Kinetics of plasma biomarkers of inflammation and lung injury in surgical patients with or without postoperative pulmonary complications
CONCLUSION: In patients undergoing abdominal surgery and at risk of developing PPCs, plasma levels of biomarkers for inflammation or lung injury showed distinct kinetics with development of PPCs, but none of the biomarkers showed sufficient prognostic value. The use of high levels of PEEP was associated with increased levels of CC-16, suggesting lung overdistension. TRIAL REGISTRATION: The PROVHILO trial, including this substudy, was registered at clinicaltrials.gov (NCT01441791). (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - March 2, 2017 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

Patient-completed, preoperative web-based anaesthetic assessment questionnaire (electronic Personal Assessment Questionnaire PreOperative): Development and validation
CONCLUSION: Initial evaluation suggests that ePAQ is acceptable to patients. Data collected using the system were found to be reliable, and its intrinsic scoring systems for ASA and BMI are comparable with values assigned by clinicians. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - March 2, 2017 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

Antibiotic therapy in the critically ill - expert opinion of the Intensive Care Medicine Scientific Subcommittee of the European Society of Anaesthesiology
This article summarises the main conclusions of the panel, namely the principles of antibiotic therapy that all physicians working with critically ill patients must know. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - March 2, 2017 Category: Anesthesiology Tags: Special article Source Type: research

European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium
The purpose of this guideline is to present evidence-based and consensus-based recommendations for the prevention and treatment of postoperative delirium. The cornerstones of the guideline are the preoperative identification and handling of patients at risk, adequate intraoperative care, postoperative detection of delirium and management of delirious patients. The scope of this guideline is not to cover ICU delirium. Considering that many medical disciplines are involved in the treatment of surgical patients, a team-based approach should be implemented into daily practice. This guideline is aimed to promote knowledge and e...
Source: European Journal of Anaesthesiology - March 2, 2017 Category: Anesthesiology Tags: Guidelines Source Type: research

Postoperative delirium guidelines: The greater the obstacle, the more glory in overcoming it
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - March 2, 2017 Category: Anesthesiology Tags: Invited commentary Source Type: research

Improving perioperative outcome: time to update protocols
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - March 2, 2017 Category: Anesthesiology Tags: Editorial Source Type: research

Manual of ICU Procedures
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - February 1, 2017 Category: Anesthesiology Tags: Book Review Source Type: research

Anaesthesia and orphan disease: Difficult ventilation following intubation in Goldenhar syndrome
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - February 1, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Anaesthesia and orphan diseases: Airway management in Proteus disease
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - February 1, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Anaesthesia and orphan disease: A child with Congenital Cataract Facial Dysmorphism neuropathy (CCFDN) syndrome: a case report
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - February 1, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Anaesthesia and orphan disease: Rapid sequence induction in systemic mastocytosis
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - February 1, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Smartphone-based behavioural intervention alleviates children's anxiety during anaesthesia induction: A randomised controlled trial
CONCLUSION: The behavioural distraction strategies using smartphones were effective in preventing an increase in children's anxiety during anaesthesia induction. TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT02246062. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - February 1, 2017 Category: Anesthesiology Tags: Paediatric Anaesthesia Source Type: research

The effect of prior tetanic stimulation on train-of-four monitoring in paediatric patients: A randomised open-label controlled trial
BACKGROUND: In clinical research, neuromuscular monitoring must present a stable response for a period of 2 to 5 min before administration of a neuromuscular blocking agent. The time required to reach this stable response may be shortened by applying a 5-s tetanic stimulus. OBJECTIVES: The aim of this study was to test whether tetanic stimulation interferes with onset and recovery times after a single dose of rocuronium 0.6 mg kg−1 followed by spontaneous recovery. DESIGN: A randomised, open-label, controlled trial. SETTING: A single-centre trial, study period from January 2014 to July 2015. PATIENTS: Fifty...
Source: European Journal of Anaesthesiology - February 1, 2017 Category: Anesthesiology Tags: Paediatric Anaesthesia Source Type: research

A survey of the dose of inhalational agents used to maintain anaesthesia in infants
BACKGROUND: Various animal studies suggest that currently used anaesthetics are toxic to the developing brain. Many reviews advise that the total anaesthetic drug exposure should be reduced but the dose usually used in clinical practice has not been clearly elucidated. OBJECTIVES: To provide an overview of the dose ranges currently used in clinical practice during the maintenance phase of anaesthesia in infants undergoing anaesthesia for noncardiac surgery and diagnostic procedures. DESIGN: A two-centre mixed prospective (London) and retrospective (Utrecht) observational cohort study. SETTING: Two independent tertiary p...
Source: European Journal of Anaesthesiology - February 1, 2017 Category: Anesthesiology Tags: Paediatric Anaesthesia Source Type: research

