Electromyographic activity of the diaphragm during neostigmine or sugammadex-enhanced recovery after neuromuscular blockade with rocuronium: A randomised controlled study in healthy volunteers
BACKGROUNDThe use of neuromuscular blocking agents has been associated with severe postoperative respiratory morbidity. Complications can be attributed to inadequate reversal, and reversal agents may themselves have adverse effects. OBJECTIVETo compare the electromyographic activity of the diaphragm (EMGdi) during recovery from neuromuscular blockade using neostigmine and sugammadex. The hypothesis was that there would be better neuromuscular coupling of the diaphragm when sugammadex was used. DESIGNA randomised, controlled, parallel-group, single-centre, double-blinded study. SETTINGDistrict general hospital in Belgium. P...
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Monitoring Source Type: research

Reliability of the surgical Pleth index for assessment of postoperative pain: A pilot study
BACKGROUNDPostoperative pain control is essential and may have a beneficial effect on postoperative outcome and morbidity. Analgesia quality is controlled using tools such as a Numerical Rating Scale (NRS). These tools require cooperation and often fail in the presence of reduced awareness. The Surgical Pleth index (SPI) has been introduced as a monitoring tool for intraoperative pain under general anaesthesia. OBJECTIVEWe investigated the correlation between SPI and pain intensity, analgesic consumption and fitness for discharge in the postanaesthesia care unit. DESIGNAn observational study. SETTINGThe central postanaesth...
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Monitoring Source Type: research

Doppler renal resistive index for early detection of acute kidney injury after major orthopaedic surgery: A prospective observational study
CONCLUSIONPostoperative resistive index appears to be effective for early detection of AKI after major orthopaedic surgery. Resistive index can be measured in the postoperative care unit in patients at risk of AKI. TRIAL REGISTRATION NUMBER29-0512. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Monitoring Source Type: research

Ultrasound confirmation of central venous catheter position via a right supraclavicular fossa view using a microconvex probe: An observational pilot study
CONCLUSIONUltrasound via a right supraclavicular view is a feasible, well tolerated and accurate approach and should be further explored. Chest radiography confirmed CVC position in the lower SVC. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Monitoring Source Type: research

Comparison of a continuous noninvasive arterial pressure device with invasive measurements in cardiovascular postsurgical intensive care patients: A prospective observational study
CONCLUSIONCNAP showed acceptable agreement defined by the ATI with invasive measurements for MAP and partially for DAP, but there was considerable variability for SAP. MAP should be preferred for clinical decision making. Cardiac arrhythmia, in contrast to catecholamine dosage or weaning procedures, impaired the accuracy, agreement and interchangeability of CNAP. TRIAL REGISTRATIONClinical trials.gov identifier NCT01003665. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Monitoring Source Type: research

Arterial pressure waveform analysis versus thermodilution cardiac output measurement during open abdominal aortic aneurysm repair: A prospective observational study
CONCLUSIONBias between arterial waveform and thermodilution cardiac output was within a predefined acceptable range, but the mean error was above the accepted range of 30%. Trending ability was poor. Arterial waveform and thermodilution cardiac outputs are, therefore, not interchangeable in patients undergoing open abdominal aortic aneurysm repair. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Monitoring Source Type: research

Calibrated versus uncalibrated arterial pressure waveform analysis in monitoring cardiac output with transpulmonary thermodilution in patients with severe sepsis and septic shock: An observational study
BACKGROUNDCardiac output (CO) measurement is often required in critically ill patients. The performances of newer, less invasive techniques require evaluation in patients with severe sepsis and septic shock. OBJECTIVESTo compare calibrated arterial pressure waveform analysis-derived CO (COap, VolumeView/EV1000) and the uncalibrated form (COfv, FloTrac/Vigileo) with transpulmonary thermodilution derived CO (COtptd). DESIGNA prospective, observational, single-centre study. SETTINGICU of a general teaching hospital. PATIENTSTwenty consecutive patients with severe sepsis or septic shock requiring haemodynamic monitoring by Vol...
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Monitoring Source Type: research

