European Journal of Pharmaceutics and Biopharmaceutics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Obtaining two polymorphic forms of paracetamol within the phase diagram with PEG 1500
Eur J Pharm Biopharm. 2023 Dec 23:114173. doi: 10.1016/j.ejpb.2023.114173. Online ahead of print.ABSTRACTStudies of the interactions between paracetamol, chosen as model active ingredient, and PEG 1500, a pharmaceutical carrier, are conducted in the solid state. Solid dispersions of PEG 1500 and paracetamol were prepared in different mass ratios. Two temperature cycles are then applied and the characterization is carried out by DSC and X-ray powder diffraction. Following this, a phase diagram is established for each cycle. On second heating, the metastable Form II of paracetamol is obtained within the PEG-based matrix. How...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 25, 2023 Category: Drugs & Pharmacology Authors: Ma ïlys Rassat Ingrid Ouandji Nicolas Guiblin Philippe Espeau Source Type: research

Corrigendum to "DEAE-Dextran coated paclitaxel nanoparticles act as multifunctional nano system for intranuclear delivery to triple negative breast cancer through VEGF and NOTCH1 inhibition" [Eur. J. Pharm. Biopharm. 122 (2018) 37-48]
Eur J Pharm Biopharm. 2023 Dec 22:114172. doi: 10.1016/j.ejpb.2023.114172. Online ahead of print.NO ABSTRACTPMID:38142168 | DOI:10.1016/j.ejpb.2023.114172 (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 23, 2023 Category: Drugs & Pharmacology Authors: Anita K Bakrania Bhavesh C Variya Lalaji V Rathod Snehal S Patel Source Type: research

Repurposing ebselen as an inhalable dry powder to treat respiratory tract infections
In this study, we developed inhalable ebselen dry powder formulations using a spray-drying technique. The amino acids leucine, methionine, and tryptophan were incorporated with ebselen to enhance the yield and aerosolization of the dry powders. The amino acid-containing ebselen dry powders showed a better yield (37-56.4 %) than the amino acid-free formulation (30.9 %). All dry powders were crystalline in nature. The mass median aerodynamic diameter (MMAD) was less than 5 µm for amino acids containing dry powders (3-4 µm) and slightly higher (5.4 µm) for amino acid free dry powder indicating their suitability for inhalat...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 21, 2023 Category: Drugs & Pharmacology Authors: Tushar Saha Nikita Lyons Deborah Bow Yue Yung Miguel E Qui ñones-Mateu Daniel Pletzer Shyamal C Das Source Type: research

Balancing competing objectives in bigel formulations using many-objective optimization algorithms and different decision-making methods
This study explores evolutionary algorithms for optimizing the microstructural, rheological, stability, and drug release properties of bigel systems formulated using structured almond oil, mixed organogelators, and carbopol. The oleogel was identified as the dispersed phase, with droplet sizes ranging from 1.43 µm to 7.37 µm, indicating improved characteristics compared to other bigels. Each formulation exhibited non-Newtonian shear-thinning and thixotropic behaviors, which were positively influenced by the proportions of the excipients. After undergoing multiple stress cycles, highly concentrated bigels exhibited phase ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 20, 2023 Category: Drugs & Pharmacology Authors: Kouider Amar Mohamed Rahal Soufiane Laidi Maamar Kouar Ibtihal Bourahla Rym Farah El-Khansaa Akouche Youcef Bouaraba Razki Source Type: research

Design space determination of pharmaceutical processes: Effects of control strategies and uncertainty
In this study, we exploit surrogate-based feasibility analysis to determine whether the process satisfies all process constraints by manipulating the process inputs and reduce the effect of uncertainty. The proposed approach is successfully tested on two simulated pharmaceutical case studies of increasing complexity, i.e., considering (i) a single pharmaceutical unit operation, and (ii) a pharmaceutical manufacturing line comprised of a sequence of connected unit operations. Results demonstrate that different control actions can be effectively exploited to operate the process in a wider range of inputs and mitigate uncerta...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 18, 2023 Category: Drugs & Pharmacology Authors: Margherita Geremia Fabrizio Bezzo Marianthi G Ierapetritou Source Type: research

CD4 < sup > + < /sup > T Cell-Targeting immunoliposomes for treatment of latent HIV reservoir
Eur J Pharm Biopharm. 2023 Dec 16:S0939-6411(23)00330-2. doi: 10.1016/j.ejpb.2023.12.006. Online ahead of print.ABSTRACTActive targeting nano-delivery is a promising approach to enhance therapeutic efficacy and specificity to the target cells. Liposomes (LPs) have been widely studied for the active targeting delivery due to their low toxicity, biodegradability, biocompatibility, and feasibility of surface medication to provide the interactions with cell receptors. One of the strategies is to functionalize the surface of LPs with monoclonal antibodies (mAbs) to obtain immunoliposomes (imLPs) that recognize specific receptor...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 18, 2023 Category: Drugs & Pharmacology Authors: Suthasinee Meeroekyai Thanapak Jaimalai Nuttee Suree Panchika Prangkio Source Type: research