European Journal of Pharmaceutics and Biopharmaceutics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Evaluating β < sub > 2 < /sub > -agonists as siRNA delivery adjuvants for pulmonary surfactant-coated nanogel inhalation therapy
Eur J Pharm Biopharm. 2024 Feb 15:114223. doi: 10.1016/j.ejpb.2024.114223. Online ahead of print.ABSTRACTThe lung is an attractive target organ for inhalation of RNA therapeutics, such as small interfering RNA (siRNA). However, clinical translation of siRNA drugs for application in the lung is hampered by many extra- and intracellular barriers. We previously developed hybrid nanoparticles consisting of an siRNA-loaded nanosized hydrogel (nanogel) core coated with Curosurf®, a clinically used pulmonary surfactant. The surfactant shell was shown to markedly improve particle stability and promote intracellular siRNA delivery...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 17, 2024 Category: Drugs & Pharmacology Authors: Pieterjan Merckx Griet Conickx Evy Blomme Tania Maes Ken Bracke Guy Brusselle Stefaan C De Smedt Koen Raemdonck Source Type: research

Rapid characterization of physical properties for the pharmaceutical pellet cores based on NIR spectroscopy and ensemble learning
Eur J Pharm Biopharm. 2024 Feb 14:114214. doi: 10.1016/j.ejpb.2024.114214. Online ahead of print.ABSTRACTDuring the development of sustained-release pellets, the physical characteristics of the pellet cores can affect drug release in the preparation. The method based on near-infrared (NIR) spectroscopy and ensemble learning was proposed to swiftly assess the physical properties of the pellet cores. In the research, the potential of three algorithms, direct standardization (DS), partial least squares regression (PLSR) and generalized regression neural network (GRNN), was investigated and compared. The performance of the DS,...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 16, 2024 Category: Drugs & Pharmacology Authors: Sijun Wu Chaoliang Jia Li Wang Cheng Ye Zheng Li Wenlong Li Source Type: research

Personalised oral dosage forms using an ultra-compact tablet press at the point of care
Eur J Pharm Biopharm. 2024 Feb 13:114220. doi: 10.1016/j.ejpb.2024.114220. Online ahead of print.ABSTRACTOver the last 10 years there is an increasing need for the design of personalised medicines at the point of care (PoC) that meet the specific needs of individual patients. A plethora of technologies has been introduced for making affordable personalised pharmaceutical products, which however, do not address manufacturing and regulatory challenges. Here we introduce a novel ultra-compact tablet press which was used for the design and compression of rosuvastatin-aspirin and amiloride-lysonipril bilayer tablets respectivel...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 15, 2024 Category: Drugs & Pharmacology Authors: Ingo Krause Rene Manigk Elena Arribas Lopez Dennis Douroumis Source Type: research

Comments on "Cocrystallization of 5-fluorouracil with gallic acid: A novel 5-fluorouracil cocrystal displaying synergistic anti-tumor activity both in oral and intraperitoneal injection administration"
Eur J Pharm Biopharm. 2024 Feb 12:114217. doi: 10.1016/j.ejpb.2024.114217. Online ahead of print.ABSTRACTThis commentary highlights the significance of the solution stability and preparation of a solution of cocrystal in evaluating anti-tumor activity. It introduces a challenging issue regarding improving the biological activity of an API in cocrystal form.PMID:38355021 | DOI:10.1016/j.ejpb.2024.114217 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 14, 2024 Category: Drugs & Pharmacology Authors: Raha Kaviani Amin Alvani Ali Shayanfar Source Type: research

Reply to comments by Dr. Ali Shayanfar
Eur J Pharm Biopharm. 2024 Feb 12:114216. doi: 10.1016/j.ejpb.2024.114216. Online ahead of print.ABSTRACTSeveral clarifications are made pertaining to the study on the cocrystallization of 5-fluorouracil (5-FU) and gallic acid (GA). Dr. Shayanfar's perspective in the solubility and biological activity of cocrystals is recognized, and his insightful guidance on solubility determination methodologies is greatly appreciated. A misconception concerning the cytotoxicity assay methodology in the Shayanfar's comments is addressed. Furthermore, the stability of the 5-FU-GA cocrystal during solubility measurement is highlighted, as...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 14, 2024 Category: Drugs & Pharmacology Authors: Han Hao Jing Wang Source Type: research

The role of phospholipids in drug delivery formulations - Recent advances presented at the Researcher's Day 2023 Conference of the Phospholipid Research Center Heidelberg
Eur J Pharm Biopharm. 2024 Feb 11:114215. doi: 10.1016/j.ejpb.2024.114215. Online ahead of print.ABSTRACTThis Focus on Meetings contribution summarizes recent advances in the research on phospholipids and their applications for drug delivery and analytical purposes that have been presented at the hybrid Researcher's Day 2023 Conference of the Phospholipid Research Center (PRC), held on July 3-5, 2023 in Bad Dürkheim, Germany. The PRC is a non-profit organization focused on expanding and sharing scientific and technological knowledge of phospholipids in pharmaceutical and other applications. This is accomplished by, e.g., ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 13, 2024 Category: Drugs & Pharmacology Authors: Richard Wibel Peter van Hoogevest Simon Drescher Source Type: research