Central venous catheter tip position: Another point of view
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Invited commentaries Source Type: research

Moderate agreement for cardiac output monitors: Moderately good or moderately bad?
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Invited commentaries Source Type: research

Reversal of neuromuscular blockade with sugammadex in patients with myasthenia gravis: A case series of 21 patients and review of the literature
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

Prophylactic parecoxib reduces the incidence of shivering after general anaesthesia
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

Etomidate can be dosed according to ideal body weight in morbidly obese patients
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

Ondansetron-induced oculogyric crisis
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

Delayed recurarisation after sugammadex reversal
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

The return of halothane anaesthesia?
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

Failure of sugammadex to reverse rocuronium-induced neuromuscular blockade: A case report
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

Evaluation of bias in predicted and measured propofol concentrations during target-controlled infusions in obese Japanese patients: An open-label comparative study
CONCLUSIONBMI influences blood propofol concentrations, leading to the possibility of overdosage of propofol in obese patients when the Marsh model is used to assess propofol concentration. Our new method using corrected Cp might improve this bias in obese, Japanese patients. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2014 Category: Anesthesiology Tags: Pharmacology Source Type: research

Differential protective effects of anaesthesia with sevoflurane or isoflurane: An animal experimental model simulating liver transplantation
BACKGROUNDThe mechanisms involved in organ protection by volatile anaesthetics are not completely understood. In the liver transplant setting, there is a lack of information in the literature about whether sevoflurane anaesthesia has a superior hepatoprotective effect when compared with isoflurane. OBJECTIVETo compare the antioxidant and protective effects of isoflurane and sevoflurane. DESIGNA randomised, comparative, experimental study. SETTINGThe study was performed in the Animal Experimentation Unit of Hospital de Clínicas de Porto Alegre, Brazil. Twenty male Wistar rats weighing between 350 and 450 g were ran...
Source: European Journal of Anaesthesiology - October 30, 2014 Category: Anesthesiology Tags: Pharmacology Source Type: research

The effect of perioperative administration of glucocorticoids on pulmonary complications after transthoracic oesophagectomy: A systematic review and meta-analysis
CONCLUSIONIn this meta-analysis, perioperative administration of glucocorticoid did not affect the risk of pulmonary complications after transthoracic oesophagectomy, nor did it cause adverse effects. A subgroup analysis showed that a weight-dependent dose of methylprednisolone 10 to 30 mg kg−1 within 30 min preoperatively might be the most promising dosing regimen for further research. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2014 Category: Anesthesiology Tags: Pharmacology Source Type: research

The influence of total intravenous anaesthesia and isoflurane anaesthesia on plasma interleukin-6 and interleukin-10 concentrations after colorectal surgery for cancer: A randomised controlled trial
BACKGROUNDAlthough it has been demonstrated that both surgery and anaesthesia induce immune suppression, it remains unclear whether there are differences between anaesthetic techniques in inducing immune suppression in cancer patients. OBJECTIVEThe aim of this present study was to compare the effects of total intravenous anaesthesia (TIVA) and isoflurane anaesthesia on plasma concentrations of interleukins IL-6 and IL-10 in patients undergoing surgery for colorectal cancer. DESIGNA randomised, controlled, open-label study. SETTINGUniversity hospital. PATIENTSSeventy patients undergoing open colorectal surgery with tumour r...
Source: European Journal of Anaesthesiology - October 30, 2014 Category: Anesthesiology Tags: Pharmacology Source Type: research

Toxic and protective effects of inhaled anaesthetics on the developing animal brain: Systematic review and update of recent experimental work
CONCLUSIONThe majority of studies have linked inhaled anaesthetics to toxic effects in the neonatal brain of rodents, piglets and primates. Only a few studies, however, could demonstrate long-lasting cognitive impairment. The results of inhalational anaesthetic-induced neuroprotection in perinatal hypoxic-ischaemic brain injury are a promising basis for more research in this field. In general, prospective clinical trials are needed to further differentiate the effects of inhaled anaesthetics on the immature brain. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2014 Category: Anesthesiology Tags: Pharmacology Source Type: research

