Crosstalk between the neuroendocrine system and bone homeostasis
Endocr Rev. 2023 Jul 17:bnad025. doi: 10.1210/endrev/bnad025. Online ahead of print.ABSTRACTThe homeostasis of bone microenvironment is the foundation of bone health and comprises two concerted events: bone formation by osteoblasts and bone resorption by osteoclasts. In the early 21st century, leptin, an adipocytes-derived hormone was found to affect bone homeostasis through hypothalamic relay and sympathetic nervous system, involving neurotransmitters like serotonin and norepinephrine. This discovery has provided a new perspective regarding the synergistic effects of endocrine and nervous systems on skeletal homeostasis. ...
Source: Endocrine Reviews - July 17, 2023 Category: Endocrinology Authors: Yuhu Zhao Xiaole Peng Qing Wang Zhiyu Zhang Liangliang Wang Yaozeng Xu Huilin Yang Jiaxiang Bai Dechun Geng Source Type: research
Radiation-Related Thyroid Cancer
This article reviews radiation doses to the thyroid and corresponding cancer risks due to planned, existing, and emergency exposure situations, and medical, public, and occupational categories of exposures. Any exposure scenario may deliver a range of doses to the thyroid, and the risk for cancer is addressed along with modifying factors. The consequences of the Chornobyl and Fukushima nuclear power plants accidents are described, summarizing the information on thyroid cancer epidemiology, treatment and prognosis, clinicopathological characteristics, and genetic alterations. The Chornobyl thyroid cancers evolve in time: be...
Source: Endocrine Reviews - July 14, 2023 Category: Endocrinology Authors: Vladimir Saenko Norisato Mitsutake Source Type: research
Biomarkers to Guide Medical Therapy in Primary Aldosteronism
Endocr Rev. 2023 Jul 13:bnad024. doi: 10.1210/endrev/bnad024. Online ahead of print.ABSTRACTPrimary aldosteronism (PA) is an endocrinopathy characterized by dysregulated aldosterone production that occurs despite suppression of renin and angiotensin II, and that is non-suppressible by volume and sodium loading. The effectiveness of surgical adrenalectomy for patients with lateralizing PA is characterized by the attenuation of excess aldosterone production leading to blood pressure reduction, correction of hypokalemia, and increases in renin; biomarkers that collectively indicate a reversal of PA pathophysiology and restora...
Source: Endocrine Reviews - July 13, 2023 Category: Endocrinology Authors: Gregory L Hundemer Alexander A Leung Gregory A Kline Jenifer M Brown Adina F Turcu Anand Vaidya Source Type: research
Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics
Endocr Rev. 2023 Jul 6:bnad020. doi: 10.1210/endrev/bnad020. Online ahead of print.ABSTRACTEndometriosis is a prevalent gynecological condition associated with pelvic pain and infertility. Despite more than a century of research, the etiology of endometriosis still eludes scientific consensus. This lack of clarity has resulted in suboptimal prevention, diagnosis, and treatment options. Evidence of genetic contributors to endometriosis is interesting but limited; however, significant progress has been made in recent years in identifying epigenetic role in the pathogenesis of endometriosis through clinical studies, in vitro ...
Source: Endocrine Reviews - July 6, 2023 Category: Endocrinology Authors: Ryan M Marquardt Dinh Nam Tran Bruce A Lessey Md Saidur Rahman Jae-Wook Jeong Source Type: research
The Hypothalamus-Pituitary-Adrenocortical response to critical illness: a concept in need of revision
Endocr Rev. 2023 Jul 6:bnad021. doi: 10.1210/endrev/bnad021. Online ahead of print.ABSTRACTBased on insights obtained during the last decade, the classical concept of an activated hypothalamus-pituitary-adrenocortical (HPA) axis in response to critical illness is in need of revision. After a brief central HPA axis activation, the vital maintenance of increased systemic cortisol availability and action in response to critical illness is predominantly driven by peripheral adaptations rather than by an ongoing centrally-activated several-fold increased production and secretion of cortisol. Besides the known reduction of corti...
Source: Endocrine Reviews - July 6, 2023 Category: Endocrinology Authors: Lies Langouche Arno T éblick Jan Gunst Greet Van den Berghe Source Type: research
Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics
Endocr Rev. 2023 Jul 6:bnad020. doi: 10.1210/endrev/bnad020. Online ahead of print.ABSTRACTEndometriosis is a prevalent gynecological condition associated with pelvic pain and infertility. Despite more than a century of research, the etiology of endometriosis still eludes scientific consensus. This lack of clarity has resulted in suboptimal prevention, diagnosis, and treatment options. Evidence of genetic contributors to endometriosis is interesting but limited; however, significant progress has been made in recent years in identifying epigenetic role in the pathogenesis of endometriosis through clinical studies, in vitro ...
Source: Endocrine Reviews - July 6, 2023 Category: Endocrinology Authors: Ryan M Marquardt Dinh Nam Tran Bruce A Lessey Md Saidur Rahman Jae-Wook Jeong Source Type: research
The Hypothalamus-Pituitary-Adrenocortical response to critical illness: a concept in need of revision
Endocr Rev. 2023 Jul 6:bnad021. doi: 10.1210/endrev/bnad021. Online ahead of print.ABSTRACTBased on insights obtained during the last decade, the classical concept of an activated hypothalamus-pituitary-adrenocortical (HPA) axis in response to critical illness is in need of revision. After a brief central HPA axis activation, the vital maintenance of increased systemic cortisol availability and action in response to critical illness is predominantly driven by peripheral adaptations rather than by an ongoing centrally-activated several-fold increased production and secretion of cortisol. Besides the known reduction of corti...
Source: Endocrine Reviews - July 6, 2023 Category: Endocrinology Authors: Lies Langouche Arno T éblick Jan Gunst Greet Van den Berghe Source Type: research
Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics
Endocr Rev. 2023 Jul 6:bnad020. doi: 10.1210/endrev/bnad020. Online ahead of print.ABSTRACTEndometriosis is a prevalent gynecological condition associated with pelvic pain and infertility. Despite more than a century of research, the etiology of endometriosis still eludes scientific consensus. This lack of clarity has resulted in suboptimal prevention, diagnosis, and treatment options. Evidence of genetic contributors to endometriosis is interesting but limited; however, significant progress has been made in recent years in identifying epigenetic role in the pathogenesis of endometriosis through clinical studies, in vitro ...
Source: Endocrine Reviews - July 6, 2023 Category: Endocrinology Authors: Ryan M Marquardt Dinh Nam Tran Bruce A Lessey Md Saidur Rahman Jae-Wook Jeong Source Type: research
The Hypothalamus-Pituitary-Adrenocortical response to critical illness: a concept in need of revision
Endocr Rev. 2023 Jul 6:bnad021. doi: 10.1210/endrev/bnad021. Online ahead of print.ABSTRACTBased on insights obtained during the last decade, the classical concept of an activated hypothalamus-pituitary-adrenocortical (HPA) axis in response to critical illness is in need of revision. After a brief central HPA axis activation, the vital maintenance of increased systemic cortisol availability and action in response to critical illness is predominantly driven by peripheral adaptations rather than by an ongoing centrally-activated several-fold increased production and secretion of cortisol. Besides the known reduction of corti...
Source: Endocrine Reviews - July 6, 2023 Category: Endocrinology Authors: Lies Langouche Arno T éblick Jan Gunst Greet Van den Berghe Source Type: research
