Effect of intravenous dexmedetomidine and remifentanil on neonatal outcomes after caesarean section under general anaesthesia: A systematic review and meta-analysis
BACKGROUND Various strategies have been used to mitigate haemodynamic instability during general anaesthesia for caesarean section. However, the safety of these strategies for neonates remains controversial. OBJECTIVE To investigate the effects of intravenous dexmedetomidine and remifentanil on neonatal outcomes during caesarean section under general anaesthesia. DESIGN Systematic review and meta-analysis of randomised controlled trials. DATA SOURCES Databases of PubMed, EMBASE and CENTRAL were searched until March 2020 and updated in February 2021. ELIGIBILITY CRITERIA Randomised controlled...
Source: European Journal of Anaesthesiology - September 16, 2021 Category: Anesthesiology Tags: Obstetrics Source Type: research

A randomised double-blind comparison of phenylephrine and norepinephrine for the management of postspinal hypotension in pre-eclamptic patients undergoing caesarean section
BACKGROUND Studies comparing phenylephrine and norepinephrine for the treatment of postspinal hypotension in pre-eclamptic patients are limited. OBJECTIVE To compare bolus doses of phenylephrine and norepinephrine for treating hypotension in pre-eclamptic mothers undergoing caesarean section under spinal anaesthesia. It was hypothesised that norepinephrine and phenylephrine use would be associated with similar neonatal outcome. DESIGN Randomised controlled study. SETTING Single centre, tertiary care, university teaching hospital, from December 2018 to March 2020. PATIENTS A total of 86 women...
Source: European Journal of Anaesthesiology - September 16, 2021 Category: Anesthesiology Tags: Obstetrics Source Type: research

Treatment of spinal anaesthesia-induced hypotension with cafedrine/theodrenaline versus ephedrine during caesarean section: Results from HYPOTENS, a national, multicentre, prospective, noninterventional study
This study relates to the cohort of patients receiving spinal anaesthesia for caesarean section. SETTING German hospitals using either C/T or ephedrine in their routine clinical practice. PATIENTS Women aged at least 18 years receiving spinal anaesthesia for caesarean section. INTERVENTIONS Bolus administration of C/T or ephedrine at the discretion of the attending anaesthesiologist. MAIN OUTCOME MEASURES Endpoints within 15 min after initial administration of C/T or ephedrine were area under the curve between the observed SBP and the minimum target SBP; and incidence of newly occurring heart ...
Source: European Journal of Anaesthesiology - September 16, 2021 Category: Anesthesiology Tags: Obstetrics Source Type: research

Factors associated with an increased risk of instrumental vaginal delivery in women with epidural analgesia for labour: A retrospective cohort study
BACKGROUND Epidural analgesia is the most effective form of labour analgesia, but is associated with an increased risk of instrumental delivery. OBJECTIVE To evaluate factors that are associated with an increased risk of instrumental delivery. DESIGN Retrospective cohort data study. SETTING Singapore's major public maternity institution. PATIENTS All obstetric patients who received labour epidural analgesia for vaginal delivery between January 2012 to December 2015. INTERVENTION None. MAIN OUTCOME MEASURES Our primary outcome was the incidence of instrumental delivery. RESUL...
Source: European Journal of Anaesthesiology - September 16, 2021 Category: Anesthesiology Tags: Obstetrics Source Type: research

The efficacy of high flow nasal oxygenation for maintaining maternal oxygenation during rapid sequence induction in pregnancy: A prospective randomised clinical trial
BACKGROUND High-flow nasal oxygenation (HFNO) for pre-oxygenation in rapid sequence induction (RSI) has only been assessed in volunteer parturients without intubation. OBJECTIVES To evaluate the efficacy of HFNO in comparison with the conventional facemask for oxygenation during RSI for caesarean section under general anaesthesia. SETTING Operating room in a tertiary hospital. DESIGN Prospective randomised, controlled study. PARTICIPANTS Thirty-four healthy parturients undergoing general anaesthesia for caesarean section. INTERVENTIONS Parturients were randomly assigned to HFNO or sta...
Source: European Journal of Anaesthesiology - September 16, 2021 Category: Anesthesiology Tags: Obstetrics Source Type: research

