Reply to: the minimum clinically important difference is fundamental to all clinical trials
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 4, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

The minimum clinically important difference is fundamental to all clinical trials
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 4, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: performance of the Eleveld pharmacokinetic model to titrate propofol in an obese Japanese patient population
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 4, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Performance of the Eleveld pharmacokinetic model to titrate propofol in an obese Japanese patient population
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 4, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Effects of five preoperative cardiovascular drugs on mortality after coronary artery bypass surgery: A retrospective analysis of an observational study of 16 192 patients
CONCLUSION: Statins appear consistently protective against perioperative mortality from CABG surgery in multiple models, an effect not shared by the other cardiovascular drugs. Further data are needed on whether statins exert class and dose-response effects. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 4, 2015 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

Comparison of hydroxyethyl starch colloids with crystalloids for surgical patients: A systematic review and meta-analysis
CONCLUSION: This meta-analysis, based on small studies with low event rates, suggests that there are currently insufficient data to identify a difference in outcomes associated with crystalloids and HES in scheduled or elective noncardiac surgery. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 4, 2015 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

Fluid replacement and respiratory function: comparison of whole blood with colloid and crystalloid: A randomised animal study
BACKGROUND: Fluid replacement with blood products, colloids and crystalloids is associated with morbidity and mortality. Despite this, the consequences of fluid administration on airway and respiratory tissue properties are not fully understood. OBJECTIVE: Comparison of respiratory effects of fluid replacement with autologous blood (Group B), colloid (HES 6% 130/0.4, Group CO) or crystalloid solution (NaCl 0.9%, Group CR) after haemorrhage with separate assessments of airway resistance and respiratory tissue mechanics. DESIGN: A randomised study. SETTING: An experimental model of surgical haemorrhage and fluid replacement ...
Source: European Journal of Anaesthesiology - December 4, 2015 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

The relationship between pulmonary artery acceleration time and mean pulmonary artery pressure in patients undergoing cardiac surgery: An observational study
CONCLUSION: Estimation of PAT with TOE in anaesthetised cardiac surgical patients is possible. PAT is good at discriminating between patients with and without pulmonary hypertension, with a cut-off of less than 107 ms detecting pulmonary hypertension with a sensitivity of 75% and specificity of 94.8%. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 4, 2015 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

Life-threatening complications after postoperative intermediate care unit discharge: A retrospective, observational study
BACKGROUND: Postoperative patients who require intensive monitoring, intervention with an arterial line, vasoactive drugs and prolonged ventilator weaning are admitted to the postoperative intermediate care unit (IMCU). OBJECTIVES: The aim of this study was to estimate the prevalence of life-threatening complications within 7 days after IMCU discharge. Furthermore, we searched for associations between perioperative risk factors and these life-threatening complications. DESIGN: A retrospective observational study. SETTING: The postoperative IMCU of a university hospital in Tokyo, Japan, between 2010 and 2012. PATIENTS: All ...
Source: European Journal of Anaesthesiology - December 4, 2015 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

Psychoacoustic analysis of noise and the application of earplugs in an ICU: A randomised controlled clinical trial
CONCLUSION: Noise in the ICU is of high clinical relevance. Diverse noise reduction methods, such as earplugs and active noise cancellation, are available. The avoidance of unnecessary noise, however, should be the primary focus. TRIAL REGISTRATION: German Clinical Trials Register (DRKS00000534). (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 4, 2015 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

Survival after long-term isoflurane sedation as opposed to intravenous sedation in critically ill surgical patients: Retrospective analysis
The objective of this study is to compare mortality after sedation with either isoflurane or propofol/midazolam. DESIGN: A retrospective analysis of data in a hospital database for a cohort of consecutive patients. SETTING: Sixteen-bed interdisciplinary surgical ICU of a German university hospital. PATIENTS: Consecutive cohort of 369 critically ill surgical patients defined within the database of the hospital information system. All patients were continuously ventilated and sedated for more than 96 h between 1 January 2005 and 31 December 2010. After excluding 169 patients (93>79 years old, 10 (Source: European Journa...
Source: European Journal of Anaesthesiology - December 4, 2015 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

Isoflurane for ICU sedation – dead or alive?
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 4, 2015 Category: Anesthesiology Tags: Invited commentary Source Type: research

History of anaesthesia: Amedeo Avogadro (1776–1856) – Do his accomplishments match his reputation?
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 4, 2015 Category: Anesthesiology Tags: Editorial Source Type: research

Ultrasound-Guided Regional Anesthesia and Pain Medicine, 2nd edn
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2015 Category: Anesthesiology Tags: Book review Source Type: research

