Diffuse retinal dysfunction following immune reconstitution uveitis in patients with prior cytomegalovirus retinitis: a novel observation
ConclusionsPatients with IRU following CMV retinitis may have continuing diffuse retinal dysfunction despite apparent recovery and normal visual acuity. An aggressive approach to inflammation control may be warranted in such patients. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - August 28, 2023 Category: Opthalmology Source Type: research
Full-field electroretinogram recorded with skin electrodes in 6- to 12-year-old children
ConclusionsWe determined the largest dataset of the LA 3 ERG and PhNR parameters in a population of healthy children, aged 6 –12 years, which may provide a useful reference value when evaluating children with potential retinal defects. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - August 2, 2023 Category: Opthalmology Source Type: research
Retinal dysfunction in Parkinson ’s disease—results of the extended protocol for photopic negative response (PHNR) full-field electroretinogram (ERG)
ConclusionThis study demonstrated reduced a-wave, b-wave and PhNR-wave amplitudes on ERG measurements in PD patients. These findings suggest that the whole ERG response, not just the PhNR, is attenuated in patient with PD, suggesting a possible involvement of the visual system in the disease. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 29, 2023 Category: Opthalmology Source Type: research
Foveal avascular zone size and mfERG metrics in diabetes and prediabetes: a pilot study of the relationship between structure and function
ConclusionFAZ area is correlated with mfERG amplitudes but not IT. This suggests a link between the structural metrics and retinal function. Longitudinal follow-up work would be helpful to determine the timing of these changes in prediabetes. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 26, 2023 Category: Opthalmology Source Type: research
Fundus autofluorescence, optical coherence tomography and electroretinography abnormalities in a patient with digoxin retinopathy that resemble those in KCNV2-associated retinopathy
ConclusionsThe patient ’s clinical findings resembled those of patients withKCNV2-associated retinopathy or temporal hyperkalemia. These disorders appear to have a common pathogenesis, which may be related to abnormal extracellular potassium levels in the retina. The on-bipolar cells seemed to be more affected than the off-bipolar cells in digoxin related retinal toxicity. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 17, 2023 Category: Opthalmology Source Type: research
Electrophysiological findings in extensive macular atrophy with pseudodrusen
ConclusionsIn this cohort, electrophysiologic evaluation demonstrated diffuse retinal dysfunction affecting all layers of the retina in patients with EMAP. The disease is associated with immune-mediated systemic conditions, chiefly rheumatic fever. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 1, 2023 Category: Opthalmology Source Type: research
Intravitreal acetazolamide implant for pseudophakic cystoid macular edema
ConclusionWe show that PCME refractory to conventional treatment improved after intravitreal acetazolamide implant injection. Further investigation is warranted to confirm these preliminary findings. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - June 28, 2023 Category: Opthalmology Source Type: research
Age-associated changes in electroretinography measures in companion dogs
ConclusionsAged companion dogs have slower and reduced amplitude responses in both rod- and cone-mediated ERG. Consideration of anxiolytic medication use should be made when conducting ERG studies in dogs. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - June 11, 2023 Category: Opthalmology Source Type: research
ISCEV guidelines for calibration and verification of stimuli and recording instruments (2023 update)
AbstractThis document developed by the International Society for Clinical Electrophysiology of Vision (ISCEV) provides guidance for calibration and verification of stimulus and recording systems specific to clinical electrophysiology of vision. This guideline provides additional information for those using ISCEV Standards and Extended protocols and supersedes earlier Guidelines. The ISCEV guidelines for calibration and verification of stimuli and recording instruments (2023 update) were approved by the ISCEV Board of Directors 01, March 2023. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - June 3, 2023 Category: Opthalmology Source Type: research
Analysis of the slope between P50 and N95 waves of the large field pattern electroretinogram as an additional indicator of ganglion cell dysfunction
ConclusionsThe slope between the P50 and N95 waves of a large field PERG is considerably less steep in patients with RGC dysfunction and could thus be an efficient biomarker, particularly in the diagnosis of early or borderline cases. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - May 26, 2023 Category: Opthalmology Source Type: research
A mild form of POC1B-associated retinal dystrophy with relatively preserved cone system function
ConclusionsWe reported the case of an older patient withPOC1B-associated retinopathy, demonstrating late-onset visual decrease, good visual acuity, and relatively preserved cone system function. The disease condition was much milder than previously reported in patients withPOC1B-associated retinopathy. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - May 25, 2023 Category: Opthalmology Source Type: research
Evaluation of correlation between Diopsys ® NOVA™ fixed-luminance flicker ERG and Diagnosys® Espion 2™ flicker ERG parameters
ConclusionsThere is a statistically significant positive correlation between light-adapted Diopsys ® NOVA™ fixed-luminance flickeramplitude and Diagnosys® flicker magnitude values. Additionally, there is a statistically significant positive correlation between Diopsys ® NOVA™ fixed-luminance flickerimplicit time (converted fromphase) and Diagnosys ® flicker implicit time values. These results imply that the Diopsys ® NOVA™ module, which utilizes the nonstandard shortened International Society for Clinical Electrophysiology of Vision (ISCEV) ERG protocol, can produce reliable light-adapted flicker ffERG m...
Source: Documenta Ophthalmologica - May 23, 2023 Category: Opthalmology Source Type: research
Electroretinographic abnormalities in Alport syndrome with a novel COL4A5 truncated variant (p.Try20GlyfsTer19)
ConclusionsOur findings revealed electroretinographic abnormalities in a patient with Alport syndrome, which predominantly indicated impairment of the inner retina. Notably, little short-term progression was observed. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - May 10, 2023 Category: Opthalmology Source Type: research
Assessment of the uniform field electroretinogram for mouse retinal ganglion cell functional analysis
ConclusionsPERG responses are markedly impaired upon ONC, while UF-ERG responses are not significantly affected by surgical trauma to RGC axons in mice. The more closely related pattern and uniform field ERGs recorded in primates suggests species-specific differences in RGC features or subpopulations corresponding to PERG and UF-ERG response generators, limiting the utility of the UF-ERG for mouse RGC functional analysis. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 28, 2023 Category: Opthalmology Source Type: research
Long-term blue light rearing does not affect in vivo retinal function in young rhesus monkeys
ConclusionsLong-term exposure to narrowband blue light did not affect photopic or scotopic ERG responses in young monkeys. Findings suggest that exposure to 12 h of daily blue light for approximately 10 months does not result in altered retinal function. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - March 30, 2023 Category: Opthalmology Source Type: research
