European Journal of Anaesthesiology 
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No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research
Effects of dexamethasone on early cognitive decline after cardiac surgery: A randomised controlled trial
BACKGROUND: Postoperative cognitive decline (POCD), a very common complication after cardiac surgery, is characterised by impairment of both memory function and intellectual ability as well as being associated with increased use of healthcare resources. The investigators focused on the role of the inflammatory response to a surgical procedure as a potential factor involved in the pathogenesis of POCD.
OBJECTIVE: The use of prophylactic dexamethasone to attenuate the inflammatory response was hypothesised to reduce the risk of POCD.
DESIGN: Randomised controlled study.
SETTING: Single university teaching hospital, from M...
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Perioperative medicine Source Type: research
Sevoflurane attenuates systemic inflammation compared with propofol, but does not modulate neuro-inflammation: A laboratory rat study
BACKGROUND: Septic encephalopathy is believed to be a result of neuro-inflammation possibly triggered by endotoxins, such as lipopolysaccharides (LPS). Modulation of the immune system is a property of volatile anaesthetics.
OBJECTIVE: We aimed to investigate the systemic and cerebral inflammatory response in a LPS-induced sepsis model in rats. We compared two different sedation strategies, intravenous propofol and the volatile anaesthetic sevoflurane, with the hypothesis that the latter may attenuate neuro-inflammatory processes.
DESIGN: Laboratory rat study.
SETTING: Basic research laboratories at the University Hospit...
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Perioperative medicine Source Type: research
Cardiac cycle efficiency and dicrotic pressure variations: new parameters for fluid therapy: An observational study
CONCLUSION: In this pilot study conducted in a population of surgical patients mechanically ventilated with a VT less than 8 ml kg−1, a dynamic model of fluid challenge assessment, including PPV, ΔCCE and ΔSAP − Pdic, enhances the prediction of fluid challenge response after 5 min of a 10-min administration.
TRIAL REGISTRATION: ACTRN12616001479493. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Perioperative medicine Source Type: research
Echocardiography and passive leg raising in the postoperative period: A prospective observational study
CONCLUSION: This is the first study showing that measurement of CO after PLR can predict volume response in spontaneously breathing postoperative patients. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Perioperative medicine Source Type: research
Evaluation of preoperative oral carbohydrate administration on insulin resistance in off-pump coronary artery bypass patients: A randomised trial
CONCLUSION: A preoperative CHO supplement significantly reduced insulin resistance and FFA concentrations compared with fasting at the beginning of the surgery, but these benefits were lost after off-pump coronary revascularisation. Despite their transient nature, these beneficial effects resulted in less myocardial injury, mandating further studies focused on the impact of preoperative CHO on myocardial ischaemia and cardiac function after coronary revascularisation.
TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT 02330263. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Perioperative medicine Source Type: research
The relative effects of dexmedetomidine and propofol on cerebral blood flow velocity and regional brain oxygenation: A randomised noninferiority trial
BACKGROUND: Dexmedetomidine constricts cerebral blood vessels without a concomitant reduction in cerebral metabolic oxygen consumption. Its safety as a sedative in patients with neurological diseases thus remains uncertain.
OBJECTIVE: Our primary objective was to test the hypothesis that dexmedetomidine is noninferior to propofol as regards cerebral blood flow (CBF) velocity and brain oxygenation.
DESIGN: Unblinded randomised trial.
SETTING: Cleveland Clinic Hospital, Cleveland, from November 2010 to July 2013.
PATIENTS: Forty-four patients scheduled for insertion of a deep-brain stimulating electrodes.
INTERVENTIONS:...
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Monitoring Source Type: research
Validation of radial artery-based uncalibrated pulse contour method (PulsioFlex) in critically ill patients: A observational study
CONCLUSION: In critically ill patients, the PulsioFlex system connected to a radial arterial catheter is inaccurate for CI measurements and does not track changes in CI adequately. We therefore recommend using validated thermodilution techniques for monitoring in the critical care setting. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Monitoring Source Type: research
The impact of continuous non-invasive arterial blood pressure monitoring on blood pressure stability during general anaesthesia in orthopaedic patients: A randomised trial
CONCLUSION: Continuous monitoring contributes to BP stability in the studied population.
