet...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 28, 2024 Category: Drugs & Pharmacology Authors: Adrian Mall én David A Narv áez-Narváez M D Pujol Estanis Navarro Josep Maria Su ñé-Negre Encarna Garc ía-Montoya Pilar P érez-Lozano Benjam ín Torrejón-Escribano Marc Su ñé-Pou Miguel Hueso Source Type: research
Minimizing pain in deer antler removal: Local anaesthetics in ZnO nanoparticle based collagen dressings as a promising solution
In this study, we investigated the performance of a ZnO collagen nanocomposites loaded with local anesthetics to improve wound management and alleviate pain associated with antler removal in red deer. The research involved the preparation of collagen nanocomposites with local anesthetics and testing the drug release rates using in vitro drug release tests. Pharmacokinetic analysis was performed to evaluate the total drug release from the collagen matrix in red deer after velvet removal. Additionally, the analgesic efficacy of these collagen nanocomposite dressings was assessed after antler removal in red deer. Functionaliz...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 26, 2024 Category: Drugs & Pharmacology Authors: Farzin Sahebjam Paul Chambers Kavitha Kongara Yi Zhang Nicholas Lopez Antony Jacob Preet Singh Sujay Prabakar Source Type: research
Minimizing pain in deer antler removal: Local anaesthetics in ZnO nanoparticle based collagen dressings as a promising solution
In this study, we investigated the performance of a ZnO collagen nanocomposites loaded with local anesthetics to improve wound management and alleviate pain associated with antler removal in red deer. The research involved the preparation of collagen nanocomposites with local anesthetics and testing the drug release rates using in vitro drug release tests. Pharmacokinetic analysis was performed to evaluate the total drug release from the collagen matrix in red deer after velvet removal. Additionally, the analgesic efficacy of these collagen nanocomposite dressings was assessed after antler removal in red deer. Functionaliz...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 26, 2024 Category: Drugs & Pharmacology Authors: Farzin Sahebjam Paul Chambers Kavitha Kongara Yi Zhang Nicholas Lopez Antony Jacob Preet Singh Sujay Prabakar Source Type: research
Analytical techniques for the characterization of nanoparticles for mRNA delivery
Eur J Pharm Biopharm. 2024 Feb 22:114235. doi: 10.1016/j.ejpb.2024.114235. Online ahead of print.ABSTRACTNanotechnology-assisted RNA delivery has gotten a tremendous boost over the last decade and made a significant impact in the development of life-changing vaccines and therapeutics. With increasing numbers of emerging lipid- and polymer-based RNA nanoparticles progressing towards the clinic, it has become apparent that the safety and efficacy of these medications depend on the comprehensive understanding of their critical quality attributes (CQAs). However, despite the rapid advancements in the field, the identification ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 24, 2024 Category: Drugs & Pharmacology Authors: Sara S Nogueira Eleni Samaridou Johanna Simon Simon Frank Moritz Beck-Broichsitter Aditi Mehta Source Type: research
RNA-encapsulating lipid nanoparticles in cancer immunotherapy: From pre-clinical studies to clinical trials
Eur J Pharm Biopharm. 2024 Feb 22:114234. doi: 10.1016/j.ejpb.2024.114234. Online ahead of print.ABSTRACTNanoparticle-based delivery systems such as RNA-encapsulating lipid nanoparticles (RNA LNPs) have dramatically advanced in function and capacity over the last few decades. RNA LNPs boast of a diverse array of external and core configurations that enhance targeted delivery and prolong circulatory retention, advancing therapeutic outcomes. Particularly within the realm of cancer immunotherapies, RNA LNPs are increasingly gaining prominence. Pre-clinical in vitro and in vivo studies have laid a robust foundation for new an...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 24, 2024 Category: Drugs & Pharmacology Authors: Tiffaney Hsia Yunching Chen Source Type: research
Analytical techniques for the characterization of nanoparticles for mRNA delivery
