Obesity-related Hypogonadism in women
Endocr Rev. 2023 Aug 10:bnad027. doi: 10.1210/endrev/bnad027. Online ahead of print.ABSTRACTObesity-related hypogonadotropic hypogonadism is a well-characterized condition in men (termed male obesity-related secondary hypogonadism; MOSH), however, an equivalent condition has not been as clearly described in women. The prevalence of polycystic ovary syndrome (PCOS) is known to increase with obesity, but PCOS is more typically characterized by increased gonadotropin releasing hormone (GnRH) (and by proxy luteinizing hormone; LH) pulsatility, rather than by the reduced gonadotropin levels observed in MOSH. Notably, LH levels ...
Source: Endocrine Reviews - August 10, 2023 Category: Endocrinology Authors: Pei Chia Eng Maria Phylactou Ambreen Qayum Casper Woods Hayoung Lee Sara Aziz Benedict Moore Alexander D Miras Alexander N Comninos Tricia Tan Steve Franks Waljit S Dhillo Ali Abbara Source Type: research
Adipose tissue dysfunction and energy balance paradigms in people living with HIV
Endocr Rev. 2023 Aug 9:bnad028. doi: 10.1210/endrev/bnad028. Online ahead of print.ABSTRACTOver the past four decades, the clinical care of people living with HIV (PLWH) evolved from treatment of acute opportunistic infections to the management of chronic, non-communicable comorbidities. Concurrently, our understanding of adipose tissue function matured to acknowledge its important endocrine contributions to energy balance. PLWH experience changes in the mass and composition of adipose tissue depots before and after initiating antiretroviral therapy (ART), including regional loss (lipoatrophy), gain (lipohypertrophy), or m...
Source: Endocrine Reviews - August 9, 2023 Category: Endocrinology Authors: Claudia E Ramirez Bustamante Neeti Agarwal Aaron R Cox Sean M Hartig Jordan E Lake Ashok Balasubramanyam Source Type: research
Treating primary aldosteronism-induced hypertension: novel approaches and future outlooks
Endocr Rev. 2023 Aug 9:bnad026. doi: 10.1210/endrev/bnad026. Online ahead of print.ABSTRACTPrimary aldosteronism (PA) is the most common cause of secondary hypertension and is associated with increased morbidity and mortality when compared to blood pressure-matched cases of primary hypertension. Current limitations in patient care stem from delayed recognition of the condition, limited access to key diagnostic procedures, and lack of a definitive therapy option for non-surgical candidates. However, several recent advances have the potential to address these barriers to optimal care. From a diagnostic perspective, machine l...
Source: Endocrine Reviews - August 9, 2023 Category: Endocrinology Authors: Nathan Mullen James Curneen Padraig T Donlon Punit Prakash Irina Bancos Mark Gurnell Michael C Dennedy Source Type: research