TRIAL REGISTRATION: NCT02519101. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Monitoring Source Type: research
Continuous non-invasive haemodynamic monitoring: a beneficial impact on patient outcome is needed to gain ‘confidence in the technology’
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Invited Commentary Source Type: research
Re-evaluation of peri-operative cardiac risk (the MET REPAIR study): Study protocol of a prospective, multicentre cohort study sponsored by the European Society of Anaesthesiology
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - October 7, 2017 Category: Anesthesiology Tags: Editorial Source Type: research
Quality and Safety in Anesthesia and Perioperative Care
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 7, 2017 Category: Anesthesiology Tags: Book review Source Type: research
Effect of intravenous dextrose administration on postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: A randomised controlled trial
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 7, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research
Transcutaneous monitoring of partial pressure of carbon dioxide during bronchoscopic procedures performed with jet ventilation: Role of the perfusion index
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 7, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research
Comparison of polyvinyl chloride and tin stylets for postoperative sore throat and hoarseness: A randomised trial
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 7, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research
Prophylactic atropine administration attenuates the negative haemodynamic effects of induction of anaesthesia with propofol and high-dose remifentanil: A randomised controlled trial
BACKGROUND: Induction of anaesthesia with propofol and remifentanil often induces unwanted bradycardia and hypotension, raising concerns regarding tissue oxygenation. The electrophysiological cardiac effects of remifentanil can be reversed by atropine.
OBJECTIVE: To investigate if prophylactic administration of atropine can attenuate the negative haemodynamic effects of propofol and a high dose of remifentanil during induction of anaesthesia.
DESIGN: A double-blind, randomised controlled trial.
SETTING: Single-centre, University Medical Center Groningen, The Netherlands.
PATIENTS: Sixty euvolaemic patients scheduled fo...
Source: European Journal of Anaesthesiology - September 7, 2017 Category: Anesthesiology Tags: Haemodynamics Source Type: research
Microvascular reactivity monitored with near-infrared spectroscopy is impaired after induction of anaesthesia in cardiac surgery patients: An observational study
BACKGROUND: Induction of anaesthesia causes significant macrohaemodynamic changes, but little is known about its effects on the microcirculation. However, alterations in microvascular perfusion are known to be associated with impaired tissue oxygenation and organ dysfunction. Microvascular reactivity can be assessed with vascular occlusion testing, which evaluates the response of tissue oxygen saturation to transient ischaemia and reperfusion.
OBJECTIVE: The aim of the current study was to evaluate the effects of an opioid-based anaesthesia induction on microvascular reactivity. We hypothesised that despite minimal blood ...
Source: European Journal of Anaesthesiology - September 7, 2017 Category: Anesthesiology Tags: Haemodynamics Source Type: research
Women awaken faster than men after electroencephalogram-monitored propofol sedation for colonoscopy: A prospective observational study
CONCLUSION: The effect of gender aspects should be considered when propofol is used as sedation for gastrointestinal endoscopy. That includes adequate dosing for women as well as caution regarding potential overdosing of male patients.
TRIAL REGISTRATION: ClinicalTrials.gov (Identifier: NCT02687568). (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 7, 2017 Category: Anesthesiology Tags: Pharmacology Source Type: research
The use of dipyrone in the ICU is associated with acute kidney injury: A retrospective cohort analysis
CONCLUSION: Increasing dipyrone dosage is a potential independent risk factor for AKI in adult ICU patients and may prolong vasopressor therapy. Clinical evidence for a benefit of dipyrone therapy in the ICU is insufficient and needs further critical evaluation. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 7, 2017 Category: Anesthesiology Tags: Pharmacology Source Type: research
Effects of anaesthesia and analgesia on long-term outcome after total knee replacement: A prospective, observational, multicentre study
CONCLUSION: Continuous regional anaesthesia provides analgesic benefit for up to 1 month after surgery, but did not influence PPSP at 6 months. Better pain control at 1 month was associated with reduced PPSP. Patients with higher expectations from surgery, enhanced basal inflammation and a pessimistic outlook are more prone to develop PPSP.
TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT02147730 (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 7, 2017 Category: Anesthesiology Tags: Pain Source Type: research
Intraoperative magnesium sulphate decreases agitation and pain in patients undergoing functional endoscopic surgery: A randomised double-blind study
BACKGROUND: Postoperative agitation is harmful for the patient as it may be associated with removal of catheters, nasal packs, oxygen masks and self-injury, and pose a danger to operating theatre staff.
OBJECTIVE: The current study investigated the potential role of magnesium sulphate in treatment of postoperative agitation following functional endoscopic sinus surgery.
DESIGN: A randomised, double-blinded, placebo-controlled trial.
SETTING: ENT operating room, Menofia University Hospitals, Egypt.
PATIENTS: A total of 312 adult patients (171 men and 141 women) were enrolled in the study. Eighteen patients (10 men and e...
Source: European Journal of Anaesthesiology - September 7, 2017 Category: Anesthesiology Tags: Pain Source Type: research
Early postoperative neuropathic pain assessed by the DN4 score predicts an increased risk of persistent postsurgical neuropathic pain
CONCLUSION: Our results suggest that early acute postsurgical neuropathic pain significantly increases the risk of persistent post-surgical neuropathic pain.
TRIAL REGISTRATION: Clinicaltrials.gov identifier: NTC NCT02826317. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 7, 2017 Category: Anesthesiology Tags: Pain Source Type: research
Acute and chronic neuropathic pain after surgery: Still a lot to learn
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 7, 2017 Category: Anesthesiology Tags: Invited commentary Source Type: research
Anaesthetic management of patients with myopathies
The anaesthetic management of patients with myopathies is challenging. Considering the low incidence and heterogeneity of these disorders, most anaesthetists are unfamiliar with key symptoms, associated co-morbidities and implications for anaesthesia. The pre-anaesthetic assessment aims at the detection of potentially undiagnosed myopathic patients and, in case of known or suspected muscular disease, on the quantification of disease progression. Ancillary testing (e.g. echocardiography, ECG, lung function testing etc.) is frequently indicated, even at a young patient age. One must differentiate between myopathies associate...
Source: European Journal of Anaesthesiology - September 7, 2017 Category: Anesthesiology Tags: Review article Source Type: research
The renoprotective properties of xenon and argon in kidney transplantation
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - September 7, 2017 Category: Anesthesiology Tags: Editorial Source Type: research
Reply to: risk prediction instruments in geriatric surgery are available but often ignored
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 3, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research
Risk prediction instruments in geriatric surgery are available but often ignored
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 3, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research
Reply to: postoperative nausea and vomiting: solutions and questions
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 3, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research
Postoperative nausea and vomiting: solutions and questions
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 3, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research
Should the transversus abdominis plane block be performed for laparoscopic colorectal surgery?
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 3, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research
Compressed air injection technique for Shamrock lumbar plexus block
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 3, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research
Plasma levels of local anaesthetic following supraclavicular block
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 3, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research
Rocuronium is more hepatotoxic than succinylcholine in vitro
CONCLUSION: An in-vitro test with a cell line showed hepatotoxicity of rocuronium that was dose-dependent. Further studies are needed to investigate the underlying mechanisms of the effects of rocuronium on hepatic cellular integrity.
