Update on Adipose Tissue and Cancer
Endocr Rev. 2023 Jun 1:bnad015. doi: 10.1210/endrev/bnad015. Online ahead of print.ABSTRACTAdipose tissue is the largest endocrine organ and an accepted contributor to overall energy homeostasis. There is strong evidence linking increased adiposity to the development of 13 types of cancer. With increased adiposity comes metabolic dysfunction and insulin resistance, and increased systemic insulin and glucose support the growth of many cancers, including those of the colon and endometrium. There is also an important direct crosstalk between adipose tissue and various organs. For example, the healthy development and function ...
Source: Endocrine Reviews - June 1, 2023 Category: Endocrinology Authors: Kristy A Brown Philipp E Scherer Source Type: research
Re-evaluating the role of progesterone in ovarian cancer: is progesterone always protective?
Endocr Rev. 2023 Jun 1:bnad018. doi: 10.1210/endrev/bnad018. Online ahead of print.ABSTRACTOvarian cancer (OC) represents a collection of rare but lethal gynecologic cancers where the difficultly of early detection due to an often-subtle range of abdominal symptoms contributes to high fatality rates. With the exception of BRCA1/2 mutation carriers, OC most often manifests as a post-menopausal disease, a time in which the ovaries regress and circulating reproductive hormones diminish. Progesterone is thought to be a "protective" hormone that counters the proliferative actions of estrogen, as can be observed in the uterus or...
Source: Endocrine Reviews - June 1, 2023 Category: Endocrinology Authors: Laura J Mauro Angela Spartz Julia R Austin Carol A Lange Source Type: research
Update on Adipose Tissue and Cancer
Endocr Rev. 2023 Jun 1:bnad015. doi: 10.1210/endrev/bnad015. Online ahead of print.ABSTRACTAdipose tissue is the largest endocrine organ and an accepted contributor to overall energy homeostasis. There is strong evidence linking increased adiposity to the development of 13 types of cancer. With increased adiposity comes metabolic dysfunction and insulin resistance, and increased systemic insulin and glucose support the growth of many cancers, including those of the colon and endometrium. There is also an important direct crosstalk between adipose tissue and various organs. For example, the healthy development and function ...
Source: Endocrine Reviews - June 1, 2023 Category: Endocrinology Authors: Kristy A Brown Philipp E Scherer Source Type: research
Re-evaluating the role of progesterone in ovarian cancer: is progesterone always protective?
Endocr Rev. 2023 Jun 1:bnad018. doi: 10.1210/endrev/bnad018. Online ahead of print.ABSTRACTOvarian cancer (OC) represents a collection of rare but lethal gynecologic cancers where the difficultly of early detection due to an often-subtle range of abdominal symptoms contributes to high fatality rates. With the exception of BRCA1/2 mutation carriers, OC most often manifests as a post-menopausal disease, a time in which the ovaries regress and circulating reproductive hormones diminish. Progesterone is thought to be a "protective" hormone that counters the proliferative actions of estrogen, as can be observed in the uterus or...
Source: Endocrine Reviews - June 1, 2023 Category: Endocrinology Authors: Laura J Mauro Angela Spartz Julia R Austin Carol A Lange Source Type: research
Treating the side effects of exogenous glucocorticoids; Can we separate the good from the bad?
Endocr Rev. 2023 May 30:bnad016. doi: 10.1210/endrev/bnad016. Online ahead of print.ABSTRACTIt is estimated that 2-3% of the population are currently prescribed systemic or topical glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver therapeutic benefit is not in doubt. However, the side effects associated with their use, including central weight gain, hypertension, insulin resistance, type 2 diabetes and osteoporosis, often collectively termed iatrogenic Cushing's syndrome, is associated with a significant health and economic burden. The precise cellular mechanisms underpinning the d...
Source: Endocrine Reviews - May 30, 2023 Category: Endocrinology Authors: Riccardo Pofi Giorgio Caratti David W Ray Jeremy W Tomlinson Source Type: research
Medullary Thyroid Cancer- Updates and Challenges
Endocr Rev. 2023 May 19:bnad013. doi: 10.1210/endrev/bnad013. Online ahead of print.ABSTRACTA personalised approach to the management of Medullary Thyroid Cancer (MTC) presents several challenges, however in the past decade significant progress has been made in both diagnostic and treatment modalities. Germline RET testing in MEN 2 & 3, and somatic RET testing in sporadic MTC have revolutionized the treatment options available to patients. PET imaging with novel radioligands has improved characterization of disease and a new international grading system can predict prognosis. Systemic therapy for persistent and metasta...
Source: Endocrine Reviews - May 19, 2023 Category: Endocrinology Authors: Matti L Gild Roderick J Clifton-Bligh Lori J Wirth Bruce G Robinson Source Type: research
Current and Future Advances in Surgical Therapy for Pituitary Adenoma
Endocr Rev. 2023 May 19:bnad014. doi: 10.1210/endrev/bnad014. Online ahead of print.ABSTRACTThe vital physiological role of the pituitary gland, alongside its proximal critical neurovascular structures means pituitary adenomas cause significant morbidity or mortality. Whilst enormous advancements have been made in the surgical care of pituitary adenomas, treatment failure and recurrence remain challenges. To meet these clinical challenges, there has been an enormous expansion of novel medical technologies (e.g. endoscopy, advanced imaging, artificial intelligence). These innovations have the potential to benefit each step ...