Determination of a cut-off value of antral area measured in the supine position for the fast diagnosis of an empty stomach in the parturient: A prospective cohort study
CONCLUSION: With a parturient lying in the supine position, a single assessment of the antral cross-sectional area may be used for the fast diagnosis of an empty stomach. This tool could be useful in assessing the risk of aspiration for parturients who require emergency anaesthesia during labour. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - February 1, 2017 Category: Anesthesiology Tags: Obstetrical Anaesthesia Source Type: research

Moderate hyperoxia induces inflammation, apoptosis and necrosis in human umbilical vein endothelial cells: An in-vitro study
CONCLUSION: Continuous moderate hyperoxia and cyclic moderate hyperoxia/anoxia-induced endothelial inflammation, apoptosis and necrosis. Given the large surface area of the vascular endothelium, moderately elevated O2 levels may contribute to cardiovascular inflammation and injury. TRIAL REGISTRATION: This in-vitro study was not registered in a database. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - February 1, 2017 Category: Anesthesiology Tags: Obstetrical Anaesthesia Source Type: research

Novel needle guide reduces time to perform ultrasound-guided femoral nerve catheter placement: A randomised controlled trial
BACKGROUND: Ultrasound-guided nerve blocks have become the standard when performing regional nerve blocks in anaesthesia. Infiniti Plus (CIVCO Medical Solutions, Kalona, Iowa, USA) is a needle guide that has been recently developed to help clinicians in performing ultrasound-guided nerve blocks. OBJECTIVES: We tested the hypothesis that femoral nerve catheter placement carried out with the Infiniti Plus needle guide will be quicker to perform than without the Infiniti Plus. Secondary aims were to assess whether the Infiniti Plus needle guide decreased the number of block attempts and also whether it improved needle visibi...
Source: European Journal of Anaesthesiology - February 1, 2017 Category: Anesthesiology Tags: Locoregional Anaesthesia Source Type: research

Double-injection technique assisted by a nerve stimulator for ultrasound-guided supraclavicular brachial plexus block results in better distal sensory–motor block: A randomised controlled trial
BACKGROUND: To evaluate the efficacy of a nerve stimulator when used with ultrasound-guided double injection in supraclavicular brachial plexus block. OBJECTIVES: We hypothesised that targeting the inferior trunk of the plexus guided by a nerve stimulator would obtain a higher success rate of ulnar nerve blockade than the traditional double-injection technique. DESIGN: A blinded randomised controlled study. SETTING: Conducted at the University Hospital from October 2015 to January 2016. PATIENTS: Ninety patients undergoing upper extremity surgery were randomised into two equal groups. INTERVENTIONS: Patients were rand...
Source: European Journal of Anaesthesiology - February 1, 2017 Category: Anesthesiology Tags: Locoregional Anaesthesia Source Type: research

The nerve: A fragile balance between physiology and pathophysiology
Regarding nerves as simple cables and electrical conduits is a gross error that does not allow us to understand the anomalies and disorders observed postoperatively. Instead, nerves should be seen as a living tissue of which physiological regulation is as complex as that of the blood–brain barrier. This review describes the basic structure and functions of this blood–nerve barrier and highlights the mechanisms of its breakdown and the resultant disorders. For clinical practice, it is important to note that the diffusion of molecules from the perineurium or from the blood is very limited, and so the blood–...
Source: European Journal of Anaesthesiology - February 1, 2017 Category: Anesthesiology Tags: Review Article Source Type: research

We may have improved but we must get better still: The never-ending story of the elderly with fractured neck of femur
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - February 1, 2017 Category: Anesthesiology Tags: Editorial Source Type: research

Complications in Neuroanesthesia
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 4, 2017 Category: Anesthesiology Tags: Book review Source Type: research

Reply to: the small details that influence postoperative pain
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 4, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

The small details that influence postoperative pain
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 4, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: volume therapy in obstetrics
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 4, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Volume therapy in obstetrics
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 4, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: association of increased N terminal B-type natriuretic propeptide levels with short-term adverse outcomes after noncardiac surgery
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 4, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Association of increased N terminal B-type natriuretic propeptide levels with short-term adverse outcomes after noncardiac surgery
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 4, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: posterior wall puncture during ultrasound-guided arterial cannulation suggests inadequate operator skills
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 4, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Posterior wall puncture during ultrasound-guided arterial cannulation suggests inadequate operator skills
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 4, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research

Does permissive hypoxaemia during extracorporeal membrane oxygenation cause long-term neurological impairment?: A study in patients with H1N1-induced severe respiratory failure
CONCLUSIONS: Permissive hypoxaemia during ECMO might not negatively affect long-term cognitive outcome if adequate organ perfusion is maintained. TRIAL REGISTRATION: at Clinicaltrials.gov NCT01763060 (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 4, 2017 Category: Anesthesiology Tags: Cardiovascular anaesthesia Source Type: research

