Ascitic Fluid Cytokines in Chronic Liver Disease: A Possible Prognostic Tool
Conclusion: Ascitic fluid levels of IL-4, IL-6 and IL-10 are higher in hepatocellular carcinoma patients than patients with cirrhosis alone. Levels of ascitic fluid IL2 and IL10 were proved to be a better prognostic tool than their levels in sera of the same patients. To conclude; patients with cirrhosis may be subjected to scheduale d examination of ascitic fluid cytokine to predect transformation into hepatocellular carcinoma. (Source: Digestive Diseases)
Source: Digestive Diseases - January 12, 2021 Category: Gastroenterology Source Type: research
Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis
Conclusions: A 30% PC containing lecithin in delayed intestinal release formulation imp roves clinical and endoscopic outcomes, histologic activity and quality of life in patients with ulcerative colitis. For the patients lack of adverse events is an important consideration. (Source: Digestive Diseases)
Source: Digestive Diseases - January 12, 2021 Category: Gastroenterology Source Type: research
Clinical and Endoscopic Characteristics of Chinese Cronkhite-Canada Syndrome Patients: A Retrospective Study of 103 cases
Conclusions: middle-aged and elderly people are the high-risk group; various GI symptoms are observed in Chinese patients; the typical endoscopic finding is multiple small sessile polyps; these GI polyps has a chance of malignant potential. Long-term endoscopic surveillance and follow-up are recommended for the Chinese CCS patients.
Key words: Cronkhite-Canada syndrome, Clinical characteristics, Endoscopy (Source: Digestive Diseases)
Source: Digestive Diseases - January 12, 2021 Category: Gastroenterology Source Type: research
Development of an online app to predict post-endoscopic retrograde cholangiopancreatography adverse events using a single center retrospective cohort
Conclusion: Our app may allow an optimization of the patients ’ care, by helping in the process of decision making, not only regarding patient or endoscopist’s selection but also definition of an adequate and tailored surveillance plan after the procedure. (Source: Digestive Diseases)
Source: Digestive Diseases - January 10, 2021 Category: Gastroenterology Source Type: research
Dual Clarithromycin and Metronidazole Resistance is the Main Cause of Failure in Ultimate Helicobacter pylori Eradication
Conclusions: Dual CLA/MET-R w as the main cause of failure in ultimate H. pylori eradication, and 7 days- bismuth quadruple or concomitant regimen would not be suitable for H. pylori eradication in dual CLA/MET-R group. (Source: Digestive Diseases)
Source: Digestive Diseases - January 10, 2021 Category: Gastroenterology Source Type: research
Co-Medication and nutrition in HCC: Potentially preventative strategies in Hepatocellular carcinoma (HCC)
Background: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide with about 841,000 new cases and 782,000 deaths annually. Given the clearly defined population at risk, mostly patients with liver cirrhosis, prevention of HCC could be highly effective.
Summary: Besides regular ultrasound surveillance, numerous publications have suggested protective effects of diverse drugs and nutrients. However, none of those preventive options has made it into clinical routine or practice guidelines. We therefore summarize the current status on preventive effects of drugs such as statins, acetylsa...
Source: Digestive Diseases - January 10, 2021 Category: Gastroenterology Source Type: research
HELICOBACTER PYLORI INFECTION in CHILDREN with CONCURRENT CELIAC DISEASE and TYPE 1 DIABETES MELLITUS
This study aimed to evaluate the association between Hp and concomitant CD+T1DM in children.
Methods: In this two-center, case-control study, children who underwent esophago-gastro-duodenoscopy were studied. CD diagnosis was established by favorable histology and serology. Hp infection was confirmed by both histology and the rapid urease test. Patients were divided into three groups as CD only (CDo), CD+T1DM, and non-CD children who underwent endoscopy as controls.
Results: Among the 1431 esophago-gastro-duodenoscopies performed, 783 cases were eligible. Overall, 215 cases had CDo (mean age: 9.12 ±4.18 years, 58.1% girl...