Source: Endocrine Reviews - May 19, 2023 Category: Endocrinology Authors: Danyal Z Khan John G Hanrahan Stephanie E Baldeweg Neil L Dorward Danail Stoyanov Hani J Marcus Source Type: research
Medullary Thyroid Cancer- Updates and Challenges
Endocr Rev. 2023 May 19:bnad013. doi: 10.1210/endrev/bnad013. Online ahead of print.ABSTRACTA personalised approach to the management of Medullary Thyroid Cancer (MTC) presents several challenges, however in the past decade significant progress has been made in both diagnostic and treatment modalities. Germline RET testing in MEN 2 & 3, and somatic RET testing in sporadic MTC have revolutionized the treatment options available to patients. PET imaging with novel radioligands has improved characterization of disease and a new international grading system can predict prognosis. Systemic therapy for persistent and metasta...
Source: Endocrine Reviews - May 19, 2023 Category: Endocrinology Authors: Matti L Gild Roderick J Clifton-Bligh Lori J Wirth Bruce G Robinson Source Type: research
Current and Future Advances in Surgical Therapy for Pituitary Adenoma
Endocr Rev. 2023 May 19:bnad014. doi: 10.1210/endrev/bnad014. Online ahead of print.ABSTRACTThe vital physiological role of the pituitary gland, alongside its proximal critical neurovascular structures means pituitary adenomas cause significant morbidity or mortality. Whilst enormous advancements have been made in the surgical care of pituitary adenomas, treatment failure and recurrence remain challenges. To meet these clinical challenges, there has been an enormous expansion of novel medical technologies (e.g. endoscopy, advanced imaging, artificial intelligence). These innovations have the potential to benefit each step ...
Source: Endocrine Reviews - May 19, 2023 Category: Endocrinology Authors: Danyal Z Khan John G Hanrahan Stephanie E Baldeweg Neil L Dorward Danail Stoyanov Hani J Marcus Source Type: research
Medullary Thyroid Cancer- Updates and Challenges
Endocr Rev. 2023 May 19:bnad013. doi: 10.1210/endrev/bnad013. Online ahead of print.ABSTRACTA personalised approach to the management of Medullary Thyroid Cancer (MTC) presents several challenges, however in the past decade significant progress has been made in both diagnostic and treatment modalities. Germline RET testing in MEN 2 & 3, and somatic RET testing in sporadic MTC have revolutionized the treatment options available to patients. PET imaging with novel radioligands has improved characterization of disease and a new international grading system can predict prognosis. Systemic therapy for persistent and metasta...
Source: Endocrine Reviews - May 19, 2023 Category: Endocrinology Authors: Matti L Gild Roderick J Clifton-Bligh Lori J Wirth Bruce G Robinson Source Type: research
Current and Future Advances in Surgical Therapy for Pituitary Adenoma
Endocr Rev. 2023 May 19:bnad014. doi: 10.1210/endrev/bnad014. Online ahead of print.ABSTRACTThe vital physiological role of the pituitary gland, alongside its proximal critical neurovascular structures means pituitary adenomas cause significant morbidity or mortality. Whilst enormous advancements have been made in the surgical care of pituitary adenomas, treatment failure and recurrence remain challenges. To meet these clinical challenges, there has been an enormous expansion of novel medical technologies (e.g. endoscopy, advanced imaging, artificial intelligence). These innovations have the potential to benefit each step ...
Source: Endocrine Reviews - May 19, 2023 Category: Endocrinology Authors: Danyal Z Khan John G Hanrahan Stephanie E Baldeweg Neil L Dorward Danail Stoyanov Hani J Marcus Source Type: research
Medullary Thyroid Cancer- Updates and Challenges
Endocr Rev. 2023 May 19:bnad013. doi: 10.1210/endrev/bnad013. Online ahead of print.ABSTRACTA personalised approach to the management of Medullary Thyroid Cancer (MTC) presents several challenges, however in the past decade significant progress has been made in both diagnostic and treatment modalities. Germline RET testing in MEN 2 & 3, and somatic RET testing in sporadic MTC have revolutionized the treatment options available to patients. PET imaging with novel radioligands has improved characterization of disease and a new international grading system can predict prognosis. Systemic therapy for persistent and metasta...
Source: Endocrine Reviews - May 19, 2023 Category: Endocrinology Authors: Matti L Gild Roderick J Clifton-Bligh Lori J Wirth Bruce G Robinson Source Type: research
Current and Future Advances in Surgical Therapy for Pituitary Adenoma
Endocr Rev. 2023 May 19:bnad014. doi: 10.1210/endrev/bnad014. Online ahead of print.ABSTRACTThe vital physiological role of the pituitary gland, alongside its proximal critical neurovascular structures means pituitary adenomas cause significant morbidity or mortality. Whilst enormous advancements have been made in the surgical care of pituitary adenomas, treatment failure and recurrence remain challenges. To meet these clinical challenges, there has been an enormous expansion of novel medical technologies (e.g. endoscopy, advanced imaging, artificial intelligence). These innovations have the potential to benefit each step ...
Source: Endocrine Reviews - May 19, 2023 Category: Endocrinology Authors: Danyal Z Khan John G Hanrahan Stephanie E Baldeweg Neil L Dorward Danail Stoyanov Hani J Marcus Source Type: research
Medullary Thyroid Cancer- Updates and Challenges
Endocr Rev. 2023 May 19:bnad013. doi: 10.1210/endrev/bnad013. Online ahead of print.ABSTRACTA personalised approach to the management of Medullary Thyroid Cancer (MTC) presents several challenges, however in the past decade significant progress has been made in both diagnostic and treatment modalities. Germline RET testing in MEN 2 & 3, and somatic RET testing in sporadic MTC have revolutionized the treatment options available to patients. PET imaging with novel radioligands has improved characterization of disease and a new international grading system can predict prognosis. Systemic therapy for persistent and metasta...
Source: Endocrine Reviews - May 19, 2023 Category: Endocrinology Authors: Matti L Gild Roderick J Clifton-Bligh Lori J Wirth Bruce G Robinson Source Type: research
