Hyperalgesia induced by low-dose opioid treatment before orthopaedic surgery: An observational case–control study
CONCLUSION: Chronic pain patients treated with low doses of opioid had hyperalgesia before surgery. These results highlight the need to personalise the management of patients treated with opioids before surgery. TRIAL REGISTRATION: ID-RCB 2011-A00304-37. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - March 10, 2015 Category: Anesthesiology Tags: Pain Source Type: research

Amitriptyline, minocycline and maropitant reduce the sevoflurane minimum alveolar concentration and potentiate remifentanil but do not prevent acute opioid tolerance and hyperalgesia in the rat: A randomised laboratory study
BACKGROUND: The antidepressant amitriptyline, the inhibitor of microglia activation minocycline, and the neurokinin-1 antagonist maropitant have all been used to prevent or treat hyperalgesia and opioid tolerance. OBJECTIVES: To determine the effect of amitriptyline, minocycline, maropitant, independently or with remifentanil, on the sevoflurane minimum alveolar concentration in rats and whether these drugs may block opioid-induced hyperalgesia and acute opioid tolerance under inhalational anaesthesia. DESIGN: A randomised, laboratory study. SETTING: Experimental Unit, La Paz University Hospital, Madrid, Spain. ANIMALS: On...
Source: European Journal of Anaesthesiology - March 10, 2015 Category: Anesthesiology Tags: Pain Source Type: research

Evaluation of anxiety-like behaviour in a rat model of acute postoperative pain
CONCLUSION: We report that a rat model of acute postoperative pain is associated with anxiety-like increased light and open arm avoidance behaviour. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - March 10, 2015 Category: Anesthesiology Tags: Pain Source Type: research

Hyperalgesia and increased sevoflurane minimum alveolar concentration induced by opioids in the rat: A randomised experimental study
BACKGROUND: Perioperative opioids reduce inhalational anaesthetic requirements. The initial hypoalgesia may, however, be followed by a rebound hyperalgesia. OBJECTIVES: To determine whether prior opioid administration influences inhalational anaesthetic requirements, which might be associated with opioid-induced hyperalgesia. DESIGN: A prospective, randomised, experimental study. SETTING: Experimental Surgery, La Paz University Hospital, Madrid, Spain. ANIMALS: Seventy-nine adult male Wistar rats. INTERVENTIONS: Sevoflurane minimum alveolar concentration (MAC) and mechanical nociceptive thresholds (MNTs) were assessed at b...
Source: European Journal of Anaesthesiology - March 10, 2015 Category: Anesthesiology Tags: Pain Source Type: research

Role of anaesthetics and opioids in perioperative hyperalgesia: One step towards familiarisation
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - March 10, 2015 Category: Anesthesiology Tags: Invited commentary Source Type: research

The challenges of anaesthesia for the next decade: The Sir Robert Macintosh Lecture 2014
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - March 10, 2015 Category: Anesthesiology Tags: Special article Source Type: research

Ethical procedures and patient consent differ in Europe: erratum
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Erratum Source Type: research

Pharmacology for anaesthesia and intensive care, 4th edn
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Book review Source Type: research

Anaesthesia and orphan disease: anaesthesia for Gomez–Lopez-Hernandez syndrome
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Anaesthesia and orphan disease: a child with Wolcott–Rallison syndrome
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Anaesthesia and orphan disease: fragile X syndrome (Martin–Bell syndrome)
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Anaesthesia and orphan disease: a child with neuronal ceroid lipofuscinosis
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Anaesthesia and orphan disease: a patient with spinal muscular atrophy type III (Wohlfart–Kugelberg–Welander syndrome) undergoing laparoscopic cholecystectomy
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: fibreoptic tracheal intubation training using bronchoscopy simulation
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Fibreoptic tracheal intubation training using bronchoscopy simulation
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: performance of videolaryngoscope and flexible fibreoptic endoscope in simulating difficult airways
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Performance of videolaryngoscope and flexible fibreoptic endoscope in simulating difficult airways
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Presepsin in the prognosis of infectious diseases and diagnosis of infectious disseminated intravascular coagulation: A prospective, multicentre, observational study
CONCLUSION: The prognosis and severity of infection may be assessed more accurately by measuring the presepsin levels until day 7. Presepsin is a useful diagnostic tool for DIC with infection. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