TRIAL REGISTRATION: Not suitable. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 3, 2017 Category: Anesthesiology Tags: Neuromuscularblocking agents Source Type: research
Effects of calcium chloride coadministered with neostigmine on neuromuscular blockade recovery: A double-blind randomised study
CONCLUSION: Calcium chloride coadministered with neostigmine enhanced neuromuscular recovery in the early period of nondepolarising neuromuscular blockade reversal. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 3, 2017 Category: Anesthesiology Tags: Neuromuscularblocking agents Source Type: research
Impact of reversal strategies on the incidence of postoperative residual paralysis after rocuronium relaxation without neuromuscular monitoring: A partially randomised placebo controlled trial
CONCLUSION: Although pharmacological reversal based on clinical signs was superior to spontaneous recovery it did not prevent PORNB, irrespective of the reversal agent.
TRIAL REGISTRATION: The study is registered under EUDRACT number 2013-001965-17. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 3, 2017 Category: Anesthesiology Tags: Neuromuscularblocking agents Source Type: research
Loss of resistance: A randomised controlled trial assessing four low-fidelity epidural puncture simulators
CONCLUSION: Two of the three dedicated epidural simulators were rated more realistic in detecting LOR than the banana, but some participants preferred the banana to the other three simulators. Given the relative cost of a banana compared with a dedicated simulator, we suggest that a banana be used to teach the technique of LOR for epidural puncture.
TRIAL REGISTRATION: KEK Nr: Req-2015-z087. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 3, 2017 Category: Anesthesiology Tags: Locoregional anaesthesia Source Type: research
Thoracic paravertebral block for postoperative pain management after renal surgery: A randomised controlled trial
BACKGROUND: Thoracic paravertebral block (ThPVB) combined with general anaesthesia is used in thoracic and general surgery. It provides effective analgesia, reduces surgical stress response and the incidence of chronic postoperative pain.
OBJECTIVE: To assess the efficacy of ThPVB in reducing opioid requirements and decreasing the intensity of pain after renal surgery.
DESIGN: A randomised, open label study.
SETTING: A single university hospital. Study conducted from August 2013 to February 2014.
PARTICIPANTS: In total, 68 patients scheduled for elective renal surgery (open nephrectomy or open nephron-sparing surgery)....
Source: European Journal of Anaesthesiology - August 3, 2017 Category: Anesthesiology Tags: Locoregional anaesthesia Source Type: research
Injectate spread following anterior sub-costal and posterior approaches to the quadratus lumborum block: A comparative cadaveric study
CONCLUSIONS: Our cadaveric study demonstrates that injection of dye on the posterior aspect of quadratus lumborum muscle led to injectate spread through the lateral and posterior abdominal wall but with limited cranial spread, whereas the anterior approach produced broader coverage of the lower to mid-thoracic region. Clinical translation of these findings to determine the practical significance is warranted. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 3, 2017 Category: Anesthesiology Tags: Locoregional anaesthesia Source Type: research
Efficacy and safety of buprenorphine in peripheral nerve blocks: A meta-analysis of randomised controlled trials
BACKGROUND: The duration of analgesia provided by nerve blocks is limited if local anaesthetics are administered alone. Therefore, a variety of additives to local anaesthetics have been investigated to prolong postoperative analgesia following single-shot nerve blocks.
OBJECTIVE(S): The aims of the current meta-analysis were to assess the efficacy and safety of the addition of perineural buprenorphine to local anaesthetic compared with local anaesthetic alone, or combined with systemic administration of buprenorphine, or other perineural opioids for peripheral nerve blocks.
DESIGN: Systematic review and meta-analysis of ...
