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Assessment and clinical utility of metagenomic next-generation sequencing for suspected lower respiratory tract infections
ConclusionsmNGS offers rapid and precise pathogen detection for patients with suspected LRTIs and shows considerable promise in diagnosingMycobacterium tuberculosis and fungal infections. By broadening the pathogen spectrum and identifying polymicrobial infections, mNGS can significantly inform and refine antibiotic therapy. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 1, 2024 Category: Research Source Type: research

Retraction Note: Protective functions of myricetin in LPS-induced cardiomyocytes H9c2 cells injury by regulation of MALAT1
(Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 1, 2024 Category: Research Source Type: research

A nomogram prediction model for hungry bone syndrome in dialysis patients with secondary hyperparathyroidism after total parathyroidectomy
ConclusionsPreoperative iPTH and preoperative ALP are the risk factors for postoperative HBS, which can be used to guide the early clinical intervention. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 28, 2024 Category: Research Source Type: research

Multi-omics cluster defines the subtypes of CRC with distinct prognosis and tumor microenvironment
ConclusionThe integrative multi-omics subtypes proposed potential biomarkers for CRC and provided valuable knowledge for precision oncology. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 28, 2024 Category: Research Source Type: research

Comprehensive analysis of the prognostic value and immunological role of IDO1 gene in pan-cancer
ConclusionThe clinical treatment of IDO1 is now better supported by a theoretical basis and guidelines provided by our study. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 27, 2024 Category: Research Source Type: research

Role of GABA pathway in motor and non-motor symptoms in Parkinson's disease: a bidirectional circuit
In conclusion, the deregulation of the GABAergic pathway in PD might be intricate in developing motor and non-motor symptoms. Improving this pathway might be a novel, beneficial approach to control PD s ymptoms. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 27, 2024 Category: Research Source Type: research

Association of novel anthropometric indices with prevalence of kidney stone disease: a  population-based cross-sectional study
ConclusionsThe findings of our study indicate that the discriminant ability of ABSI and BRI for KSD is significantly superior to that of BMI and waist circumference. Consequently, ABSI and BRI have the potential to more accurately identify an individual ’s risk of developing KSD in a clinical setting. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 27, 2024 Category: Research Source Type: research

Threshold-modifying effect of the systemic inflammatory response index on kidney function decline in hypertensive patients
ConclusionsThe association between the SIRI and renal function in hypertensive patients was significant and was particularly dominated by the association between the SIRI and the ACR. This difference may be due to the mediating effect of diastolic blood pressure. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 27, 2024 Category: Research Source Type: research

Relationship between albumin-corrected anion gap and non-alcoholic fatty liver disease varied in different waist circumference groups: a cross-sectional study
ConclusionsACAG level is independently associated with NAFLD but not CSF. ACAG might be a novel and reliable biomarker for predicting NAFLD clinically especially in the central obesity population. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 27, 2024 Category: Research Source Type: research

Cortical lipid metabolic pathway alteration of early Alzheimer ’s disease and candidate drugs screen
ConclusionsAD cortical lipid metabolism disorder was associated with the dysregulation of the PPAR signaling pathway, glycerophospholipid metabolism, adipocytokine signaling pathway, fatty acid biosynthesis, fatty acid degradation, ferroptosis, biosynthesis of unsaturated fatty acids, and fatty acid elongation. Candidate drugs including bisphenol A, benzo(a)pyrene, ethinyl estradiol, and active compounds including adenosine phosphate, oxidized Photinus luciferin, and BMS-488043 have potential therapeutic effects on cortical lipid metabolism disorder of early AD. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 25, 2024 Category: Research Source Type: research

2- to 20-year myelomeningocele follow-up outcomes from a referral center in Southern Iran: the Shiraz experience
ConclusionsThis study is the first to characterize the long-term outcomes of MMC patients in Iran. This study illustrates that there is a great need for improved access to and coordination of care in antenatal, perioperative, and long-term stages to improve morbidity and mortality. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 25, 2024 Category: Research Source Type: research

Acute exacerbation of  idiopathic pulmonary fibrosis disease: a diagnosis model in China
ConclusionA diagnosis model was developed and validated that used information collected from HIS  system and LIS system and may be used to risk stratify idiopathic pulmonary fibrosis patients experiencing acute exacerbations. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 25, 2024 Category: Research Source Type: research

Diagnostic value of serum COMP and ADAMTS7 for intervertebral disc degeneration
ConclusionsIncreases in circulating COMP and ADAMTS7 correlate with IVDD progression and may play regulatory roles. Assays for sCOMP and/or sADAMTS7 levels can discriminate between healthy subjects and IVDD patients, warranting further clinical assessment. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 25, 2024 Category: Research Source Type: research

A genetic survey of patients with familial idiopathic intracranial hypertension residing in a Middle Eastern village: genetic association study
ConclusionsWe discovered new loci possibly associated with IIH by employing a GWAS technique to estimate the associations with haplotypes instead of specific SNPs. This method can in all probability be used in cases where there is a limited amount of samples but strong familial connections. Several loci were identified that might be strong candidates for follow-up studies in other well-phenotypes cohorts. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 25, 2024 Category: Research Source Type: research

Will coronal alignment postoperatively be deteriorating in adult spinal deformity after long-fusion surgery?
ConclusionsThe coronal alignments in ASD patients underwent long-fusion surgeries may deteriorate during follow-up, for which the risk factors include the consistency CA, age  ≥ 60, fixed-vertebra ≥ 8, CBD-correction ≥ 30 mm and pelvic fixation. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - March 25, 2024 Category: Research Source Type: research