Expression of Concern: Fisetin rescues retinal functions by suppressing inflammatory response in a DBA/2J mouse model of glaucoma
The Editor-in-Chief of Documenta Ophthalmologica is publishing an editorial expression of concern for the manuscript"Fisetin rescues retinal functions by suppressing inflammatory response in a DBA/2J mouse model of glaucoma ” by Li et al. (2019) [1]. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - November 14, 2019 Category: Opthalmology Source Type: research
Screening for diabetic retinopathy in diabetic patients with a mydriasis-free, full-field flicker electroretinogram recording device
ConclusionThe DR assessment protocol in RETeval device was effective in screening for DR (mild NPDR, moderate NPDR, severe NPDR, PDR) and VTDR in patients with diabetes. It could be helpful in referring and managing patients with T2DM in primary healthcare setting. However, caution should be taken that optimal cutoff value of DR assessment protocol may vary in different ethnic populations. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - November 11, 2019 Category: Opthalmology Source Type: research
Unique retinal signaling defect in GNB5 -related disease
ConclusionThis report identifies for the first time a unique retinopathy associated with biallelic mutations inGNB5. The observed phenotype is consistent with a dual retinal signaling defect reminiscent of features of bradyopsia and rod ON-bipolar dysfunction. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - November 11, 2019 Category: Opthalmology Source Type: research
Effects of DTL electrode position on the amplitude and implicit time of the electroretinogram
ConclusionsFor monitoring purposes in patients, we conclude that based on relative variability, no position is preferable above the other. However, because in most diseases amplitudes are decreased, the LLP may be chosen because it yields higher amplitudes. Whatever the choice, it is important to ensure that the DTL position remains stable during an ERG recording. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - November 3, 2019 Category: Opthalmology Source Type: research
Increase in electroretinogram rod-driven peak frequency of oscillatory potentials and dark-adapted responses in a cohort of myopia patients
ConclusionWe found significant positive correlation between the peak frequency of rod-driven OPs, as well as the amplitudes of rod-driven ERG a- and b-waves, and the refractive power. The results suggest that the rod system function was changing during the progress of myopia, while the cone system function appeared unaffected. The peak frequency of OPs appeared as a novel ERG parameter for myopia, a common ocular condition. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - October 27, 2019 Category: Opthalmology Source Type: research
Evaluation of visual evoked potential binocular summation after corneal refractive surgery
ConclusionsRefractive surgery can degrade binocular visual performance throughout the change in visual evoked potential binocular summation. However, monocular function deteriorates less than binocular function after refractive surgery. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - October 24, 2019 Category: Opthalmology Source Type: research
Functional –structural assessment of the optic pathways in patients with optic neuritis
ConclusionsAbnormality is potentially measurable (via reduced RNFLt and focal analyses with mfVEP amplitude) in patients suspected of having a first episode of ON where pVEP reports no abnormality. The mfVEP and SD-OCT may together be of value as supplementary tools in diagnosing ON in this patient group. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - October 16, 2019 Category: Opthalmology Source Type: research
Verifying complaints of difficulties in night vision using electroretinography and dark adaptation tests
ConclusionOur findings indicate that ERG is an essential, but not sufficient test for verifying patient ’s complaint on visual difficulties in the dark. We suggest using both electroretinography and psychophysical dark adaptation to test patients complaining of reduced night vision. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - October 15, 2019 Category: Opthalmology Source Type: research
Linezolid-induced photoreceptor dysfunction masquerading as autoimmune retinopathy
ConclusionsLinezolid has previously been reported to cause a toxic optic neuropathy. Reversible photoreceptor dysfunction on full-field electroretinography has never been reported in conjunction with linezolid toxicity. This novel case suggests that linezolid toxicity should be considered in cases of photoreceptor dysfunction. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - October 4, 2019 Category: Opthalmology Source Type: research
Evaluation of the “Freiburg Acuity VEP” on Commercial Equipment
ConclusionsThe successful implementation of the Freiburg Acuity VEP “heuristic algorithm” on a commercial system makes this capability available to a wider group of users. The limits of agreement of ± 0.31 LogMAR are close to the original implementation at the University of Freiburg and we believe are clinically acceptable for a fully automatic, largely obj ective assessment of visual acuity. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - October 3, 2019 Category: Opthalmology Source Type: research
Coexistence of GNAT1 and ABCA4 variants associated with Nougaret-type congenital stationary night blindness and childhood-onset cone-rod dystrophy
ConclusionsThis is the second report of a Nougaret-type CSNB family with theGNAT1 variant. Our novel findings suggest that coexistence of theGNAT1 and biallelicABCA4 variants is associated with an overlapping phenotype with both Nougaret-type CSNB and CORD. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - October 2, 2019 Category: Opthalmology Source Type: research
Impact of contact lens materials on the mfERG response of the human retina
ConclusionsHydrophobic CL slightly attenuated the strength of the mfERG signal, especially at the middle to peripheral retinal areas, while hydrophilic CL slightly changed the implicit time of the response. Different hydrophilic CL materials might affect the mfERG response differently. When considering the measurement of mfERG obtained with a CL in place, researchers should bear in mind that some changes can be related to CL material. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - September 30, 2019 Category: Opthalmology Source Type: research
The photopic negative response of the Light-adapted 3.0 ERG in clinical settings
ConclusionThe strong correlation between the two PhNR troughs could allow using PhNR1 when PhNR2 is poorly defined due to artifacts. Different methods of PhNR measurement lead to different correlations with other ERG parameters, and this needs to be considered when analyzing and comparing PhNR data between studies. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - September 30, 2019 Category: Opthalmology Source Type: research
57th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV 2019)
(Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - September 27, 2019 Category: Opthalmology Source Type: research
ISCEV 2019 Symposium Author Index
(Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - September 27, 2019 Category: Opthalmology Source Type: research
