The Search for the Causes of Common Hyperandrogenism, 1965 to circa 2015
Endocr Rev. 2024 Mar 8:bnae007. doi: 10.1210/endrev/bnae007. Online ahead of print.ABSTRACTFrom 1965-2015, immense strides were made into understanding the mechanisms underlying the common androgen excess disorders, premature adrenarche and polycystic ovary syndrome (PCOS). The author reviews the critical discoveries of this era from his perspective investigating these disorders, commencing with his early discoveries of the unique pattern of plasma androgens in premature adrenarche and the elevation of an index of the plasma free testosterone concentration in most hirsute women. The molecular genetic basis, though not the ...
Source: Endocrine Reviews - March 8, 2024 Category: Endocrinology Authors: Robert L Rosenfield Source Type: research
Mini-Puberty, Physiological and Disordered: Consequences, and Potential for Therapeutic Replacement
Endocr Rev. 2024 Mar 4:bnae003. doi: 10.1210/endrev/bnae003. Online ahead of print.ABSTRACTThere are 3 physiological waves of central hypothalamic-pituitary-gonadal (HPG) axis activity over the lifetime. The first occurs during fetal life, the second-termed "mini-puberty"-in the first months after birth, and the third at puberty. After adolescence, the axis remains active all through adulthood. Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic disorder characterized by a deficiency in hypothalamic gonadotropin-releasing hormone (GnRH) secretion or action. In cases of severe CHH, all 3 waves of GnRH pulsatili...
Source: Endocrine Reviews - March 4, 2024 Category: Endocrinology Authors: Julia Rohayem Emma C Alexander Sabine Heger Anna Nordenstr öm Sasha R Howard Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: Endocrine Reviews - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
