Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics
Endocr Rev. 2023 Jul 6:bnad020. doi: 10.1210/endrev/bnad020. Online ahead of print.ABSTRACTEndometriosis is a prevalent gynecological condition associated with pelvic pain and infertility. Despite more than a century of research, the etiology of endometriosis still eludes scientific consensus. This lack of clarity has resulted in suboptimal prevention, diagnosis, and treatment options. Evidence of genetic contributors to endometriosis is interesting but limited; however, significant progress has been made in recent years in identifying epigenetic role in the pathogenesis of endometriosis through clinical studies, in vitro ...
Source: Endocrine Reviews - July 6, 2023 Category: Endocrinology Authors: Ryan M Marquardt Dinh Nam Tran Bruce A Lessey Md Saidur Rahman Jae-Wook Jeong Source Type: research
The Hypothalamus-Pituitary-Adrenocortical response to critical illness: a concept in need of revision
Endocr Rev. 2023 Jul 6:bnad021. doi: 10.1210/endrev/bnad021. Online ahead of print.ABSTRACTBased on insights obtained during the last decade, the classical concept of an activated hypothalamus-pituitary-adrenocortical (HPA) axis in response to critical illness is in need of revision. After a brief central HPA axis activation, the vital maintenance of increased systemic cortisol availability and action in response to critical illness is predominantly driven by peripheral adaptations rather than by an ongoing centrally-activated several-fold increased production and secretion of cortisol. Besides the known reduction of corti...
Source: Endocrine Reviews - July 6, 2023 Category: Endocrinology Authors: Lies Langouche Arno T éblick Jan Gunst Greet Van den Berghe Source Type: research
Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics
Endocr Rev. 2023 Jul 6:bnad020. doi: 10.1210/endrev/bnad020. Online ahead of print.ABSTRACTEndometriosis is a prevalent gynecological condition associated with pelvic pain and infertility. Despite more than a century of research, the etiology of endometriosis still eludes scientific consensus. This lack of clarity has resulted in suboptimal prevention, diagnosis, and treatment options. Evidence of genetic contributors to endometriosis is interesting but limited; however, significant progress has been made in recent years in identifying epigenetic role in the pathogenesis of endometriosis through clinical studies, in vitro ...
Source: Endocrine Reviews - July 6, 2023 Category: Endocrinology Authors: Ryan M Marquardt Dinh Nam Tran Bruce A Lessey Md Saidur Rahman Jae-Wook Jeong Source Type: research
The Hypothalamus-Pituitary-Adrenocortical response to critical illness: a concept in need of revision
Endocr Rev. 2023 Jul 6:bnad021. doi: 10.1210/endrev/bnad021. Online ahead of print.ABSTRACTBased on insights obtained during the last decade, the classical concept of an activated hypothalamus-pituitary-adrenocortical (HPA) axis in response to critical illness is in need of revision. After a brief central HPA axis activation, the vital maintenance of increased systemic cortisol availability and action in response to critical illness is predominantly driven by peripheral adaptations rather than by an ongoing centrally-activated several-fold increased production and secretion of cortisol. Besides the known reduction of corti...
Source: Endocrine Reviews - July 6, 2023 Category: Endocrinology Authors: Lies Langouche Arno T éblick Jan Gunst Greet Van den Berghe Source Type: research
Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns
Endocr Rev. 2023 Jun 26:bnad019. doi: 10.1210/endrev/bnad019. Online ahead of print.ABSTRACTRecent research has unveiled an expansive role of NAD+ in cellular energy generation, redox reactions, and as a substrate or co-substrate in signaling pathways that regulate health-span and aging. This review provides a critical appraisal of the clinical pharmacology and the pre-clinical and clinical evidence for therapeutic effects of NAD+ precursors for age-related conditions, with a particular focus on cardiometabolic disorders, and discusses gaps in current knowledge. NAD+ levels decrease throughout life; age-related decline in ...
Source: Endocrine Reviews - June 26, 2023 Category: Endocrinology Authors: Shalender Bhasin Douglas Seals Marie Migaud Nicolas Musi Joseph A Baur Source Type: research
The Pregnancy-Associated Plasma Protein-A (PAPP-A) Story
Endocr Rev. 2023 Jun 2:bnad017. doi: 10.1210/endrev/bnad017. Online ahead of print.ABSTRACTPregnancy-associated plasma protein-A PAPP-A) was first identified in the early 1970s as a placental protein of unknown function present at high concentrations in the circulation of pregnant women. In the mid-to-late 1990s, PAPP-A was discovered to be a metzincin metalloproteinase expressed by many non-placental cells that regulates local insulin-like growth factor (IGF) activity through cleavage of high-affinity IGF binding proteins (IGFBPs), in particular IGFBP-4. With PAPP-A as a cell surface-associated enzyme, the reduced affinit...
Source: Endocrine Reviews - June 2, 2023 Category: Endocrinology Authors: Cheryl A Conover Claus Oxvig Source Type: research
