European guidelines on perioperative venous thromboembolism prophylaxis: Patients with preexisting coagulation disorders and after severe perioperative bleeding
In patients with inherited bleeding disorders undergoing surgery, we recommend assessment of individual risk for venous thromboembolism, taking into account the nature of the surgery and anaesthetic, type and severity of bleeding disorder, age, BMI, history of thrombosis, the presence of malignancy and other high-risk comorbidities. Venous thromboembolism risk should be balanced against the increased bleeding risk associated with anticoagulant use in patients with known bleeding disorders (Grade 1C). In these patients undergoing major surgery, we recommend against routine postoperative use of pharmacological thromboprophyl...
Source: European Journal of Anaesthesiology - January 2, 2018 Category: Anesthesiology Tags: Guidelines Source Type: research

European guidelines on perioperative venous thromboembolism prophylaxis: Neurosurgery
Although there are numerous publications addressing venous thromboembolism and its prevention in neurosurgery, there are relatively few high-quality studies to guide decisions regarding thromboprophylaxis. In patients undergoing craniotomy, we recommend that if intermittent pneumatic compression (IPC) is used, it should be applied before the surgical procedure or on admission (Grade 1C). In craniotomy patients at particularly high risk for venous thromboembolism, we suggest considering the initiation of mechanical thromboprophylaxis with IPC preoperatively with addition of low molecular weight heparin (LMWH) postoperativel...
Source: European Journal of Anaesthesiology - January 2, 2018 Category: Anesthesiology Tags: Guidelines Source Type: research

European guidelines on perioperative venous thromboembolism prophylaxis: Cardiovascular and thoracic surgery
None of the predictive models for venous thromboembolism (VTE) prophylaxis have been designed for and validated in patients undergoing cardiothoracic and vascular surgery. The presence of one or more risk factors [age over 70 years old, transfusion of more than 4 U of red blood cells/fresh frozen plasma/cryoprecipitate, mechanical ventilation lasting more than 24 h, postoperative complication (e.g. acute kidney injury, infection/sepsis, neurological complication)] should place the cardiac population at high risk for VTE. In this context, we suggest the use of pharmacological prophylaxis as soon as satisfactory haemosta...
Source: European Journal of Anaesthesiology - January 2, 2018 Category: Anesthesiology Tags: Guidelines Source Type: research

European Guidelines on perioperative venous thromboembolism prophylaxis: Executive summary
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 2, 2018 Category: Anesthesiology Tags: Executive summary Source Type: research

European guidelines on perioperative venous thromboembolism prophylaxis
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 2, 2018 Category: Anesthesiology Tags: Editorial Source Type: research

Reply to: dobutamine and its haemodynamic effects in pleural effusion
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Dobutamine and its haemodynamic effects in pleural effusion
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: aprotinin and coronary artery bypass surgery
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Aprotinin and coronary artery bypass surgery
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: high versus low positive end-expiratory pressure for abdominal surgery
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

High versus low PEEP for abdominal surgery
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: predictive models for acute kidney injury after cardiac surgery
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Predictive models for acute kidney injury after cardiac surgery
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: alveolar recruitment manoeuvres after cardiac surgery
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Alveolar recruitment manoeuvres after cardiac surgery
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: estimating and reporting rates, and detecting improvements
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Estimating and reporting error rates, and detecting improvements
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Clinical signs and electroencephalographic patterns of emergence from sevoflurane anaesthesia in children: An observational study
CONCLUSION Several clinical signs occur sequentially during emergence, and are independent of exposure to nitrous oxide. Eye position is poorly correlated with other clinical signs or ETsevoflurane. EEG spectral characteristics may aid prediction of clinical–behavioural signs in children more than 3 months. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Paediatric anaesthesia Source Type: research

Median effective dose of intranasal dexmedetomidine sedation for transthoracic echocardiography examination in postcardiac surgery and normal children: An up-and-down sequential allocation trial
BACKGROUND Dexmedetomidine (DEX) has been used for sedation in young infants and children undergoing transthoracic echocardiography (TTE). The median effective dose of intranasal DEX has not been described for postcardiac surgery children. Postcardiac surgery children could require more DEX to achieve satisfactory sedation for TTE examination than children suspected of congenital heart disease. OBJECTIVES To study whether postcardiac surgery children need a larger dose of DEX for TTE than normal children. DESIGN A double-blind sequential allocation trial with doses determined by the Dixon and Massey up-and-down met...
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Paediatric anaesthesia Source Type: research

Blood glucose concentrations in prehospital trauma patients with traumatic shock: A retrospective analysis
BACKGROUND Deranged glucose metabolism after moderate to severe trauma with either high or low concentrations of blood glucose is associated with poorer outcome. Data on prehospital blood glucose concentrations and trauma are scarce. OBJECTIVES The primary aim was to describe the relationship between traumatic shock and prehospital blood glucose concentrations. The secondary aim was to determine the additional predictive value of prehospital blood glucose concentration for traumatic shock when compared with vital parameters alone. DESIGN Retrospective analysis of the predefined, observational database of a nationwi...
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Trauma Source Type: research