Comparative analysis of resuscitation using human serum albumin and crystalloids or 130/0.4 hydroxyethyl starch and crystalloids on skeletal muscle metabolic profile during experimental haemorrhagic shock in swine: A randomised experimental study
BACKGROUND: Protection against acute skeletal muscle metabolic dysfunction and oxidative stress could be a therapeutic target in volume expansion for severely bleeding patients. OBJECTIVES: This experimental pilot study in swine aims at comparing 130/0.4 hydroxyethyl starch (HES) with 4% albumin along with crystalloid perfusion for first-line volume expansion in haemorrhagic shock with a particular emphasis on oxidative stress and muscular mitochondrial function. DESIGN: Randomised experimental study. SETTING: Digestive Cancer Research Institute Preclinical Laboratory, Strasbourg University Hospital, France, from Februa...
Source: European Journal of Anaesthesiology - January 4, 2017 Category: Anesthesiology Tags: Cardiovascular anaesthesia Source Type: research

External validation of predictive models for acute kidney injury following cardiac surgery: A prospective multicentre cohort study
CONCLUSION: Overall, the lack of calibration of these models and the difficulty in using the models clinically because of the large number of variables limit their applicability. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 4, 2017 Category: Anesthesiology Tags: Cardiovascular anaesthesia Source Type: research

Assessment of a smartphone app (Capstesia) for measuring pulse pressure variation: agreement between two methods: A Cross-sectional study
CONCLUSIONS: Photograph of the screenshots obtained with the Capstesia app show a good concordance with analysis of the original screenshots. Either approach could be used to monitor the haemodynamic variables assessed. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 4, 2017 Category: Anesthesiology Tags: Cardiovascular anaesthesia Source Type: research

Lung recruitment improves right ventricular performance after cardiopulmonary bypass: A randomised controlled trial
BACKGROUND: Atelectasis after cardiopulmonary bypass (CPB) can affect right ventricular (RV) performance by increasing its outflow impedance. OBJECTIVE: The aim of this study was to determine whether a lung recruitment manoeuvre improves RV function by re-aerating the lung after CPB. DESIGN: Randomised controlled study. SETTING: Single-institution study, community hospital, Córdoba, Argentina. PATIENTS: Forty anaesthetised patients with New York Heart Association class I or II, preoperative left ventricular ejection fraction at least 50% and Euroscore 6 or less scheduled for cardiac surgery with CPB. INTERVENTI...
Source: European Journal of Anaesthesiology - January 4, 2017 Category: Anesthesiology Tags: Cardiovascular anaesthesia Source Type: research

Bilateral sternal infusion of ropivacaine and length of stay in ICU after cardiac surgery with increased respiratory risk: A randomised controlled trial
CONCLUSION: Because of a small size effect, and despite significant analgesic effects, this strategy failed to reduce the time spent in ICU. TRIAL REGISTRATION: EudraCT (N°: 2012-005225-69); ClinicalTrials.gov (NCT01828788). (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 4, 2017 Category: Anesthesiology Tags: Cardiovascular anaesthesia Source Type: research

Minimally invasive analgesia after cardiac surgery
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 4, 2017 Category: Anesthesiology Tags: Invited Commentary Source Type: research

Developing standardised advanced training in neuroanaesthesia: Results of a Europe-wide survey
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 4, 2017 Category: Anesthesiology Tags: Editorial Source Type: research

Drugs in Anaesthesia and Intensive Care, 5th edn
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 2, 2016 Category: Anesthesiology Tags: Book review Source Type: research

Peritonsillar morphine infiltration to prevent early postoperative pain after tonsillectomy
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 2, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: regional or general anaesthesia for carotid endarterectomy
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 2, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Regional or general anaesthesia for carotid endarterectomy
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 2, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: preoperative fluid loading in major abdominal surgery
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 2, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Preoperative fluid loading in major abdominal surgery
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 2, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: psychological distress, burnout and personality traits in Dutch anaesthesiologists
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 2, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Psychological distress, burnout and personality traits in Dutch anaesthesiologists
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 2, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: are transdermal opioids contraindicated in patients at risk of suicide?
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 2, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Are transdermal opioids contraindicated in patients at risk of suicide?
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 2, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: thrombin generation tests and viscoelastic testing in cirrhosis: comparing apples and oranges?
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 2, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Thrombin generation tests and viscoelastic testing in cirrhosis: comparing apples and oranges?
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 2, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: assessment of haemostasis in patients with liver cirrhosis
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - December 2, 2016 Category: Anesthesiology Tags: Correspondence Source Type: research