Misaligned foveal morphology and sector retinal dysfunction in AKT1-mosaic Proteus syndrome
ConclusionWe propose this patient has asymmetric foveal development and concomitant sector retinal dysfunction as the result of the mosaic AKT1 mutation, either through disruption in the retinal PI3K-AKT1 signalling pathway or through mechanical distortion of ocular growth, resulting in disproportionate inner retinal development. The findings expand the ocular phenotype of Proteus syndrome and encourage early assessment to identify any incipient ocular abnormalities. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - July 2, 2020 Category: Opthalmology Source Type: research

Unilaterally extinguished electroretinograms in an eye with normal visual acuity and visual field
ConclusionsThe pathogenesis of this patient ’s condition still remains unknown, while unilateral retinitis pigmentosa, unilateral pigmentary retinopathy, acute zonal occult outer retinopathy, and autoimmune retinopathy can all be considered as possible explanations. The uniqueness of this case study is that the extinguished ERG responses ar e predictive of the functional alteration in the affected eye, when the initial visual acuity and the visual field were normal. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - June 25, 2020 Category: Opthalmology Source Type: research

Rod bipolar cell dysfunction in POLG retinopathy
ConclusionThis is the first documented case of an electronegative ERG in aPOLG-related disorder consistent with generalized rod ON-bipolar dysfunction. The rest of the proband ’s systemic and ophthalmological features were consistent with SANDO but some features overlapped with otherPOLG-related disorders such as Alpers –Huttenlocher syndrome and autosomal dominant progressive external ophthalmoplegia demonstrating the wide phenotypic overlap expected due toPOLG mutations. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - June 21, 2020 Category: Opthalmology Source Type: research

Oscillatory potentials in patients with birdshot chorioretinopathy
This study compares ERG parameters, including OPs, between patients with birdshot chorioretinopathy, other posterior uveitis, and controls.MethodsThis was a retrospective case –control study. Sixty-four patients seen at a clinical practice had a total of 93 visits during which ERG was performed on both eyes. ERG data from 93 age-matched controls were also collected. Root-mean-squared (RMS) energy of the OPs was calculated using Fourier analysis for 88 patients and 88 ag e-matched controls for whom complete data were available. Photopic flicker amplitudes, photopic flicker latencies, scotopic b-wave amplitudes, and OP...
Source: Documenta Ophthalmologica - June 15, 2020 Category: Opthalmology Source Type: research

The rapid N-wave as a potentially useful measure of the photopic negative response
ConclusionsThe N-wave appears to be a component of the longer PhNR, though its exact origin and significance remain unclear. As a rapid waveform that is independent of baseline, the N-wave is in many ways easier to measure accurately than the slower PhNR, which is highly dependent on baseline stability. The N-wave may prove useful clinically if further studies can optimize its stimulation, show its behavior in normal individuals and find correlation with markers of optic nerve disease. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - June 7, 2020 Category: Opthalmology Source Type: research

Flash VEP in clinically stable pre-term and full-term infants
ConclusionsOur results demonstrate that, compared with full-term infants, clinically stable pre-term infants exhibit abnormal flash VEPs, with a delay in P2 peak time and a reduction in P2 amplitude. These findings support a potential dysfunction of the visual pathway in clinically stable pre-term infants as compared to full-term infants. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - June 6, 2020 Category: Opthalmology Source Type: research

Normal to supernormal 30-Hz flicker ERGs predict visual function and prognosis in central retinal artery occlusion
AbstractPurposeTo determine whether normal to supernormal 30-Hz flicker ERGs are associated with visual function and prognosis in patients with central retinal artery occlusion (CRAO).MethodsA total of 133 patients diagnosed with unilateral acute non-arteritic CRAO by examination with electroretinography (ERG) were examined. Thirty-hertz flicker ERG amplitudes were analyzed according to the severity of CRAO, and their correlation with visual function and prognosis was assessed. All patients were categorized into one of three groups according to the flicker ERG amplitude ratios between affected and fellow eyes:  ≥...
Source: Documenta Ophthalmologica - June 6, 2020 Category: Opthalmology Source Type: research