Intra-operative open-lung ventilatory strategy reduces postoperative complications after laparoscopic colorectal cancer resection: A randomised controlled trial
BACKGROUND The role of the positive end-expiratory pressure (PEEP) and lung recruitment manoeuvre (LRM) combination (termed open-lung strategy, OLS) during intra-operative mechanical ventilation is not clear. OBJECTIVE To determine whether an open-lung strategy constituting medium PEEP (6–8 cmH2O) and repeated LRMs protects against postoperative complications in at-risk patients undergoing laparoscopic colorectal cancer resection under low-tidal-volume ventilation. DESIGN A prospective, assessor-blinded, randomised controlled trial. SETTING Single university-affiliated hospital, conducted from ...
Source: European Journal of Anaesthesiology - September 16, 2021 Category: Anesthesiology Tags: Ventilation Source Type: research

Sex difference and intra-operative tidal volume: Insights from the LAS VEGAS study
BACKGROUND One key element of lung-protective ventilation is the use of a low tidal volume (VT). A sex difference in use of low tidal volume ventilation (LTVV) has been described in critically ill ICU patients. OBJECTIVES The aim of this study was to determine whether a sex difference in use of LTVV also exists in operating room patients, and if present what factors drive this difference. DESIGN, PATIENTS AND SETTING This is a posthoc analysis of LAS VEGAS, a 1-week worldwide observational study in adults requiring intra-operative ventilation during general anaesthesia for surgery in 146 hospitals in 29 c...
Source: European Journal of Anaesthesiology - September 16, 2021 Category: Anesthesiology Tags: Ventilation Source Type: research

Effects of positive end-expiratory pressure/recruitment manoeuvres compared with zero end-expiratory pressure on atelectasis in children: A randomised clinical trial
CONCLUSIONS The reduced atelectasis provided by lung-protective ventilation does not persist from 15 min after extubation onwards. Further studies are needed to determine if it yields better results in other types of surgery. TRIAL REGISTRATION Chictr.org.cn (ChiCTR2000033469). (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 16, 2021 Category: Anesthesiology Tags: Ventilation Source Type: research

Optimal positive end-expiratory pressure to prevent anaesthesia-induced atelectasis in infants: A prospective, randomised, double-blind trial
CONCLUSION To reduce anaesthesia-induced atelectasis measured by ultrasound in healthy infants undergoing low abdominal, genitourinary or superficial regional operations, 6 cmH2O of PEEP was more effective than 3 cmH2O. PEEP of 9 cmH2O was comparable with 6 cmH2O. TRIAL REGISTRATION ClinicalTrials.gov identifier NCT03969173 (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 16, 2021 Category: Anesthesiology Tags: Ventilation Source Type: research

Effect of positive end-expiratory pressure during anaesthesia induction on non-hypoxic apnoea time in infants: A randomised controlled trial
CONCLUSION Positive end-expiratory pressure during anaesthesia induction with face mask ventilation increased nonhypoxic apnoea time in infants. CLINICAL TRIAL REGISTRATION www.clinicaltrials.gov, NCT03540940. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 16, 2021 Category: Anesthesiology Tags: Ventilation Source Type: research

Communication in the ICU during the COVID-19 pandemic
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 16, 2021 Category: Anesthesiology Tags: Editorial Source Type: research

More notable names in anaesthesia
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 12, 2021 Category: Anesthesiology Tags: Book review Source Type: research

Kidney dysfunction has a major impact on the effect of idarucizumab for dabigatran reversal
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 12, 2021 Category: Anesthesiology Tags: Correspondence Source Type: research

Short-term administration of nonsteroidal anti-inflammatory drugs in older patients with hip fracture: A cohort study
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 12, 2021 Category: Anesthesiology Tags: Correspondence Source Type: research

Tapentadol versus oxycodone analgesia and side effects after laparoscopic hysterectomy: A randomised controlled trial
CONCLUSION We found tapentadol to be similar in analgesic efficacy to oxycodone during the first 24 h after hysterectomy, but with significantly less nausea. TRIAL REGISTRATION ClinicalTrials.gov, NCT03314792. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 12, 2021 Category: Anesthesiology Tags: Pain Source Type: research