Archaeal ether lipids improve internalization and transfection with mRNA lipid nanoparticles
This study shows the high value of archaeal ether lipids for mRNA delivery and provides a solid foundation for future in vivo experiments and further research.PMID:38346479 | DOI:10.1016/j.ejpb.2024.114213 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 12, 2024 Category: Drugs & Pharmacology Authors: Viktor Laurin Sedlmayr Silvia Schobesberger Sarah Spitz Peter Ertl David Johannes Wurm Julian Quehenberger Oliver Spadiut Source Type: research

In situ triggered, floating delivery systems of capsaicin for prolonged gastroprotection
Eur J Pharm Biopharm. 2024 Feb 9:114212. doi: 10.1016/j.ejpb.2024.114212. Online ahead of print.ABSTRACTCapsaicin (CAP) has been implicated as a gastroprotective agent in the treatment of peptic ulcers. However, its oral administration is hampered by its poor aqueous solubility and caustic effect at high administered doses. To address these limitations, we describe the development of gastric floating, sustained release electrospun films loaded with CAP. The nanofiber films were formulated using the polymers Eudragit RL/RS and sodium bicarbonate (SB) as the effervescent agent. The films were tested for their physicochemical...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 11, 2024 Category: Drugs & Pharmacology Authors: Konstantina Chachlioutaki Pedro H D M Prazeres S érgio R A Scalzo Pelagia Bakirtzi Samson Afewerki Pedro P G Guimaraes Nikolaos Bouropoulos Dimitrios G Fatouros Christina Karavasili Source Type: research

Enhanced anti-malarial efficacy of mefloquine delivered via cationic liposome in a murine model of experimental cerebral malaria
Eur J Pharm Biopharm. 2024 Feb 8:114210. doi: 10.1016/j.ejpb.2024.114210. Online ahead of print.ABSTRACTMalaria is a longstanding global health challenge that continues to afflict over 90 countries located in tropical and subtropical regions of the globe. The rise of drug-resistant malarial parasites has curtailed the therapeutic efficacy of a number of once-effective anti-malarials, including mefloquine. In the present study, we have taken advantage of drug encapsulation approach to elevate the anti-malarial potential of mefloquine. Encouragingly, our findings unveil that liposomal formulations of mefloquine outperform eq...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 10, 2024 Category: Drugs & Pharmacology Authors: Mohsin Raza Hina Bharti Charu Chauhan Aakriti Singal Deepa Jha Prahlad C Ghosh Alo Nag Source Type: research

Evidence of the protective effect of anti-pollution products against oxidative stress in skin ex vivo using EPR spectroscopy and autofluorescence measurements
Eur J Pharm Biopharm. 2024 Feb 8:114211. doi: 10.1016/j.ejpb.2024.114211. Online ahead of print.ABSTRACTThe concentration of air pollution is gradually increasing every year so that daily skin exposure is unavoidable. Dietary supplements and topical formulations currently represent the protective strategies to guard against the effects of air pollution on the body and the skin. Unfortunately, there are not yet enough methods available to measure the effectiveness of anti-pollution products on skin. Here, we present two ex vivo methods for measuring the protective effect against air pollution of different cream formulations...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 10, 2024 Category: Drugs & Pharmacology Authors: Phuong Thao Tran Johannes Schleusener Burkhard Kleuser Katinka Jung Martina C Meinke Silke B Lohan Source Type: research

Polymeric microneedles for the eye: An overview of advances and ocular applications for minimally invasive drug delivery
Eur J Pharm Biopharm. 2024 Feb 7:114209. doi: 10.1016/j.ejpb.2024.114209. Online ahead of print.ABSTRACTOcular drug delivery is challenging due to the presence of tissue barriers and clearance mechanisms. Most widely used topical formulations need frequent application because of poor permeability, short retention, and low bioavailability. Invasive intraocular injections and implants that deliver drugs at the target site are associated with infections, inflammation, and even vision loss post-use. These gaps can be addressed by a delivery platform that can efficiently deliver drug with minimal tissue damage. Microneedles wer...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 9, 2024 Category: Drugs & Pharmacology Authors: Madhura Mulkutkar Mansi Damani Sujata Sawarkar Source Type: research

Combination of self-assembling system and N,O-carboxymethyl chitosan improves ocular residence of anti-glaucoma drug
Eur J Pharm Biopharm. 2024 Feb 7:114208. doi: 10.1016/j.ejpb.2024.114208. Online ahead of print.ABSTRACTGlaucoma is known to be one of the principal causes of vision loss due to elevated intraocular pressure. Currently, latanoprost eye drops is used as first-line treatment for glaucoma; however, it possesses low bioavailability due to rapid precorneal clearance. A novel delivery system with a mucoadhesive property could overcome this problem. Therefore, we attempt to develop a combination of self-assembling latanoprost nanomicelles (Latcel) and a mucoadhesive polymer (N,O-carboxymethyl chitosan: N,O-CMC) to improve the cor...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 9, 2024 Category: Drugs & Pharmacology Authors: Velmurugan Kailasam Bommanahalli Nagaraju Kumara K Sudhakara Prasad Jayabalan Nirmal Source Type: research