Fibrinogen on Admission in Trauma score: Early prediction of low plasma fibrinogen concentrations in trauma patients
CONCLUSION The FibAT score accurately predicts plasma fibrinogen levels 1.5 g l−1 or less on admission in trauma patients. This easy-to-use score could allow early, goal-directed therapy to trauma patients. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Trauma Source Type: research

European Society of Anaesthesiology and European Board of Anaesthesiology guidelines for procedural sedation and analgesia in adults
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Guidelines Source Type: research

Procedural sedation and analgesia for adults in Europe: Safety first
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Invited commentary Source Type: research

Safety and quality of procedural sedation and analgesia practice for adult patients throughout Europe: A step forward
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 5, 2017 Category: Anesthesiology Tags: Invited commentary Source Type: research

Capillary glucose meters cannot substitute serum glucose measurement to determine the cerebrospinal fluid to blood glucose ratio: A prospective observational study
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 1, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Impact of prior smoking cessation on postoperative pulmonary complications in the elderly: secondary analysis of a prospective cohort study
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 1, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Flow-assisted basophil activation test for sevoflurane hypersensitivity: A dose-finding in-vitro experimental study
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 1, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Perioperative cerebral oxygenation in patients undergoing aortic valve replacement
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 1, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Evaluation of the ‘no pain, no gain theory’ in postoperative care following cardiac surgery
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 1, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Predicting outcome after cardiac arrest with serum S-100B protein and procalcitonin: A prospective observational study
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 1, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Can nonstandardised, simplified autonomic function tests be used for risk profiling in the anaesthesia population?
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 1, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Serious game versus online course for pretraining medical students before a simulation-based mastery learning course on cardiopulmonary resuscitation: A randomised controlled study
CONCLUSION: The serious game used in this study was not superior to an online course to pretrain medical students in the management of a cardiac arrest. The absence of any correlation between the performances of students evaluated during two training sessions separated by 4 months suggests that some elements in the management of cardiac arrest such as compression depth can only be partially learned and retained after a simulation-based training. TRIAL REGISTRATION: ClinicalTrials.gov-NCT02758119. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 1, 2017 Category: Anesthesiology Tags: Research and education Source Type: research

Role of the internet as an information resource before anaesthesia consultation: A French prospective multicentre survey
BACKGROUND: Use of the internet as an information search tool has increased dramatically. Our study assessed preoperative use of the internet by patients to search for information regarding anaesthesia, surgery, pain or outcomes. OBJECTIVE(S): The aim of this study was to test whether patients used the internet prior to surgery and what kinds of information they looked for (anaesthetic technique, pain, adverse events, outcomes and surgery). Correlation between patient age and information sought about surgery from the internet was also explored. DESIGN: A prospective multicentre observational study. SETTING: In total, 14...
Source: European Journal of Anaesthesiology - November 1, 2017 Category: Anesthesiology Tags: Research and education Source Type: research

Research ethics committee approval as reported for abstracts submitted to the annual Euroanaesthesia meeting
BACKGROUND: The annual congress of the European Society of Anaesthesiology (ESA) is one of the largest anaesthesia congresses in the world and exhibits more than 1200 abstracts annually. OBJECTIVES: The aims of this study were to quantify the frequency of inadequate evidence of ethical approval for abstracts submitted to the ESA congress and to examine whether abstracts without appropriate ethical approval were subsequently accepted. DESIGN AND SETTING: All abstracts submitted in 2015 were adjudicated according to European ethical criteria. MAIN OUTCOME MEASURE: The proportion of submitted abstracts that lacked evidence...
Source: European Journal of Anaesthesiology - November 1, 2017 Category: Anesthesiology Tags: Research and education Source Type: research

Anaesthesiology research in the European Union and the European Free Trade Association: An overview from 2001 to 2015
CONCLUSION: Between 2001 and 2015, in the EU and EFTA countries, the number of publications increased, whereas the number of original articles decreased. Germany published most, but Denmark had most publications per anaesthesiologist and per capita, and also achieved the highest impact factor per article. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 1, 2017 Category: Anesthesiology Tags: Research and education Source Type: research

High quality of evidence is uncommon in Cochrane systematic reviews in Anaesthesia, Critical Care and Emergency Medicine
CONCLUSION: It was common for conclusive statements to be made about the effects of interventions despite evidence for the primary outcome being rated less than high quality. Improving methodological quality of trials would have the greatest impact on improving the quality of evidence. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 1, 2017 Category: Anesthesiology Tags: Research and education Source Type: research

