Early recognition of CLN3 disease facilitated by visual electrophysiology and multimodal imaging
ConclusionsCLN3 patients presented at median age 6.2 years with visual decline. Early onset maculopathy with an electronegative ERG and variable cognitive and motor decline should prompt further investigations including neuropaediatric evaluation and genetic assessment forCLN3 disease. The structural parameters such as EZ and FAF will facilitate ocular monitoring. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - March 25, 2023 Category: Opthalmology Source Type: research
60th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV 2023 Kyoto)
(Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - March 16, 2023 Category: Opthalmology Source Type: research
Pediatric abusive head trauma: visual outcomes, evoked potentials, diffusion tensor imaging, and relationships to retinal hemorrhages
DiscussionMechanisms causing traumatic retinoschisis, or traumatic abnormalities of the macula, are associated with significant long-term visual pathway dysfunction. AHT associated abnormalities of the macula, and visual cortical pathways were more fully captured by VEPs than visual acuity or DTI metrics. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - March 7, 2023 Category: Opthalmology Source Type: research
ISCEV 2023 Symposium Author Index
(Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - March 4, 2023 Category: Opthalmology Source Type: research
60th annual symposium of the international society for clinical electrophysiology of vision (ISCEV 2023 Kyoto)
(Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - March 1, 2023 Category: Opthalmology Source Type: research
Retinitis pigmentosa and nanophthalmos in a patient with attenuated Hunter ’s syndrome
ConclusionThe case report is about a patient presented an attenuated form of the syndrome, with no cognitive impairment. Ophthalmologic follow-up is still an important part of multidisciplinary treatment for Hunter ’s syndrome. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - February 20, 2023 Category: Opthalmology Source Type: research
Rod photoreceptor activation and deactivation in early-stage diabetic eye disease
ConclusionsOnly phototransduction sensitivity was abnormal in this sample of diabetic subjects. The normal deactivation kinetics suggests that circulating rod current is normal. These findings begin to constrain possible explanations for abnormal rod function in early diabetic retinal disease. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - February 10, 2023 Category: Opthalmology Source Type: research
Multifocal electroretinography increases following experimental glaucoma in nonhuman primates with retinal ganglion cell axotomy
ConclusionsThe RMS amplitudes of the short-latency mfERG K1 waveforms are not altered following axotomy but undergo marked increases following elevated IOP. This suggests that the increase in mfERG amplitude was not solely a result of RGC loss and may reflect photoreceptor and bipolar cell dysfunction and/or changes in M üller cells. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - February 10, 2023 Category: Opthalmology Source Type: research
Occult retinopathy following treatment of Hepatitis C with glecaprevir/pibrentasvir (Mavyret)
ConclusionsGiven the temporal relationship between Mavyret administration and vision loss in our patient, and the absence of an underlying cause after extensive evaluation, we propose that Mavyret may be associated with a toxic occult retinopathy characterized by panretinal dysfunction without clinically apparent structural findings. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - February 10, 2023 Category: Opthalmology Source Type: research
Correction to: Temporal frequency dependence of the polarity inversion between upper and lower visual field in the pattern-onset steady-state visual evoked potential
(Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - January 28, 2023 Category: Opthalmology Source Type: research
Frequency-domain analysis of transient visual evoked potentials in schizophrenia
ConclusionsOverall, frequency-domain measures were shown to be objective and recommended as an alternative to conventional, subjective time-domain measures for analyzing tVEPs and in distinguishing between groups (patients vs. controls and patient subgroups). The findings implicated a loss of excitatory input to V1 in schizophrenia. Acuity as measured in the current study reflected disease status, and medication level was associated with improved tVEP responses. These novel tVEP techniques may be useful in revealing neurophysiological processes affected in schizophrenia and as a clinical tool. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - January 27, 2023 Category: Opthalmology Source Type: research
Electrophysiological assessment of nutritional optic neuropathy: a case report
ConclusionsNutritional deficiencies are increasing in high-income countries and may be linked to the rise of gastrointestinal disorders, strict vegan and vegetarian diets and avoidant restrictive food intake disorder (ARFID) associated with conditions such as depression and autism spectrum syndrome (ASD). Our findings highlight the value of electrodiagnostic testing alongside imaging in complex nutritional optic neuropathies to help monitor, guide treatment and preserve remaining sight in a child. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - January 19, 2023 Category: Opthalmology Source Type: research
The role of visual electrodiagnostics in management of children with neurofibromatosis type 1
ConclusionsElectrodiagnostics has multifactorial role and importance in children with NF1, either when visual pathway function is impaired in young children, even before MRI under general anaesthesia and other psychophysical tests can be performed, as well as for a more precise monitoring of the visual pathway function before potential treatment of OPG, or after it, to evaluate its success. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - January 18, 2023 Category: Opthalmology Source Type: research
Message from the editor
(Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - January 13, 2023 Category: Opthalmology Source Type: research
Assessment of digital light processing (DLP) projector stimulators for visual electrophysiology
This study consisted of two sections. The first was a photometric study of two DLP laser projectors (Viewsonic LS831WU and HiSense 100L5FTUK) to assess luminance, contrast, spectral and temporal characteristics of the stimulus. The second was a physiological study comparing pattern electroretinograms (PERG) and visual evoked potentials (PVEPs) amplitudes and peak-times recorded using a DLP laser projector, photometrically and spatially matched to existing plasma VDUs at our institution (Pioneer Electronics Corporation, PDP422MXE).ResultsThe Viewsonic DLP laser projector was capable of high luminance levels (0 –587.5 cd/...
Source: Documenta Ophthalmologica - January 8, 2023 Category: Opthalmology Source Type: research
