European Journal of Medical Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

LASSO regression shows histidine and sphingosine 1 phosphate are linked to both sepsis mortality and endothelial damage
AbstractSepsis is a major cause of death worldwide, with a mortality rate that has remained stubbornly high. The current gold standard of risk stratifying sepsis patients provides limited mechanistic insight for therapeutic targeting. An improved ability to predict sepsis mortality and to understand the risk factors would allow better treatment targeting. Sepsis causes metabolic dysregulation in patients; therefore, metabolomics offers a promising tool to study sepsis. It is also known that that in sepsis endothelial cells affecting their function regarding blood clotting and vascular permeability. We integrated metabolomi...
Source: European Journal of Medical Research - January 20, 2024 Category: Research Source Type: research

Correction: N7 ‑methylguanosin regulators‑mediated methylation modification patterns and characterization of the immune microenvironment in lower‑grade glioma
(Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 19, 2024 Category: Research Source Type: research

Assessment of different continence definitions in the context of the randomized multicenter prospective LAP-01 trial —Does the best definition change over time?
ConclusionThe best continence definition according to the patients ’ perspective changes over time, “0 pads” being the superior criterion in the long-term. We recommend using the 0-pad definition for standardized continence reporting, as it is simple yet as accurate as possible given the inevitably high subjectivity of continence perception.Trial registration The LAP-01 trial was registered with the U.S. National Library of Medicine clinical trial registry (clinicaltrials.gov), NCT number: NCT03682146, and with the German Clinical Trial registry (Deutsches Register Klinischer Studien), DRKS ID number: DRKS00007138 (S...
Source: European Journal of Medical Research - January 18, 2024 Category: Research Source Type: research

Risk of flare or relapse in patients with immune-mediated diseases following SARS-CoV-2 vaccination: a systematic review and meta-analysis
ConclusionThe risk of flare/relapse/exacerbation in AI-IMD patients is found to be minimal, especially with vector-based vaccines. Vaccination against COVID-19 is recommended in this population. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 17, 2024 Category: Research Source Type: research

Androgen deficiency is associated with a better prognosis in glioblastoma
ConclusionCirculating testosterone levels are associated with the prognosis of glioblastoma because patients with AD show a better prognosis than those with normal androgenic status. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 17, 2024 Category: Research Source Type: research

The influence of gender on the epidemiology of and outcome from sepsis associated acute kidney injury in ICU: a retrospective propensity-matched cohort study
ConclusionsGender may affect the incidence and outcomes of SA-AKI, further research is needed to fully understand the impact of gender on SA-AKI patients. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 17, 2024 Category: Research Source Type: research

Causal relationships between type 1 diabetes mellitus and Alzheimer ’s disease and Parkinson’s disease: a bidirectional two-sample Mendelian randomization study
ConclusionThis MR study reveals that T1DM is associated with a reduced genetic susceptibility to PD, whereas no significant genetic susceptibility is observed between T1DM and AD. These findings suggest that T1DM may have a distinct role in the development of neurodegenerative diseases compared to T2D. Further investigations are warranted to elucidate the underlying mechanisms and provide a more comprehensive understanding of this relationship. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 16, 2024 Category: Research Source Type: research

Epigenetic characterization of sarcopenia-associated genes based on machine learning and network screening
AbstractTo screen characteristic genes related to sarcopenia by bioinformatics and machine learning, and to verify the accuracy of characteristic genes in the diagnosis of sarcopenia. Download myopia-related data sets from geo public database, find the differential genes through R language limma package after merging, STRING database to build protein interaction network, and do Go analysis and GSEA analysis to understand the functions and molecular signal pathways that may be affected by the differential genes. Further screen the characteristic genes through LASSO and SVM-RFE machine algorithms, make the ROC curve of the c...
Source: European Journal of Medical Research - January 16, 2024 Category: Research Source Type: research

Deciphering the significance of anoikis in bladder cancer and systematic analysis of S100A7 as a potential therapeutic target
ConclusionWe established and validated a bladder cancer prognostic model consisting of three genes, which can effectively evaluate the prognosis of bladder cancer patients. Additionally, through cellular experiments, we demonstrated the significant role of S100A7 in the metastasis and invasion of bladder cancer, suggesting its potential as a novel target for future treatments. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 12, 2024 Category: Research Source Type: research

The synthetic cannabinoids menace: a review of health risks and toxicity
AbstractSynthetic cannabinoids (SCs) are chemically classified as psychoactive substances that target the endocannabinoid system in many body organs. SCs can initiate pathophysiological changes in many tissues which can be severe enough to damage the normal functionality of our body systems. The majority of SCs-related side effects are mediated by activating Cannabinoid Receptor 1 (CB1R) and Cannabinoid Receptor 2 (CB2R). The activation of these receptors can enkindle many downstream signalling pathways, including oxidative stress, inflammation, and apoptosis that ultimately can produce deleterious changes in many organs. ...
Source: European Journal of Medical Research - January 12, 2024 Category: Research Source Type: research

Antioxidants and the risk of stroke: results from NHANES and two-sample Mendelian randomization study
ConclusionsEvidence suggests that diet-derived antioxidants may reduce the risk of stroke, as indicated by the protective effects of retinol and selenium against SAH. However, more research is needed to fully understand how antioxidants prevent stroke. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 12, 2024 Category: Research Source Type: research

Prediction of clinical progression in nervous system diseases: plasma glial fibrillary acidic protein (GFAP)
AbstractGlial fibrillary acidic protein (GFAP), an intracellular type III intermediate filament protein, provides structural support and maintains the mechanical integrity of astrocytes. It is predominantly found in the astrocytes which are the most abundant subtypes of glial cells in the brain and spinal cord. As a marker protein of astrocytes, GFAP may exert a variety of physiological effects in neurological diseases. For example, previous published literatures showed that autoimmune GFAP astrocytopathy is an inflammatory disease of the central nervous system (CNS). Moreover, the studies of GFAP in brain tumors mainly fo...
Source: European Journal of Medical Research - January 12, 2024 Category: Research Source Type: research

Impact of congenital uterine anomalies on reproductive outcomes of IVF/ICSI-embryo transfer: a retrospective study
ConclusionsBoth canalization defects and unification defects were associated with lower fertility outcomes, including lower live birth rates, lower clinical pregnancy rates, and higher early miscarriage rates. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 11, 2024 Category: Research Source Type: research

Identification of an ADME-related gene for forecasting the prognosis and responding to immunotherapy in sarcomas
In this study, a risk score signature was created. The SARC cohort was downloaded from The Cancer Genome Atlas (TCGA) database, and divided into high-risk group and low-risk group according to the median value of risk score. Compared with high-risk group, low-risk group has a longer survival time, which is also verified in osteosarcoma cohort from Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. In addition, the relationship between the signature and immunophenotypes, including status of immune cell infiltration and immune checkpoint expression, was explored. Then, we found that high-...
Source: European Journal of Medical Research - January 11, 2024 Category: Research Source Type: research

Identification of potential crucial genes and therapeutic targets for epilepsy
ConclusionsThe results of this study highlightPTPRO andGADD45A as potential genes for the diagnosis and treatment of epilepsy. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 11, 2024 Category: Research Source Type: research