European Journal of Medical Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Accuracy of migraine diagnosis and treatment by neurologists in the Baltic states: e-survey with clinical case challenge
ConclusionsMigraine diagnostic accuracy is improved through practical patient counseling and modern treatment prescription. Although the neurologists in the Baltic states follow current European guidelines, there is room for improvement in diagnostic accuracy to reduce migraine burden. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 18, 2023 Category: Research Source Type: research

Improved oxygenation in prone positioning of mechanically ventilated patients with COVID-19 acute respiratory distress syndrome is associated with decreased pulmonary shunt fraction: a prospective multicenter study
ConclusionsImproved oxygenation by prone positioning in COVID-19 ARDS patients was primarily associated with a decrease in pulmonary shunt fraction. Dead space remained high and the global V ’A/Q ’ measure could not explain the differences in gas exchange. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 16, 2023 Category: Research Source Type: research

Association between clonal hematopoiesis-related gene mutations and unfavorable functional outcome in patients with large-artery atherosclerotic stroke
ConclusionCHIP is associated with unfavorable functional outcomes in patients with LAA stroke and hyper-inflammation. Genetic IL-6 signaling inhibition might attenuate the risk of unfavorable functional outcomes in CHIP carriers, especially in LAA stroke patients. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 16, 2023 Category: Research Source Type: research

Correction: Effects of metformin therapy on HMGB1 levels in rheumatoid arthritis patients
(Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 16, 2023 Category: Research Source Type: research

Circulating microRNAs and hepcidin as predictors of iron homeostasis and anemia among school children: a biochemical and cross-sectional survey analysis
ConclusionMolecular microRNAs such as miR-146a, miR-125b, and miR-122 were shown to provide an additional means of controlling or regulating cellular iron uptake or metabolism either via the oxidative stress pathway or regulation of hepcidin expression via activating genes encoding Hfe and Hjv activators, which promote iron regulation. Thus, circulating miRNAs as molecular markers and serum hepcidin could provide an additional means of controlling or regulating cellular iron and be associated as valuable markers in diagnosing and treating cases with different iron deficiencies. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 15, 2023 Category: Research Source Type: research

Identification of ANXA3 as a biomarker associated with pyroptosis in ischemic stroke
ConclusionThis study identified ANXA3 as a possible pyroptosis-related gene marker in IS through bioinformatics and experiments. ANXA3 could inhibit pyroptosis through the NLRC4/AIM2 axis. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 15, 2023 Category: Research Source Type: research

A retrospective analysis of the clinical efficacy of pancreatic duct stent implantation in the management of acute biliary pancreatitis requiring ERCP
ConclusionIn the stent group, feeding time and hospital stay were significantly shorter than those in the non-stent group. No significant differences were observed between the two groups in the incidence of complications and mortality. The HCT value decreased more rapidly in the stent group. Early pancreatic stent implantation demonstrated the potential to shorten the eating and hospitalization duration of patients with ABP, facilitating their prompt recovery.Trial Registration: This study was registered as a single-center, retrospective case series (ChiCTR1800019734) at chictr.org.cn. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 15, 2023 Category: Research Source Type: research

Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma
In this report, we mined the published cholangiocarcinoma transcriptome data set (GSE26566), compared it with the ubiquitination-as sociated gene (GO:0016567), and identified that UBE2C was highly expressed in cholangiocarcinoma tumor tissue. Moreover, high expression of UBE2C was markedly correlated with surgical margin, primary tumor, histological variants, and histological grade. More specifically, high expression of UBE2C wa s negatively associated with overall survival, disease-specific survival, local recurrence-free survival, and metastasis-free survival in patients with cholangiocarcinoma. Our findings demonstrate ...
Source: European Journal of Medical Research - December 15, 2023 Category: Research Source Type: research

Triosephosphate isomerase 1 may be a risk predictor in laryngeal squamous cell carcinoma: a multi-centered study integrating bulk RNA, single-cell RNA, and protein immunohistochemistry
ConclusionsTPI1 is dramatically overexpressed in LSCC than in normal tissue, and the high expression of TPI1 may promote LSCC deterioration through its metabolic and non-metabolic functions. This study contributes to advancing our knowledge of LSCC pathogenesis and may have implications for the development of targeted therapies in the future. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 15, 2023 Category: Research Source Type: research

Factors assessed in the first year of a longitudinal study predict subsequent study visit compliance: the TEDDY study
ConclusionsSociodemographic variables, maternal characteristics —including study satisfaction—and fathers’ participation in the first year of a longitudinal study were associated with subsequent study visit compliance in a sample of children genetically at-risk for T1D followed for 4 years. This information can inform future strategies designed to improve study visit compliance in longitudinal pediatric studies.Trial registration: NCT00279318, 06/09/2004. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 15, 2023 Category: Research Source Type: research

CHKB-AS1 enhances proliferation and resistance to NVP-BEZ235 of renal cancer cells via regulating the phosphorylation of MAP4 and PI3K/AKT/mTOR signaling
This study aims to elucidate these aspects, enhancing our understanding of NVP-BEZ235's future clinical utility. To investigate resistance mechanisms, renal cancer cell lines were exposed to progressively increasing concentrations of NVP-BEZ235, leading to the development of stable resistance. These resistant cells underwent extensive RNA-sequencing analysis. We implemented gene interference techniques using plasmid vectors and lentivirus and conducted regular IC50 assessments. To pinpoint the role of LncRNAs, we utilized FISH and immunofluorescence staining assays, supplemented by RNA pull-down and RIP assays to delineate...
Source: European Journal of Medical Research - December 14, 2023 Category: Research Source Type: research

Identification of ACBD3 as a new molecular biomarker in pan-cancers through bioinformatic analysis: a preclinical study
ConclusionAccording to our pan-cancer analysis,ACBD3 may serve as a remarkable prognostic and diagnostic biomarker of pan-cancers as well as contribute to tumor development.ACBD3 may also provide new directions for cancer treatment targets in the future. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 14, 2023 Category: Research Source Type: research

MRPL48 is a novel prognostic and predictive biomarker of hepatocellular carcinoma
ConclusionsWe demonstrated that MRPL48 expression may be associated with HCC development and prognosis. These findings may open up new research directions and opportunities for the development of HCC treatments. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 14, 2023 Category: Research Source Type: research

The clinical association between coagulation indexes, platelet-related parameters, and bone metastasis of newly diagnosed prostate cancer
ConclusionsHigher platelet, D-dimer, prostate-specific antigen, Gleason score, and fibrinogen levels may predict a worse prognosis in patients with Pca. PLT, DD, and Fib, as readily available and relatively inexpensive indicators, help predict bone metastasis of Pca. It is suggested that PLT, DD and Fib may be helpful in the risk stratification of Pca. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 13, 2023 Category: Research Source Type: research

Research progress of metabolomics in cervical cancer
ConclusionWith the continuous, in-depth research on metabolomics research technology, it will bring more benefits in the screening, diagnosis and treatment of cervical cancer with its advantages of holistic and dynamic nature. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 13, 2023 Category: Research Source Type: research