VEP estimation of visual acuity: a systematic review
ConclusionsThe VEP SF limit has great utility as an objective acuity estimator, especially in pre-verbal children or patients of any age with motor or learning impairments which prevent reliable measurement of behavioural acuity. Its diagnostic power depends heavily on adequate, age-stratified, reference data, age-stratified empirical calibration with behavioural acuity, and interpretation in the light of other electrophysiological and clinical findings. Future developments could encompass faster, more objective and robust techniques such as real-time, adaptive control.Registration International prospective register of sys...
Source: Documenta Ophthalmologica - June 2, 2020 Category: Opthalmology Source Type: research

A case of melanoma-associated retinopathy with autoantibodies against TRPM1
ConclusionsThe clinical features of MAR patients with positive anti-TRPM1 autoantibodies can be manifested as severe vision loss, and the identification of autoantibodies can be helpful for confirming the diagnosis. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - May 29, 2020 Category: Opthalmology Source Type: research

Vision training with VEP biofeedback in amblyopia after the critical period
AbstractPurposeThe purpose of this study was to investigate the benefits of vision training with visual evoked potentials (VEP) biofeedback in amblyopia after the critical period in 8 to 17-year (11.5  ± 3.1) old children.MethodsTen participants with monocular amblyopia after the critical period underwent a 10-week, 20-session vision training program with the Retimax Vision Trainer device. During each session, the participants were instructed to be as focused as possible onto the fixation point in the middle of the screen. The size of the fixation point and the pitch of the background sound were changi...
Source: Documenta Ophthalmologica - May 28, 2020 Category: Opthalmology Source Type: research

Central serous chorioretinopathy and achromatopsia: a case report
ConclusionThis case highlights a case of CSC and ACHM. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - May 18, 2020 Category: Opthalmology Source Type: research

Comparison of the performance of six stimulus paradigms in visual acuity assessment based on steady-state visual evoked potentials
ConclusionExcept for brief-onset vertical sinusoidal gratings, all the five stimulus paradigms of reverse vertical sinusoidal gratings, reverse horizontal sinusoidal gratings, reverse vertical square-wave gratings, reversal checkerboards and oscillating expansion –contraction concentric-rings performed quite well in objective SSVEP visual acuity assessment. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - May 13, 2020 Category: Opthalmology Source Type: research

Oguchi disease caused by a homozygous novel SAG splicing alteration associated with the multiple evanescent white dot syndrome: A 15-month follow-up
ConclusionsThis work is the first long-term case study of a patient with Oguchi disease associated with the MEWDS. The recovery period of symptoms caused by the MEWDS was much longer than that in typical patients with MEWDS. Molecular genetics demonstrate that this is the first case of Oguchi disease caused by splicing alterations in theSAG gene. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 24, 2020 Category: Opthalmology Source Type: research

High myopic patients with and without foveoschisis: morphological and functional characteristics
AbstractPurposeMyopic foveoschisis (MF) is characterized by the splitting of the retinal layers in the fovea of patients with high myopia (HM). MF may progress into foveal detachment or macular hole formation with consequent loss of central vision. The aim of this study is to investigate morphological and functional changes of the macular region in myopic subjects with and without foveoschisis.DesignObservational, cross-sectional, comparative study.MethodsForty-eight patients with HM and 24 healthy controls were evaluated by spectral domain-optical coherence tomography (SD-OCT), multifocal electroretinography (mfERG) and m...
Source: Documenta Ophthalmologica - April 22, 2020 Category: Opthalmology Source Type: research

Retinal dysfunction of syphilitic outer retinopathy
ConclusionsSyphilitic outer retinopathy affected the retinal structures and function that can be restored by antibiotic treatments. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 4, 2020 Category: Opthalmology Source Type: research