Influence of polyvinyl chloride infusion extension tube on propofol injection pain: A randomised controlled study
BACKGROUNDPropofol injection pain is a common and unsolved anaesthesia problem. OBJECTIVESThe present study attempted to confirm that the plasticiser di(2-ethylhexyl) phthalate in polyvinyl chloride (PVC) infusion tubes may increase propofol injection pain by increasing the aqueous propofol concentration. DESIGNA randomised controlled study. SETTINGUniversity teaching hospital, 1 April to 25 June 2013. PATIENTSOne hundred patients scheduled for elective surgery were allocated randomly to the PVC or the control (C) group. The PVC group received a propofol (Diprivan) infusion via a 1-m PVC infusion extension tube, whereas gr...
Source: European Journal of Anaesthesiology - October 30, 2014 Category: Anesthesiology Tags: Pharmacology Source Type: research

The effect of ketamine on hypoventilation during deep sedation with midazolam and propofol: A randomised, double-blind, placebo-controlled trial
CONCLUSIONKetamine decreased the duration and severity of hypercapnia in patients undergoing deep sedation with propofol. The addition of ketamine may reduce hypoventilation and adverse effects in patients having procedures under sedation. TRIAL REGISTRATIONclinicaltrials.gov identifier: NCT01535976. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2014 Category: Anesthesiology Tags: Pharmacology Source Type: research

The 2014 consensus guidelines for the management of postoperative nausea and vomiting: A leapfrog towards a postoperative nausea and vomiting-free hospital
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2014 Category: Anesthesiology Tags: Editorial Source Type: research

Combination of ultrasonographic supraclavicular block and general anaesthesia for arthroscopic shoulder surgery in a patient with haemophilia A
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 4, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

Successful use of ‘Epidrum’ loss-of-resistance device for thoracic paravertebral blockade in patients undergoing breast cancer surgery: A case series
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 4, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

Chiari malformation unmasked by accidental dural puncture
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 4, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

Differential cytotoxic properties of drugs used for intra-articular injection on human chondrocytes: An experimental in-vitro study
CONCLUSIONMorphine and dexamethasone showed no cytotoxic effects in our study and might thus be better alternatives to the clinically frequently applied bupivacaine. S-ketamine induced an intensive dose-dependent cytotoxic effect and should probably be avoided for intra-articular injection. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 4, 2014 Category: Anesthesiology Tags: Locoregional anaesthesia Source Type: research

Effect of levobupivacaine on articular chondrocytes: An in-vitro investigation
CONCLUSIONIn-vitro 0.5% levobupivacaine is more chondrotoxic than saline in human articular cartilage after 1 h of exposure. Bupivacaine seems to be less chondrotoxic than levobupivacaine. With shorter exposures, no clear chondrotoxic effect was shown. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 4, 2014 Category: Anesthesiology Tags: Locoregional anaesthesia Source Type: research

Distal infrared thermography and skin temperature after ultrasound-guided interscalene brachial plexus block: A prospective observational study
BACKGROUNDIncreases in skin temperature may be used as an early predictor of the success of interscalene brachial plexus block (IBPB), but we lack detailed information on the thermographic response. OBJECTIVETo investigate and characterise the thermographic response after IBPBs. DESIGNProspective observational study. SETTINGUniversity hospital and private hospital. PATIENTSTwenty-nine male and 17 female patients scheduled for ambulatory shoulder surgery. Exclusion criteria were age less than 18 years, body weight more than 120 kg and any coagulation abnormality. INTERVENTIONSInfrared thermographic imaging of the hand bef...
Source: European Journal of Anaesthesiology - October 4, 2014 Category: Anesthesiology Tags: Locoregional anaesthesia Source Type: research