Source: European Journal of Anaesthesiology - August 3, 2017 Category: Anesthesiology Tags: Locoregional anaesthesia Source Type: research
History of anaesthesia: The ketamine story – past, present and future
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 3, 2017 Category: Anesthesiology Tags: Editorials Source Type: research
Anaesthesiology and ethics: Presumed consent with real consequences
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - August 3, 2017 Category: Anesthesiology Tags: Editorials Source Type: research
Mobile phone text messaging reminder decreases the rate of nonattendance at a preoperative anaesthesia clinic
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - July 8, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research
A case series of life-threatening succinylcholine-induced anaphylaxis
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - July 8, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research
Anaesthesia and orphan disease: Management of a case of Strumpell–Lorrain disease and review of the literature
No abstract available (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - July 8, 2017 Category: Anesthesiology Tags: Correspondence Source Type: research
Muscle relaxation for tracheal intubation during paediatric anaesthesia: A meta-analysis and trial sequential analysis
CONCLUSION: The current meta-analysis shows that the use of MR during tracheal intubation might improve the quality of intubation conditions. Further studies, including at least 81 children, are required to confirm this and determine the impact of MR on complications related to intubation. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - July 8, 2017 Category: Anesthesiology Tags: Paediatric Anaesthesia Source Type: research
Frequency and risk factors for malnutrition in children undergoing general anaesthesia in a French university hospital: A cross-sectional observational study
BACKGROUND: Malnutrition is often underdiagnosed in hospitalised children, although it is associated with postoperative complications, longer hospital lengths of stay and increased healthcare-related costs.
OBJECTIVE: We aimed to estimate the frequency of, and identify factors associated with, malnutrition in children undergoing anaesthesia.
DESIGN: Cross-sectional observational study.
SETTING: Paediatric anaesthesia department at the University Children's Hospital, Bordeaux, France.
PARTICIPANTS: A total of 985 patients aged less than 18 years.
MAIN OUTCOME MEASURES: Anthropometric measurements, American Society of A...
Source: European Journal of Anaesthesiology - July 8, 2017 Category: Anesthesiology Tags: Paediatric Anaesthesia Source Type: research
Ventilation with high versus low peep levels during general anaesthesia for open abdominal surgery does not affect postoperative spirometry: A randomised clinical trial
CONCLUSION: Postoperative spirometry is not affected by PEEP and RM during intraoperative ventilation for open abdominal surgery in nonobese patients at a high risk of PPCs, but rather is associated with the development of PPCs.
TRIAL REGISTRATION: ClinicalTrials.gov NCT01441791. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - July 8, 2017 Category: Anesthesiology Tags: Ventilation Source Type: research
Pulse photoplethysmographic amplitude and heart rate variability during laparoscopic cholecystectomy: A prospective observational study
CONCLUSION: The study endorses the use of pulse photoplethysmographic indices ANSS and ANSSi as surrogates to estimate changes of autonomic modulation of the cardiovascular system in healthy adults during surgery under general anaesthesia.
Orcid ID: orcid.org/0000–0002–9616–803X. (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - July 8, 2017 Category: Anesthesiology Tags: Ventilation Source Type: research
Effects of different fresh gas flows with or without a heat and moisture exchanger on inhaled gas humidity in adults undergoing general anaesthesia: A systematic review and meta-analysis of randomised controlled trials
BACKGROUND: The minimum inhaled gas absolute humidity level is 20 mgH2O l−1 for short-duration use in general anaesthesia and 30 mgH2O l−1 for long-duration use in intensive care to avoid respiratory tract dehydration.
OBJECTIVE: The aim is to compare the effects of different fresh gas flows (FGFs) through a circle rebreathing system with or without a heat and moisture exchanger (HME) on inhaled gas absolute humidity in adults undergoing general anaesthesia.
DESIGN: Systematic review and meta-analyses of randomised controlled trials. We defined FGF (l min−1) as minimal (0.25 to 0.5), low (0.6 to 1...
Source: European Journal of Anaesthesiology - July 8, 2017 Category: Anesthesiology Tags: Ventilation Source Type: research
Magnesium sulphate improves pulmonary function after video-assisted thoracoscopic surgery: A randomised double-blind placebo-controlled study
CONCLUSION: Intraoperative administration of MgSO4 improved pulmonary function and reduced the need for rocuronium and postoperative analgesics in patients who underwent VATS.
TRIAL REGISTRATION: cris.nih.go.kr identifier: KCT0001410 (Source: European Journal of Anaesthesiology)
Source: European Journal of Anaesthesiology - July 8, 2017 Category: Anesthesiology Tags: Ventilation Source Type: research