Biomarkers in Usher syndrome: ultra-widefield fundus autofluorescence and optical coherence tomography findings and their correlation with visual acuity and electrophysiology findings
AbstractPurposeTo investigate the functional and structural biomarkers and their correlation with Usher syndrome (USH).MethodsMedical records, imaging and electrophysiology test results of USH patients attending the Save Sight Institute between 2012 and 2017 were reviewed. Best corrected visual acuity (BCVA), ultra-widefield autofluorescence (UW-FAF), spectral-domain optical coherence tomography (SD-OCT), full-field electroretinogram and pattern electroretinogram (pERG) were performed. SD-OCT scans assessed central macular thickness (CMT), greatest linear diameter of preserved outer retinal layers —macular island (MI...
Source: Documenta Ophthalmologica - April 2, 2020 Category: Opthalmology Source Type: research

Improvement of reduced electroretinographic responses in thymoma-associated retinopathy: a case report and literature review
ConclusionsTo our knowledge, improvement of reduced rod-mediated ERG responses has not been described in seven previously reported patients with thymoma-associated retinopathy. The good visual prognosis of our patient may be associated with well-timed intervention. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 1, 2020 Category: Opthalmology Source Type: research

Changes of focal macular and full-field electroretinograms after intravitreal aflibercept in patients with central retinal vein occlusion
ConclusionsIVA injections by the TAE regimen led to a continuous improvement of the macular function in patients with ME associated with a CRVO. However, the function of the whole retina changed differently than the macula after the treatment. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - March 25, 2020 Category: Opthalmology Source Type: research

Chromatic visual evoked potentials indicate early dysfunction of color processing in young patients with demyelinating disease
AbstractPurposeChromatic visual evoked potentials (cVEP) primarily reflect the parvocellular visual pathway function, which has been shown to be predominantly affected in demyelinating disease (DD). The purpose of this study was to evaluate cVEP responses and to compare them with other structural and functional findings in young patients with DD.MethodsThirty patients (8 –28 years of age) with DD with or without a history of optic neuritis (ON) were investigated. Twenty-five eyes had at least one episode of ON (ON-group) and 35 eyes had no clinically evident episode of ON (nON-group). OCT imaging was performed u...
Source: Documenta Ophthalmologica - March 10, 2020 Category: Opthalmology Source Type: research

Long-term PERG monitoring of untreated and treated glaucoma suspects
AbstractPurposeTo investigate long-term structural and functional progression of untreated and treated glaucoma suspects (UGS and TGS).MethodsRetrospective analysis of serial steady-state pattern electroretinogram (PERG), mean retinal nerve fiber layer thickness (RNFLT), and standard automated perimetry mean deviation (SAP-MD) in UGS (N = 20) and TGS (N = 18). Outcome measures were the rates of change (linear regression slopes) of PERG amplitude, PERG phase, mean RNFLT, and SAP-MD over 9.8 ± 1.3 years (15.6 ± 4.2 visits).ResultsThe number of patient...
Source: Documenta Ophthalmologica - March 9, 2020 Category: Opthalmology Source Type: research

Wide-field true-colour imaging and clinical characterization of a novel GRK1 mutation in Oguchi disease
ConclusionsHere, we demonstrate how characterizing this condition with single-shot true-colour wide-field imaging has distinct advantages over scanning laser technology, which applies artificial colouration, or stitched true-colour images. Images captured with wide-field systems create a much better representation of the native and dark-adapted fundus than can be observed by the ophthalmologist using direct fundoscopy and are essential in the clinical characterization of new mutations. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - March 7, 2020 Category: Opthalmology Source Type: research

Changes in cone-driven functions after intravitreal aflibercept injections in patients with age-related macular degeneration
AbstractPurposeTo determine the changes in the cone-driven functions in patients with age-related macular degeneration (AMD) treated with intravitreal aflibercept.MethodsWe studied 44 eyes of 44 patients diagnosed with AMD whose mean age was 75  years. The contralateral unaffected eyes served as controls. All patients were initially treated with 3 consecutive monthly intravitreal aflibercept injections and thereafter with bimonthly injections for 12 months. Full-field cone electroretinograms (cone ERGs) were recorded at the baseline and at 3, 6, and 12 months after beginning the intravitreal aflibercept inje...
Source: Documenta Ophthalmologica - February 25, 2020 Category: Opthalmology Source Type: research

