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A promising natural killer cell-based model and a nomogram for the prognostic prediction of clear-cell renal cell carcinoma
ConclusionsThe six-gene model based on NK cell-related gene expression was validated and found to accurately mirror immune microenvironment and predict clinical outcomes, contributing to enhanced risk stratification and therapy response for ccRCC patients. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 24, 2024 Category: Research Source Type: research

Predictive modeling for acute kidney injury after percutaneous coronary intervention in patients with acute coronary syndrome: a machine learning approach
ConclusionOur analyses showed that ML models can predict AKI with acceptable performance. This has potential clinical utility for assessing the individualized risk of AKI in ACS patients undergoing PCI. Additionally, the identified features in the models may aid in mitigating these risk factors.Graphical Abstract (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 24, 2024 Category: Research Source Type: research

Correction: Exploring the association between triglyceride-glucose index and thyroid function
(Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 24, 2024 Category: Research Source Type: research

circNINL facilitates aerobic glycolysis, proliferation, invasion, and migration in lung cancer by sponging miR-3918 to mediate FGFR1 expression
This study aimed to delineate the biological role of circNINL in LC and to unveil its potential molecular mechanisms. We discovered elevated expression levels of circNINL and Fibroblast Growth Factor Receptor 1 (FGFR1) concomitant with diminished expression of microRNA-3918 (miR-3918) in LC specimens. Knockdown of circNINL led to a marked decrease in cell proliferation, migration, invasion, and aerobic glycolysis, alongside an upsurge in apoptosis in LC cells. Either downregulation of miR-3918 or overexpression of FGFR1 mitigated the suppressive impact of circNINL knockdown on LC pathogenesis. Mechanistic studies validated...
Source: European Journal of Medical Research - January 20, 2024 Category: Research Source Type: research

Chalcone-derivative L6H21 attenuates the OVA-induced asthma by targeting MD2
The objective of this study was to explore the impact of MD2 on the progression of asthma using L6H21, a novel MD2 inhibitor, to identify potential targets and drug candidates for asthma treatment. To establish an asthma-related murine model and evaluate the effects of L6H21, ovalbumin (OVA) was used to sensitize and challenge mice. Pathological changes were examined with various staining techniques, such as H&E staining, glycogen staining, and Masson staining. Inflammatory cell infiltration and excessive cytokine secretion were evaluated by analyzing BALF cell count, RT-PCR, and ELISA. The TLR4/MD2 complex formation, ...
Source: European Journal of Medical Research - January 20, 2024 Category: Research Source Type: research

Amifostine ameliorates bleomycin-induced murine pulmonary fibrosis via NAD+/SIRT1/AMPK pathway-mediated effects on mitochondrial function and cellular metabolism
ConclusionAmifostine inhibits bleomycin-induced pulmonary fibrosis by restoring mitochondrial function and cellular metabolism. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 20, 2024 Category: Research Source Type: research

Prone positioning effect on tracheal intubation rate, mortality and oxygenation parameters in awake non-intubated severe COVID-19-induced respiratory failure: a review of reviews
ConclusionProne positioning can be recommended in conscious ICU patients with COVID-19 pneumonia to reduce mortality and intubation.Systematic review registration: PROSPERO registration number: CRD42022326951. Registered 25 April 2022.Graphical Abstract (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 20, 2024 Category: Research Source Type: research

N-Nitrosomorpholine-induced oncocytic transformation in rat endocrine organs
ConclusionsWe showed that NMO induced an oncocytic change in pancreas, thyroid, pituitary, and adrenal glands. To date, no identified specific environmental risk factors that lead to an oncocytic transformation in endocrine glands have been reported previously. Given the increasing prevalence of endocrine-disrupting chemicals in the environment, personal care products, manufactured goods, and food sources, there is a need to advance our understanding of the pathological mechanisms underlying oncocytosis in endocrine organs. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 20, 2024 Category: Research Source Type: research

SOX9 gene shows association with adolescent idiopathic scoliosis predisposition in Northwest Indians
ConclusionThe present study is the first to demonstrate the association of SOX9 enhancer locus variants with AIS in any South Asian Indian population. The results are interesting as rs1042667, a 3' untranslated region (UTR) variant in the exon 3 and upstream variants of the SOX9 gene, were associated with AIS susceptibility in the Northwest Indian population. This provides evidence that the variants in the enhancer region ofSOX9 might regulate its gene expression, thus leading to AIS pathology and might act as an important gene for AIS susceptibility. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 20, 2024 Category: Research Source Type: research

Rapid weather changes are associated with daily hospital visitors for atrial fibrillation accompanied by abnormal ECG repolarization: a case-crossover study
ConclusionThis study highlights a significant correlation between meteorological factors and daily hospital visits for AF accompanied by abnormal ECG repolarization in Shanghai, China. In addition, AF patients with abnormal ECG repolarization were found to be more vulnerable to rapid daily changes in pressure and temperature compared to AF patients without such repolarization abnormalities. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 20, 2024 Category: Research Source Type: research

Salidroside protects RGC from pyroptosis in diabetes-induced retinopathy associated with NLRP3, NFEZL2 and NGKB1, revealed by network pharmacology analysis and experimental validation
ConclusionSalidroside can significantly improve diabetes-inducedRGC pyrotosis in retina, in which, the underlying mechanism is associated with the NLRP3, NFEZL2 and NGKB1 regulation. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 20, 2024 Category: Research Source Type: research

Multidisciplinary-derived clinical score for accurate prediction of long-term mortality in fibrotic lung disease patients
ConclusionThe clinical score composite of DLCO, mMRC Dyspnea Scale, and 6MWT distance could provide an accurate prediction for long-term mortality in ILD patients, laying out a helpful tool for managing and following these patients. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 20, 2024 Category: Research Source Type: research

Nafamostat mesylate versus regional citrate anticoagulation for continuous renal replacement therapy in patients at high risk of bleeding: a retrospective single-center study
ConclusionOur study suggests that nafamostat mesylate's anticoagulant efficacy and safety are not inferior to regional citrate anticoagulation for continuous renal replacement therapy in patients at high risk of bleeding. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 20, 2024 Category: Research Source Type: research

Bioinformatics analysis identifies GLUD1 as a prognostic indicator for clear cell renal cell carcinoma
ConclusionsThese findings provide new ideas for finding new prognostic molecular markers and therapeutic targets for ccRCC. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 20, 2024 Category: Research Source Type: research

Skeletal muscle index together with body mass index is associated with secondary osteoporosis in patients with rheumatoid arthritis
ConclusionBMI and SMI are associated with the occurrence of OP in RA patients, and both SMI and BMI are important protective factors for OP secondary to RA. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 20, 2024 Category: Research Source Type: research