Preclinical rodent models for human bone disease including a focus on cortical bone

We describe here how trabecular and cortical bone structure develop, are maintained, and degenerate with ageing in mice, rats, and humans, and how cortical bone structure is changed in preclinical models of endocrine conditions (e.g., postmenopausal osteoporosis, chronic kidney disease, hyperparathyroidism, diabetes). We provide examples of preclinical models used to identify and test current therapies for osteoporosis, and discuss common concerns raised when comparing rodent preclinical models to the human skeleton. We focus especially on cortical bone, because it differs between small and larger mammals in its organizational structure. We discuss mechanisms common to mouse and human controlling cortical bone strength and structure, including recent examples revealing genetic contributors to cortical porosity and osteocyte network configurations during growth, maturity, and ageing. We conclude with guidelines for clear reporting on mouse models with a goal for better consistency in the use and interpretation of these models.PMID:38315213 | DOI:10.1210/endrev/bnae004
Source: Endocrine Reviews - Category: Endocrinology Authors: Source Type: research