Macular function following intravitreal ranibizumab for macular edema associated with branch retinal vein occlusion: 12-month results
AbstractPurposeTo evaluate the 12-month effects of intravitral ranibizumab (IVR) injections on the physiology and morphology of the macula in eyes with a branch retinal vein occlusion with macular edema (BRVOME).MethodsWe studied 13 eyes of 13 patients with a BRVOME. All patients were initially treated with IVR injections at 3 consecutive monthly intervals, the initiation phase. Additional treatments were done according to the pro re nata (PRN) regimen. The physiology of the macula was assessed by the focal macular electroretinograms (fmERGs) and the best-corrected visual acuity (BCVA). The morphology of the macular area w...
Source: Documenta Ophthalmologica - February 25, 2020 Category: Opthalmology Source Type: research

Ring analysis of multifocal oscillatory potentials (mfOPs) in cCSNB suggests near-normal ON –OFF pathways at the fovea only
AbstractPurposeTo investigate the center-periphery distribution of ON and OFF retinal responses in complete congenital stationary night blindness (cCSNB).MethodsPhotopic full-field flash ERGs (photopic ffERGs) and OPs (photopic ffOPs) and slowm-sequence (to enhance OP prominence) mfERGs (and filtered mfOPs) evoked by a 37 hexagon stimulus array were recorded from normal subjects and cCSNB patients. Discrete wavelet transform (DWT) analysis of photopic ffERGs and mfERGs was also performed in order to assess the contribution of the ON and OFF retinal pathways (i.e., OFF-to-ON ratio) in both cohorts.ResultsAs expected, the ph...
Source: Documenta Ophthalmologica - February 14, 2020 Category: Opthalmology Source Type: research

XEN Gel Stent in the management of primary open-angle glaucoma
AbstractPurposeTo assess the efficacy and safety of the XEN Gel Stent in patients with primary open-angle glaucoma.Materials and methodsTwenty eyes of 17 patients (6 males, 11 females) with primary open-angle glaucoma were implanted with XEN Gel Stent. The following data were ascertained in each participant at baseline and at 1, 3, 6, 9 and 12  months following implanting procedure: intraocular pressure, number of anti-glaucoma medications, retinal sensitivity (PS 24/2 w/w), pattern electroretinogram (ISCEV standard), as well as the number of complications.ResultsThe mean intraocular pressure reduction in a 1-year fol...
Source: Documenta Ophthalmologica - February 12, 2020 Category: Opthalmology Source Type: research

Retinal and visual function in infants with non-accidental trauma and retinal hemorrhages
ConclusionsRetinal dysfunction was common during the acute phase of NAT. A near normal appearing fundus did not imply normal retinal function, and ERG abnormality did not always predict a poor visual acuity outcome. However, a negative ERG waveform was associated severe visual acuity loss. Potential artifacts of retinal hemorrhages and anesthesia could not fully account for multifocal ERG abnormalities. Retinal function can be preserved in areas adjacent to traumatic retinoschisis. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - February 12, 2020 Category: Opthalmology Source Type: research

Multimodal imaging in a family with Cockayne syndrome with a novel pathogenic mutation in the ERCC8 gene, and significant phenotypic variability
ConclusionThe clinical presentation and genetic studies confirmed a diagnosis of Cockayne syndrome in both sisters caused by compound heterozygous mutations in theERCC8 gene on chromosome 10. Multimodal ocular imaging and systemic findings revealed wide phenotypic variability between the affected siblings. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - February 11, 2020 Category: Opthalmology Source Type: research

Insights for mfVEPs from perimetry using large spatial frequency-doubling and near frequency-doubling stimuli in glaucoma
ConclusionThe lower temporal frequency R9 stimuli had similar diagnostic power to the FDT-C20 stimuli. CCA indicated the both stimuli drove similar neural mechanisms, possibly suggesting no advantage of FD stimuli for mfVEPs. Given that the contrast-threshold mfVEPs were non-viable, we used the present and published results to make recommendations for future mfVEP tests. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - February 8, 2020 Category: Opthalmology Source Type: research