Eur J Pharm Biopharm. 2024 Feb 22:114235. doi: 10.1016/j.ejpb.2024.114235. Online ahead of print.ABSTRACTNanotechnology-assisted RNA delivery has gotten a tremendous boost over the last decade and made a significant impact in the development of life-changing vaccines and therapeutics. With increasing numbers of emerging lipid- and polymer-based RNA nanoparticles progressing towards the clinic, it has become apparent that the safety and efficacy of these medications depend on the comprehensive understanding of their critical quality attributes (CQAs). However, despite the rapid advancements in the field, the identification ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 24, 2024 Category: Drugs & Pharmacology Authors: Sara S Nogueira Eleni Samaridou Johanna Simon Simon Frank Moritz Beck-Broichsitter Aditi Mehta Source Type: research
RNA-encapsulating lipid nanoparticles in cancer immunotherapy: From pre-clinical studies to clinical trials
Eur J Pharm Biopharm. 2024 Feb 22:114234. doi: 10.1016/j.ejpb.2024.114234. Online ahead of print.ABSTRACTNanoparticle-based delivery systems such as RNA-encapsulating lipid nanoparticles (RNA LNPs) have dramatically advanced in function and capacity over the last few decades. RNA LNPs boast of a diverse array of external and core configurations that enhance targeted delivery and prolong circulatory retention, advancing therapeutic outcomes. Particularly within the realm of cancer immunotherapies, RNA LNPs are increasingly gaining prominence. Pre-clinical in vitro and in vivo studies have laid a robust foundation for new an...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 24, 2024 Category: Drugs & Pharmacology Authors: Tiffaney Hsia Yunching Chen Source Type: research
Analytical techniques for the characterization of nanoparticles for mRNA delivery
Eur J Pharm Biopharm. 2024 Feb 22:114235. doi: 10.1016/j.ejpb.2024.114235. Online ahead of print.ABSTRACTNanotechnology-assisted RNA delivery has gotten a tremendous boost over the last decade and made a significant impact in the development of life-changing vaccines and therapeutics. With increasing numbers of emerging lipid- and polymer-based RNA nanoparticles progressing towards the clinic, it has become apparent that the safety and efficacy of these medications depend on the comprehensive understanding of their critical quality attributes (CQAs). However, despite the rapid advancements in the field, the identification ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 24, 2024 Category: Drugs & Pharmacology Authors: Sara S Nogueira Eleni Samaridou Johanna Simon Simon Frank Moritz Beck-Broichsitter Aditi Mehta Source Type: research
RNA-encapsulating lipid nanoparticles in cancer immunotherapy: From pre-clinical studies to clinical trials
Eur J Pharm Biopharm. 2024 Feb 22:114234. doi: 10.1016/j.ejpb.2024.114234. Online ahead of print.ABSTRACTNanoparticle-based delivery systems such as RNA-encapsulating lipid nanoparticles (RNA LNPs) have dramatically advanced in function and capacity over the last few decades. RNA LNPs boast of a diverse array of external and core configurations that enhance targeted delivery and prolong circulatory retention, advancing therapeutic outcomes. Particularly within the realm of cancer immunotherapies, RNA LNPs are increasingly gaining prominence. Pre-clinical in vitro and in vivo studies have laid a robust foundation for new an...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 24, 2024 Category: Drugs & Pharmacology Authors: Tiffaney Hsia Yunching Chen Source Type: research
Efficient polymeric nanoparticles for RNAi in macrophage reveal complex effects on polarization markers upon knockdown of STAT3/STAT6
In conclusion, we identify certain tyrosine-modified PEI- or PPI-based nanoparticles as particularly efficient for macrophage transfection, and the specific, siRNA-mediated STAT6 knockdown as a promising approach for macrophage repolarization and enhancement of their tumor cell suppressive role.PMID:38395176 | DOI:10.1016/j.ejpb.2024.114232 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 23, 2024 Category: Drugs & Pharmacology Authors: Maximilian Walther Robert Jenke Achim Aigner Alexander Ewe Source Type: research
