Anti-angiogenic activity and safety of intraocular application of triterpenes
ConclusionsTriterpenes at 100 µmol L−1 or lupenone at 500 µmol L−1 were considered safe for potential ophthalmic use. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - May 26, 2021 Category: Opthalmology Source Type: research
VEP-based acuity estimation: unaffected by translucency of contralateral occlusion
ConclusionThe type of occlusion for the contralateral eye does not substantially affect the outcome of VEP-based acuity estimation. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - May 11, 2021 Category: Opthalmology Source Type: research
Evolution of the retinal function by flash-ERG in one child suffering from neuronal ceroid lipofuscinosis CLN2 treated with cerliponase alpha: case report
We report the case of one patient suffering from CLN2 treated with intracerebroventricular infusions of cerliponase alpha 300 mg every two weeks. Evolution of his retinal function was assessed by three successive flash-ERG and flash-VEP recordings throughout his treatment over a 4-year period.ResultsBefore treatment at the age of 4 years 5 months, patient’s retinas were normal (normal fundi and normal flash-ERG). After 29 infusions at the age of 6 years 10 months, a-wave combined response was absent, while cone and flicker responses were normal. After 80 infusions at the age of 8 years 9 months, a-wave cone resp...
Source: Documenta Ophthalmologica - May 6, 2021 Category: Opthalmology Source Type: research
Epileptic seizure? Certainly uncertain
(Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 30, 2021 Category: Opthalmology Source Type: research
Insufficient evidence to support the clinical diagnosis of an epileptic seizure
(Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 28, 2021 Category: Opthalmology Source Type: research
The influence of temporal frequency and stimulus size on the relative contribution of luminance and L-/M-cone opponent mechanisms in heterochromatic flicker ERGs
ConclusionsThe ERGs to heterochromatic stimuli can be fully described in terms of linear combinations of responses in the (magnocellular) luminance and the (parvocellular) L-/M-opponent retino-geniculate pathways. The non-invasive study of these pathways in human subjects may have implications for basic research and for clinical research. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 22, 2021 Category: Opthalmology Source Type: research
Reference ranges for clinical electrophysiology of vision
DiscussionGood quality reference limits minimise false-positive and false-negative results, thereby maximising the clinical utility and patient benefit. Quality indicators include using appropriately sized reference datasets with appropriate numerical handling for reporting; using subject-based reference limits where appropriate; and limiting tests for each patient to only those which are clinically indicated, independent and highly discriminating. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 21, 2021 Category: Opthalmology Source Type: research
Long-term follow-up of a patient with JAG1 -associated retinopathy
ConclusionThis is the first report of the long-term detailed follow-up of a patient with Alagille syndrome whose most striking ophthalmic finding was bilateral well-demarcated, anterior circumferential chorioretinal atrophy. During follow-up, this finding remained stable, suggesting that this may be developmental in origin. This is in contrast with the progressive deterioration in the posterior pole retinal and macular function. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 20, 2021 Category: Opthalmology Source Type: research
Evaluation of the neuronal and microvascular components of the macula in patients with diabetic retinopathy
ConclusionThe existence of significant correlations between PERG and OCT-A parameters in diabetic patients has shown that vascular and neuronal changes in the macula affect each other in diabetic patients. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 16, 2021 Category: Opthalmology Source Type: research
Effect of biological factors on latency of pattern-reversal visual evoked potentials associated with cathode ray tubes and liquid crystal display monitors in normal young subjects
ConclusionsThese findings suggest that the following aspects should be considered when assessing biological factors that may affect latency: components might influence latency changes; a young age could be related to an early appearance of peak latencies; inter-individual differences might cause latency change. These biological factors should be considered as possible causes for the varying latencies in an LCD monitor. Further studies should include healthy adults with a wider age range to assess the effects of age on latency. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 13, 2021 Category: Opthalmology Source Type: research
Case of cystoid macular edema induced by systemic administration of paclitaxel: evaluations with electroretinograms
ConclusionThese results suggest that the ERGs can be used to monitor the changes in the overall retinal function in patients receiving paclitaxel. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 11, 2021 Category: Opthalmology Source Type: research
ERG assessment of altered retinal function in canine models of retinitis pigmentosa and monitoring of response to translatable gene augmentation therapy
ConclusionsModeling of rod and cone a-waves and the luminance –response function of the scotopic b-wave characterized the loss of rod photoreceptor function in two dog models of retinitis pigmentosa and showed the effectiveness of gene augmentation therapy in restoring normal functional parameters. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 5, 2021 Category: Opthalmology Source Type: research
Repeated measurements of ERGs and VEPs using chloral hydrate sedation and propofol anesthesia in young children
ConclusionsLight-adapted flash ERG waveforms were generally similar with chloral hydrate and with propofol. Larger PERGs with later peaks, found in the second session (propofol) could reflect maturation of the PERG generators, as the differences found were associated with a greater age difference between the sessions, but we do not rule out that small differences in the waveforms may be drug-related. There are insufficient VEP data from these children with ONH to identify drug-related or maturational effects on VEPs. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - March 29, 2021 Category: Opthalmology Source Type: research
The electrophysiological tests in the early detection of the visual pathway dysfunction in patients with microadenoma
ConclusionsIn patients with microadenoma, the abnormalities in the electrophysiological tests are registered even without clinical evidence of visual impairment from the routine ophthalmological examination, SAP, OCT and chiasmal compression in MRI. The mVEPs have the most significant role in the diagnosis of the visual pathway dysfunction in patients with microadenoma. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - March 20, 2021 Category: Opthalmology Source Type: research
Transient electroretinographic abnormalities that mimic those of KCNV2 retinopathy: a case report
ConclusionsThe abnormal electroretinographic findings might be associated with the transient increase in serum potassium level. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - March 18, 2021 Category: Opthalmology Source Type: research