Safety and effectiveness of bilateral continuous sciatic nerve block for bilateral orthopaedic foot surgery: A cohort study
CONCLUSIONThe complication rate, effectiveness and patient satisfaction of bilateral continuous popliteal sciatic nerve block was comparable with unilateral continuous sciatic popliteal nerve block. The follow-up showed that bilateral continuous sciatic popliteal nerve block does not increase the complication rate. However, an outpatient-based study should confirm these data prior to introduction in the ambulatory setting. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 4, 2014 Category: Anesthesiology Tags: Locoregional anaesthesia Source Type: research

MRI of axillary brachial plexus blocks: A randomised controlled study
CONCLUSIONDistal to the elbow, the triple-deposit method had the highest sensory block success rate. This could be explained to some extent by analysis of the magnetic resonance images. TRIAL REGISTRATIONClinicalTrials.gov identifier: NCT01033006. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 4, 2014 Category: Anesthesiology Tags: Locoregional anaesthesia Source Type: research

Complications associated with 27 031 ultrasound-guided axillary brachial plexus blocks: A web-based survey of 36 French centres
CONCLUSIONWe have reported a large series of ultrasound-guided axillary brachial plexus blocks in a multicentre study. Our results confirm the low incidence of local anaesthetic systemic toxicity and postoperative neurological complications as previously described. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 4, 2014 Category: Anesthesiology Tags: Locoregional anaesthesia Source Type: research

Effect of increasing age on the haemodynamic response to thoracic epidural anaesthesia: An observational study
BACKGROUNDSympathetic blockade with thoracic epidural anaesthesia (TEA) results in circulatory changes and may directly alter cardiac function. Ageing is associated with an impairment of autonomic nervous system control and a deterioration of myocardial diastolic performance. OBJECTIVESWe postulated that haemodynamic changes induced by TEA could vary with age. DESIGNAn observational study. SETTINGSTertiary, university hospital. PATIENTSThirty-five patients scheduled for pulmonary surgery and TEA stratified into three age groups: 18 to 45 years; 46 to 65 years; and at least 66 years. INTERVENTIONSCardiac performance was eva...
Source: European Journal of Anaesthesiology - October 4, 2014 Category: Anesthesiology Tags: Locoregional anaesthesia Source Type: research

Seven years of patient-controlled epidural analgesia in a Swedish hospital: A prospective survey
CONCLUSIONOur prospective survey indicates that PCEA in combination with CEI is effective and relatively well tolerated. The incidence of side effects is generally low and severe adverse events very rare. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 4, 2014 Category: Anesthesiology Tags: Locoregional anaesthesia Source Type: research

History of anaesthesia: The conception and birth of the European Academy of Anaesthesiology
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 4, 2014 Category: Anesthesiology Tags: Editorial Source Type: research

Local anaesthetics: 10 essentials
This review seeks to address 10 essential questions regarding the clinical use of local anaesthetics. Each local anaesthetic has distinctive physicochemical properties but with the same mode of action; they block voltage-gated sodium channels in the axon. Sodium channel block is brought about by a conformational change and the creation of a positive charge in the channel pore. Different local anaesthetics can reach the local anaesthetic binding site in the axon from the cytoplasmic compartment (classic hydrophilic pathway), or directly via its lipid membrane (hydrophobic pathway), or can enter via large-pore channels (alte...
Source: European Journal of Anaesthesiology - October 4, 2014 Category: Anesthesiology Tags: Review Source Type: research

2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management: The Joint Task Force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA)
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 1, 2014 Category: Anesthesiology Tags: Guidelines Source Type: research

2014 European Society of Cardiology/European Society of Anaesthesiology guidelines on non-cardiac surgery: cardiovascular assessment and management: A short explanatory statement from the European Society of Anaesthesiology members who participated in the European Task Force
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 1, 2014 Category: Anesthesiology Tags: Invited commentary Source Type: research

Safety of HES 130/0.4 (Voluven ® ) in patients with preoperative renal dysfunction undergoing abdominal aortic surgery: a prospective, randomized, controlled, parallel-group multicentre trial
Research Articles G. Godet, J.-J. Lehot, G. Janvier, A. Steib, V. De Castro, P. Coriat, European Journal of Anaesthesiology, Volume 25 Issue 12, pp 986-994Abstract (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 17, 2014 Category: Anesthesiology Source Type: research