Investigation of a cause–effect relationship between flexible bronchoscopy and pneumothorax in patients with severe acute respiratory distress syndrome
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Evolution of ventilator settings during general anaesthesia for neurosurgery: An observational study in a German centre over 15 years
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Value of ultrasound with a single linear transducer to confirm correct positioning of central venous catheter in low body weight neonates
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Anaesthesia and orphan disease: Anaesthetic management of a child with Hamamy syndrome
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Anaesthesia and orphan disease: A septuagenarian patient with Segawa's dystonia
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Anaesthesia and orphan disease: 22q11.2 microdeletion disorder (DiGeorge syndrome)
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Preoxygenation by spontaneous breathing or noninvasive positive pressure ventilation with and without positive end-expiratory pressure: A randomised controlled trial
The objective of this study is to compare the time to achieve an expired O2 fraction FeO2 of 90% (FeO2 90%) during preoxygenation with spontaneous breathing and positive pressure ventilation with and without positive end-expiratory pressure (PEEP). DESIGN: A randomised controlled trial. SETTING: Primary care in a university hospital in France from October 2006 to January 2008. PATIENTS: Adults patients scheduled for elective surgery. Exclusion criteria were rapid sequence induction, anticipated difficult airway management and refusal to provide consent. INTERVENTION: Patients were randomly allocated to preoxygenation with ...
Source: European Journal of Anaesthesiology - October 30, 2015 Category: Anesthesiology Tags: Ventilation Source Type: research

Systemic and alveolar inflammatory response in the dependent and nondependent lung in patients undergoing lung resection surgery: A prospective observational study
BACKGROUND: Measurement of inflammatory mediators in bronchoalveolar lavage (BAL) during lung resection surgery with periods of one-lung ventilation (OLV) has revealed an intense local pulmonary response. The role of each lung in the inflammation that occurs during this procedure has never been investigated. OBJECTIVE(S): The primary objective of our study was to compare the inflammatory response in the dependent lung with that of the nondependent lung by measuring inflammatory markers in BAL. Our secondary objective was to assess the behaviour of these inflammatory mediators in patients with and without postoperative pulm...
Source: European Journal of Anaesthesiology - October 30, 2015 Category: Anesthesiology Tags: Ventilation Source Type: research

Effects of melatonin premedication to prevent emergence agitation after general anaesthesia in children: A systematic review and meta-analysis with trial sequential analysis
CONCLUSION: Compared with placebo, melatonin premedication may be effective in preventing emergence agitation in children (GRADE: low). This TSA suggests that further studies are required to confirm the results. Compared with midazolam, high-dose melatonin might have a significant effect in preventing emergence agitation (GRADE: very low). The study protocol was registered in the UMIN Clinical Trials Registry (registration number: UMIN000011841). (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2015 Category: Anesthesiology Tags: Paediatric anaesthesia Source Type: research

Impact of preoperative fasting times on blood glucose concentration, ketone bodies and acid–base balance in children younger than 36 months: A prospective observational study
The objective of this study was to evaluate the effect of preoperative fasting on glucose concentration, ketone bodies and acid–base balance in children. DESIGN: A prospective, noninterventional, clinical observational study. SETTING: A single-centre trial, study period from June 2014 to November 2014. PATIENTS: One hundred children aged 0 to 36 months scheduled for elective paediatric surgery. MAIN OUTCOME MEASURES: Patient demographics, fasting times, haemodynamic data, glucose and ketone body concentrations, and acid–base parameters after induction of anaesthesia were documented using a standardised case rep...
Source: European Journal of Anaesthesiology - October 30, 2015 Category: Anesthesiology Tags: Paediatric anaesthesia Source Type: research

Plasma levels of levobupivacaine during continuous infusion via a wound catheter after major surgery in newborn infants: An observational study
CONCLUSION: The studied infusion regimen was associated with plasma levels of levobupivacaine well below those associated with toxicity. Adequate wound healing, low pain scores and a reduced need for opioids were also noted. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2015 Category: Anesthesiology Tags: Paediatric anaesthesia Source Type: research

Effective tranexamic acid concentration for 95% inhibition of tissue-type plasminogen activator induced hyperfibrinolysis in children with congenital heart disease: A prospective, controlled, in-vitro study
BACKGROUND: Although recent studies have assessed tranexamic acid (TXA) pharmacokinetics in different subgroups, the effective concentration of TXA required to completely inhibit fibrinolysis remains to be determined. OBJECTIVE: An in-vitro determination of the effective TXA concentration needed for 95% inhibition (EC95) of tissue-type plasminogen activator (t-PA) activated fibrinolysis, using an experimental model designed for thromboelastometry (ROTEM). DESIGN: A prospective interventional study. SETTING: Department of Anaesthesiology, Queen Fabiola Children's University Hospital and Laboratory of Haematology and Haemost...
Source: European Journal of Anaesthesiology - October 30, 2015 Category: Anesthesiology Tags: Paediatric anaesthesia Source Type: research

