A novel system for measuring visual potentials evoked by passive head-mounted display stimulators
ConclusionThe proposed solution opens the door for a new generation of non-invasive first-level diagnostic devices of optic nerve pathologies inexpensive and easy to access. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - October 18, 2021 Category: Opthalmology Source Type: research
Monitoring for glaucoma progression with SAP, electroretinography (PERG and PhNR) and OCT
ConclusionsAlthough PERG and PhNR are sensitive for early detection of glaucomatous damage, they have limited usefulness in monitoring glaucoma progression in clinical practice, mainly due to high inter-session variability. On the contrary, OCT measures show low inter-session variability and might have a predicting value for early discrimination of progressing cases. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - October 15, 2021 Category: Opthalmology Source Type: research
Long-term follow-up of a patient with JAG1-associated retinopathy
ConclusionThis is the first report of the long-term detailed follow-up of a patient with Alagille syndrome whose most striking ophthalmic finding was bilateral well-demarcated, anterior circumferential chorioretinal atrophy. During follow-up, this finding remained stable, suggesting that this may be developmental in origin. This is in contrast with the progressive deterioration in the posterior pole retinal and macular function. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - October 1, 2021 Category: Opthalmology Source Type: research
Effects of fixed cutoff filtering on dark- and light-adapted ERG components and the application of variable cutoff filter
ConclusionsThe present report shows that DA OPs may be isolated from ERGs using filtering procedures with high-pass cutoff frequency at about 75 Hz as recommended by ISCEV. On the other hand, the spectral distribution of low-frequency and high-frequency LA ERG components may overlap. Accordingly, filtering the signal using different cutoff frequencies is not necessarily separating b-wave and OPs. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - September 24, 2021 Category: Opthalmology Source Type: research
Interpretation of electrophysiological responses and generalization of findings requires knowledge of physical stimulus characteristics
(Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - September 18, 2021 Category: Opthalmology Source Type: research
Response to letter interpretation of electrophysiological responses and generalization of findings requires knowledge of physical stimulus characteristics
(Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - September 16, 2021 Category: Opthalmology Source Type: research
Effect of spatial averaging on the amplitude ring ratio in multifocal electroretinography
ConclusionsFor all ring ratios used in this analysis, spatial averaging has a substantial effect on the ring ratio, which could affect the interpretation of the results. Therefore, use of spatial averaging should be avoided when analyzing mfERG results for HCQ screening. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - September 10, 2021 Category: Opthalmology Source Type: research
Subclinical maculopathy and retinopathy in transcobalamin deficiency: a 10-year follow-up
We report the electrophysiological results of one TC-deficient patient diagnosed at the age of 4 months immediately and continuosly treated by hydroxocobalamin IM. Her visual function was followed by eight ophthalmological assessments, eight flash-ERG, six EOG, one mf-ERG, and seven P-ERG recordings over a 10-year period, between the age of 2y 9 m and 12y 6 m.ResultsHer ophthalmological assessment including visual acuity, fundi, optical coherent tomography (OCT), and retinal nerve fiber layer (RNFL) remained normal. From the age of 2y 9 m to 5y, dark-adapted and light-adapted flash-ERGs, EOGs and pattern-ERG were nor...
Source: Documenta Ophthalmologica - September 7, 2021 Category: Opthalmology Source Type: research
Proliferative diabetic retinopathy treated with intravitreal ranibizumab and photocoagulation directed at ischemic retinal areas —A randomized study
ConclusionsPIR + IVR or PRP + IVR are comparable strategies regarding FLA control in PDR and led to similar retinal function impairment, based on ERG changes up to one-year follow-up.Trial registration numberNCT03904056, date of registration 02/11/2019, retrospectively registered. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - August 4, 2021 Category: Opthalmology Source Type: research
Compound Heterozygous Mutations in ZNF408 in a Patient with a Late Onset Pigmentary Retinopathy and Relatively Preserved Central Retina
ConclusionsZNF408-associated retinal dystrophies can present with predominantly retinal findings and should be considered in the differential diagnosis of retinitis pigmentosa. Our study revealed a novel variant p.L566H, which to our knowledge has not previously been reported. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 14, 2021 Category: Opthalmology Source Type: research
Electrophysiological and neuroimaging findings in a patient who developed visual loss after attempted suicide by hanging
ConclusionHanging survivors can develop visual loss after their recovery. The visual loss may be a result of simultaneous ischemic insult to the occipital lobe cortex, optic nerve and retina. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 6, 2021 Category: Opthalmology Source Type: research
New criteria for evaluation of electroretinogram in patients with retinitis pigmentosa
ConclusionRP can cause changes in the time and time –frequency components of the ERG. The area index could represent a new view of the characteristics of the ERG in the time–frequency domain. This criterion can help the ophthalmologist to have a better evaluation of retinal disease. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - June 30, 2021 Category: Opthalmology Source Type: research
Correlation between electroretinography, foveal anatomy and visual acuity in aniridia due to PAX6 mutations
ConclusionsHigher amplitude on mfERG correlated with poorer visual acuity in rings 4 and 5 in patients withPAX6 mutations. The slope of the change in amplitude from central to peripheral rings on the mfERG is significantly different in aniridia patients compared to controls, with a slower drop-off of amplitude from center to periphery. Additionally, mfERG in aniridia showed lower amplitudes than controls in rings 1 –3. These changes along with the lack of correlation between visual acuity and central macular thickness/OCT score suggest that changes in electrical topography may be important to visual deficits in patients ...
Source: Documenta Ophthalmologica - June 26, 2021 Category: Opthalmology Source Type: research
Is white the right light for the clinical electrooculogram?
ConclusionsConsideration may be given to using a short wavelength monochromatic stimulus that is more comfortable for the subject than the current 100 cd.m−2 illuminant. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - June 23, 2021 Category: Opthalmology Source Type: research
Homozygous single nucleotide duplication of SLC38A8 in autosomal recessive foveal hypoplasia: The first Japanese case report
ConclusionsThis report is the first report on the clinical and genetic characteristics ofSLC38A8-associated foveal hypoplasia in the Japanese population. This is also the first report of normal rod- and cone-mediated responses in a patient with this disorder. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - May 26, 2021 Category: Opthalmology Source Type: research