Testing a conceptual model on early opening of the microcirculation in severe sepsis and septic shock: A randomised controlled pilot study
CONCLUSION: Early opening of the microcirculation in patients with severe sepsis and septic shock using nitroglycerin, enoximone, dopamine and corticosteroids did not result in a faster reduction in organ failure than standard resuscitation. TRIAL REGISTRATION: Clinicaltrials.gov identifier NCT00484133. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

Monocyte hyporesponsiveness and Toll-like receptor expression profiles in coronary artery bypass grafting and its clinical implications for postoperative inflammatory response and pneumonia: An observational cohort study
BACKGROUND: Cardiac surgery with cardiopulmonary bypass has a major impact on the congenital immune response, in which Toll-like receptors (TLRs) are the first line of defence. Decreased surface expression of TLRs and impaired monocyte responsiveness to TLR ligands occur following surgery. However, the clinical implications of this altered immune response are not clear. OBJECTIVES: To study cardiac surgery induced changes in perioperative TLR expression and monocyte responsiveness, and the association with postoperative inflammatory complications. DESIGN: A prospective cohort study. SETTING: Single university hospital, enr...
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

Anaesthetic and ICU management of aneurysmal subarachnoid haemorrhage: A survey of European practice
BACKGROUND: Many aspects of the perioperative management of aneurysmal subarachnoid haemorrhage (SAH) remain controversial. It would be useful to assess differences in the treatment of SAH in Europe to identify areas for improvement. OBJECTIVE: To determine the clinical practice of physicians treating SAH and to evaluate any discrepancy between practice and published evidence. DESIGN: An electronic survey. PARTICIPANTS: Physicians identified through each national society of neuroanaesthesiology and neurocritical care. INTERVENTIONS: A 31-item online questionnaire was distributed by the ENIG group. Questions were designed t...
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

PREPARE: the prevalence of perioperative anaemia and need for patient blood management in elective orthopaedic surgery: A multicentre, observational study
BACKGROUND: Patient blood management (PBM) can prevent preoperative anaemia, but little is known about practice in Europe. OBJECTIVE: To assess the pre and postoperative prevalence and perioperative management of anaemia in patients undergoing elective orthopaedic surgery in Europe. DESIGN: An observational study; data were collected from patient records via electronic case report forms. SETTING: Seventeen centres in six European countries. Centres were stratified according to whether they had a PBM programme or not. PATIENTS: One thousand five hundred and thirty-four patients undergoing major elective hip, knee or spine s...
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

The impact of preoperative testing for blood glucose concentration and haemoglobin A1c on mortality, changes in management and complications in noncardiac elective surgery: A systematic review
CONCLUSION: Preoperative blood glucose testing and testing for HbA1c is not required in nondiabetic patients unless there are clinical sings arousing suspicion. Patients scheduled for vascular and orthopaedic surgery carry an elevated risk justifying preoperative testing for blood glucose or HbA1c as a screening tool. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

Postoperative delirium is an independent risk factor for posttraumatic stress disorder in the elderly patient: A prospective observational study
This study was carried out between March 2009 and May 2010 in a German university hospital in Berlin and was part of a larger study focusing on depth of anaesthesia. PATIENTS: Inclusion criteria: at least 60 years of age; noncardiac surgery with general anaesthesia. Exclusion criteria: impaired preoperative cognitive function [mini-mental state examination (MMSE) score (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Perioperative medicine Source Type: research

From cocaine to lidocaine: Great progress with a tragic ending
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 29, 2015 Category: Anesthesiology Tags: Editorial Source Type: research

A practical approach to cardiac anesthesia, 5th edn
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 3, 2015 Category: Anesthesiology Tags: Book review Source Type: research

Depression and the surgical patient: Glimpse of current and future literature
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 3, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Safety and performance of an infusion pump designed specifically for the MRI environment
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 3, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Gastric perforation after mouth-to-mouth ventilation: A case report
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 3, 2015 Category: Anesthesiology Tags: Correspondence Source Type: research

Sleep disorders among French anaesthesiologists and intensivists working in public hospitals: A self-reported electronic survey
CONCLUSION: French anaesthesiologists did not report more sleep disorders than the general population, but their alertness is impaired by a factor of two. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 3, 2015 Category: Anesthesiology Tags: Miscellaneous Source Type: research