Novel biallelic splice-site BBS1 variants in Bardet –Biedle syndrome: a case report of the first Japanese patient
ConclusionsThis is the first report of a BBS patient with biallelic splice-siteBBS1 variants in the Japanese population. Disparity between funduscopic and ERG findings may be a feature ofBBS1-associated rod-cone dystrophy. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - January 29, 2020 Category: Opthalmology Source Type: research

ERG shrinks by 10% when reducing dark adaptation time to 10  min, but only for weak flashes
AbstractPurposeTo compare dark-adapted (DA) ERG between 10, 15 and 20  min of dark adaptation (DA).MethodsIn a counterbalanced random block design, 40 healthy adult subjects were dark-adapted for 10, 15 or 20  min before we recorded ERGs to nine flash strengths from 0.001 to 10.0 cd s/m2 (dilated pupils) with a DTL-like electrode. Before and between sessions, the room was lit. Apart from choosing a wider range of stimulus strengths, and adding shorter DA times, the recordings fully complied with the ISCEV ERG  Standard, namely using corneal electrodes, mydriasis and a standard DA sequence.ResultsTh...
Source: Documenta Ophthalmologica - January 29, 2020 Category: Opthalmology Source Type: research

Evaluation of retinal fiber thickness and visual pathways with optic coherence tomography and pattern visual evoked potential in different clinical stages of obstructive sleep apnea syndrome
AbstractPurposeTo investigate the possible changes in retinal nerve fiber layer (RNFL) by optic coherence tomography and in the amplitudes and peak times (PTs) in pattern visual evoked potential (pVEP) and to compare them in obstructive sleep apnea syndrome (OSAS).MethodsThis prospective study included patients with mild OSAS (n = 30), severe OSAS (n = 30), and 30 control subjects. All patients were assessed after obtaining the approval from our hospital’s ethics committee.ResultsThere was no difference in age and gender between the groups (p = 0.184,p = 0.954)....
Source: Documenta Ophthalmologica - January 24, 2020 Category: Opthalmology Source Type: research

Analysis of retinal structure and function in cone dystrophy with supernormal rod response
ConclusionThis is the largest cohort of CDSRR from a single ethnic background. Rod dysfunction and reduced 30-Hz flicker response were demonstrated in all patients. In contrast to previous descriptions in the literature, a supernormal combined dark-adapted rod-cone ERG was present in the majority of the patients at standard stimulus intensity. Considering the consistent genotype and the demonstration of likely pathogenic genetic variants in all the patients, we argue that the combination of delayed rod b-wave and subnormal flicker response strongly suggests the diagnosis of CDSRR. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - January 20, 2020 Category: Opthalmology Source Type: research

Acknowledgement to scientific referees 2019
(Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - January 13, 2020 Category: Opthalmology Source Type: research

Electrophysiological and SD-OCT findings in patients receiving chloroquine therapy in relation to cumulative dosage and duration of treatment
AbstractPurposeAssessment of multifocal ERG (mfERG) changes in patients treated with chloroquine and their correlation with morphological abnormalities, detected by spectral-domain optical coherence tomography in relation to cumulative dosage.MethodsData from 37 eyes of 20 patients were retrospectively collected, and one randomly selected eye per patient was considered for statistical analysis. Eyes were divided into three groups according to mfERG and visual acuity findings: normal, early and advanced maculopathy. Functional measures of the first three mfERG rings were compared with retinal thickness measures of the corre...
Source: Documenta Ophthalmologica - January 11, 2020 Category: Opthalmology Source Type: research

Late presentation of RPE65 retinopathy in three siblings
ConclusionsRPE65 retinopathy seems to be relatively common on the Arabian peninsula, and in addition it may be underdiagnosed. To the best of our knowledge, this is the first detailed presentation, including multimodal retinal imaging and electrophysiological assessment, of such patients from this region. Patients with late presentation ofRPE65 retinopathy may be eligible for gene therapy, in terms of remaining retinal function and structural preservation. The therapeutic window of such therapy remains to be determined. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - January 10, 2020 Category: Opthalmology Source Type: research