Metamizole for postoperative pain therapy in 1177 children: A prospective, multicentre, observational, postauthorisation safety study
BACKGROUND: Due to possible serious adverse drug reactions (ADRs), the use of metamizole for postoperative pain therapy in children is a subject of debate. Safety studies with large sample sizes have not been published as yet. OBJECTIVE: The aim of this study was to evaluate the use of metamizole in children aged up to 6 years undergoing surgery with a particular focus on serious ADRs such as haemodynamic, anaphylactic or respiratory reactions and agranulocytosis. DESIGN: A multicentre, prospective, noninterventional, observational postauthorisation safety study (PASS). SETTING: The study was conducted in six different pae...
Source: European Journal of Anaesthesiology - October 30, 2015 Category: Anesthesiology Tags: Paediatric anaesthesia Source Type: research

Use of metamizole in children and the risk of agranulocytosis: Is the benefit worth the risk?
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2015 Category: Anesthesiology Tags: Invited commentary Source Type: research

How to minimise ventilator-induced lung injury in transplanted lungs: The role of protective ventilation and other strategies
Lung transplantation is the treatment of choice for end-stage pulmonary diseases. In order to avoid or reduce pulmonary and systemic complications, mechanical ventilator settings have an important role in each stage of lung transplantation. In this respect, the use of mechanical ventilation with a tidal volume of 6 to 8 ml kg−1 predicted body weight, positive end-expiratory pressure of 6 to 8 cmH2O and a plateau pressure lower than 30 cmH2O has been suggested for the donor during surgery, and for the recipient both during and after surgery. For the present review, we systematically searched the PubMed databas...
Source: European Journal of Anaesthesiology - October 30, 2015 Category: Anesthesiology Tags: Review Source Type: research

“A Time to Act” – Anaesthesiologists in resuscitation help save 200,000 lives per year worldwide: School children, lay resuscitation, telephone-CPR, IOM and more
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 30, 2015 Category: Anesthesiology Tags: Editorial Source Type: research

Master Techniques in Upper and Lower Airway Management
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 3, 2015 Category: Anesthesiology Tags: Book review Source Type: research

Urapidil versus nicardipine in preeclamptic toxaemia: A randomised feasibility study
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 3, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Weight and BMI are the most important predictors influencing the needle insertion distance to the thoracic epidural space
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 3, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

The effects of adding upper and lower subcostal transversus abdominis plane blocks to a lateral transversus abdominis plane block after laparoscopic cholecystectomy: A randomised, double-blind clinical trial
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 3, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Quadratus lumborum block for postoperative pain after caesarean section: A randomised controlled trial
BACKGROUND: Effective postoperative analgesia after caesarean section is important because it enables early ambulation and facilitates breast-feeding. Several case reports have shown that local anaesthetic injection around the quadratus lumborum muscle is effective in providing pain relief after various abdominal operations and in patients with chronic pain. The quadratus lumborum block (QLB) is performed in close proximity to the surface and uses a fascial compartment path to extend the distribution of local anaesthesia into the posterior abdominal wall and paravertebral space. This central effect can be of vital importan...
Source: European Journal of Anaesthesiology - October 3, 2015 Category: Anesthesiology Tags: Regional anaesthesia Source Type: research

Clonidine versus sufentanil as an adjuvant to ropivacaine in patient-controlled epidural labour analgesia: A randomised double-blind trial
BACKGROUND: Adjuvants to local anaesthetics for epidural labour analgesia are useful if they reduce side-effects or personnel requirements. Epidural clonidine improves analgesia and provides a significant local anaesthetic-sparing effect. OBJECTIVE: To compare the number of rescue doses administered by the anaesthesiologist when clonidine or sufentanil is added to epidural ropivacaine. DESIGN: A randomised double-blind trial. SETTING: Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium, from June 2009 to June 2010. PATIENTS: One hundred and ninety-five women in labour. INTERVENTIO...
Source: European Journal of Anaesthesiology - October 3, 2015 Category: Anesthesiology Tags: Regional anaesthesia Source Type: research

Comparison of efficacy and safety of lateral-to-medial continuous transversus abdominis plane block with thoracic epidural analgesia in patients undergoing abdominal surgery: A randomised, open-label feasibility study
CONCLUSION: Continuous bilateral LM-TAP block can be initiated preoperatively and may provide comparable analgesia to TEA in patients undergoing laparotomy. CLINICAL TRIALS REGISTRY: not registered because registration was not mandatory at the time of starting the trial. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 3, 2015 Category: Anesthesiology Tags: Regional anaesthesia Source Type: research