Ethical procedures and patient consent differ in Europe
CONCLUSION: There is a considerable variation in the administrative requirements for approval procedures by research ethics committees in Europe. This results in variation of the extent of information and consent procedures for the patients involved. TRIAL REGISTRATION: euCPSP in Clinicaltrials.gov identifier: NCT01467102; PAIN-OUT in Clinicaltrials.gov identifier: NCT02083835. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 3, 2015 Category: Anesthesiology Tags: Miscellaneous Source Type: research

CONSORT item adherence in top ranked anaesthesiology journals in 2011: A retrospective analysis
CONCLUSION: Adherence to the CONSORT criteria remains low in top-ranked anaesthesiology journals. We found only a very weak correlation between the number of citations and fulfilment of the requirements of the CONSORT statement. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 3, 2015 Category: Anesthesiology Tags: Miscellaneous Source Type: research

Airway reactions and emergence times in general laryngeal mask airway anaesthesia: A meta-analysis
CONCLUSION: When using an LMA, upper airway adverse reactions in association with desflurane anaesthesia were no different from those noted with sevoflurane, isoflurane or propofol anaesthesia. Emergence from general anaesthesia with desflurane is significantly faster than all the other anaesthetics. Due to interstudy variations and the small size of the trials, further large-scale, multicentre studies are required to confirm or refute the results of this meta-analysis. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 3, 2015 Category: Anesthesiology Tags: Miscellaneous Source Type: research

Standards for definitions and use of outcome measures for clinical effectiveness research in perioperative medicine: European Perioperative Clinical Outcome (EPCO) definitions: A statement from the ESA-ESICM joint taskforce on perioperative outcome measures
This report describes definitions for 22 individual adverse events with a system of severity grading for each. In addition, four composite outcome measures were identified, which were designed to evaluate postoperative outcomes. The group also agreed on standards for four outcome measures for the evaluation of healthcare resource use and quality of life. Guidance for use of these outcome measures is provided, with particular emphasis on appropriate duration of follow-up. This report provides clearly defined and patient-relevant outcome measures for large clinical trials in perioperative medicine. These outcome measures may...
Source: European Journal of Anaesthesiology - January 3, 2015 Category: Anesthesiology Tags: Guidelines Source Type: research

When may systematic reviews and meta-analyses be considered reliable?
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 3, 2015 Category: Anesthesiology Tags: Invited commentaries Source Type: research

Standardisation of perioperative outcome measures
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 3, 2015 Category: Anesthesiology Tags: Invited commentaries Source Type: research

The medical procedure pathway: Creating a global standard methodology to benefit patients
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 3, 2015 Category: Anesthesiology Tags: Editorials Source Type: research

Minimal clinically important difference: A novel approach to measure changes in outcome in perioperative medicine
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 3, 2015 Category: Anesthesiology Tags: Editorials Source Type: research

A case for competency-based anaesthesiology training with entrustable professional activities: An agenda for development and research
We describe the potential benefits of working with EPAs in anaesthesiology training and set an agenda for curriculum development and research in this area. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - January 3, 2015 Category: Anesthesiology Tags: Review Source Type: research

Lippincott's anesthesia review: 1001 questions and answers
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Book review Source Type: research

Reply to: intravenous bolus injection of dexamethasone and transient excruciating perineal pain
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

Intravenous bolus injection of dexamethasone and transient excruciating perineal pain
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

Reply to: on the reliability of central venous oxygen saturation as a target in fluid resuscitation
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

On the reliability of the central venous oxygen saturation as a target in fluid resuscitation
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

Train-of-four count 0 ensured optimal surgical conditions during laparoscopic hysterectomy
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

Deep neuromuscular blockade and laparoscopy: Which level improves surgical conditions?
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

Iatrogenic jugular-carotid fistula despite ultrasound-guided vascular access
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

Clinical evaluation of acoustic respiration rate monitoring compared with conventional systems in the postanaesthesia care unit
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

Cephalic and digital pulse oximetry in cardiac surgery: A comparative pilot study with arterial oximetry
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research

Area difference ratio for assessing nociceptive balance during laryngoscopy and intubation under intravenous anaesthesia: Preliminary investigation of a novel photoplethysmographic variable
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - November 28, 2014 Category: Anesthesiology Tags: Correspondence Source Type: research