European Journal of Medical Research 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.ZNF692 promotes cell proliferation, invasion and migration of human prostate cancer cells by targeting the EMT signaling pathway
ConclusionZNF692 can be used as a new prognostic marker and a potential biologic therapeutic target for PCa. By inhibiting the expression of c-myc and cyclinA1, the EMT signaling pathway is regulated to provide evidence for its potential molecular mechanism. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 30, 2024 Category: Research Source Type: research
Evaluating the association between gingival crevicular blood glucose levels and finger capillary blood glucose levels according to periodontal status
ConclusionThe study observed a positive association between GCBG and FCBG. However, the relationship with periodontal status appeared to be relatively weak. Further research may be needed to determine the potential efficacy of GCBG in diabetes screening during periodontal examinations. Clinical relevance: Most patients with diabetes do not have proper periodontal health, so it may be helpful to screen for diabetes during periodontal examinations. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 30, 2024 Category: Research Source Type: research
Paclitaxel and its semi-synthetic derivatives: comprehensive insights into chemical structure, mechanisms of action, and anticancer properties
AbstractCancer is a disease that can cause abnormal cell growth and can spread throughout the body. It is among the most significant causes of death worldwide, resulting in approx. 10 million deaths annually. Many synthetic anticancer drugs are available, but they often come with side effects and can interact negatively with other medications. Additionally, many chemotherapy drugs used for cancer treatment can develop resistance and harm normal cells, leading to dose-limiting side effects. As a result, finding effective cancer treatments and developing new drugs remains a significant challenge. However, plants are a potent...
Source: European Journal of Medical Research - January 30, 2024 Category: Research Source Type: research
Factors influencing long-term outcomes in fibrotic interstitial lung disease (F-ILD) diagnosed through multidisciplinary discussion (MDD): a prospective cohort study
ConclusionThe long-term mortality rate of IPF patients was higher than that of CTD-ILD patients. The GAP score and UIP patterns were significant mortality predictors for both IPF and CTD-ILD patients. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 30, 2024 Category: Research Source Type: research
Single-cell combined bioinformatics analysis: construction of immune cluster and risk prognostic model in kidney renal clear cells based on CD8+ T cell-associated genes
ConclusionWe proposed and constructed an immunological risk prognostic model for CD8+ T cell-associated genes and identifiedLAG3 as a pivotal gene for KIRC progression and CD8+ T-cell infiltration. The model comprehensively explained the immune microenvironment and provided novel immune-related therapeutic targets and biomarkers in KIRC. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 30, 2024 Category: Research Source Type: research
Automated localization of mandibular landmarks in the construction of mandibular median sagittal plane
ConclusionDeep learning can automatically segment the mandible, identify anatomic landmarks, and address medicinal demands in people without mandibular deformities. The most accurate MMSP was the B-Gn-F plane. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 29, 2024 Category: Research Source Type: research
Mean compression ratio of a self-expandable valve is associated with the need for pacemaker implantation after transcatheter aortic valve replacement
ConclusionsThe compression ratio of the SEV was positively associated with the risk of PPMI after TAVR, and the association was most significant in the annular and supravalvular planes. The compression ratio may also affect the time to PPMI. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 29, 2024 Category: Research Source Type: research
Development and validation of a nomogram for predicting in-hospital mortality of patients with cervical spine fractures without spinal cord injury
ConclusionWe explored the in-hospital mortality of patients with cervical spine fractures without spinal cord injury and constructed a nomogram to predict their prognosis. This could help doctors assess the patient ’s status and implement interventions to improve prognosis accordingly. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 29, 2024 Category: Research Source Type: research
Differentially expressed long non-coding RNAs and mRNAs of cadmium exposure on learning disability of offspring rats
ConclusionOverall, this study provides novel insights into the molecular effects of first generation Cd exposure on the cognitive ability of offspring. The target genes and signaling pathways investigated in this study could serve as potential targets for improving neurodevelopment and cognitive ability in children. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 29, 2024 Category: Research Source Type: research
Exploring clinical indicator variations in stroke patients with multiple risk factors: focus on hypertension and inflammatory reactions
ConclusionAge is correlated with an elevated risk of stroke. Individuals exhibiting multiple stroke risk factors and diverse ischemic stroke subtypes commonly present with abnormal lipid levels and imbalances in Th1/Th2 cytokines. These factors significantly contribute to the onset and progression of stroke. Furthermore, inflammatory responses, particularly those induced by atherosclerosis, play a pivotal role in the genesis of stroke and exert a substantial influence on its prognosis. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 29, 2024 Category: Research Source Type: research
Comment on: Proposal for a new diagnostic classification of photodistributed Stevens –Johnson syndrome and toxic epidermal necrolysis
AbstractStevens –Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap (SJS/TEN), collectively referred to SJS/TEN, form a spectrum of severe life-threatening adverse drug reactions whose pathomechanism is not fully understood. The article"Photodistributed Stevens –Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review and Proposal for a New Diagnostic Classification" by McKinley et. al., discusses a distinct distribution of epidermal necrosis in SJS/TEN, attributable to preceding exposure to ultraviolet radiation (UVR), and relative sparing of photo-protected areas. Afte...
Source: European Journal of Medical Research - January 29, 2024 Category: Research Source Type: research
No causal association between allergic rhinitis and migraine: a Mendelian randomization study
ConclusionsThis MR study did not reveal a clear causal association between AR and migraine risk. More research is warranted to reveal the complex association between AR and migraine. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 27, 2024 Category: Research Source Type: research
MDM4 was associated with poor prognosis and tumor-immune infiltration of cancers
AbstractMDM4 is one of the MDM protein family and is generally recognized as the key negative regulator of p53. As a cancer-promoting factor, it plays a non-negligible role in tumorigenesis and development. In this article, we analyzed the expression levels ofMDM4 in pan-cancer through multiple databases. We also investigated the correlations betweenMDM4 expression and prognostic value, immune features, genetic mutation, and tumor-related pathways. We found thatMDM4 overexpression is often accompanied by adverse clinical features, poor prognosis, oncogenic mutations, tumor-immune infiltration and aberrant activation of onc...
Source: European Journal of Medical Research - January 27, 2024 Category: Research Source Type: research
Hotspots and trends of microglia in Alzheimer's disease: a bibliometric analysis during 2000 –2022
ConclusionNLRP3 inflammasome, TREM2, gut microbiota, mitochondrial dysfunction, exosomes are research hotspots. The relationship between microglia-mediated neuroinflammation and Alzheimer's disease have been the focus of current research and the development trend of future research. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 24, 2024 Category: Research Source Type: research
Dietary Insulin Index (DII) and Dietary Insulin load (DIL) and Caveolin gene variant interaction on cardiometabolic risk factors among overweight and obese women: a cross-sectional study
ConclusionThe findings of the present study indicate that people who carry the caveolin rs3807992 (A) allele and have greater DII and DIL scores are at higher risk for several cardiovascular disease and metabolic syndrome biomarkers. These results highlight that diet, gene variants, and their interaction, should be considered in the risk evaluation of developing CVD. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 24, 2024 Category: Research Source Type: research
