The emerging therapeutic potential of kisspeptin and neurokinin B
Endocr Rev. 2023 Jul 20:bnad023. doi: 10.1210/endrev/bnad023. Online ahead of print.ABSTRACTKisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) neuronal activity and pulsatile GnRH secretion. Their critical role in reproductive health was first identified after inactivating variants in genes encoding for KP or NKB signaling were shown to result in congenital hypogonadotropic hypogonadism (CHH) and a failure of pubertal development. Over the past two decades since their discovery, a wealth of evidence from ...
Source: Endocrine Reviews - July 19, 2023 Category: Endocrinology Authors: Bijal Patel Kanyada Koysombat Edouard G Mills Jovanna Tsoutsouki Alexander N Comninos Ali Abbara Waljit S Dhillo Source Type: research
