Associations between steady-state pattern electroretinography and estimated retinal ganglion cell count in glaucoma suspects
ConclusionSteady-state PERG parameters demonstrated linear correlations with estimated RGC count. The associations among ssPERG parameters and structural measures were mediated by estimated RGC count. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 4, 2022 Category: Opthalmology Source Type: research
Short-term delay in neural response with multifocal contact lens might start at the retinal level
Conclusionssignificant changes in the mfERGs responses were found with the MF lens, being most noticeable with the center-near MF lens design. The present results suggest that the observed delay in cortical response described during the adaptation to multifocality may partially begin at the retina level. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 2, 2022 Category: Opthalmology Source Type: research
Qualitative and quantitative comparison of ERGs with contact lens and adhesive skin electrodes
ConclusionsOur best estimate for the conversion factor between ERG amplitudes recorded with adhesive skin electrodes and contact lens electrodes is 0.349 —amplitudes with skin electrodes are about 1/3 the amplitudes recorded simultaneously from the same eyes with contact lens electrodes, with a high correlation. Implicit times are nearly identical for the two electrode types. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - March 18, 2022 Category: Opthalmology Source Type: research
Polypoidal choroidal vasculopathy in a patient with DMPK-associated myotonic dystrophy
ConclusionsThis is the first patient with DM1 complicated with PCV. Widespread retinal dysfunction may be associated with expanded CTG repeats, which is significantly longer than the mean repeat number of patients with DM1. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - March 13, 2022 Category: Opthalmology Source Type: research
Suppression of electromagnetic interference in electroretinography from a patient with an implanted left ventricular assist device (LVAD)
ConclusionsLVAD interference in ERG waveforms can be successfully removed using simple digital filters. If post hoc data processing capabilities are unavailable, a large amount of interference can be removed by narrowing the acquisition bandwidth and averaging additional repeats of each stimulus response. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - March 5, 2022 Category: Opthalmology Source Type: research
Use of extended protocols with nonstandard stimuli to characterize rod and cone contributions to the canine electroretinogram
ConclusionsUsing extended protocols of the full-field electroretinogram provides additional characterization of the health and function of different populations of cells in the normal retina and enables quantifiable comparison between phenotypically normal dogs and those with retinal disease. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - March 5, 2022 Category: Opthalmology Source Type: research
Electrophysiological evaluation and 18-month follow-up of two regimens with aflibercept for neovascular age-related macular degeneration
ConclusionsAfter 18 months, both treatments arms have received a similar number of injections at comparable intervals. Electrophysiological evaluation shows no signs of toxicity concerning cone function. But ffERGs for the combined and isolated rod response have declined, possibly reflecting either toxic effects of t he drug to rods or the natural course of the disease itself. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - February 26, 2022 Category: Opthalmology Source Type: research
Message from the Editor
(Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - February 11, 2022 Category: Opthalmology Source Type: research
Vogt-Koyanagi-Harada syndrome-like uveitis after nivolumab administration as a treatment for ovarian cancer
ConclusionNivolumab is a human IgG4 monoclonal antibody and an immune checkpoint inhibitor. It is associated with the upregulation of T-cell activity by interfering with the interaction between the programmed death-1 (PD-1) receptor and the PD-ligand. Targeted therapy using immunotherapy agents has been widely used for malignant melanoma, lung cancer, renal cell carcinoma, and other cancers. However, immunotherapy agents such as nivolumab can induce autoimmune-related adverse events including uveitis. This report suggests that VKH syndrome-like posterior uveitis could be induced by nivolumab administration for an ovarian c...
Source: Documenta Ophthalmologica - January 8, 2022 Category: Opthalmology Source Type: research
Delayed-onset hypoxic cortical blindness: coming back from the abyss
ConclusionDelayed-onset hypoxic cortical blindness is a rare presentation of cortical blindness that develops few days after a cerebral hypoxic stress. While initial presentation can be catastrophic, visual improvement may be spectacular and enhanced with visual rehabilitation. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - January 3, 2022 Category: Opthalmology Source Type: research
Removing mains interference from the mfERG by applying a post-processing digital notch filter: for the good or the bad?
ConclusionThe application of a 50-Hz digital notch filter to mfERG traces causes a mild amplitude reduction which will not normally affect the clinical interpretation of the data. The situation is even more favorable with a 60-Hz digital notch filter. Caution is necessary if the assumption of linear additivity of retinal signal and mains interference is violated. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - November 30, 2021 Category: Opthalmology Source Type: research
The second Japanese family with Malattia Leventinese/Doyne honeycomb retinal dystrophy
ConclusionThis is the first report of ML/DHRD in a patient who developed bilateral CNV and received anti-VEGF treatment in both eyes. Although multifocal ERG exhibited worsening of macular function, the generalized photoreceptor function was preserved until middle age. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - November 25, 2021 Category: Opthalmology Source Type: research
Electroretinogram responses in myopia: a review
AbstractThe stretching of a myopic eye is associated with several structural and functional changes in the retina and posterior segment of the eye. Recent research highlights the role of retinal signaling in ocular growth. Evidence from studies conducted on animal models and humans suggests that visual mechanisms regulating refractive development are primarily localized at the retina and that the visual signals from the retinal periphery are also critical for visually guided eye growth. Therefore, it is important to study the structural and functional changes in the retina in relation to refractive errors. This review will...
Source: Documenta Ophthalmologica - November 17, 2021 Category: Opthalmology Source Type: research
A novel 5-ring multifocal electroretinography stimulus for detecting hydroxychloroquine retinal toxicity
ConclusionsIn this exploratory study, our novel 5-ring mfERG protocol significantly shortened data acquisition time while providing comparable results to the standard 61-hexagon stimulus for detecting HCQ-induced electrophysiological changes that are correlated with HCQ dosages and treatment duration. Our protocol has the potential to be more clinically practical by simplifying routine screening. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - November 11, 2021 Category: Opthalmology Source Type: research
A three-year longitudinal study of retinal function and structure in patients with multiple sclerosis
ConclusionsRetinal bipolar cell function may be affected by changes in disability in patients with MS; however, recent non-ON MS clinical relapses appear not to affect ERG or OCT results. As ERG changes in MS patients over 3 years are likely to be small and of uncertain clinical relevance, longitudinal studies of retinal function in MS should be planned over an extended period. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - October 27, 2021 Category: Opthalmology Source Type: research
