Late-onset night blindness with peripheral flecks accompanied by progressive trickle-like macular degeneration

ConclusionsThe six cases had some common features with the flecked retina syndrome, familial drusen, and late-onset retinal degeneration although none had pathogenic variants causative for these disorders. These cases may represent a subset of severe trickling AMD or a new clinical entity of acquired pan-retinal visual cycle deficiency of unknown etiology.
Source: Documenta Ophthalmologica - Category: Opthalmology Source Type: research

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Abstract BACKGROUND/AIMS: In order to address the eye care needs of the increasing numbers of elderly Chinese globally, there is a need for comprehensive understanding on the longitudinal trends of age-related eye diseases among Chinese. We herein report the key findings from the baseline Singapore Chinese Eye Study (SCES-1), and describe the rationale and methodology of the 6-year follow-up study (SCES-2). METHODS: 3353 Chinese adults who participated in the baseline SCES-1 (2009-2011) were invited for the 6-year follow-up SCES-2 (2015-2017). Examination procedures for SCES-2 included standardised ocular, sy...
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
Age-related macular degeneration (AMD) is the primary cause of blindness and severe vision loss in developed countries and is responsible for 8.7% of blindness globally. Ultraviolet radiation can induce DNA br...
Source: BMC Ophthalmology - Category: Opthalmology Authors: Tags: Research article Source Type: research
Authors: Wei Q, Hu W, Lou Q, Yu J Abstract Age-related macular degeneration (AMD) is a leading cause of blindness and is becoming a global crisis, with the number of affected people expected to reach 288 million by 2040 worldwide. Retinal pigment epithelium (RPE) performs a number of highly diverse functions that are essential to maintaining the normal health and function of the retina. Alterations to retinal metabolism and remodeling are an early feature of AMD. The pathology of AMD is associated with mitochondrial dysfunction. Mitophagy is vital to promote a metabolic shift towards glycolysis that is required for...
Source: Discovery Medicine - Category: Research Tags: Discov Med Source Type: research
AbstractAge-related macular degeneration (AMD) is a leading cause of blindness in the world. While dozens of independent genomic variants are associated with AMD, about one-third of AMD heritability is still unexplained. To identify novel variants and loci for AMD, we analyzed Illumina HumanExome chip data from 87 Amish individuals with early or late AMD, 79 unaffected Amish individuals, and 15 related Amish individuals with unknown AMD affection status. We retained 37,428 polymorphic autosomal variants across 175 samples for association and linkage analyses. After correcting for multiple testing (n = 37,428)...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
Protective effects of delphinidin against H2O2‑induced oxidative injuries in human retinal pigment epithelial cells. Biosci Rep. 2019 Jul 25;: Authors: Ni T, Yang W, Xing Y Abstract Age-related macular degeneration (AMD) is now one of the leading causes of blindness in the elderly population and oxidative stress-induced damage to retinal pigment epithelial (RPE) cells occurs as part of the pathogenesis of AMD. In the present study, we evaluated the protective effect of delphinidin against H2O2-induced toxicity in human ARPE-19 cells and its molecular mechanism. MTT assay and flow cytometry demonstra...
Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research
Conclusion: Visual impairment and blindness are frequent in PXE, particularly in patients older than 50 years. Although choroidal neovascularization is associated with the majority of vision loss, macular atrophy is also common. The proportion of visual impairment in PXE is comparable with late age-related macular degeneration but manifests earlier in life.
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
This article is protected by copyright. All rights reserved. PMID: 31330059 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - Category: Drugs & Pharmacology Authors: Tags: Clin Exp Pharmacol Physiol Source Type: research
Background: Age-related macular degeneration (AMD), a disease that causes irreversible reduction of visual function, is the leading cause of blindness in developed countries. Epidemiological studies have suggested that dietary patterns impact on AMD development and progression. Our aim was to systematically review all the prospective cohort studies available that have evaluated the consumption of different food groups and alcohol in relation to the development and progression of AMD.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
Conclusion: Further prospective, randomized studies of ziv-aflibercept are needed, particularly in eyes with nAMD. PMID: 31314638 [PubMed - as supplied by publisher]
Source: Seminars in Ophthalmology - Category: Opthalmology Tags: Semin Ophthalmol Source Type: research
Because age-related macular degeneration (AMD) has been and remains a leading cause of bilateral blindness, the fellow eye of patients with unilateral neovascular AMD has been studied intensively during the past 50 years. These investigations have aimed to identify the characteristics of eyes and patients that affect the risk of second eye involvement, not only to inform patients of their prognosis but also to increase knowledge about the pathological processes that are involved in the development and progression of AMD.
Source: JAMA Ophthalmology - Category: Opthalmology Source Type: research
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