Correction to: "ER Stress in Cardiometabolic Diseases: From Molecular Mechanisms to Therapeutics"
Endocr Rev. 2024 Feb 19:bnae006. doi: 10.1210/endrev/bnae006. Online ahead of print.NO ABSTRACTPMID:38372366 | DOI:10.1210/endrev/bnae006 (Source: Endocrine Reviews)
Source: Endocrine Reviews - February 19, 2024 Category: Endocrinology Source Type: research
Preclinical rodent models for human bone disease including a focus on cortical bone
We describe here how trabecular and cortical bone structure develop, are maintained, and degenerate with ageing in mice, rats, and humans, and how cortical bone structure is changed in preclinical models of endocrine conditions (e.g., postmenopausal osteoporosis, chronic kidney disease, hyperparathyroidism, diabetes). We provide examples of preclinical models used to identify and test current therapies for osteoporosis, and discuss common concerns raised when comparing rodent preclinical models to the human skeleton. We focus especially on cortical bone, because it differs between small and larger mammals in its organizati...
Source: Endocrine Reviews - February 5, 2024 Category: Endocrinology Authors: Natalie Yy Koh Justyna J Miszkiewicz Mary Louise Fac Natalie Ky Wee Natalie A Sims Source Type: research
Genetic and Epigenetic Landscape for Drug Development in Polycystic Ovary Syndrome
Endocr Rev. 2024 Jan 31:bnae002. doi: 10.1210/endrev/bnae002. Online ahead of print.ABSTRACTThe treatment of polycystic ovary syndrome (PCOS) faces challenges as all known treatments are merely symptomatic. The U.S. Food and Drug Administration (FDA) has not approved any drug specifically for treating PCOS. As the significance of genetics and epigenetics rises in drug development, their pivotal insights have greatly enhanced the efficacy and success of drug target discovery and validation, offering promise for guiding the advancement of PCOS treatments. In this context, we outline the genetic and epigenetic advancement in ...
Source: Endocrine Reviews - February 1, 2024 Category: Endocrinology Authors: Yi Chen Guiquan Wang Jingqiao Chen Congying Wang Xi Dong Hsun-Ming Chang Shuai Yuan Yue Zhao Liangshan Mu Source Type: research
The Basis for Weekly Insulin Therapy: Evolving Evidence With Insulin Icodec and Insulin Efsitora Alfa
Endocr Rev. 2024 Jan 16:bnad037. doi: 10.1210/endrev/bnad037. Online ahead of print.ABSTRACTBasal insulin continues to be a vital part of therapy for many people with diabetes. First attempts to prolong the duration of insulin formulations were through the development of suspensions that required homogenization prior to injection. These insulins, which required once- or twice-daily injections, introduced wide variations in insulin exposure contributing to unpredictable effects on glycemia. Advances over the last 2 decades have resulted in long-acting, soluble basal insulin analogues with prolonged and less variable pharmac...
Source: Endocrine Reviews - January 15, 2024 Category: Endocrinology Authors: Julio Rosenstock Rattan Juneja John M Beals Julie S Moyers Liza Ilag Rory J McCrimmon Source Type: research
Imaging of Pheochromocytomas and Paragangliomas
Endocr Rev. 2024 Jan 11:bnae001. doi: 10.1210/endrev/bnae001. Online ahead of print.ABSTRACTPheochromocytomas/paragangliomas are unique in their highly variable molecular landscape driven by genetic alterations, either germline or somatic. These mutations translate into different clusters with distinct tumor locations, biochemical/metabolomic features, tumor cell characteristics (e.g. receptors, transporters) and disease course. Such tumor heterogeneity calls for different imaging strategies in order to provide proper diagnosis and follow-up. This also warrants selection of the most appropriate and locally available imagin...
Source: Endocrine Reviews - January 11, 2024 Category: Endocrinology Authors: Henri J L M Timmers David Ta ïeb Karel Pacak Jacques W M Lenders Source Type: research
The molecular biology of midgut neuroendocrine neoplasms
Endocr Rev. 2023 Dec 20:bnad034. doi: 10.1210/endrev/bnad034. Online ahead of print.ABSTRACTMidgut neuroendocrine neoplasms (NENs) are one of the most common subtypes of NEN, and their incidence is rising globally. Despite being the most frequently diagnosed malignancy of the small intestine, little is known about their underlying molecular biology. Their unusually low mutational burden compared to other solid tumours, and the unexplained occurrence of multi-focal tumours makes the molecular biology of midgut NENs a particularly fascinating field of research. This review provides an overview of recent advances in the under...
Source: Endocrine Reviews - December 20, 2023 Category: Endocrinology Authors: Amy P Webster Chrissie Thirlwell Source Type: research
