European Journal of Medical Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Optimizing cardiac amyloidosis assessment: utility of 1-h and 3-h 99mTc-PYP imaging
ConclusionOur study suggests that both 1-h and 3-h incubation times for99mTc-PYP imaging have different benefits for ATTR cardiac amyloidosis. A one-hour incubation may be preferable for differential diagnostic purposes, while a three-hour incubation may provide greater utility in evaluating disease severity. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 6, 2024 Category: Research Source Type: research

Assessing causality between inflammatory bowel diseases with frailty index and sarcopenia: a bidirectional Mendelian randomization study
ConclusionThe MR analysis showed a positive causal association between IBD and FI, indicating that IBD patients may exhibit aging-related characteristics. Therefore, frailty assessments should be conducted as early as possible in IBD patients. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 5, 2024 Category: Research Source Type: research

Comprehensive analysis of a tryptophan metabolism-related model in the prognostic prediction and immune status for clear cell renal carcinoma
ConclusionWe identified 2 molecular subtypes of ccRCC based on the expression of TMR genes and constructed a prognosis-related model that may be used as a powerful tool to guide the prediction of ccRCC prognosis and personalized therapy. In addition, CYP1B1, KMO, and TDO2 can be regarded as the risk prognostic genes for ccRCC. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 5, 2024 Category: Research Source Type: research

Biological and glucocorticoids treatment impair the medium-term immunogenicity to SARS-CoV-2 mRNA vaccines in autoimmune inflammatory rheumatic diseases
ConclusionsThe SARS-CoV-2 vaccine booster strategy effectively elicited a sustained antibody immune response in AIRD patients. However, patients under biological therapies exhibited a reduced response to the booster dose, particularly when combined with GCs. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 5, 2024 Category: Research Source Type: research

28-day perioperative pediatric mortality and its predictors in a tertiary teaching hospital in Ethiopia: a prospective cohort study
ConclusionsIn this study, the perioperative mortality of pediatric patients was high in the 28-day follow-up. Neonatal age, transfusion, and America Society of Anesthesiology physical status III and above were significant predictors of pediatric mortality. Therefore, perioperative surgical teams should give special attention to neonates, the America Society of Anesthesiology physical status III and above, and transfusion to reduce pediatric mortality. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 5, 2024 Category: Research Source Type: research

Refining mutanome-based individualised immunotherapy of melanoma using artificial intelligence
AbstractUsing the particular nature of melanoma mutanomes to develop medicines that activate the immune system against specific mutations is a game changer in immunotherapy individualisation. It offers a viable solution to the recent rise in resistance to accessible immunotherapy alternatives, with some patients demonstrating innate resistance to these drugs despite past sensitisation to these agents. However, various obstacles stand in the way of this method, most notably the practicality of sequencing each patient's mutanome, selecting immunotherapy targets, and manufacturing specific medications on a large scale. With t...
Source: European Journal of Medical Research - January 5, 2024 Category: Research Source Type: research

Survival and treatment in older patients with ewing sarcoma: an analysis of the national cancer database
ConclusionAn age over 40 is associated with decreased survival for patients with EWS. Due to the rarity of EWS in this cohort, the optimal role of systemic treatment remains unknown and has yet to be clearly elucidated. Consequently, our findings suggest that older patients receive disparities in treatment which may be contributing to decreased survival rates. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 5, 2024 Category: Research Source Type: research

Radiopharmaceuticals: navigating the frontier of precision medicine and therapeutic innovation
AbstractThis review article explores the dynamic field of radiopharmaceuticals, where innovative developments arise from combining radioisotopes and pharmaceuticals, opening up exciting therapeutic possibilities. The in-depth exploration covers targeted drug delivery, delving into passive targeting through enhanced permeability and retention, as well as active targeting using ligand-receptor strategies. The article also discusses stimulus-responsive release systems, which orchestrate controlled release, enhancing precision and therapeutic effectiveness. A significant focus is placed on the crucial role of radiopharmaceutic...
Source: European Journal of Medical Research - January 5, 2024 Category: Research Source Type: research

The efficacy of tixagevimab/cilgavimab (Evusheld) in prophylaxis and treatment of COVID-19 in immunocompromised patients: a systematic review and meta-analysis
ConclusionThis result indicated that Evusheld was an effective prophylactic and therapeutic drug for COVID-19 infection, especially for immunocompromised patients, but there was no considerable variation between the high and low doses. Further prospective and randomized controlled trials (RCTs) with increased population sizes are necessary to show the valuable benefit of the high dose of Evusheld in COVID-19 prevention and treatment and to compare the difference between the two doses within adverse events. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 5, 2024 Category: Research Source Type: research

The effects of apoptosis inhibitor of macrophage in kidney diseases
AbstractKidney disease is a progressive and irreversible condition in which immunity is a contributing factor that endangers human health. It is widely acknowledged that macrophages play a significant role in developing and causing numerous kidney diseases. The increasing focus on the mechanism by which macrophages express apoptosis inhibitor of macrophages (AIM) in renal diseases has been observed. AIM is an apoptosis inhibitor that stops different things that cause apoptosis from working. This keeps AIM-bound cell types alive. Notably, the maintenance of immune cell viability regulates immunity. As our investigation prog...
Source: European Journal of Medical Research - January 4, 2024 Category: Research Source Type: research

The impact of SLC10A3 on prognosis and immune microenvironment in colorectal adenocarcinoma
ConclusionThe study underscores the importance of elevated SLC10A3 in CRC, associating it with decreased survival and immune infiltration, proposing it as a diagnostic biomarker and appealing immunotherapy target, given its significant overexpression and influence on the immune microenvironment and prognosis through methylation patterns.Graphical Abstract (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 4, 2024 Category: Research Source Type: research

A literature review and meta-analysis of the optimal factors study of repetitive transcranial magnetic stimulation in post-infarction aphasia
ConclusionsThe optimal treatment effects of rTMS for PSA may be obtained with a total pulse of 40,000, a pulse/session of 1000, and an RMT of 80%. Further rigorous randomized controlled studies are required to substantiate the validity of these results. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 3, 2024 Category: Research Source Type: research

Exploring the prognostic potential of m6A methylation regulators in low-grade glioma: implications for tumor microenvironment modulation
ConclusionOur results present that the m6A regulators play vital role in regulating PD-L1/PD-1 expression and the infiltration of immune cells, thereby exerting a sizable impact on the TIME of LGG. Therefore, m6A regulators have precise predictive value in the prognosis of LGG. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 3, 2024 Category: Research Source Type: research

Circulating inflammatory biomarkers and risk of intracranial aneurysm: a Mendelian randomization study
ConclusionsNo causality of inflammatory biomarkers on the risk of IA subtypes was identified. Future large-scale studies are in need to evaluate the temporal dynamics of cytokines in conjunction with IA. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 3, 2024 Category: Research Source Type: research

WD repeat domain 76 predicts poor prognosis in lower grade glioma and provides an original target for immunotherapy
ConclusionsThis study shows for the first time the diagnostic and prognostic value ofWDR76 in LGG and provides a novel personalized biomarker for future targeted therapy and immunotherapy. Thus,WDR76 may significantly improve the prognosis of patients with LGG. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - January 3, 2024 Category: Research Source Type: research