Late-onset night blindness with peripheral flecks accompanied by progressive trickle-like macular degeneration
ConclusionsThe six cases had some common features with the flecked retina syndrome, familial drusen, and late-onset retinal degeneration although none had pathogenic variants causative for these disorders. These cases may represent a subset of severe trickling AMD or a new clinical entity of acquired pan-retinal visual cycle deficiency of unknown etiology. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 7, 2019 Category: Opthalmology Source Type: research
Full-field electroretinography, visual acuity and visual fields in Usher syndrome: a multicentre European study
ConclusionsThere are differences in the phenotypes of RP in USH subtypes, most visible in the progression of visual fields between USH1 and USH2. The perimetric reduction occurs earlier in USH1 than in USH2. In both subtypes, visual acuity decreases significantly with age and the ERG is not detectable already at early ages. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 1, 2019 Category: Opthalmology Source Type: research
Central and peripheral steady-state visual evoked potentials in children with optic pathway gliomas
ConclusionSteady-state visual evoked potentials could eventually be implemented in the clinical assessment and follow-up of central visual field deficits in uncooperative or nonverbal children but seem to have limited usefulness for evaluation of peripheral visual field deficits. Additional studies are needed to identify testing parameters for full visual field assessment. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - June 25, 2019 Category: Opthalmology Source Type: research
Objective and quantitative assessment of visual acuity and contrast sensitivity based on steady-state motion visual evoked potentials using concentric-ring paradigm
ConclusionOur study proved that SSMVEPs can be an objective and quantitative method to measure visual acuity and contrast sensitivity. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - June 17, 2019 Category: Opthalmology Source Type: research
Acuity VEP: improved with machine learning
ConclusionsThe ML approach appears to be a useful alternative to rule-based analysis of acuity-VEP data. The achieved accuracy is comparable or better (in no case the ML-based acuity differed more than ± 0.29 LogMAR from behavioral acuity), and testability is higher, nearly 100%. Possible pitfalls are examined. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - June 10, 2019 Category: Opthalmology Source Type: research
Can VEP-based acuity estimates in one eye be improved by applying knowledge from the other eye?
ConclusionsKnowledge about the discrepancy between objective and subjective acuity values in one eye does not help improving the accuracy of acuity estimates in the other eye. The lack of a significant correlation between eyes even at the same acuity level suggests that a major part of the discrepancies between subjective acuity and VEP-based acuity is not the result of factors that would equally apply to both eyes, such as cortical morphology. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - June 2, 2019 Category: Opthalmology Source Type: research
Electrophysiological and pupillometric measures of inner retina function in nonproliferative diabetic retinopathy
ConclusionAbnormalities of the pERG, PhNR, and PIPR suggest inner retina neural dysfunction in diabetics who have clinically apparent vascular abnormalities. Taken together, these measures provide a noninvasive, objective approach to study neural dysfunction in these individuals. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 22, 2019 Category: Opthalmology Source Type: research
A case of X-linked retinoschisis with atypical fundus appearance
ConclusionWe present a case of atypical retinoschisis with clinical findings of retinitis pigmentosa. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 19, 2019 Category: Opthalmology Source Type: research
Visual evoked and event-related brain potentials in HIV-infected adults: a longitudinal study over 2.5 years
ConclusionOur aim was to evaluate whether antiretroviral treatment in HIV+ patients is sufficient to preserve brain visual function. The optic nerve and primary visual cortex function tested by the P-VEPs seem to be preserved. The prolongation of the M-VEPs suggests an individually detectable decline in CNS function, but these changes did not show a progression during the follow-up. From a longitudinal perspective, the trends in peak time prolongation of the 20 ′ P-VEP, peripheral M-VEP, ERP and reaction time suggest a faster decline than that caused by aging in healthy populations, as previously described in a cross-sec...
Source: Documenta Ophthalmologica - April 15, 2019 Category: Opthalmology Source Type: research
Macular function following intravitreal ranibizumab for macular edema associated with branch retinal vein occlusion
ConclusionsIVRs improved the macular function not only on the occluded side but also on the non-occluded side. On the occluded side, the BRVOME affects the function of all retinal layers of the macula. Even after the IVR, the function of the photoreceptors and retinal ganglion cells remained abnormal. On the non-occluded side, the inner retinal function improved after the IVR. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 11, 2019 Category: Opthalmology Source Type: research
Flicker electroretinogram recorded with portable ERG device in prematurely born schoolchildren with and without ROP
ConclusionsPrematurely born schoolchildren exhibit longer implicit time of the 30-Hz flicker ERG response compared to controls, suggesting a possible abnormality of the retinal cone system function. Under such circumstances, portable ERG device might be used clinically as a screening tool for retinal function evaluation in prematurely born children. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 10, 2019 Category: Opthalmology Source Type: research
Retinal dystrophies with bull ’s-eye maculopathy along with negative ERGs
ConclusionsThe five patients with bull ’s-eye maculopathy along with a negative ERG had differing genotypes. Mutations were found in theCRX gene (2 patients), theABCA4 gene (1 patient), and theGUCY2D gene (2 patients). (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 2, 2019 Category: Opthalmology Source Type: research
Adaptation time, electroretinography, and pupillography in healthy subjects
ConclusionsCone-driven ERG can be recorded, even in 5 min of light adaptation time without any special light condition, whereas rod-driven ERG and pupillary response results can be obtained in 10 min or longer of dark adaptation time in complete darkness. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - March 31, 2019 Category: Opthalmology Source Type: research
ISCEV extended protocol for the stimulus –response series for the dark-adapted full-field ERG b-wave
AbstractThe International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum protocol for clinical testing but encourages more extensive testing where appropriate. This ISCEV extended protocol describes an extension of the ISCEV full-field ERG standard, in which methods to record and evaluate the growth of the dark-adapted (DA) ERG b-wave with increasing stimulus energy are described. The flashes span a range that includes the weakest flash required to generate a reliable DA ERG b-wave and that required to generate a maximal b-wave amplitude. The D...
Source: Documenta Ophthalmologica - March 29, 2019 Category: Opthalmology Source Type: research
ISCEV extended protocol for the stimulus –response series for light-adapted full-field ERG
AbstractThe International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum protocol for clinical testing but encourages additional ERG testing when appropriate. This ISCEV extended protocol describes methods to record and evaluate a light-adapted (LA) ERG stimulus –response series with increasing flash strengths. The LA ERG stimulus–response series (also referred to as the luminance–response or intensity–response series in the published literature) can characterise generalised cone system function more comprehensively than the ISCEV stand...
Source: Documenta Ophthalmologica - March 29, 2019 Category: Opthalmology Source Type: research