Safety of HES 130/0.4 (Voluven ® ) in patients with preoperative renal dysfunction undergoing abdominal aortic surgery: a prospective, randomized, controlled, parallel-group multicentre trial
Research Articles G. Godet, J.-J. Lehot, G. Janvier, A. Steib, V. De Castro, P. Coriat, European Journal of Anaesthesiology, Volume 25 Issue 12, pp 1042-1042Abstract (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 17, 2014 Category: Anesthesiology Source Type: research

Ketamine in PCA: what is the effective dose?
Letter G. Mion, J. P. Tourtier, J. M. Rousseau, European Journal of Anaesthesiology, Volume 25 Issue 12, pp 1040-1041Abstract (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 17, 2014 Category: Anesthesiology Source Type: research

Inhibition of the histamine-induced Ca 2+ influx in primary human endothelial cells (HUVEC) by volatile anaesthetics
Research Articles P. W. L. Tas, C. Stößel, N. Roewer, European Journal of Anaesthesiology, Volume 25 Issue 12, pp 976-985Abstract (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 17, 2014 Category: Anesthesiology Source Type: research

General anaesthesia and TrkA mRNA in peripheral blood mononuclear cells
Letter K. Tsugita, M. Hirose, E. Murata, S. Iho, European Journal of Anaesthesiology, Volume 25 Issue 12, pp 1032-1033Abstract (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 17, 2014 Category: Anesthesiology Source Type: research

The difference between peripheral venous pressure and central venous pressure (CVP) decreases with increasing CVP
Letter G. Cave, M. Harvey, European Journal of Anaesthesiology, Volume 25 Issue 12, pp 1037-1040Abstract (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 17, 2014 Category: Anesthesiology Source Type: research

Spinal anaesthesia with 0.5% isobaric bupivacaine in patients with diabetes mellitus: the influence of CSF composition on sensory and motor block
Research Articles M. Echevarria, A. Hachero, A. Martinez, E. Ramallo, D. García-Bernal, M. Ramos, A. Fernández, European Journal of Anaesthesiology, Volume 25 Issue 12, pp 1014-1019Abstract (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 17, 2014 Category: Anesthesiology Source Type: research

Dexmedetomidine causes prolonged recovery when compared with midazolam/fentanyl combination in outpatient shock wave lithotripsy
Research Articles P. Zeyneloglu, A. Pirat, S. Candan, S. Kuyumcu, I. Tekin, G. Arslan, European Journal of Anaesthesiology, Volume 25 Issue 12, pp 961-967Abstract (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 17, 2014 Category: Anesthesiology Source Type: research

Addition of remifentanil to patient-controlled tramadol for postoperative analgesia: a double-blind, controlled, randomized trial after major abdominal surgery
Research Articles H. Unlugenc, S. Tetiker, G. Isik, European Journal of Anaesthesiology, Volume 25 Issue 12, pp 968-975Abstract (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 17, 2014 Category: Anesthesiology Source Type: research

Ropivacaine vs. levobupivacaine combined with sufentanil for epidural analgesia after lung surgery
Research Articles G. De Cosmo, E. Congedo, C. Lai, M. Sgreccia, A. Amato, G. Beccia, P. Aceto, European Journal of Anaesthesiology, Volume 25 Issue 12, pp 1020-1025Abstract (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 17, 2014 Category: Anesthesiology Source Type: research

Spontaneous hyperactivity in mutant mice lacking the NMDA receptor GluRε1 subunit is aggravated during exposure to 0.1 MAC sevoflurane and is preserved after emergence from sevoflurane anaesthesia
Research Articles A. B. Petrenko, T. Kohno, J. Wu, K. Sakimura, H. Baba, European Journal of Anaesthesiology, Volume 25 Issue 12, pp 953-960Abstract (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 17, 2014 Category: Anesthesiology Source Type: research