Investigating the heat sensitivity of frequently used excipients with varying particle sizes
Eur J Pharm Biopharm. 2023 Sep 14:S0939-6411(23)00243-6. doi: 10.1016/j.ejpb.2023.09.010. Online ahead of print.ABSTRACTDuring tablet manufacturing an increase in the production temperature can lead to an alteration of tablet characteristics. In the present study, the influence of the initial particle size on the tableting behavior of ductile polymers upon temperature rise was investigated. Different grades of the respective materials were tableted at temperatures ranging from 22-70 °C. Alterations in tableting behavior were affected by the initial particle size. Smaller particle sizes led to a more pronounced decrease in...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 16, 2023 Category: Drugs & Pharmacology Authors: Hanna Dorothea Grumann Peter Kleinebudde Source Type: research

Investigating the heat sensitivity of frequently used excipients with varying particle sizes
Eur J Pharm Biopharm. 2023 Sep 14:S0939-6411(23)00243-6. doi: 10.1016/j.ejpb.2023.09.010. Online ahead of print.ABSTRACTDuring tablet manufacturing an increase in the production temperature can lead to an alteration of tablet characteristics. In the present study, the influence of the initial particle size on the tableting behavior of ductile polymers upon temperature rise was investigated. Different grades of the respective materials were tableted at temperatures ranging from 22-70 °C. Alterations in tableting behavior were affected by the initial particle size. Smaller particle sizes led to a more pronounced decrease in...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 16, 2023 Category: Drugs & Pharmacology Authors: Hanna Dorothea Grumann Peter Kleinebudde Source Type: research

Investigating the heat sensitivity of frequently used excipients with varying particle sizes
Eur J Pharm Biopharm. 2023 Sep 14:S0939-6411(23)00243-6. doi: 10.1016/j.ejpb.2023.09.010. Online ahead of print.ABSTRACTDuring tablet manufacturing an increase in the production temperature can lead to an alteration of tablet characteristics. In the present study, the influence of the initial particle size on the tableting behavior of ductile polymers upon temperature rise was investigated. Different grades of the respective materials were tableted at temperatures ranging from 22-70 °C. Alterations in tableting behavior were affected by the initial particle size. Smaller particle sizes led to a more pronounced decrease in...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 16, 2023 Category: Drugs & Pharmacology Authors: Hanna Dorothea Grumann Peter Kleinebudde Source Type: research

Investigating the heat sensitivity of frequently used excipients with varying particle sizes
Eur J Pharm Biopharm. 2023 Sep 14:S0939-6411(23)00243-6. doi: 10.1016/j.ejpb.2023.09.010. Online ahead of print.ABSTRACTDuring tablet manufacturing an increase in the production temperature can lead to an alteration of tablet characteristics. In the present study, the influence of the initial particle size on the tableting behavior of ductile polymers upon temperature rise was investigated. Different grades of the respective materials were tableted at temperatures ranging from 22-70 °C. Alterations in tableting behavior were affected by the initial particle size. Smaller particle sizes led to a more pronounced decrease in...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 16, 2023 Category: Drugs & Pharmacology Authors: Hanna Dorothea Grumann Peter Kleinebudde Source Type: research

Investigating the heat sensitivity of frequently used excipients with varying particle sizes
Eur J Pharm Biopharm. 2023 Sep 14:S0939-6411(23)00243-6. doi: 10.1016/j.ejpb.2023.09.010. Online ahead of print.ABSTRACTDuring tablet manufacturing an increase in the production temperature can lead to an alteration of tablet characteristics. In the present study, the influence of the initial particle size on the tableting behavior of ductile polymers upon temperature rise was investigated. Different grades of the respective materials were tableted at temperatures ranging from 22-70 °C. Alterations in tableting behavior were affected by the initial particle size. Smaller particle sizes led to a more pronounced decrease in...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 16, 2023 Category: Drugs & Pharmacology Authors: Hanna Dorothea Grumann Peter Kleinebudde Source Type: research