Clinical trial registry use in anaesthesiology systematic reviews: A cross-sectional study of systematic reviews published in anaesthesiology journals and the Cochrane Library
CONCLUSION: The majority of systematic reviews in anaesthesiology did not include data from clinical trial registries. Exclusion of statistically nonsignificant data may lead to a biased interpretation of the data and hence inappropriate clinical interventions. TRIAL REGISTRATION: Registered in University hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN000021932). (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 1, 2017 Category: Anesthesiology Tags: Research and education Source Type: research

KIDS SAVE LIVES: School children education in resuscitation for Europe and the world
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 1, 2017 Category: Anesthesiology Tags: Editorials Source Type: research

The European Society of Anaesthesiology research support programme at 15 years: a lot done, still more to do
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 1, 2017 Category: Anesthesiology Tags: Editorials Source Type: research

Oh Excellent Air Bag - Under the influence of Nitrous Oxide, 1799–1920
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Book review Source Type: research

Reply to: comparing C-MAC videolaryngoscope with direct laryngoscopy for emergency intubation
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Comparing C-MAC videolaryngoscope with direct laryngoscopy for emergency intubation
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Effects of dexamethasone on early cognitive decline after cardiac surgery: A randomised controlled trial
BACKGROUND: Postoperative cognitive decline (POCD), a very common complication after cardiac surgery, is characterised by impairment of both memory function and intellectual ability as well as being associated with increased use of healthcare resources. The investigators focused on the role of the inflammatory response to a surgical procedure as a potential factor involved in the pathogenesis of POCD. OBJECTIVE: The use of prophylactic dexamethasone to attenuate the inflammatory response was hypothesised to reduce the risk of POCD. DESIGN: Randomised controlled study. SETTING: Single university teaching hospital, from M...
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

Sevoflurane attenuates systemic inflammation compared with propofol, but does not modulate neuro-inflammation: A laboratory rat study
BACKGROUND: Septic encephalopathy is believed to be a result of neuro-inflammation possibly triggered by endotoxins, such as lipopolysaccharides (LPS). Modulation of the immune system is a property of volatile anaesthetics. OBJECTIVE: We aimed to investigate the systemic and cerebral inflammatory response in a LPS-induced sepsis model in rats. We compared two different sedation strategies, intravenous propofol and the volatile anaesthetic sevoflurane, with the hypothesis that the latter may attenuate neuro-inflammatory processes. DESIGN: Laboratory rat study. SETTING: Basic research laboratories at the University Hospit...
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

Cardiac cycle efficiency and dicrotic pressure variations: new parameters for fluid therapy: An observational study
CONCLUSION: In this pilot study conducted in a population of surgical patients mechanically ventilated with a VT less than 8 ml kg−1, a dynamic model of fluid challenge assessment, including PPV, ΔCCE and ΔSAP − Pdic, enhances the prediction of fluid challenge response after 5 min of a 10-min administration. TRIAL REGISTRATION: ACTRN12616001479493. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

Echocardiography and passive leg raising in the postoperative period: A prospective observational study
CONCLUSION: This is the first study showing that measurement of CO after PLR can predict volume response in spontaneously breathing postoperative patients. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

Evaluation of preoperative oral carbohydrate administration on insulin resistance in off-pump coronary artery bypass patients: A randomised trial
CONCLUSION: A preoperative CHO supplement significantly reduced insulin resistance and FFA concentrations compared with fasting at the beginning of the surgery, but these benefits were lost after off-pump coronary revascularisation. Despite their transient nature, these beneficial effects resulted in less myocardial injury, mandating further studies focused on the impact of preoperative CHO on myocardial ischaemia and cardiac function after coronary revascularisation. TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT 02330263. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

The relative effects of dexmedetomidine and propofol on cerebral blood flow velocity and regional brain oxygenation: A randomised noninferiority trial
BACKGROUND: Dexmedetomidine constricts cerebral blood vessels without a concomitant reduction in cerebral metabolic oxygen consumption. Its safety as a sedative in patients with neurological diseases thus remains uncertain. OBJECTIVE: Our primary objective was to test the hypothesis that dexmedetomidine is noninferior to propofol as regards cerebral blood flow (CBF) velocity and brain oxygenation. DESIGN: Unblinded randomised trial. SETTING: Cleveland Clinic Hospital, Cleveland, from November 2010 to July 2013. PATIENTS: Forty-four patients scheduled for insertion of a deep-brain stimulating electrodes. INTERVENTIONS:...
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Monitoring Source Type: research

Validation of radial artery-based uncalibrated pulse contour method (PulsioFlex) in critically ill patients: A observational study
CONCLUSION: In critically ill patients, the PulsioFlex system connected to a radial arterial catheter is inaccurate for CI measurements and does not track changes in CI adequately. We therefore recommend using validated thermodilution techniques for monitoring in the critical care setting. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Monitoring Source Type: research

The impact of continuous non-invasive arterial blood pressure monitoring on blood pressure stability during general anaesthesia in orthopaedic patients: A randomised trial
CONCLUSION: Continuous monitoring contributes to BP stability in the studied population. TRIAL REGISTRATION: NCT02519101. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Monitoring Source Type: research