Corrigendum to "Evaluation the injectability of injectable microparticle delivery systems on the basis of injection force and discharged rate" [Eur. J. Pharm. Biopharm. 190 (2023) 58-72]
Eur J Pharm Biopharm. 2023 Dec 15:S0939-6411(23)00246-1. doi: 10.1016/j.ejpb.2023.09.013. Online ahead of print.NO ABSTRACTPMID:38103996 | DOI:10.1016/j.ejpb.2023.09.013 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 16, 2023 Category: Drugs & Pharmacology Authors: Chuncao Zhao Zhihan Zhu Xingchen Cao Feng Pan Fang Li Man Xue Yilin Guo Yanhong Zhao Jia Zeng Yu Liu Ziyi Yang Yan Liu Fuzheng Ren Linglin Feng Source Type: research

Corrigendum to "Evaluation the injectability of injectable microparticle delivery systems on the basis of injection force and discharged rate" [Eur. J. Pharm. Biopharm. 190 (2023) 58-72]
Eur J Pharm Biopharm. 2023 Dec 15:S0939-6411(23)00246-1. doi: 10.1016/j.ejpb.2023.09.013. Online ahead of print.NO ABSTRACTPMID:38103996 | DOI:10.1016/j.ejpb.2023.09.013 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 16, 2023 Category: Drugs & Pharmacology Authors: Chuncao Zhao Zhihan Zhu Xingchen Cao Feng Pan Fang Li Man Xue Yilin Guo Yanhong Zhao Jia Zeng Yu Liu Ziyi Yang Yan Liu Fuzheng Ren Linglin Feng Source Type: research

Comprehensive physicochemical and functional analysis of pembrolizumab based on controlled degradation studies: Impact on antigen-antibody binding
Eur J Pharm Biopharm. 2023 Dec 13:S0939-6411(23)00329-6. doi: 10.1016/j.ejpb.2023.12.005. Online ahead of print.ABSTRACTMonoclonal antibodies-based medicines are widely used in the treatment of different diseases. These medicines are very sensitive to exposure to different environmental conditions and their handling in hospitals may affect their safety and efficacy. This is the case for pembrolizumab (Keytruda®, 25 mg/mL), for which there is not yet much information on its risk behaviour associated with routine handling or unintentional mishandling. Here we performed a wider physicochemical and functional analysis of pemb...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 15, 2023 Category: Drugs & Pharmacology Authors: Anabel Torrente-L ópez Jes ús Hermosilla Antonio Salmer ón-García Jos é Cabeza Adolfina Ruiz-Mart ínez Natalia Navas Source Type: research

Aggregation of human plasma and of human blood induced in vitro by filgrastim originator product; effect of PEGylation
Eur J Pharm Biopharm. 2023 Dec 12:S0939-6411(23)00328-4. doi: 10.1016/j.ejpb.2023.12.004. Online ahead of print.ABSTRACTWe herein report that filgrastim product Neupogen® and the filgrastim formulation buffer induced aggregate formation when mixed in vitro with human plasma, and formation of large membranous erythrocyte aggregates when mixed with human blood, similar to the aggregation induced by pegfilgrastim and by pegfilgrastim buffer [T. Arvinte, E. Poirier, N. Ersayin, G. Darpin, A. Cudd, J. Dowd, S. Brokx, Aggregation of human plasma and of human blood induced in vitro by pegfilgrastim originator formulation buffer ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 14, 2023 Category: Drugs & Pharmacology Authors: Tudor Arvinte Emilie Poirier Amelia Cudd Nuri Ersayin Guillaume Darpin Jason Dowd Stephen Brokx Source Type: research

Aggregation of human plasma and of human blood induced in vitro by filgrastim originator product; effect of PEGylation
Eur J Pharm Biopharm. 2023 Dec 12:S0939-6411(23)00328-4. doi: 10.1016/j.ejpb.2023.12.004. Online ahead of print.ABSTRACTWe herein report that filgrastim product Neupogen® and the filgrastim formulation buffer induced aggregate formation when mixed in vitro with human plasma, and formation of large membranous erythrocyte aggregates when mixed with human blood, similar to the aggregation induced by pegfilgrastim and by pegfilgrastim buffer [T. Arvinte, E. Poirier, N. Ersayin, G. Darpin, A. Cudd, J. Dowd, S. Brokx, Aggregation of human plasma and of human blood induced in vitro by pegfilgrastim originator formulation buffer ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 14, 2023 Category: Drugs & Pharmacology Authors: Tudor Arvinte Emilie Poirier Amelia Cudd Nuri Ersayin Guillaume Darpin Jason Dowd Stephen Brokx Source Type: research

