Retinal vasculature –function correlation in non-proliferative diabetic retinopathy
ConclusionMacular VD in both superficial and deep capillary plexus correlated with ERG implicit time and amplitude in mild-to-severe NPDR. OCTA and FERG may both be useful in detection of preclinical DR and early DR, but once the disease deteriorates, FERG may be more sensitive to discern progression of DR. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - September 23, 2019 Category: Opthalmology Source Type: research
Comparison of the uniform-field electroretinogram and the pattern electroretinogram to checkerboard and bar gratings
ConclusionsThe UF-ERG to light onset and offset can be reliably recorded in human subjects. The extent to which the simulated PERG recapitulates the actual PERG response is better with checkerboard rather than bar-grating stimuli. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - September 22, 2019 Category: Opthalmology Source Type: research
Novel REEP6 gene mutation associated with autosomal recessive retinitis pigmentosa
ConclusionsThis report is not only the first description of a Cameroonian patient with arRP associated with aREEP6 mutation, but also this particular genetic alteration. Substitution of p.Glu99Lys in REEP6 likely disrupts the interactions between REEP6 and the ER membrane. NIR-AF imaging may be particularly useful for assessing functional photoreceptor cells and show an “avocado” pattern of hyperautofluorescence in patients with theREEP6 mutation. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - September 18, 2019 Category: Opthalmology Source Type: research
Identification of clusters in multifocal electrophysiology recordings to maximize discriminant capacity (patients vs. control subjects)
ConclusionThis paper demonstrates the effectiveness of a method able to determine the arbitrary clustering of multifocal responses that possesses the greatest capacity to discriminate between control subjects and patients when applied to the visual field of mfERG or mfVEP recordings. The method may prove helpful in diagnosing any disease that is identifiable in patients ’ mfERG or mfVEP recordings and is extensible to other clinical tests, such as optical coherence tomography. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - September 18, 2019 Category: Opthalmology Source Type: research
Electrophysiological measures of dysfunction in early-stage diabetic retinopathy: No correlation between cone phototransduction and oscillatory potential abnormalities
ConclusionOP amplitude losses do not appear to be related to reduced cone sensitivity in early-stage diabetic retinopathy. This suggests that diabetes may separately affect cone function, as evidenced by cone phototransduction sensitivity losses, and inner-retina function, as evidenced by OP amplitude losses. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - September 10, 2019 Category: Opthalmology Source Type: research
Rathke ’s cleft cyst presenting as incomplete cavernous sinus syndrome and disc edema: a case report with literature review
ConclusionA case of RCC presenting as multiple cranial nerve palsy was reported. RCCs are benign and usually asymptomatic. Symptomatic RCCs often manifest as headache or visual problems, such as reduced visual acuity and visual field defect. Multiple cranial nerve involvement is uncommon and indicates inflammation or compression of the cavernous sinus and optic nerve. Neuropathy may resolve after surgery; therefore, surgery is indicated for symptomatic RCCs. Further, RCC should be included in the differential diagnosis of patients with disc edema. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - September 5, 2019 Category: Opthalmology Source Type: research
Use of diffusing filters for artificially reducing visual acuity when testing equipment and procedures
ConclusionsThe Luminit filters, which have a Gaussian light diffusion profile, appear to be a good choice for artificial reduction of acuity. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - September 4, 2019 Category: Opthalmology Source Type: research
Central mfERG amplitude ratio as a predictor for visual outcome of macular hole surgery
ConclusionRetinal function assessed using the ratio between central and peripheral mfERG responses might be used as predictor of visual acuity outcome after macular surgery for MH. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - September 2, 2019 Category: Opthalmology Source Type: research
A comparison of contrast sensitivity and sweep visual evoked potential (sVEP) acuity estimates in normal humans
ConclusionsSimilar to previous publications, the sVEP acuity estimate was less than the optotype chart acuity. The acuity determined with the sVEP and the CSFs with letter and grating stimuli were not statistically different, suggesting that the difference in acuity with the sVEP and optotype charts does not result from stimulus differences. Other methodological differences must account for the discrepancy in sVEP and optotype chart acuity. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - August 13, 2019 Category: Opthalmology Source Type: research
Two cases of unilateral cone-rod dysfunction with negative electroretinograms
ConclusionsNegative ERGs with severely reduced cone and rod components suggest that both the cone and rod bipolar cell visual pathways may be disturbed. Slightly decreased a-wave suggests minor abnormality of photoreceptors. It is important to determine whether these patients represent a new clinical entity or a phenotypic variation of an already described retinal disorder. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - August 1, 2019 Category: Opthalmology Source Type: research
Using sellar region tumor ’s size as a predictor of psychophysical and electrophysiological perimetric visual losses: a logistic regression approach
ConclusionTumor size as a predictor of visual loss has potential to assist in the clinical intervention and to prevent the irreversible visual impairment caused by tumors of the sellar region. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 22, 2019 Category: Opthalmology Source Type: research
Multifocal electroretinogram in eyes with intravitreal silicone oil and changes following silicone oil removal
ConclusionmfERG may be reliably performed for the assessment of macular function in SO-filled eyes. Intravitreal SO exerts an insulating effect on the density of the electric potentials. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 19, 2019 Category: Opthalmology Source Type: research
Test –retest repeatability of the pattern electroretinogram and flicker electroretinogram
ConclusionsThe PERG and Flicker ERG protocols, delivered by an office-based testing platform, were shown to have good-to-excellent test –retest repeatability when tests were performed in the same order and in immediate succession. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 15, 2019 Category: Opthalmology Source Type: research
Novel findings in enhanced S-cone syndrome: a case with macular retinal neovascularization and severe retinal vasculitis
ConclusionThis case highlights novel associations of retinal neovascularization and vasculitis with ESCS. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 9, 2019 Category: Opthalmology Source Type: research
Electrophysiological findings in delayed discovery of a metallic intraocular foreign body in a child: case report
ConclusionIn this young girl perforating ocular trauma with metallic material was lately diagnosed with strabismus as a sign of alert. Prompt surgical intervention and proper management were essential to provide reasonable visual function including some degree of stereopsis, even though retinal dysfunction characterized by ERG was persistent. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 7, 2019 Category: Opthalmology Source Type: research