Multifocal electroretinography in patients with macular telangiectasia type 2
ConclusionmfERG reflects localised inner retinal dysfunction in MacTel type 2. Correlation with BCVA reinforces that mfERG should be used to objectively assess the macular function in these patients. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - January 7, 2020 Category: Opthalmology Source Type: research

A novel method for electroretinogram assessment in patients with central retinal vein occlusion
ConclusionThe proposed features have made it possible to distinguish between healthy and CRVO eyes. This method could be helpful in some cases with no definite diagnosis or to estimate the severity of CRVO. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - January 7, 2020 Category: Opthalmology Source Type: research

ISCEV extended protocol for derivation and analysis of the strong flash rod-isolated ERG a-wave
AbstractThe International Society for the Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum set of tests, but encourages the use of additional protocols for clinical ERG testing. This extended protocol describes recording methods and derivations that will allow analysis of rod-driven components of the dark-adapted (DA) strong flash ERG a-wave, more closely related to rod phototransduction than ISCEV standard DA ERGs. The method involves recording ERGs to a flash strength equivalent to 30  cd s m2 under conditions of dark adaptation and addition...
Source: Documenta Ophthalmologica - January 4, 2020 Category: Opthalmology Source Type: research

Electroretinographic abnormalities associated with pregabalin: a case report
ConclusionsThis is the first report to indicate that ERG abnormalities might be associated with pregabalin treatment. Our results suggest that pregabalin may affect LTCC function via theα2 –δ1/α2 –δ2 subunits, which leads to defective synaptic transmission from rod/cone photoreceptors to bipolar cells. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - January 3, 2020 Category: Opthalmology Source Type: research

A new electrophysiological non-invasive method to assess retinocortical conduction time in the Dark Agouti rat through the simultaneous recording of electroretinogram and visual evoked potential
AbstractPurposeTo develop a non-invasive method exploiting simultaneous recording of epidermal visual evoked potential (VEP) and epicorneal electroretinogram (ERG) to study retinocortical function and to evaluate its reliability and repeatability over time.MethodsFemale wild-type DA rats were anesthetized with ketamine/xylazine (40/5  mg/kg). Epidermal VEP (Ag/AgCl cup electrode on scalp) and epicorneal ERG (gold ring electrode on eye surface) were recorded simultaneously in response to flash stimulation.ResultsANOVA for repeated measures showed that peak times of ERG b-wave and of VEP N1 and P2 were stable across 6 &...
Source: Documenta Ophthalmologica - December 12, 2019 Category: Opthalmology Source Type: research

Electroretinograms of eyes with Stickler syndrome
ConclusionsThe reduced or absent full-field ERGs in eyes with Stickler syndrome indicate that the physiology of the entire retina was negatively altered. The greater reduction in the ERGs with increasing age suggests that the physiological alterations of the retina are progressive. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - November 28, 2019 Category: Opthalmology Source Type: research

Foveation dynamics in congenital nystagmus IV: vergence
ConclusionsTarget foveation qualities during fixation of targets at various near distances were equivalent to that during fixation of a far target. Stereo discrimination was limited by the foveation quality of the eye with the higher NAFX waveform. Foveation period slopes during vergence tracking demonstrated vergence movements despite the ongoing CN oscillation. Similar to what we found with fixation, pursuit, and the vestibulo-ocular systems, these findings establish that vergence in both static and dynamic viewing conditions functions normally in the presence of the CN oscillation. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - November 27, 2019 Category: Opthalmology Source Type: research

ISCEV extended protocol for the S-cone ERG
AbstractThe International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure for testing generalized retinal function but encourages more extensive testing. This extended protocol describes a method of assessing the function of the short-wavelength-sensitive cone (S-cone) retinal pathway, using a short-wavelength flash superimposed on a background that saturates the rods and adapts the L/M-cones to elicit a response, known as the S-cone ERG. Stimulus parameters such as the strength and luminance of the flash and background, respectively, ...
Source: Documenta Ophthalmologica - November 20, 2019 Category: Opthalmology Source Type: research