Intranasal administration of sertraline ensures sustained brain delivery and antidepressant effect in a mouse model of depression
Eur J Pharm Biopharm. 2023 Dec 11:S0939-6411(23)00326-0. doi: 10.1016/j.ejpb.2023.12.002. Online ahead of print.ABSTRACTThe pursuit of more potent and efficacious antidepressant therapies is of utmost significance. Herein, intranasal (IN) route was investigated for sertraline brain delivery, encompassing a comparative pharmacokinetic study after a single-dose administration to mice by IN, intravenous (IV) (4.87 mg/kg) and oral (10 mg/kg) routes, and an efficacy/toxicity study to explore the therapeutic effect in mice subjected to the unpredictable chronic mild stress (UCMS) protocol. Neurotransmitters and melatonin were qu...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 13, 2023 Category: Drugs & Pharmacology Authors: Soraia Silva Carla Fonseca Joana Bicker Am ílcar Falcão Ana Fortuna Source Type: research

Intranasal administration of sertraline ensures sustained brain delivery and antidepressant effect in a mouse model of depression
Eur J Pharm Biopharm. 2023 Dec 11:S0939-6411(23)00326-0. doi: 10.1016/j.ejpb.2023.12.002. Online ahead of print.ABSTRACTThe pursuit of more potent and efficacious antidepressant therapies is of utmost significance. Herein, intranasal (IN) route was investigated for sertraline brain delivery, encompassing a comparative pharmacokinetic study after a single-dose administration to mice by IN, intravenous (IV) (4.87 mg/kg) and oral (10 mg/kg) routes, and an efficacy/toxicity study to explore the therapeutic effect in mice subjected to the unpredictable chronic mild stress (UCMS) protocol. Neurotransmitters and melatonin were qu...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 13, 2023 Category: Drugs & Pharmacology Authors: Soraia Silva Carla Fonseca Joana Bicker Am ílcar Falcão Ana Fortuna Source Type: research

The proteolytic airway environment associated with pneumonia acts as a barrier for treatment with anti-infective antibodies
Eur J Pharm Biopharm. 2023 Dec 10:S0939-6411(23)00327-2. doi: 10.1016/j.ejpb.2023.12.003. Online ahead of print.ABSTRACTLike pneumonia, coronavirus disease 2019 (COVID-19) is characterized by a massive infiltration of innate immune cells (such as polymorphonuclear leukocytes) into the airways and alveolar spaces. These cells release proteases that may degrade therapeutic antibodies and thus limit their effectiveness. Here, we investigated the in vitro and ex vivo impact on anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) IgG1s and other IgG subclasses (IgG2 and IgG4) of the neutrophil elastase, proteinase 3...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 12, 2023 Category: Drugs & Pharmacology Authors: Timoth ée Blin Christelle Parent Gabrielle Pichon Antoine Guillon Youenn Jouan Hassan Allouchi Nicolas Aubrey Fanny Boursin Roxane Domain Baris Korkmaz Thomas S écher Nathalie Heuz é-Vourc'h Source Type: research

The proteolytic airway environment associated with pneumonia acts as a barrier for treatment with anti-infective antibodies
Eur J Pharm Biopharm. 2023 Dec 10:S0939-6411(23)00327-2. doi: 10.1016/j.ejpb.2023.12.003. Online ahead of print.ABSTRACTLike pneumonia, coronavirus disease 2019 (COVID-19) is characterized by a massive infiltration of innate immune cells (such as polymorphonuclear leukocytes) into the airways and alveolar spaces. These cells release proteases that may degrade therapeutic antibodies and thus limit their effectiveness. Here, we investigated the in vitro and ex vivo impact on anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) IgG1s and other IgG subclasses (IgG2 and IgG4) of the neutrophil elastase, proteinase 3...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 12, 2023 Category: Drugs & Pharmacology Authors: Timoth ée Blin Christelle Parent Gabrielle Pichon Antoine Guillon Youenn Jouan Hassan Allouchi Nicolas Aubrey Fanny Boursin Roxane Domain Baris Korkmaz Thomas S écher Nathalie Heuz é-Vourc'h Source Type: research

Lipoamino bundle LNPs for efficient mRNA transfection of dendritic cells and macrophages show high spleen selectivity
In this study, we demonstrate lipoamino xenopeptide carriers as components of highly efficient mRNA LNPs. These lipo-xenopeptides are defined as 2D sequences in different 3D topologies (bundles or different U-shapes). The polar artificial amino acid tetraethylene pentamino succinic acid (Stp) and various lipophilic tertiary lipoamino fatty acids (LAFs) act as ionizable amphiphilic units, connected in different ratios via bisamidated lysines as branching units. A series of more lipophilic LAF4-Stp1 carriers with bundle topology is especially well suited for efficient encapsulation of mRNA into LNPs, facilitated cellular upt...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 8, 2023 Category: Drugs & Pharmacology Authors: Franziska Haase Jana P öhmerer Mina Yazdi Melina Grau Yanira Zeyn Ulrich Wilk Tobias Burghardt Miriam H öhn Christoph Hieber Matthias Bros Ernst Wagner Simone Berger Source Type: research