A pharmacodynamic evaluation of dexmedetomidine as an additive drug to ropivacaine for peripheral nerve blockade: A randomised, triple-blind, controlled study in volunteers
The objective of this study is to assess the dose-dependency of dexmedetomidine when injected with ropivacaine for peripheral nerve blockade. DESIGN: A randomised, triple-blind, controlled study in volunteers. SETTING: Department of Clinical Pharmacology, Medical University of Vienna. PARTICIPANTS: Twenty-four volunteers. INTERVENTIONS: All volunteers received an ulnar nerve block with 22.5 mg ropivacaine alone (R), or mixed with 50 (RD50), 100 (RD100) or 150 μg (RD150) dexmedetomidine. MAIN OUTCOME MEASURES: The primary outcome was the duration of complete sensory block to pinprick and time to complete recovery of ...
Source: European Journal of Anaesthesiology - October 3, 2015 Category: Anesthesiology Tags: Regional anaesthesia Source Type: research

Ropivacaine 0.375% vs. 0.75% with prilocaine for intermediate cervical plexus block for carotid endarterectomy: A randomised trial
BACKGROUND: Carotid endarterectomy is widely performed under regional anaesthesia. Ultrasound guidance is increasingly used in many regional anaesthetic procedures to improve safety and efficacy, and because it can reduce the amount of local anaesthetic required. Despite this, an ideal approach and dosing regimen for cervical plexus block remain elusive. OBJECTIVE: The aim of this study was to compare two different concentrations of ropivacaine in terms of analgesic adequacy, haemodynamic effects and plasma concentration using an ultrasound-guided triple approach for intermediate cervical plexus blockade. DESIGN: A randomi...
Source: European Journal of Anaesthesiology - October 3, 2015 Category: Anesthesiology Tags: Regional anaesthesia Source Type: research

Influence of arm position on ultrasound visibility of the axillary brachial plexus
CONCLUSION: The visibility of the radial nerve was not improved by varying positions of the arm. S180°/E0° provided the best overall visibility and accessibility of nerves. TRIAL REGISTRATION: https://www.toetsingonline.nl/to/ccmo_search.nsf/Searchform?OpenForm Identifier: NL42116.018.12. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 3, 2015 Category: Anesthesiology Tags: Regional anaesthesia Source Type: research

The Shamrock lumbar plexus block: A dose-finding study
CONCLUSION: A volume of 20.4 ml ropivacaine 0.5% provided a successful Shamrock lumbar plexus block in 50% of the patients. A volume of 36.0 ml would be successful in 95% of the patients. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT01956617. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 3, 2015 Category: Anesthesiology Tags: Regional anaesthesia Source Type: research

Determination of the minimum initial intrathecal dose of isobaric 0.5% bupivacaine for the surgical repair of a proximal femoral fracture: A prospective, observational trial
CONCLUSION: Our findings may influence clinicians’ initial dose selection for spinal anaesthesia when a spinal catheter is used. The dose may be less than previously thought. TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT01680120. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 3, 2015 Category: Anesthesiology Tags: Regional anaesthesia Source Type: research

Combination of dexamethasone and local anaesthetic solution in peripheral nerve blocks: A meta-analysis of randomised controlled trials
The objective of this study is to evaluate the effect of combining dexamethasone with local anaesthetic on sensory and motor peripheral nerve blockade in adults. DESIGN: A systematic review with meta-analysis of randomised controlled trials. DATA SOURCES: We systematically searched in Medline, Embase, Google Scholar and Cochrane Controlled Trials Register up to December 2013. ELIGIBILITY CRITERIA: Randomised trials testing dexamethasone combined with local anaesthetic. RESULTS: Twelve trials (1054 patients, 512 receiving perineural dexamethasone) were included. Ten studies evaluated dexamethasone for brachial plexus nerve ...
Source: European Journal of Anaesthesiology - October 3, 2015 Category: Anesthesiology Tags: Regional anaesthesia Source Type: research

Is pholcodine a dangerous cough suppressant?
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 3, 2015 Category: Anesthesiology Tags: Editorial Source Type: research

Intraoperative temperature monitoring with zero heat flux technology (3 M SpotOn sensor) in comparison with sublingual and nasopharyngeal temperature: An observational study: Erratum
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 2, 2015 Category: Anesthesiology Tags: Erratum Source Type: research

Paediatric anaesthesia emergency data manual
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 2, 2015 Category: Anesthesiology Tags: Book Review Source Type: research

Shoulder pain after hepatectomy occurs more frequently on the right side: A retrospective observational analysis
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 2, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Failure of sugammadex to reverse rocuronium-induced neuromuscular blockade: Simply an outlier or are we missing something?
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 2, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Neostigmine dose: Comparison between theory and practice
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 2, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Tramadol-induced hyperalgesia and its prevention by ketamine in rats: A randomised experimental study
CONCLUSION: Tramadol-induced hyperalgesia in the rat lasted for several weeks and was associated with an increase in the MAC of sevoflurane. Prior administration of ketamine blocked both phenomena. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 2, 2015 Category: Anesthesiology Tags: Pain Source Type: research