Biochemical Assessment of Pheochromocytoma and Paraganglioma
Endocr Rev. 2023 Mar 30:bnad011. doi: 10.1210/endrev/bnad011. Online ahead of print.ABSTRACTPheochromocytoma and paraganglioma (PPGL) require prompt consideration and efficient diagnosis and treatment to minimize associated morbidity and mortality. Once considered, appropriate biochemical testing is key to diagnosis. Advances in understanding catecholamine metabolism clarified why measurements of the O-methylated catecholamine metabolites rather than the catecholamines themselves are important for effective diagnosis. These metabolites, normetanephrine and metanephrine, produced respectively from norepinephrine and epineph...
Source: Endocrine Reviews - March 30, 2023 Category: Endocrinology Authors: Graeme Eisenhofer Christina Pamporaki Jacques W M Lenders Source Type: research