Source: Digestive Diseases - January 10, 2021 Category: Gastroenterology Source Type: research
Skeletal muscle depletion: a risk factor for pneumonia following gastric endoscopic submucosal dissection in elderly patients
Conclusions: SMD was not a rare entity in patients aged ≥80 years with gastric neoplasms. SMD was a significant risk factor for pneumonia related to gastric ESD in elderly patients. (Source: Digestive Diseases)
Source: Digestive Diseases - January 10, 2021 Category: Gastroenterology Source Type: research
Humoral immune responses and Hepatitis B Infection
Background- Chronicity or seroclearance of HBV antigens is determined by the host immune responses. Current approaches to treat Hepatitis B (HBV) patients are based on inhibition of replication using different antivirals (nucleoside or nucleotide analogues) as monotherapy or along with immune modulators as combination therapy is being used worldwide for reducing the viral load. Understanding the role of immune cellular therapies with currently available treatments for persistent viral-mediated responses in HBV patients is unexplored. However, the generation of antibodies against a surface (HBs) and envelop (HBe) antigen of...
Source: Digestive Diseases - January 10, 2021 Category: Gastroenterology Source Type: research
Reflux aspiration associated with oesophageal dysmotility but not delayed liquid gastric emptying
Abstract
Introduction
Severe oesophageal dysmotility is associated with treatment resistant reflux and pulmonary reflux aspiration. Delayed solid gastric emptying (SGE) has been associated with oesophageal dysmotility, however the role of delayed liquid gastric emptying (LGE) in the pathophysiology of sev ere reflux disease remains unknown. The purpose of this study is to examine the relationship between delayed LGE, reflux aspiration and oesophageal dysmotility.
Methods
Data was extracted from a prospectively populated database of patients with severe treatment resistant gastro-oesophageal reflux disease (GORD). All ...
Source: Digestive Diseases - December 29, 2020 Category: Gastroenterology Source Type: research
Prognostic Significance of ACP5 in Human Gastric Cancer
Conclusions: The expression of ACP5 in GC tissue was significantly higher than that in normal tissues and its overexpression was associated with a poorer prognosis, suggesting its potential roles in preventing and treating GC. (Source: Digestive Diseases)
Source: Digestive Diseases - December 13, 2020 Category: Gastroenterology Source Type: research
Worse Response to Ursodeoxycholic Acid in Primary Biliary Cholangitis Patients with Autoimmune Hepatitis Features
This study was to elucidate the clinical characteristics of PBC patients with features of AIH.
Methods: We included patients with diagnostic criteria of PBC. All patients were treated with ursodeoxycholic acid (UDCA) and without immunosuppressive agents for more than one year. The biochemical response was evaluated at one year after treatment of UCDA.
Results: Among 432 patients with PBC, 166 (38.4%) patients did not achieve biochemical response within one year of UDCA treatment. Non-responders had lower albumin (ALB) level and higher immunoglobulin G (IgG), alanine transaminase (ALT), alanine aminotransferase (AST), alk...
Source: Digestive Diseases - November 24, 2020 Category: Gastroenterology Source Type: research
LncRNA PMS2L2 downregulates miR-24 through methylation to suppress cell apoptosis in ulcerative colitis
Conclusion: PMS2L2 may downregulate miR-24 via methylation to suppress cell apoptosis in UC. (Source: Digestive Diseases)
Source: Digestive Diseases - November 24, 2020 Category: Gastroenterology Source Type: research
Prevalence of the Metabolic Syndrome in Severely Obese Patients Presenting for Bariatric Surgery
Conclusion: In severely obese patie nts the prevalence of the MS and the number of criteria met was high. However, over 20% of severely obese individuals have no MS and thus may be at lower risk for cardiovascular complications of obesity. It is currently unclear whether treatment strategies with respect to obesity should differ betwe en severely obese individuals with and without the MS. (Source: Digestive Diseases)
Source: Digestive Diseases - November 15, 2020 Category: Gastroenterology Source Type: research
Does perianal disease influence the efficacy of combination therapy in Crohn ’s disease?
Conclusion: In the first year of combination therapy, perianal disease is associated with an 80% decrease in endoscopic and clinical remission rates and higher ratio of disease relapse. (Source: Digestive Diseases)
Source: Digestive Diseases - November 15, 2020 Category: Gastroenterology Source Type: research