Lipoamino bundle LNPs for efficient mRNA transfection of dendritic cells and macrophages show high spleen selectivity
In this study, we demonstrate lipoamino xenopeptide carriers as components of highly efficient mRNA LNPs. These lipo-xenopeptides are defined as 2D sequences in different 3D topologies (bundles or different U-shapes). The polar artificial amino acid tetraethylene pentamino succinic acid (Stp) and various lipophilic tertiary lipoamino fatty acids (LAFs) act as ionizable amphiphilic units, connected in different ratios via bisamidated lysines as branching units. A series of more lipophilic LAF4-Stp1 carriers with bundle topology is especially well suited for efficient encapsulation of mRNA into LNPs, facilitated cellular upt...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 8, 2023 Category: Drugs & Pharmacology Authors: Franziska Haase Jana P öhmerer Mina Yazdi Melina Grau Yanira Zeyn Ulrich Wilk Tobias Burghardt Miriam H öhn Christoph Hieber Matthias Bros Ernst Wagner Simone Berger Source Type: research

Lipoamino bundle LNPs for efficient mRNA transfection of dendritic cells and macrophages show high spleen selectivity
In this study, we demonstrate lipoamino xenopeptide carriers as components of highly efficient mRNA LNPs. These lipo-xenopeptides are defined as 2D sequences in different 3D topologies (bundles or different U-shapes). The polar artificial amino acid tetraethylene pentamino succinic acid (Stp) and various lipophilic tertiary lipoamino fatty acids (LAFs) act as ionizable amphiphilic units, connected in different ratios via bisamidated lysines as branching units. A series of more lipophilic LAF4-Stp1 carriers with bundle topology is especially well suited for efficient encapsulation of mRNA into LNPs, facilitated cellular upt...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 8, 2023 Category: Drugs & Pharmacology Authors: Franziska Haase Jana P öhmerer Mina Yazdi Melina Grau Yanira Zeyn Ulrich Wilk Tobias Burghardt Miriam H öhn Christoph Hieber Matthias Bros Ernst Wagner Simone Berger Source Type: research

Co-processed materials testing as excipients to produce Orally Disintegrating Tablets (ODT) using binder jet 3D-printing technology
Eur J Pharm Biopharm. 2023 Dec 2:S0939-6411(23)00313-2. doi: 10.1016/j.ejpb.2023.11.023. Online ahead of print.ABSTRACTThe use of co-processed materials for Orally Disintegrating Tablets (ODT) preparation by direct compression is well consolidated. However, the evaluation of their potential for ODT preparation by 3D printing technology remains almost unexplored. The present study aimed to estimate the use of commercially available co-processed excipients, conventionally applied in compression protocols, for the preparation of ODTs with binder jetting-3D printing technology. The latter was selected among the 3D printing tec...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 4, 2023 Category: Drugs & Pharmacology Authors: Evelyn Ochoa Lucia Morelli Lucia Salvioni Marco Giustra Beatrice De Santes Francesca Spena Linda Barbieri Stefania Garbujo Matteo Vigan ò Brian Novati Giulia Tomaino Saliha Moutaharrik Davide Prosperi Luca Palugan Miriam Colombo Source Type: research

Mucoactive drugs and multiple applications in pulmonary disease therapy
Eur J Pharm Biopharm. 2023 Dec 2:S0939-6411(23)00321-1. doi: 10.1016/j.ejpb.2023.12.001. Online ahead of print.ABSTRACTMucus is a complex polymeric hydrogel that serves as a critical defense in several organs. In the lungs, it provides a formidable barrier against inhaled particles such as microorganisms. In addition, mucus is essential for normal lung physiology, as it promotes immune tolerance and facilitates a normal commensal pulmonary microbiome. Hypersecretion of airway mucus is a characteristic of numerous respiratory diseases, such as Chronic Obstructive Pulmonary Disease (COPD) and Cystic Fibrosis (CF), and create...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 4, 2023 Category: Drugs & Pharmacology Authors: Alexis Hocquigny H élène Hugerot Rosy Ghanem Tanguy Haute V éronique Laurent Virginie Cogulet Tristan Montier Source Type: research

Co-processed materials testing as excipients to produce Orally Disintegrating Tablets (ODT) using binder jet 3D-printing technology
Eur J Pharm Biopharm. 2023 Dec 2:S0939-6411(23)00313-2. doi: 10.1016/j.ejpb.2023.11.023. Online ahead of print.ABSTRACTThe use of co-processed materials for Orally Disintegrating Tablets (ODT) preparation by direct compression is well consolidated. However, the evaluation of their potential for ODT preparation by 3D printing technology remains almost unexplored. The present study aimed to estimate the use of commercially available co-processed excipients, conventionally applied in compression protocols, for the preparation of ODTs with binder jetting-3D printing technology. The latter was selected among the 3D printing tec...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 4, 2023 Category: Drugs & Pharmacology Authors: Evelyn Ochoa Lucia Morelli Lucia Salvioni Marco Giustra Beatrice De Santes Francesca Spena Linda Barbieri Stefania Garbujo Matteo Vigan ò Brian Novati Giulia Tomaino Saliha Moutaharrik Davide Prosperi Luca Palugan Miriam Colombo Source Type: research