Expression of Concern: Fisetin rescues retinal functions by suppressing inflammatory response in a DBA/2J mouse model of glaucoma
The Editor-in-Chief of Documenta Ophthalmologica is publishing an editorial expression of concern for the manuscript"Fisetin rescues retinal functions by suppressing inflammatory response in a DBA/2J mouse model of glaucoma ” by Li et al. (2019) [1]. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - November 15, 2019 Category: Opthalmology Source Type: research

Screening for diabetic retinopathy in diabetic patients with a mydriasis-free, full-field flicker electroretinogram recording device
AbstractPurposeTo investigate the accuracy of the RETeval full-field flicker ERG in the screening of diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) and to determine a suitable range of DR diagnostic reference for patients with type 2 diabetes mellitus (T2DM).MethodsThis was a cross-sectional study involving 172 subjects with T2DM, including 71 subjects without clinically detectable DR (NDR), 25 subjects with mild non-proliferative diabetic retinopathy (NPDR), 24 subjects with moderate NPDR, 27 subjects with severe NPDR and 25 subjects with proliferative diabetic retinopathy (PDR). All the subj...
Source: Documenta Ophthalmologica - November 12, 2019 Category: Opthalmology Source Type: research

Unique retinal signaling defect in GNB5 -related disease
ConclusionThis report identifies for the first time a unique retinopathy associated with biallelic mutations inGNB5. The observed phenotype is consistent with a dual retinal signaling defect reminiscent of features of bradyopsia and rod ON-bipolar dysfunction. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - November 12, 2019 Category: Opthalmology Source Type: research

Effects of DTL electrode position on the amplitude and implicit time of the electroretinogram
ConclusionsFor monitoring purposes in patients, we conclude that based on relative variability, no position is preferable above the other. However, because in most diseases amplitudes are decreased, the LLP may be chosen because it yields higher amplitudes. Whatever the choice, it is important to ensure that the DTL position remains stable during an ERG recording. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - November 4, 2019 Category: Opthalmology Source Type: research

Increase in electroretinogram rod-driven peak frequency of oscillatory potentials and dark-adapted responses in a cohort of myopia patients
AbstractPurposeTo study whether rod- and cone-driven electroretinogram (ERG) responses are altered in myopia patients.MethodsDark- and light-adapted ERGs were recorded from 57 myopic eyes of 32 patients aged 22 –30 and 19 emmetropic eyes of 10 age-matched normal subjects. The myopic eyes were divided into 3 groups according to spherical equivalent (SE) of manifest refraction: 18 low myopia eyes (≤ − 3.00 diopter (D), 23 moderate myopia eyes (− 3.25 to − 6.00 D), and 16 high myopia eyes (>  − 6.25 D). The amplitudes of the dark- and light-adapted ...
Source: Documenta Ophthalmologica - October 28, 2019 Category: Opthalmology Source Type: research

Evaluation of visual evoked potential binocular summation after corneal refractive surgery
AbstractPurposeTo explore whether visual evoked binocular summation is affected in eyes with refractive errors after refractive surgery.MethodsTwenty participants (6M, 14F) aged 20 –35 years (mean 26.7 ± 4.4) were assessed through pattern-reversal visual evoked potential viewing with their every eye (first right eye and then left eye) and then with both eyes while wearing their best correction before undergoing surgery. Also, parameters of the P100 component of pattern -reversal visual evoked potential were evaluated after 3 months of refractive surgery in two different check sizes. Mon...
Source: Documenta Ophthalmologica - October 25, 2019 Category: Opthalmology Source Type: research

Functional –structural assessment of the optic pathways in patients with optic neuritis
ConclusionsAbnormality is potentially measurable (via reduced RNFLt and focal analyses with mfVEP amplitude) in patients suspected of having a first episode of ON where pVEP reports no abnormality. The mfVEP and SD-OCT may together be of value as supplementary tools in diagnosing ON in this patient group. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - October 17, 2019 Category: Opthalmology Source Type: research